Select a medication above to begin.
Adult Dosing .
Dosage forms: INJ
hepatitis A disease prevention
- [1 mL IM x2 doses 6-12mo apart]
- Start: within 2wk prior to expected HAV exposure; Info: may give initial dose with 0.1-0.2 mL/kg immune globulin (human) for travel to endemic areas within 2wk if patients >40 yo, immunocompromised, chronic liver disease, other chronic conditions; search 'immunization' for epocrates Adult Immunization and CDC Pre-Travel Vaccine decision tools including links to CDC/ACIP schedules and recommendations
hepatitis A post-exposure prophylaxis (off-label)
- [1 mL IM x1]
- Start: within 2wk of exposure; Info: for patients who have not previously completed the 2-dose hepatitis A vaccine series; may give with 0.1 mL/kg immune globulin (human) in patients >40 yo; give with 0.1 mL/kg immune globulin (human) if immunocompromised, chronic liver disease, other chronic conditions; give 2nd dose per schedule to complete vaccine series
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
- Dosage forms: INJ
hepatitis A disease prevention
- [12 mo and older]
- Dose: 0.5 mL IM x2 doses at least 6-12mo apart; Start: within 2wk prior to expected HAV exposure; Info: may give with 0.1-0.2 mL/kg immune globulin (human) if immunocompromised, chronic liver disease, other chronic conditions; search 'immunization' for epocrates Child/Adolescent Immunization and CDC Pre-Travel Vaccine decision tools including links to CDC/ACIP schedules and recommendations
hepatitis A prophylaxis (off-label)
- [pre-exposure, 6 mo and older]
- Dose: 0.5 mL IM x1; Info: for patients traveling to endemic countries; not counted toward routine 2-dose series if 6-11 mo; may give with 0.1-0.2 mL/kg immune globulin (human) in patients 12 mo and older if immunocompromised, chronic liver disease, other chronic conditions; search 'immunization' for epocrates CDC Pre-Travel Vaccine decision tools including links to CDC recommendations
- [post-exposure]
- Dose: 0.5 mL IM x1; Start: within 2wk of exposure; Info: for patients 12 mo and older who have not previously completed the 2-dose hepatitis A series; give with 0.1 mL/kg immune globulin (human) if immunocompromised, chronic liver disease, other chronic conditions; give 2nd dose per schedule to complete routine vaccine series
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- hypersensitivity to neomycin
- caution: immunocompromised patients
- caution: illness, acute moderate-severe
Drug Interactions .
Overview
hepatitis A vaccine
vaccine
- non-live vaccine
Avoid/Use Alternative
- interferon gamma 1b
Monitor/Modify Tx
- abatacept
- abemaciclib
- abrocitinib
- acalabrutinib
- adalimumab
- ado-trastuzumab emtansine
- afamitresgene autoleucel
- aldesleukin
- alemtuzumab
- amivantamab
- anakinra
- anifrolumab
- anti-thymocyte globulin
- asciminib
- atezolizumab
- atidarsagene autotemcel
- avelumab
- avutometinib
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- baricitinib
- basiliximab
- belantamab mafodotin
- belatacept
- belimumab
- belinostat
- belzutifan
- bendamustine
- betamethasone
- bimekizumab
- blinatumomab
- bortezomib
- brentuximab vedotin
- brexucabtagene autoleucel
- brodalumab
- budesonide
- budesonide rectal
- busulfan
- cabazitaxel
- canakinumab
- capecitabine
- capmatinib
- carboplatin
- carfilzomib
- carmustine
- cemiplimab
- certolizumab pegol
- chlorambucil
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- cladribine oral
- clofarabine
- copanlisib
- corticotropin
- cortisone
- cosibelimab
- cyclophosphamide
- cyclosporine
- cytarabine
- dactinomycin
- daratumumab
- dasatinib
- daunorubicin
- decitabine
- defactinib
- deflazacort
- delgocitinib topical
- deucravacitinib
- deuruxolitinib
- dexamethasone
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- docetaxel
- dordaviprone
- dostarlimab
- doxorubicin
- dupilumab
- durvalumab
- duvelisib
- efgartigimod alfa
- elivaldogene autotemcel
- elotuzumab
- elranatamab
- emapalumab
- epcoritamab
- epirubicin
- erdafitinib
- eribulin
- etanercept
- etoposide
- etrasimod
- etuvetidigene autotemcel
- everolimus
- fam-trastuzumab deruxtecan
- fingolimod
- floxuridine
- fludarabine
- fludrocortisone
- fluorouracil
- fruquintinib
- futibatinib
- gemcitabine
- gemtuzumab ozogamicin
- glofitamab
- golimumab
- guselkumab
- hydrocortisone
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- icotrokinra
- idarubicin
- idecabtagene vicleucel
- idelalisib
- ifosfamide
- imatinib
- inebilizumab
- infliximab
- inotuzumab ozogamicin
- ipilimumab
- irinotecan
- isatuximab
- ixabepilone
- ixekizumab
- lazertinib
- lebrikizumab
- leflunomide
- lenalidomide
- linvoseltamab
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- lurbinectedin
- lymphocyte immune globulin, anti-thymocyte globulin
- margetuximab
- melphalan
- mercaptopurine
- methotrexate
- methylprednisolone
- mirikizumab
- mitomycin
- mitoxantrone
- mogamulizumab
- momelotinib
- monomethyl fumarate
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- natalizumab
- nelarabine
- nemolizumab
- nilotinib
- nipocalimab
- nivolumab
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- olaparib
- oxaliplatin
- ozanimod
- paclitaxel
- palbociclib
- pembrolizumab
- pemetrexed
- penpulimab
- pentostatin
- pertuzumab
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- ponesimod
- prednisolone
- prednisone
- procarbazine
- regorafenib
- retifanlimab
- revumenib
- rilonacept
- rilzabrutinib
- ripretinib
- risankizumab
- ritlecitinib
- rituximab
- romidepsin
- ropeginterferon alfa-2b
- rozanolixizumab
- rucaparib
- ruxolitinib
- sarilumab
- satralizumab
- secukinumab
- selinexor
- selumetinib
- sevabertinib
- sibeprenlimab
- siltuximab
- siponimod
- sirolimus
- sirolimus albumin-bound
- sirolimus topical
- sorafenib
- spesolimab
- sunitinib
- sunvozertinib
- tacrolimus
- tafasitamab
- taletrectinib
- talquetamab
- tarlatamab
- teclistamab
- telisotuzumab vedotin
- temozolomide
- temsirolimus
- teplizumab
- teriflunomide
- thioguanine
- thiotepa
- tildrakizumab
- tisagenlecleucel
- tislelizumab
- tocilizumab
- tofacitinib
- topotecan
- toripalimab
- trabectedin
- tralokinumab
- trastuzumab
- tremelimumab
- triamcinolone
- ublituximab
- upadacitinib
- ustekinumab
- vamorolone
- vandetanib
- vedolizumab
- venetoclax
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- zanidatamab
- zanubrutinib
- zenocutuzumab
- ziftomenib
- zongertinib
Adverse Reactions .
Serious Reactions
- anaphylactoid reaction
- anaphylaxis
- angioedema
- erythema multiforme
- hepatotoxicity
- thrombocytopenia
- neurotoxicity
- Guillain-Barre syndrome
- encephalopathy
- seizures
- lymphadenopathy
Common Reactions
- injection site reaction
- irritability
- anorexia
- fatigue
- headache
- fever
- malaise
- nausea
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
Havrix confused with: Heptavax
hepatitis A vaccine, inactivated confused with: hepatitis B vaccine, recombinant
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; risk of fetal harm not expected based on limited human data
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm not expected based on vaccine properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for hepatitis A vaccine: other; CYP450: unknown
Excretion: for hepatitis A vaccine: unknown; Half-life: unknown
Subclass: Hepatitis A (HAV) Vaccines ; Routine Adult Vaccines ; Routine Pediatric Vaccines ; Travel Vaccines
Mechanism of Action
for hepatitis A vaccine: exact mechanism of action unknown; induces antibody formation
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.