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amcinonide topical
generic
Adult Dosing .
Dosage forms: OINT: 0.1%; CRM: 0.1%; LOTION: 0.1%
Special Note
- [strength clarification]
- Info: amcinonide 0.1% ointment = high potency; 0.1% cream, lotion = high/medium potency
- [additional info]
- Info: search Topical Corticosteroid Potencies for Rx and OTC products classified by potency w/ dosage forms and strengths
dermatoses, steroid-responsive
- [apply bid-tid]
atopic dermatitis (off-label)
- [apply qd-bid]
- Info: consider applying medium potency product 2x/wk after clinical effect achieved for maintenance tx
Peds Dosing .
- Dosage forms: OINT: 0.1%; CRM: 0.1%; LOTION: 0.1%
Special Note
- [strength clarification]
- Info: amcinonide 0.1% ointment = high potency; 0.1% cream, lotion = high/medium potency
- [additional info]
- Info: search Topical Corticosteroid Potencies for Rx and OTC products classified by potency w/ dosage forms and strengths
atopic dermatitis (off-label)
- [1 yo and older]
- Dose: apply qd-bid; Info: consider applying medium potency product 2x/wk after clinical effect achieved for maintenance tx
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: hypersensitivity to corticosteroids
- caution: skin infection
- caution: peds patients
Drug Interactions .
Overview
amcinonide topical
corticosteroid topical
- hyperglycemic effects
Monitor/Modify Tx
- acarbose
- alogliptin
- bexagliflozin
- bromocriptine
- canagliflozin
- colesevelam
- dapagliflozin
- dulaglutide
- empagliflozin
- ertugliflozin
- exenatide
- glimepiride
- glipizide
- glyburide
- insulin
- linagliptin
- liraglutide
- lixisenatide
- metformin
- miglitol
- nateglinide
- pioglitazone
- pramlintide
- repaglinide
- rosiglitazone
- saxagliptin
- semaglutide
- sitagliptin
- tirzepatide
Adverse Reactions .
Serious Reactions
- HPA axis suppression (prolonged use)
- Cushing syndrome (prolonged use)
- hyperglycemia (prolonged use)
- cataracts (prolonged use)
- glaucoma (prolonged use)
- intracranial HTN (prolonged use in peds patients)
Common Reactions
- burning
- pruritus
- irritation
- dryness
- folliculitis
- hypertrichosis
- acneiform dermatitis
- hypopigmentation
- perioral dermatitis
- allergic contact dermatitis
- maceration
- secondary infection
- skin atrophy
- striae
- miliaria
Safety/Monitoring .
Monitoring Parameters
ACTH stimulation test if HPA axis suppression risk
Pregnancy/Lactation .
Pregnancy
Clinical Summary
consider lower potency steroid during pregnancy w/ long-term use or if large application site; no human data available, though risk of fetal harm low based on potential systemic absorption
Lactation
Clinical Summary
may use short-term while breastfeeding, otherwise weigh risk/benefit; use lowest potency steroid if used on breast and thoroughly remove before breastfeeding; inadequate human data available, though possible risk of infant harm w/ long-term extensive use or infant oral ingestion; no human data available to assess effects on milk production
Pharmacology .
Metabolism: liver primarily; CYP450: unknown; Info: systemic absorption varies w/ application area and site, occlusion, and patient-specific factors
Excretion: urine; Half-life: unknown
Subclass: Corticosteroids, Topical 2: High Potency ; Corticosteroids, Topical 3: High/Medium Potency
Mechanism of Action
exact mechanism of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: generic
DEA/FDA: Rx
Retail Price
Estimated prices only. For current pricing, visit GoodRx.
topical ointment:
- 0.1 % (1 tube of ointment, 60 g): $280.00
topical cream:
- 0.1 % (1 tube of cream, 60 g): $192.00
topical cream:
- 0.1 % (1 tube of cream, 30 g): $101.00
topical cream:
- 0.1 % (1 tube of cream, 15 g): $56.00
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