Select a medication above to begin.
Tradjenta
linagliptin
Adult Dosing .
Dosage forms: TAB: 5 mg
diabetes mellitus, type 2
- [5 mg PO qd]
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- diabetes mellitus, type 1
- caution: angioedema history, DPP-4 inhibitor-associated
- caution: heart failure risk
- caution: pancreatitis risk
Drug Interactions .
Overview
linagliptin
DPP-4 inhibitor
- CYP3A4 substrate
- P-gp substrate
- antidiabetic agent
- cardiotoxic effects
Avoid/Use Alternative
- alogliptin
- apalutamide
- butalbital
- carbamazepine
- danshen
- dicloxacillin
- efavirenz
- encorafenib
- enzalutamide
- epirubicin
- fosphenytoin
- idarubicin
- ivosidenib
- lorlatinib
- lumacaftor/ivacaftor
- mitotane
- pentobarbital
- phenobarbital
- phenytoin
- primidone
- rifabutin
- rifampin
- rifapentine
- saxagliptin
- sitagliptin
- St. John's wort
- tipranavir
- turmeric
- vaborbactam
Monitor/Modify Tx
- acebutolol
- adalimumab
- ado-trastuzumab emtansine
- aficamten
- alclometasone topical
- aldesleukin
- aloe
- alpelisib
- amcinonide topical
- anagrelide
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- arsenic trioxide
- asciminib
- asenapine
- ashwagandha
- asparaginase
- aspirin
- atazanavir
- avelumab
- axitinib
- benazepril
- berberine
- betamethasone
- betamethasone topical
- bevacizumab
- bezlotoxumab
- binimetinib
- bismuth subsalicylate
- bortezomib
- bosutinib
- brentuximab vedotin
- brexpiprazole
- brigatinib
- bromocriptine
- budesonide
- bumetanide
- calaspargase
- canagliflozin
- capecitabine
- capivasertib
- carfilzomib
- cariprazine
- carvedilol
- cassia cinnamon
- ceritinib
- certolizumab pegol
- chloroquine
- chlorothiazide
- chlorthalidone
- chromium
- cilostazol
- ciprofloxacin
- clarithromycin
- clobetasol topical
- clocortolone topical
- clozapine
- cobimetinib
- colesevelam
- copanlisib
- corticotropin
- cortisone
- cyclophosphamide
- dabrafenib
- danazol
- darunavir
- daunorubicin
- decitabine
- deflazacort
- delafloxacin
- desogestrel (contraceptive)
- desonide topical
- desoximetasone topical
- dexamethasone
- diazoxide
- dienogest (contraceptive)
- diflorasone topical
- disopyramide
- doxorubicin
- dronedarone
- drospirenone (contraceptive)
- eleuthero
- enfortumab vedotin
- ensartinib
- entrectinib
- ephedra
- epinephrine
- ertugliflozin
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- etanercept
- ethacrynic acid
- ethanol (alcoholic beverage)
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethionamide
- ethynodiol (contraceptive)
- etonogestrel (contraceptive)
- everolimus
- exenatide
- fam-trastuzumab deruxtecan
- fenugreek
- flaxseed
- fludrocortisone
- fluocinolone otic
- fluocinolone topical
- fluocinonide topical
- fluorouracil
- fluoxetine
- flurandrenolide topical
- fluticasone propionate topical
- fosamprenavir
- furosemide
- garlic
- ginkgo
- ginseng, American
- ginseng, Asian
- glimepiride
- glipizide
- glyburide
- golimumab
- goserelin
- gymnema
- halcinonide topical
- halobetasol topical
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroxychloroquine
- ibrutinib
- ifosfamide
- iloperidone
- imatinib
- inavolisib
- indapamide
- infliximab
- insulin
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- isocarboxazid
- isoniazid
- itraconazole
- lanreotide
- lapatinib
- lenvatinib
- leuprolide
- levofloxacin
- levonorgestrel (contraceptive)
- levothyroxine
- linezolid
- liothyronine
- liraglutide
- lisinopril
- lixisenatide
- lopinavir/ritonavir
- lumateperone
- lurasidone
- lutetium Lu 177 dotatate
- margetuximab
- mavacamten
- mecasermin
- medroxyprogesterone (contraceptive)
- megestrol
- meropenem
- methylprednisolone
- methyltestosterone
- metolazone
- metreleptin
- milk thistle
- milsaperidone
- mirdametinib
- mitoxantrone
- mobocertinib
- mometasone topical
- moxifloxacin
- nadolol
- nateglinide
- nelfinavir
- niacin (vitamin B3)
- norelgestromin (contraceptive)
- norepinephrine
- norethindrone (contraceptive)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- octreotide
- ofloxacin
- olanzapine
- osimertinib
- oxcarbazepine
- paliperidone
- paltusotine
- pasireotide
- pazopanib
- pegaspargase
- peginterferon alfa 2a
- peginterferon beta 1a
- pegvisomant
- pentamidine
- pertuzumab
- phenelzine
- phenylephrine
- pindolol
- pioglitazone
- plozasiran
- ponatinib
- pramlintide
- prednicarbate topical
- prednisolone
- prednisone
- propafenone
- pseudoephedrine
- quetiapine
- quinine
- repaglinide
- ribose
- ripretinib
- risperidone
- ritonavir
- ropeginterferon alfa-2b
- rosiglitazone
- sacrosidase
- segesterone (contraceptive)
- selumetinib
- semaglutide
- sirolimus albumin-bound
- somapacitan
- somatrogon
- somatropin
- sorafenib
- sotagliflozin
- sotalol
- spironolactone
- sucralfate
- sunitinib
- temsirolimus
- teprotumumab
- tesamorelin
- testosterone
- thyroid
- timolol
- tivozanib
- torsemide
- trabectedin
- tramadol
- trametinib
- trandolapril
- tranylcypromine
- trastuzumab
- triamcinolone
- triamcinolone topical
- triamterene
- triptorelin
- vamorolone
- vandetanib
- vorinostat
- zanidatamab
- zenocutuzumab
- ziprasidone
- zongertinib
Adverse Reactions .
Serious Reactions
- hypersensitivity reaction
- anaphylaxis
- angioedema
- hypoglycemia
- heart failure
- pancreatitis
- arthralgia, severe
- rhabdomyolysis
- bullous pemphigoid
Common Reactions
- nasopharyngitis
- diarrhea
- uric acid incr.
- hyperlipasemia
- cough
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
Tradjenta confused with: Tanzeum; Toujeo; Tresiba; Trulicity
linaGLIPtin confused with: linaCLOtide
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 49x MRHD
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for linagliptin: minimal; CYP450: 3A4 substrate
Excretion: for linagliptin: feces 80% (100% unchanged), urine 5% (100% unchanged); Half-life: 11-12h; Info: terminal half-life 200h due to DPP-4 saturable binding
Subclass: Diabetes: DPP-4 Inhibitors
Mechanism of Action
for linagliptin: inhibits dipeptidyl peptidase-4, slowing incretin metabolism, increasing insulin synthesis/release, decreasing glucagon levels
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.