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Tradjenta
linagliptin
Adult Dosing .
Dosage forms: TAB: 5 mg
diabetes mellitus, type 2
- [5 mg PO qd]
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- diabetes mellitus, type 1
- caution: heart failure risk
- caution: pancreatitis risk
Drug Interactions .
Overview
linagliptin
DPP-4 inhibitor
- CYP3A4 substrate
- P-gp substrate
- antidiabetic agent
- cardiotoxic effects
Avoid/Use Alternative
- alogliptin
- apalutamide
- butalbital
- carbamazepine
- danshen
- dicloxacillin
- efavirenz
- encorafenib
- enzalutamide
- epirubicin
- fosphenytoin
- idarubicin
- ivosidenib
- lorlatinib
- lumacaftor/ivacaftor
- mitotane
- pentobarbital
- phenobarbital
- phenytoin
- primidone
- rifabutin
- rifampin
- rifapentine
- saxagliptin
- sitagliptin
- St. John's wort
- tipranavir
- turmeric
Monitor/Modify Tx
- acebutolol
- adalimumab
- ado-trastuzumab emtansine
- alclometasone topical
- aldesleukin
- aloe
- alpelisib
- amcinonide topical
- aripiprazole bimonthly injection
- aripiprazole lauroxil
- aripiprazole monthly injection
- aripiprazole oral
- arsenic trioxide
- asciminib
- asenapine
- ashwagandha
- asparaginase
- aspirin
- atazanavir
- avelumab
- axitinib
- benazepril
- berberine
- betamethasone
- betamethasone topical
- bevacizumab
- bezlotoxumab
- binimetinib
- bismuth subsalicylate
- bortezomib
- brentuximab vedotin
- brexpiprazole
- brigatinib
- bromocriptine
- budesonide
- bumetanide
- calaspargase
- canagliflozin
- capecitabine
- capivasertib
- carfilzomib
- cariprazine
- carvedilol
- cassia cinnamon
- ceritinib
- certolizumab pegol
- chloroquine
- chlorothiazide
- chlorthalidone
- chromium
- ciprofloxacin
- clarithromycin
- clobetasol topical
- clocortolone topical
- clozapine
- colesevelam
- copanlisib
- corticotropin
- cortisone
- cyclophosphamide
- dabrafenib
- danazol
- darunavir
- daunorubicin
- decitabine
- deflazacort
- delafloxacin
- desogestrel (contraceptive)
- desonide topical
- desoximetasone topical
- dexamethasone
- diazoxide
- dienogest (contraceptive)
- diflorasone topical
- disopyramide
- doxorubicin
- drospirenone (contraceptive)
- eleuthero
- enfortumab vedotin
- ensartinib
- ephedra
- epinephrine
- ertugliflozin
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethacrynic acid
- ethanol
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethionamide
- ethynodiol (contraceptive)
- etonogestrel (contraceptive)
- everolimus
- exenatide
- fam-trastuzumab deruxtecan
- fenugreek
- flaxseed
- fludrocortisone
- fluocinolone otic
- fluocinolone topical
- fluocinonide topical
- fluoxetine
- flurandrenolide topical
- fluticasone propionate topical
- fosamprenavir
- furosemide
- garlic
- ginkgo
- ginseng, American
- ginseng, Asian
- glimepiride
- glipizide
- glyburide
- goserelin
- gymnema
- halcinonide topical
- halobetasol topical
- histrelin
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroxychloroquine
- ibrutinib
- ifosfamide
- iloperidone
- imatinib
- inavolisib
- indapamide
- infliximab
- insulin
- interferon beta 1a
- interferon beta 1b
- isocarboxazid
- isoniazid
- lanreotide
- lenvatinib
- leuprolide
- levofloxacin
- levonorgestrel (contraceptive)
- levothyroxine
- linezolid
- liothyronine
- liraglutide
- lisinopril
- lixisenatide
- lopinavir/ritonavir
- lumateperone
- lurasidone
- lurbinectedin
- lutetium Lu 177 dotatate
- margetuximab
- mavacamten
- mecasermin
- medroxyprogesterone (contraceptive)
- megestrol
- meropenem
- methylprednisolone
- methyltestosterone
- metolazone
- metreleptin
- milk thistle
- mirdametinib
- mitoxantrone
- mometasone topical
- moxifloxacin
- nadolol
- nateglinide
- nelfinavir
- niacin (vitamin B3)
- norelgestromin (contraceptive)
- norepinephrine
- norethindrone (contraceptive)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- octreotide
- ofloxacin
- olanzapine
- oxcarbazepine
- paliperidone
- pasireotide
- pazopanib
- pegaspargase
- peginterferon alfa 2a
- peginterferon beta 1a
- pegvisomant
- pentamidine
- pertuzumab
- phenelzine
- phenylephrine
- pindolol
- pioglitazone
- ponatinib
- pramlintide
- prednicarbate topical
- prednisolone
- prednisone
- propafenone
- pseudoephedrine
- quetiapine
- quinine
- repaglinide
- ribose
- ripretinib
- risperidone
- ritonavir
- rosiglitazone
- sacrosidase
- segesterone (contraceptive)
- selumetinib
- semaglutide
- sirolimus albumin-bound
- somapacitan
- somatrogon
- somatropin
- sorafenib
- sotagliflozin
- sotalol
- spironolactone
- sucralfate
- sunitinib
- temsirolimus
- teprotumumab
- tesamorelin
- testosterone
- thyroid
- timolol
- tivozanib
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trastuzumab
- triamcinolone
- triamcinolone topical
- triamterene
- triptorelin
- vaborbactam
- vamorolone
- vorinostat
- zanidatamab
- zenocutuzumab
- ziprasidone
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
- hypoglycemia
- heart failure
- pancreatitis
- arthralgia, severe
- rhabdomyolysis
- bullous pemphigoid
Common Reactions
- nasopharyngitis
- hypoglycemia
- diarrhea
- hyperuricemia
- hyperlipasemia
- cough
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Look/Sound-Alike Drug Names
linaGLIPtin confused with: linaCLOtide
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 49x recommended human dose
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: minimal; CYP450: 3A4 substrate
Excretion: feces 80%, urine 5% (90% unchanged); Half-life: 11-12h
Subclass: Diabetes: DPP-4 Inhibitors
Mechanism of Action
inhibits dipeptidyl peptidase-4, slowing incretin metabolism, increasing insulin synthesis/release, decreasing glucagon levels
Formulary .
No Formulary Selected
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