Trintellix

Overview

vortioxetine

serotonin modulator

• CYP2B6 substrate
• CYP2C8 substrate
• CYP2C9 substrate
• CYP2C19 substrate
• CYP2D6 substrate
• CYP3A4 substrate
• antiplatelet effects
• hyponatremia
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• isocarboxazid
Trintellix (vortioxetine)

+

isocarboxazid

1 interaction

Contraindicated

vortioxetine + isocarboxazid

contraindicated; may initiate vortioxetine 14 days after isocarboxazid D/C; may initiate isocarboxazid 21 days after vortioxetine D/C: combo may incr. risk of serotonin syndrome (additive effects)

• linezolid
Trintellix (vortioxetine)

+

linezolid

1 interaction

Contraindicated

vortioxetine + linezolid

contraindicated; hold vortioxetine if urgent use; monitor sodium, serotonin syndrome sx x21 days after vortioxetine D/C or 24h after last linezolid dose; may resume vortioxetine 24h after last linezolid dose: combo may incr. risk of serotonin syndrome, hyponatremia (additive effects, linezolid reversibly inhibits monoamine oxidase)

• methylene blue injection
Trintellix (vortioxetine)

+

methylene blue injection

1 interaction

Contraindicated

vortioxetine + methylene blue injection

contraindicated; hold vortioxetine if emergency use; monitor serotonin syndrome sx x21 days after vortioxetine D/C or 24h after last methylene blue dose; may resume vortioxetine 24h after last methylene blue dose: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• phenelzine
Trintellix (vortioxetine)

+

phenelzine

1 interaction

Contraindicated

vortioxetine + phenelzine

contraindicated; may initiate vortioxetine 14 days after phenelzine D/C; may initiate phenelzine 21 days after vortioxetine D/C: combo may incr. risk of serotonin syndrome (additive effects)

• selegiline transdermal
Trintellix (vortioxetine)

+

selegiline transdermal

1 interaction

Contraindicated

vortioxetine + selegiline transdermal

contraindicated; may initiate vortioxetine 14 days after selegiline D/C; may initiate selegiline 21 days after vortioxetine D/C: combo may incr. risk of serotonin syndrome (additive effects)

• tranylcypromine
Trintellix (vortioxetine)

+

tranylcypromine

1 interaction

Contraindicated

vortioxetine + tranylcypromine

contraindicated; may initiate vortioxetine 14 days after tranylcypromine D/C; may initiate tranylcypromine 21 days after vortioxetine D/C: combo may incr. risk of serotonin syndrome (additive effects)

Avoid/Use Alternative

• 5-HTP
Trintellix (vortioxetine)

+

5-HTP

1 interaction

Avoid/Use Alternative

vortioxetine + 5-HTP

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• alfentanil
Trintellix (vortioxetine)

+

alfentanil

1 interaction

Avoid/Use Alternative

vortioxetine + alfentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• almotriptan
Trintellix (vortioxetine)

+

almotriptan

1 interaction

Avoid/Use Alternative

vortioxetine + almotriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• amitriptyline
Trintellix (vortioxetine)

+

amitriptyline

1 interaction

Avoid/Use Alternative

vortioxetine + amitriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• amoxapine
Trintellix (vortioxetine)

+

amoxapine

1 interaction

Avoid/Use Alternative

vortioxetine + amoxapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• amphetamine
Trintellix (vortioxetine)

+

amphetamine

1 interaction

Avoid/Use Alternative

vortioxetine + amphetamine

use alternative or decr. amphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• black cohosh
Trintellix (vortioxetine)

+

black cohosh

1 interaction

Avoid/Use Alternative

vortioxetine + black cohosh

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• bromocriptine
Trintellix (vortioxetine)

+

bromocriptine

1 interaction

Avoid/Use Alternative

vortioxetine + bromocriptine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• buprenorphine
Trintellix (vortioxetine)

+

buprenorphine

1 interaction

Avoid/Use Alternative

vortioxetine + buprenorphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• buspirone
Trintellix (vortioxetine)

+

buspirone

1 interaction

Avoid/Use Alternative

vortioxetine + buspirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• butorphanol
Trintellix (vortioxetine)

+

butorphanol

1 interaction

Avoid/Use Alternative

vortioxetine + butorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• carbamazepine
Trintellix (vortioxetine)

+

carbamazepine

1 interaction

Avoid/Use Alternative

vortioxetine + carbamazepine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider incr. vortioxetine dose up to 3x maintenance dose if carbamazepine coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy; may incr. risk of hyponatremia, seizures, serotonin syndrome (hepatic metab. induced; additive effects)

• citalopram
Trintellix (vortioxetine)

+

citalopram

1 interaction

Avoid/Use Alternative

vortioxetine + citalopram

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• clomipramine
Trintellix (vortioxetine)

+

clomipramine

1 interaction

Avoid/Use Alternative

vortioxetine + clomipramine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of hyponatremia, serotonin syndrome (additive effects)

• cocaine
Trintellix (vortioxetine)

+

cocaine

1 interaction

Avoid/Use Alternative

vortioxetine + cocaine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
Trintellix (vortioxetine)

+

codeine

1 interaction

Avoid/Use Alternative

vortioxetine + codeine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• cyclobenzaprine
Trintellix (vortioxetine)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

vortioxetine + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• desipramine
Trintellix (vortioxetine)

+

desipramine

1 interaction

Avoid/Use Alternative

vortioxetine + desipramine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, hyponatremia (additive effects)

• desvenlafaxine
Trintellix (vortioxetine)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

vortioxetine + desvenlafaxine

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• dexmethylphenidate
Trintellix (vortioxetine)

+

dexmethylphenidate

1 interaction

Avoid/Use Alternative

vortioxetine + dexmethylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
Trintellix (vortioxetine)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

vortioxetine + dextroamphetamine

use alternative or decr. dextroamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
Trintellix (vortioxetine)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

vortioxetine + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dihydrocodeine
Trintellix (vortioxetine)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

vortioxetine + dihydrocodeine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dihydroergotamine
Trintellix (vortioxetine)

+

dihydroergotamine

1 interaction

Avoid/Use Alternative

vortioxetine + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• doxepin
Trintellix (vortioxetine)

+

doxepin

1 interaction

Avoid/Use Alternative

vortioxetine + doxepin

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• doxepin topical
Trintellix (vortioxetine)

+

doxepin topical

1 interaction

Avoid/Use Alternative

vortioxetine + doxepin topical

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• duloxetine
Trintellix (vortioxetine)

+

duloxetine

1 interaction

Avoid/Use Alternative

vortioxetine + duloxetine

avoid combo: combo may incr. vortioxetine levels, risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• edoxaban
Trintellix (vortioxetine)

+

edoxaban

1 interaction

Avoid/Use Alternative

vortioxetine + edoxaban

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eletriptan
Trintellix (vortioxetine)

+

eletriptan

1 interaction

Avoid/Use Alternative

vortioxetine + eletriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• enoxaparin
Trintellix (vortioxetine)

+

enoxaparin

1 interaction

Avoid/Use Alternative

vortioxetine + enoxaparin

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ergotamine
Trintellix (vortioxetine)

+

ergotamine

1 interaction

Avoid/Use Alternative

vortioxetine + ergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• escitalopram
Trintellix (vortioxetine)

+

escitalopram

1 interaction

Avoid/Use Alternative

vortioxetine + escitalopram

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, duplicate tx)

• fenfluramine
Trintellix (vortioxetine)

+

fenfluramine

1 interaction

Avoid/Use Alternative

vortioxetine + fenfluramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• fentanyl
Trintellix (vortioxetine)

+

fentanyl

1 interaction

Avoid/Use Alternative

vortioxetine + fentanyl

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• fluoxetine
Trintellix (vortioxetine)

+

fluoxetine

1 interaction

Avoid/Use Alternative

vortioxetine + fluoxetine

avoid combo: combo may incr. vortioxetine levels, risk of serotonin syndrome, bleeding (incl. life-threatening), hyponatremia, other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• fluvoxamine
Trintellix (vortioxetine)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

vortioxetine + fluvoxamine

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• fondaparinux
Trintellix (vortioxetine)

+

fondaparinux

1 interaction

Avoid/Use Alternative

vortioxetine + fondaparinux

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• frovatriptan
Trintellix (vortioxetine)

+

frovatriptan

1 interaction

Avoid/Use Alternative

vortioxetine + frovatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• gepirone
Trintellix (vortioxetine)

+

gepirone

1 interaction

Avoid/Use Alternative

vortioxetine + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• granisetron
Trintellix (vortioxetine)

+

granisetron

1 interaction

Avoid/Use Alternative

vortioxetine + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydrocodone
Trintellix (vortioxetine)

+

hydrocodone

1 interaction

Avoid/Use Alternative

vortioxetine + hydrocodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydromorphone
Trintellix (vortioxetine)

+

hydromorphone

1 interaction

Avoid/Use Alternative

vortioxetine + hydromorphone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• imipramine
Trintellix (vortioxetine)

+

imipramine

1 interaction

Avoid/Use Alternative

vortioxetine + imipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• isoniazid
Trintellix (vortioxetine)

+

isoniazid

1 interaction

Avoid/Use Alternative

vortioxetine + isoniazid

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• lasmiditan
Trintellix (vortioxetine)

+

lasmiditan

1 interaction

Avoid/Use Alternative

vortioxetine + lasmiditan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• levomilnacipran
Trintellix (vortioxetine)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

vortioxetine + levomilnacipran

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• levorphanol
Trintellix (vortioxetine)

+

levorphanol

1 interaction

Avoid/Use Alternative

vortioxetine + levorphanol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lisdexamfetamine
Trintellix (vortioxetine)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

vortioxetine + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
Trintellix (vortioxetine)

+

lithium

1 interaction

Avoid/Use Alternative

vortioxetine + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• meperidine
Trintellix (vortioxetine)

+

meperidine

1 interaction

Avoid/Use Alternative

vortioxetine + meperidine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metaxalone
Trintellix (vortioxetine)

+

metaxalone

1 interaction

Avoid/Use Alternative

vortioxetine + metaxalone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methadone
Trintellix (vortioxetine)

+

methadone

1 interaction

Avoid/Use Alternative

vortioxetine + methadone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methamphetamine
Trintellix (vortioxetine)

+

methamphetamine

1 interaction

Avoid/Use Alternative

vortioxetine + methamphetamine

use alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylene blue oral
Trintellix (vortioxetine)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

vortioxetine + methylene blue oral

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Trintellix (vortioxetine)

+

methylergonovine

1 interaction

Avoid/Use Alternative

vortioxetine + methylergonovine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylphenidate
Trintellix (vortioxetine)

+

methylphenidate

1 interaction

Avoid/Use Alternative

vortioxetine + methylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metoclopramide
Trintellix (vortioxetine)

+

metoclopramide

1 interaction

Avoid/Use Alternative

vortioxetine + metoclopramide

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• milnacipran
Trintellix (vortioxetine)

+

milnacipran

1 interaction

Avoid/Use Alternative

vortioxetine + milnacipran

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• mirtazapine
Trintellix (vortioxetine)

+

mirtazapine

1 interaction

Avoid/Use Alternative

vortioxetine + mirtazapine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of hyponatremia, serotonin syndrome (additive effects)

• morphine
Trintellix (vortioxetine)

+

morphine

1 interaction

Avoid/Use Alternative

vortioxetine + morphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• nalbuphine
Trintellix (vortioxetine)

+

nalbuphine

1 interaction

Avoid/Use Alternative

vortioxetine + nalbuphine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• naratriptan
Trintellix (vortioxetine)

+

naratriptan

1 interaction

Avoid/Use Alternative

vortioxetine + naratriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• nefazodone
Trintellix (vortioxetine)

+

nefazodone

1 interaction

Avoid/Use Alternative

vortioxetine + nefazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• nortriptyline
Trintellix (vortioxetine)

+

nortriptyline

1 interaction

Avoid/Use Alternative

vortioxetine + nortriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• oliceridine
Trintellix (vortioxetine)

+

oliceridine

1 interaction

Avoid/Use Alternative

vortioxetine + oliceridine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• ondansetron
Trintellix (vortioxetine)

+

ondansetron

1 interaction

Avoid/Use Alternative

vortioxetine + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opium
Trintellix (vortioxetine)

+

opium

1 interaction

Avoid/Use Alternative

vortioxetine + opium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• oxycodone
Trintellix (vortioxetine)

+

oxycodone

1 interaction

Avoid/Use Alternative

vortioxetine + oxycodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• oxymorphone
Trintellix (vortioxetine)

+

oxymorphone

1 interaction

Avoid/Use Alternative

vortioxetine + oxymorphone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• palonosetron
Trintellix (vortioxetine)

+

palonosetron

1 interaction

Avoid/Use Alternative

vortioxetine + palonosetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• paroxetine
Trintellix (vortioxetine)

+

paroxetine

1 interaction

Avoid/Use Alternative

vortioxetine + paroxetine

avoid combo: combo may incr. vortioxetine levels, risk of bleeding (incl. life-threatening), serotonin syndrome, hyponatremia, other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• pentazocine
Trintellix (vortioxetine)

+

pentazocine

1 interaction

Avoid/Use Alternative

vortioxetine + pentazocine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• procarbazine
Trintellix (vortioxetine)

+

procarbazine

1 interaction

Avoid/Use Alternative

vortioxetine + procarbazine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, procarbazine inhibits monoamine oxidase)

• protriptyline
Trintellix (vortioxetine)

+

protriptyline

1 interaction

Avoid/Use Alternative

vortioxetine + protriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• rasagiline
Trintellix (vortioxetine)

+

rasagiline

1 interaction

Avoid/Use Alternative

vortioxetine + rasagiline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• remifentanil
Trintellix (vortioxetine)

+

remifentanil

1 interaction

Avoid/Use Alternative

vortioxetine + remifentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• rizatriptan
Trintellix (vortioxetine)

+

rizatriptan

1 interaction

Avoid/Use Alternative

vortioxetine + rizatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• safinamide
Trintellix (vortioxetine)

+

safinamide

1 interaction

Avoid/Use Alternative

vortioxetine + safinamide

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• SAMe
Trintellix (vortioxetine)

+

SAMe

1 interaction

Avoid/Use Alternative

vortioxetine + SAMe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• selegiline
Trintellix (vortioxetine)

+

selegiline

1 interaction

Avoid/Use Alternative

vortioxetine + selegiline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sertraline
Trintellix (vortioxetine)

+

sertraline

1 interaction

Avoid/Use Alternative

vortioxetine + sertraline

avoid combo: combo may incr. risk of serotonin syndrome, bleeding (incl. life-threatening), hyponatremia, other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• St. John's wort
Trintellix (vortioxetine)

+

St. John's wort

1 interaction

Avoid/Use Alternative

vortioxetine + St. John's wort

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; consider incr. vortioxetine dose up to 3x maintenance dose if St. John's wort coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy; may incr. risk of serotonin syndrome (hepatic metab. induced; additive effects)

• sufentanil
Trintellix (vortioxetine)

+

sufentanil

1 interaction

Avoid/Use Alternative

vortioxetine + sufentanil

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sumatriptan
Trintellix (vortioxetine)

+

sumatriptan

1 interaction

Avoid/Use Alternative

vortioxetine + sumatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• tapentadol
Trintellix (vortioxetine)

+

tapentadol

1 interaction

Avoid/Use Alternative

vortioxetine + tapentadol

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• tramadol
Trintellix (vortioxetine)

+

tramadol

1 interaction

Avoid/Use Alternative

vortioxetine + tramadol

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of severe hyponatremia, serotonin syndrome (additive effects)

• trazodone
Trintellix (vortioxetine)

+

trazodone

1 interaction

Avoid/Use Alternative

vortioxetine + trazodone

avoid combo: combo may incr. risk of hyponatremia, bleeding (incl. life-threatening), serotonin syndrome, other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• trimipramine
Trintellix (vortioxetine)

+

trimipramine

1 interaction

Avoid/Use Alternative

vortioxetine + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• venlafaxine
Trintellix (vortioxetine)

+

venlafaxine

1 interaction

Avoid/Use Alternative

vortioxetine + venlafaxine

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• vilazodone
Trintellix (vortioxetine)

+

vilazodone

1 interaction

Avoid/Use Alternative

vortioxetine + vilazodone

use alternative or monitor sodium, bleeding s/sx, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of hyponatremia, bleeding (incl. life-threatening), serotonin syndrome (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• yohimbe
Trintellix (vortioxetine)

+

yohimbe

1 interaction

Avoid/Use Alternative

vortioxetine + yohimbe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, yohimbe inhibits monoamine oxidase)

• ziprasidone
Trintellix (vortioxetine)

+

ziprasidone

1 interaction

Avoid/Use Alternative

vortioxetine + ziprasidone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• zolmitriptan
Trintellix (vortioxetine)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

vortioxetine + zolmitriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

Monitor/Modify Tx

• abrocitinib
Trintellix (vortioxetine)

+

abrocitinib

1 interaction

Monitor/Modify Tx

vortioxetine + abrocitinib

monitor platelets, bleeding s/sx, especially during abrocitinib tx initiation or if abrocitinib 200 mg/day: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• acalabrutinib
Trintellix (vortioxetine)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

vortioxetine + acalabrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ado-trastuzumab emtansine
Trintellix (vortioxetine)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

vortioxetine + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• afatinib
Trintellix (vortioxetine)

+

afatinib

1 interaction

Monitor/Modify Tx

vortioxetine + afatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• alteplase
Trintellix (vortioxetine)

+

alteplase

1 interaction

Monitor/Modify Tx

vortioxetine + alteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• amiloride
Trintellix (vortioxetine)

+

amiloride

1 interaction

Monitor/Modify Tx

vortioxetine + amiloride

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• anacaulase topical
Trintellix (vortioxetine)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

vortioxetine + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• anagrelide
Trintellix (vortioxetine)

+

anagrelide

1 interaction

Monitor/Modify Tx

vortioxetine + anagrelide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• antithrombin
Trintellix (vortioxetine)

+

antithrombin

1 interaction

Monitor/Modify Tx

vortioxetine + antithrombin

monitor bleeding s/sx: combo may incr. risk of severe bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• apalutamide
Trintellix (vortioxetine)

+

apalutamide

1 interaction

Monitor/Modify Tx

vortioxetine + apalutamide

consider incr. vortioxetine dose up to 3x maintenance dose if apalutamide coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• apixaban
Trintellix (vortioxetine)

+

apixaban

1 interaction

Monitor/Modify Tx

vortioxetine + apixaban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• argatroban
Trintellix (vortioxetine)

+

argatroban

1 interaction

Monitor/Modify Tx

vortioxetine + argatroban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• asparaginase
Trintellix (vortioxetine)

+

asparaginase

1 interaction

Monitor/Modify Tx

vortioxetine + asparaginase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• aspirin
Trintellix (vortioxetine)

+

aspirin

1 interaction

Monitor/Modify Tx

vortioxetine + aspirin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• avapritinib
Trintellix (vortioxetine)

+

avapritinib

1 interaction

Monitor/Modify Tx

vortioxetine + avapritinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• axitinib
Trintellix (vortioxetine)

+

axitinib

1 interaction

Monitor/Modify Tx

vortioxetine + axitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bevacizumab
Trintellix (vortioxetine)

+

bevacizumab

1 interaction

Monitor/Modify Tx

vortioxetine + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• binimetinib
Trintellix (vortioxetine)

+

binimetinib

1 interaction

Monitor/Modify Tx

vortioxetine + binimetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bivalirudin
Trintellix (vortioxetine)

+

bivalirudin

1 interaction

Monitor/Modify Tx

vortioxetine + bivalirudin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bosentan
Trintellix (vortioxetine)

+

bosentan

1 interaction

Monitor/Modify Tx

vortioxetine + bosentan

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• brentuximab vedotin
Trintellix (vortioxetine)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

vortioxetine + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bromelain
Trintellix (vortioxetine)

+

bromelain

1 interaction

Monitor/Modify Tx

vortioxetine + bromelain

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bromfenac ophthalmic
Trintellix (vortioxetine)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

vortioxetine + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bumetanide
Trintellix (vortioxetine)

+

bumetanide

1 interaction

Monitor/Modify Tx

vortioxetine + bumetanide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• bupropion
Trintellix (vortioxetine)

+

bupropion

1 interaction

Monitor/Modify Tx

vortioxetine + bupropion

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metab. inhibited, additive effects)

• butalbital
Trintellix (vortioxetine)

+

butalbital

1 interaction

Monitor/Modify Tx

vortioxetine + butalbital

consider incr. vortioxetine dose up to 3x maintenance dose if butalbital coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• cabazitaxel
Trintellix (vortioxetine)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

vortioxetine + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cabozantinib
Trintellix (vortioxetine)

+

cabozantinib

1 interaction

Monitor/Modify Tx

vortioxetine + cabozantinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• calaspargase
Trintellix (vortioxetine)

+

calaspargase

1 interaction

Monitor/Modify Tx

vortioxetine + calaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cangrelor
Trintellix (vortioxetine)

+

cangrelor

1 interaction

Monitor/Modify Tx

vortioxetine + cangrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• caplacizumab
Trintellix (vortioxetine)

+

caplacizumab

1 interaction

Monitor/Modify Tx

vortioxetine + caplacizumab

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• carfilzomib
Trintellix (vortioxetine)

+

carfilzomib

1 interaction

Monitor/Modify Tx

vortioxetine + carfilzomib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• celecoxib
Trintellix (vortioxetine)

+

celecoxib

1 interaction

Monitor/Modify Tx

vortioxetine + celecoxib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cenobamate
Trintellix (vortioxetine)

+

cenobamate

1 interaction

Monitor/Modify Tx

vortioxetine + cenobamate

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• chlorothiazide
Trintellix (vortioxetine)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

vortioxetine + chlorothiazide

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• chlorthalidone
Trintellix (vortioxetine)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

vortioxetine + chlorthalidone

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• cilostazol
Trintellix (vortioxetine)

+

cilostazol

1 interaction

Monitor/Modify Tx

vortioxetine + cilostazol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cisplatin
Trintellix (vortioxetine)

+

cisplatin

1 interaction

Monitor/Modify Tx

vortioxetine + cisplatin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• clopidogrel
Trintellix (vortioxetine)

+

clopidogrel

1 interaction

Monitor/Modify Tx

vortioxetine + clopidogrel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• collagenase clostridium histolyticum
Trintellix (vortioxetine)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

vortioxetine + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, incl. severe (additive effects)

• cyclophosphamide
Trintellix (vortioxetine)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

vortioxetine + cyclophosphamide

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• cysteamine
Trintellix (vortioxetine)

+

cysteamine

1 interaction

Monitor/Modify Tx

vortioxetine + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dabigatran
Trintellix (vortioxetine)

+

dabigatran

1 interaction

Monitor/Modify Tx

vortioxetine + dabigatran

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dabrafenib
Trintellix (vortioxetine)

+

dabrafenib

1 interaction

Monitor/Modify Tx

vortioxetine + dabrafenib

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• dacomitinib
Trintellix (vortioxetine)

+

dacomitinib

1 interaction

Monitor/Modify Tx

vortioxetine + dacomitinib

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metab. inhibited)

• dalteparin
Trintellix (vortioxetine)

+

dalteparin

1 interaction

Monitor/Modify Tx

vortioxetine + dalteparin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• danshen
Trintellix (vortioxetine)

+

danshen

1 interaction

Monitor/Modify Tx

vortioxetine + danshen

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dasatinib
Trintellix (vortioxetine)

+

dasatinib

1 interaction

Monitor/Modify Tx

vortioxetine + dasatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• deferasirox
Trintellix (vortioxetine)

+

deferasirox

1 interaction

Monitor/Modify Tx

vortioxetine + deferasirox

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• defibrotide
Trintellix (vortioxetine)

+

defibrotide

1 interaction

Monitor/Modify Tx

vortioxetine + defibrotide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• desmopressin
Trintellix (vortioxetine)

+

desmopressin

1 interaction

Monitor/Modify Tx

vortioxetine + desmopressin

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• deuruxolitinib
Trintellix (vortioxetine)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

vortioxetine + deuruxolitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac
Trintellix (vortioxetine)

+

diclofenac

1 interaction

Monitor/Modify Tx

vortioxetine + diclofenac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac ophthalmic
Trintellix (vortioxetine)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

vortioxetine + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac topical
Trintellix (vortioxetine)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

vortioxetine + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dicloxacillin
Trintellix (vortioxetine)

+

dicloxacillin

1 interaction

Monitor/Modify Tx

vortioxetine + dicloxacillin

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• diflunisal
Trintellix (vortioxetine)

+

diflunisal

1 interaction

Monitor/Modify Tx

vortioxetine + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dimethyl fumarate
Trintellix (vortioxetine)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

vortioxetine + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dinutuximab
Trintellix (vortioxetine)

+

dinutuximab

1 interaction

Monitor/Modify Tx

vortioxetine + dinutuximab

monitor sodium: combo may incr. risk of severe hyponatremia (additive effects)

• diosmin
Trintellix (vortioxetine)

+

diosmin

1 interaction

Monitor/Modify Tx

vortioxetine + diosmin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dipyridamole
Trintellix (vortioxetine)

+

dipyridamole

1 interaction

Monitor/Modify Tx

vortioxetine + dipyridamole

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diroximel fumarate
Trintellix (vortioxetine)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

vortioxetine + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• efavirenz
Trintellix (vortioxetine)

+

efavirenz

1 interaction

Monitor/Modify Tx

vortioxetine + efavirenz

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• encorafenib
Trintellix (vortioxetine)

+

encorafenib

1 interaction

Monitor/Modify Tx

vortioxetine + encorafenib

monitor bleeding s/sx; consider incr. vortioxetine dose up to 3x maintenance dose if encorafenib coadmin. for >14 day: combo may incr. risk of GI or other bleeding, incl. life-threatening; may decr. vortioxetine levels, efficacy (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; hepatic metab. induced)

• enzalutamide
Trintellix (vortioxetine)

+

enzalutamide

1 interaction

Monitor/Modify Tx

vortioxetine + enzalutamide

consider incr. vortioxetine dose up to 3x maintenance dose if enzalutamide coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• epoprostenol
Trintellix (vortioxetine)

+

epoprostenol

1 interaction

Monitor/Modify Tx

vortioxetine + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eptifibatide
Trintellix (vortioxetine)

+

eptifibatide

1 interaction

Monitor/Modify Tx

vortioxetine + eptifibatide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• erlotinib
Trintellix (vortioxetine)

+

erlotinib

1 interaction

Monitor/Modify Tx

vortioxetine + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eslicarbazepine acetate
Trintellix (vortioxetine)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

vortioxetine + eslicarbazepine acetate

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures (additive effects)

• ethacrynic acid
Trintellix (vortioxetine)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

vortioxetine + ethacrynic acid

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• ethanol
Trintellix (vortioxetine)

+

ethanol

1 interaction

Monitor/Modify Tx

vortioxetine + ethanol

monitor bleeding s/sx w/ orally ingested alcohol: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• etodolac
Trintellix (vortioxetine)

+

etodolac

1 interaction

Monitor/Modify Tx

vortioxetine + etodolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• etravirine
Trintellix (vortioxetine)

+

etravirine

1 interaction

Monitor/Modify Tx

vortioxetine + etravirine

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• evening primrose oil
Trintellix (vortioxetine)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

vortioxetine + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenoprofen
Trintellix (vortioxetine)

+

fenoprofen

1 interaction

Monitor/Modify Tx

vortioxetine + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenugreek
Trintellix (vortioxetine)

+

fenugreek

1 interaction

Monitor/Modify Tx

vortioxetine + fenugreek

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fexinidazole
Trintellix (vortioxetine)

+

fexinidazole

1 interaction

Monitor/Modify Tx

vortioxetine + fexinidazole

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• flurbiprofen
Trintellix (vortioxetine)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

vortioxetine + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flurbiprofen ophthalmic
Trintellix (vortioxetine)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

vortioxetine + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fosphenytoin
Trintellix (vortioxetine)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

vortioxetine + fosphenytoin

consider incr. vortioxetine dose up to 3x maintenance dose if fosphenytoin coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• fruquintinib
Trintellix (vortioxetine)

+

fruquintinib

1 interaction

Monitor/Modify Tx

vortioxetine + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• furosemide
Trintellix (vortioxetine)

+

furosemide

1 interaction

Monitor/Modify Tx

vortioxetine + furosemide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• garlic
Trintellix (vortioxetine)

+

garlic

1 interaction

Monitor/Modify Tx

vortioxetine + garlic

monitor bleeding s/sx, especially w/ supplemental garlic; dietary intake OK: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gefitinib
Trintellix (vortioxetine)

+

gefitinib

1 interaction

Monitor/Modify Tx

vortioxetine + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gemtuzumab ozogamicin
Trintellix (vortioxetine)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

vortioxetine + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ginkgo
Trintellix (vortioxetine)

+

ginkgo

1 interaction

Monitor/Modify Tx

vortioxetine + ginkgo

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• heparin
Trintellix (vortioxetine)

+

heparin

1 interaction

Monitor/Modify Tx

vortioxetine + heparin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• hydrochlorothiazide
Trintellix (vortioxetine)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

vortioxetine + hydrochlorothiazide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• hydrocortisone
Trintellix (vortioxetine)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

vortioxetine + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibrutinib
Trintellix (vortioxetine)

+

ibrutinib

1 interaction

Monitor/Modify Tx

vortioxetine + ibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibuprofen
Trintellix (vortioxetine)

+

ibuprofen

1 interaction

Monitor/Modify Tx

vortioxetine + ibuprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibuprofen lysine
Trintellix (vortioxetine)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

vortioxetine + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• icosapent ethyl
Trintellix (vortioxetine)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

vortioxetine + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ifosfamide
Trintellix (vortioxetine)

+

ifosfamide

1 interaction

Monitor/Modify Tx

vortioxetine + ifosfamide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• iloprost inhaled
Trintellix (vortioxetine)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

vortioxetine + iloprost inhaled

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• imatinib
Trintellix (vortioxetine)

+

imatinib

1 interaction

Monitor/Modify Tx

vortioxetine + imatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• indapamide
Trintellix (vortioxetine)

+

indapamide

1 interaction

Monitor/Modify Tx

vortioxetine + indapamide

monitor sodium: combo may incr. risk of severe hyponatremia (additive effects)

• indomethacin
Trintellix (vortioxetine)

+

indomethacin

1 interaction

Monitor/Modify Tx

vortioxetine + indomethacin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ivosidenib
Trintellix (vortioxetine)

+

ivosidenib

1 interaction

Monitor/Modify Tx

vortioxetine + ivosidenib

consider incr. vortioxetine dose up to 3x maintenance dose if ivosidenib coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• ketoprofen
Trintellix (vortioxetine)

+

ketoprofen

1 interaction

Monitor/Modify Tx

vortioxetine + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ketorolac
Trintellix (vortioxetine)

+

ketorolac

1 interaction

Monitor/Modify Tx

vortioxetine + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ketorolac ophthalmic
Trintellix (vortioxetine)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

vortioxetine + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lenvatinib
Trintellix (vortioxetine)

+

lenvatinib

1 interaction

Monitor/Modify Tx

vortioxetine + lenvatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lifileucel
Trintellix (vortioxetine)

+

lifileucel

1 interaction

Monitor/Modify Tx

vortioxetine + lifileucel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lopinavir/ritonavir
Trintellix (vortioxetine)

+

lopinavir/ ritonavir

1 interaction

Monitor/Modify Tx

vortioxetine + lopinavir/ ritonavir

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• lorlatinib
Trintellix (vortioxetine)

+

lorlatinib

1 interaction

Monitor/Modify Tx

vortioxetine + lorlatinib

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• lumacaftor/ivacaftor
Trintellix (vortioxetine)

+

lumacaftor/ ivacaftor

1 interaction

Monitor/Modify Tx

vortioxetine + lumacaftor/ ivacaftor

consider incr. vortioxetine dose up to 3x maintenance dose if lumacaftor/ivacaftor coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• magnesium citrate
Trintellix (vortioxetine)

+

magnesium citrate

1 interaction

Monitor/Modify Tx

vortioxetine + magnesium citrate

monitor sodium, especially if magnesium citrate bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• magnesium salicylate
Trintellix (vortioxetine)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

vortioxetine + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mannitol
Trintellix (vortioxetine)

+

mannitol

1 interaction

Monitor/Modify Tx

vortioxetine + mannitol

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures (additive effects)

• mavacamten
Trintellix (vortioxetine)

+

mavacamten

1 interaction

Monitor/Modify Tx

vortioxetine + mavacamten

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• mavorixafor
Trintellix (vortioxetine)

+

mavorixafor

1 interaction

Monitor/Modify Tx

vortioxetine + mavorixafor

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metab. inhibited)

• meclofenamate
Trintellix (vortioxetine)

+

meclofenamate

1 interaction

Monitor/Modify Tx

vortioxetine + meclofenamate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mefenamic acid
Trintellix (vortioxetine)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

vortioxetine + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• meloxicam
Trintellix (vortioxetine)

+

meloxicam

1 interaction

Monitor/Modify Tx

vortioxetine + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• methotrexate
Trintellix (vortioxetine)

+

methotrexate

1 interaction

Monitor/Modify Tx

vortioxetine + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• methyl salicylate topical
Trintellix (vortioxetine)

+

methyl salicylate topical

1 interaction

Monitor/Modify Tx

vortioxetine + methyl salicylate topical

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, systemic salicylate absorption may occur from topical use)

• metolazone
Trintellix (vortioxetine)

+

metolazone

1 interaction

Monitor/Modify Tx

vortioxetine + metolazone

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• mitapivat
Trintellix (vortioxetine)

+

mitapivat

1 interaction

Monitor/Modify Tx

vortioxetine + mitapivat

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• mitotane
Trintellix (vortioxetine)

+

mitotane

1 interaction

Monitor/Modify Tx

vortioxetine + mitotane

consider incr. vortioxetine dose up to 3x maintenance dose if mitotane coadmin. for >14 days; monitor bleeding s/sx: combo may decr. vortioxetine levels, efficacy; may incr. risk of bleeding, incl. life-threatening (hepatic metab. induced; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• modafinil
Trintellix (vortioxetine)

+

modafinil

1 interaction

Monitor/Modify Tx

vortioxetine + modafinil

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• monomethyl fumarate
Trintellix (vortioxetine)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

vortioxetine + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mycophenolate mofetil
Trintellix (vortioxetine)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

vortioxetine + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mycophenolic acid
Trintellix (vortioxetine)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

vortioxetine + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nabumetone
Trintellix (vortioxetine)

+

nabumetone

1 interaction

Monitor/Modify Tx

vortioxetine + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nafcillin
Trintellix (vortioxetine)

+

nafcillin

1 interaction

Monitor/Modify Tx

vortioxetine + nafcillin

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• naproxen
Trintellix (vortioxetine)

+

naproxen

1 interaction

Monitor/Modify Tx

vortioxetine + naproxen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nattokinase
Trintellix (vortioxetine)

+

nattokinase

1 interaction

Monitor/Modify Tx

vortioxetine + nattokinase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nepafenac ophthalmic
Trintellix (vortioxetine)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

vortioxetine + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• niacin (vitamin B3)
Trintellix (vortioxetine)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

vortioxetine + niacin (vitamin B3)

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nilotinib
Trintellix (vortioxetine)

+

nilotinib

1 interaction

Monitor/Modify Tx

vortioxetine + nilotinib

monitor sodium, bleeding s/sx: combo may incr. risk of hyponatremia, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nintedanib
Trintellix (vortioxetine)

+

nintedanib

1 interaction

Monitor/Modify Tx

vortioxetine + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nusinersen
Trintellix (vortioxetine)

+

nusinersen

1 interaction

Monitor/Modify Tx

vortioxetine + nusinersen

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• omega-3-acid
Trintellix (vortioxetine)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

vortioxetine + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxaliplatin
Trintellix (vortioxetine)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

vortioxetine + oxaliplatin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxaprozin
Trintellix (vortioxetine)

+

oxaprozin

1 interaction

Monitor/Modify Tx

vortioxetine + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxcarbazepine
Trintellix (vortioxetine)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

vortioxetine + oxcarbazepine

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• oxytocin
Trintellix (vortioxetine)

+

oxytocin

1 interaction

Monitor/Modify Tx

vortioxetine + oxytocin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• pacritinib
Trintellix (vortioxetine)

+

pacritinib

1 interaction

Monitor/Modify Tx

vortioxetine + pacritinib

monitor platelets, bleeding s/sx; consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy; may incr. risk of bleeding, incl. life-threatening (hepatic metab. induced; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pazopanib
Trintellix (vortioxetine)

+

pazopanib

1 interaction

Monitor/Modify Tx

vortioxetine + pazopanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pegaspargase
Trintellix (vortioxetine)

+

pegaspargase

1 interaction

Monitor/Modify Tx

vortioxetine + pegaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• penicillin G
Trintellix (vortioxetine)

+

penicillin G

1 interaction

Monitor/Modify Tx

vortioxetine + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pentobarbital
Trintellix (vortioxetine)

+

pentobarbital

1 interaction

Monitor/Modify Tx

vortioxetine + pentobarbital

consider incr. vortioxetine dose up to 3x maintenance dose if pentobarbital coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• pentosan polysulfate sodium
Trintellix (vortioxetine)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

vortioxetine + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pentoxifylline
Trintellix (vortioxetine)

+

pentoxifylline

1 interaction

Monitor/Modify Tx

vortioxetine + pentoxifylline

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pexidartinib
Trintellix (vortioxetine)

+

pexidartinib

1 interaction

Monitor/Modify Tx

vortioxetine + pexidartinib

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• phenobarbital
Trintellix (vortioxetine)

+

phenobarbital

1 interaction

Monitor/Modify Tx

vortioxetine + phenobarbital

consider incr. vortioxetine dose up to 3x maintenance dose if phenobarbital coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• phenytoin
Trintellix (vortioxetine)

+

phenytoin

1 interaction

Monitor/Modify Tx

vortioxetine + phenytoin

consider incr. vortioxetine dose up to 3x maintenance dose if phenytoin coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• piperacillin
Trintellix (vortioxetine)

+

piperacillin

1 interaction

Monitor/Modify Tx

vortioxetine + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• piroxicam
Trintellix (vortioxetine)

+

piroxicam

1 interaction

Monitor/Modify Tx

vortioxetine + piroxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pirtobrutinib
Trintellix (vortioxetine)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

vortioxetine + pirtobrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• plasminogen, human
Trintellix (vortioxetine)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

vortioxetine + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• polyethylene glycol
Trintellix (vortioxetine)

+

polyethylene glycol

1 interaction

Monitor/Modify Tx

vortioxetine + polyethylene glycol

monitor sodium, especially if polyethylene glycol bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• polyethylene glycol/electrolytes
Trintellix (vortioxetine)

+

polyethylene glycol/ electrolytes

1 interaction

Monitor/Modify Tx

vortioxetine + polyethylene glycol/ electrolytes

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• ponatinib
Trintellix (vortioxetine)

+

ponatinib

1 interaction

Monitor/Modify Tx

vortioxetine + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• porfimer
Trintellix (vortioxetine)

+

porfimer

1 interaction

Monitor/Modify Tx

vortioxetine + porfimer

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pralsetinib
Trintellix (vortioxetine)

+

pralsetinib

1 interaction

Monitor/Modify Tx

vortioxetine + pralsetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• prasugrel
Trintellix (vortioxetine)

+

prasugrel

1 interaction

Monitor/Modify Tx

vortioxetine + prasugrel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• primidone
Trintellix (vortioxetine)

+

primidone

1 interaction

Monitor/Modify Tx

vortioxetine + primidone

consider incr. vortioxetine dose up to 3x maintenance dose if primidone coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• quinidine (antiarrhythmic)
Trintellix (vortioxetine)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

vortioxetine + quinidine (antiarrhythmic)

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metab. inhibited)

• quinidine (CYP2D6 inhibitor)
Trintellix (vortioxetine)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Monitor/Modify Tx

vortioxetine + quinidine (CYP2D6 inhibitor)

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metab. inhibited)

• ramucirumab
Trintellix (vortioxetine)

+

ramucirumab

1 interaction

Monitor/Modify Tx

vortioxetine + ramucirumab

monitor sodium, bleeding s/sx: combo may incr. risk of hyponatremia, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ranibizumab
Trintellix (vortioxetine)

+

ranibizumab

1 interaction

Monitor/Modify Tx

vortioxetine + ranibizumab

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• regorafenib
Trintellix (vortioxetine)

+

regorafenib

1 interaction

Monitor/Modify Tx

vortioxetine + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• repotrectinib
Trintellix (vortioxetine)

+

repotrectinib

1 interaction

Monitor/Modify Tx

vortioxetine + repotrectinib

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• resveratrol
Trintellix (vortioxetine)

+

resveratrol

1 interaction

Monitor/Modify Tx

vortioxetine + resveratrol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• reteplase
Trintellix (vortioxetine)

+

reteplase

1 interaction

Monitor/Modify Tx

vortioxetine + reteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• revakinagene taroretcel
Trintellix (vortioxetine)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

vortioxetine + revakinagene taroretcel

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• rifabutin
Trintellix (vortioxetine)

+

rifabutin

1 interaction

Monitor/Modify Tx

vortioxetine + rifabutin

consider incr. vortioxetine dose up to 3x maintenance dose if rifabutin coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• rifampin
Trintellix (vortioxetine)

+

rifampin

1 interaction

Monitor/Modify Tx

vortioxetine + rifampin

consider incr. vortioxetine dose up to 3x maintenance dose if rifampin coadmin. for >14 days: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• rifapentine
Trintellix (vortioxetine)

+

rifapentine

1 interaction

Monitor/Modify Tx

vortioxetine + rifapentine

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• rivaroxaban
Trintellix (vortioxetine)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

vortioxetine + rivaroxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• romidepsin
Trintellix (vortioxetine)

+

romidepsin

1 interaction

Monitor/Modify Tx

vortioxetine + romidepsin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• salsalate
Trintellix (vortioxetine)

+

salsalate

1 interaction

Monitor/Modify Tx

vortioxetine + salsalate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• saw palmetto
Trintellix (vortioxetine)

+

saw palmetto

1 interaction

Monitor/Modify Tx

vortioxetine + saw palmetto

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• selinexor
Trintellix (vortioxetine)

+

selinexor

1 interaction

Monitor/Modify Tx

vortioxetine + selinexor

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• selpercatinib
Trintellix (vortioxetine)

+

selpercatinib

1 interaction

Monitor/Modify Tx

vortioxetine + selpercatinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• selumetinib
Trintellix (vortioxetine)

+

selumetinib

1 interaction

Monitor/Modify Tx

vortioxetine + selumetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet and anticoagulant effects augmented by vortioxetine inhibition of platelet serotonin uptake and vitamin E content in selumetinib capsules)

• sirolimus albumin-bound
Trintellix (vortioxetine)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

vortioxetine + sirolimus albumin-bound

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sorafenib
Trintellix (vortioxetine)

+

sorafenib

1 interaction

Monitor/Modify Tx

vortioxetine + sorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sotatercept
Trintellix (vortioxetine)

+

sotatercept

1 interaction

Monitor/Modify Tx

vortioxetine + sotatercept

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. severe or life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sotorasib
Trintellix (vortioxetine)

+

sotorasib

1 interaction

Monitor/Modify Tx

vortioxetine + sotorasib

consider vortioxetine dose adjustment: combo may decr. vortioxetine levels, efficacy (hepatic metab. induced)

• spironolactone
Trintellix (vortioxetine)

+

spironolactone

1 interaction

Monitor/Modify Tx

vortioxetine + spironolactone

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• sulfate bowel prep
Trintellix (vortioxetine)

+

sulfate bowel prep

1 interaction

Monitor/Modify Tx

vortioxetine + sulfate bowel prep

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• sulindac
Trintellix (vortioxetine)

+

sulindac

1 interaction

Monitor/Modify Tx

vortioxetine + sulindac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sunitinib
Trintellix (vortioxetine)

+

sunitinib

1 interaction

Monitor/Modify Tx

vortioxetine + sunitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tenecteplase
Trintellix (vortioxetine)

+

tenecteplase

1 interaction

Monitor/Modify Tx

vortioxetine + tenecteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• terbinafine
Trintellix (vortioxetine)

+

terbinafine

1 interaction

Monitor/Modify Tx

vortioxetine + terbinafine

decr. vortioxetine dose 50%: combo may incr. vortioxetine levels, risk of adverse effects (hepatic metab. inhibited)

• ticagrelor
Trintellix (vortioxetine)

+

ticagrelor

1 interaction

Monitor/Modify Tx

vortioxetine + ticagrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tipranavir
Trintellix (vortioxetine)

+

tipranavir

1 interaction

Monitor/Modify Tx

vortioxetine + tipranavir

monitor bleeding s/sx; consider vortioxetine dose adjustment: combo may incr. or decr. vortioxetine levels, incr. risk of bleeding (incl. life-threatening), other adverse effects or decr. efficacy (hepatic metab. altered; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tirofiban
Trintellix (vortioxetine)

+

tirofiban

1 interaction

Monitor/Modify Tx

vortioxetine + tirofiban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tisotumab vedotin
Trintellix (vortioxetine)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

vortioxetine + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tivozanib
Trintellix (vortioxetine)

+

tivozanib

1 interaction

Monitor/Modify Tx

vortioxetine + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tolmetin
Trintellix (vortioxetine)

+

tolmetin

1 interaction

Monitor/Modify Tx

vortioxetine + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• torsemide
Trintellix (vortioxetine)

+

torsemide

1 interaction

Monitor/Modify Tx

vortioxetine + torsemide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• tovorafenib
Trintellix (vortioxetine)

+

tovorafenib

1 interaction

Monitor/Modify Tx

vortioxetine + tovorafenib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• trametinib
Trintellix (vortioxetine)

+

trametinib

1 interaction

Monitor/Modify Tx

vortioxetine + trametinib

monitor bleeding s/sx, especially w/ concomitant dabrafenib use: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• treprostinil
Trintellix (vortioxetine)

+

treprostinil

1 interaction

Monitor/Modify Tx

vortioxetine + treprostinil

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• triamterene
Trintellix (vortioxetine)

+

triamterene

1 interaction

Monitor/Modify Tx

vortioxetine + triamterene

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• upadacitinib
Trintellix (vortioxetine)

+

upadacitinib

1 interaction

Monitor/Modify Tx

vortioxetine + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vadadustat
Trintellix (vortioxetine)

+

vadadustat

1 interaction

Monitor/Modify Tx

vortioxetine + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• valproic acid
Trintellix (vortioxetine)

+

valproic acid

1 interaction

Monitor/Modify Tx

vortioxetine + valproic acid

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vandetanib
Trintellix (vortioxetine)

+

vandetanib

1 interaction

Monitor/Modify Tx

vortioxetine + vandetanib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vasopressin
Trintellix (vortioxetine)

+

vasopressin

1 interaction

Monitor/Modify Tx

vortioxetine + vasopressin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• vinpocetine
Trintellix (vortioxetine)

+

vinpocetine

1 interaction

Monitor/Modify Tx

vortioxetine + vinpocetine

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vorapaxar
Trintellix (vortioxetine)

+

vorapaxar

1 interaction

Monitor/Modify Tx

vortioxetine + vorapaxar

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• warfarin
Trintellix (vortioxetine)

+

warfarin

1 interaction

Monitor/Modify Tx

vortioxetine + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (synergistic effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• willow bark
Trintellix (vortioxetine)

+

willow bark

1 interaction

Monitor/Modify Tx

vortioxetine + willow bark

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; willow bark may contain salicylates)

• zanubrutinib
Trintellix (vortioxetine)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

vortioxetine + zanubrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ziv-aflibercept
Trintellix (vortioxetine)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

vortioxetine + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)