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Flonase Allergy Relief
fluticasone propionate nasal
Dosing .
allergy sx
- [ 4-11 yo ]
- Dose: 1 actuation in each nostril qd; Max: 1 actuation in each nostril/day
- [ 12 yo and older ]
- Dose: 1-2 actuations in each nostril qd; Start: 2 actuations in each nostril qd x1wk; Max: 2 actuations in each nostril/day
nasal polyp (off-label)
- [ adults ]
- Dose: 2-4 actuations in each nostril bid; Max: 8 actuations in each nostril/day
renal dosing
- [ not defined ]
- renal impairment: not defined
- HD/PD: not defined
hepatic dosing
- [ not defined ]
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- nasal septal ulcer, unhealed
- nasal wound, unhealed
- caution: hypersensitivity to corticosteroids
- caution: peds pts (long-term use)
- caution: hepatic impairment
- caution: long-term systemic corticosteroid use, recent
- caution: measles exposure
- caution: varicella exposure
- caution: local infection, untreated
- caution: systemic infection, untreated
- caution: TB infection
- caution: ocular HSV infection
- caution: glaucoma
- caution: glaucoma risk
- caution: cataract
- caution: decr. BMD risk
Drug Interactions .
Overview
fluticasone propionate
corticosteroid
Interaction Characteristics:
- CYP3A4 substrate
- immunosuppressive effects
- interferes w/ ACTH analog test
Contraindicated
- desmopressin
Avoid/Use Alternative
- adagrasib
- atazanavir
- ceritinib
- chloramphenicol
- cladribine oral
- clarithromycin
- cobicistat
- conivaptan
- darunavir
- fosamprenavir
- idelalisib
- itraconazole
- ketoconazole
- levoketoconazole
- lonafarnib
- lopinavir/ritonavir
- mifepristone
- natalizumab
- nefazodone
- nelfinavir
- pimecrolimus topical
- posaconazole
- ribociclib
- ritonavir
- tipranavir
- tucatinib
- voriconazole
Monitor/Modify Tx
- carfilzomib
- cosyntropin
- everolimus
- metyrapone
- temsirolimus
Caution Advised
- abatacept
- abemaciclib
- abrocitinib
- acalabrutinib
- adalimumab
- afamitresgene autoleucel
- aldesleukin
- alemtuzumab
- anakinra
- anifrolumab
- anti-thymocyte globulin
- atidarsagene autotemcel
- avacopan
- axicabtagene ciloleucel
- azacitidine
- azathioprine
- baricitinib
- basiliximab
- beclomethasone inhaled
- beclomethasone nasal
- belatacept
- belimumab
- belinostat
- bendamustine
- betamethasone
- bimekizumab
- blinatumomab
- bortezomib
- brentuximab vedotin
- brexucabtagene autoleucel
- brodalumab
- budesonide
- budesonide inhaled
- budesonide nasal
- budesonide rectal
- busulfan
- cabazitaxel
- canakinumab
- carboplatin
- carmustine
- certolizumab pegol
- chlorambucil
- ciltacabtagene autoleucel
- cisplatin
- cladribine injection
- clobetasol ophthalmic
- clofarabine
- copanlisib
- corticotropin
- cortisone
- crovalimab
- cyclophosphamide
- cyclosporine
- cytarabine
- dactinomycin
- danicopan
- daratumumab
- daunorubicin
- decitabine
- deflazacort
- deucravacitinib
- deuruxolitinib
- dexamethasone
- dexamethasone ophthalmic
- difluprednate ophthalmic
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- docetaxel
- doxorubicin
- dupilumab
- duvelisib
- eculizumab
- efgartigimod alfa
- elivaldogene autotemcel
- elotuzumab
- elranatamab
- emapalumab
- epcoritamab
- epirubicin
- eribulin
- etanercept
- etoposide
- etrasimod
- fingolimod
- floxuridine
- fludarabine
- fludrocortisone
- flunisolide nasal
- fluocinolone intravitreal
- fluorometholone ophthalmic
- fluorouracil
- fluticasone furoate
- fruquintinib
- gemcitabine
- gemtuzumab ozogamicin
- glofitamab
- golimumab
- guselkumab
- hydrocortisone
- hydrocortisone ophthalmic
- hydroxyurea
- ibritumomab tiuxetan
- ibrutinib
- idarubicin
- idecabtagene vicleucel
- ifosfamide
- inebilizumab
- infliximab
- inotuzumab ozogamicin
- iptacopan
- irinotecan
- isatuximab
- ixabepilone
- ixekizumab
- lebrikizumab
- leflunomide
- lenalidomide
- lisocabtagene maraleucel
- lomustine
- loncastuximab tesirine
- loteprednol ophthalmic
- lymphocyte immune globulin, anti-thymocyte globulin
- melphalan
- mercaptopurine
- methacholine inhaled
- methotrexate
- methylprednisolone
- mirikizumab
- mitoxantrone
- mogamulizumab
- momelotinib
- mometasone implant
- mometasone inhaled
- mometasone nasal
- monomethyl fumarate
- mosunetuzumab
- mycophenolate mofetil
- mycophenolic acid
- nelarabine
- nipocalimab
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- oxaliplatin
- ozanimod
- paclitaxel
- panobinostat
- pegcetacoplan
- pentostatin
- pirtobrutinib
- polatuzumab vedotin
- pomalidomide
- ponatinib
- ponesimod
- pozelimab
- prednisolone
- prednisolone ophthalmic
- prednisone
- procarbazine
- quizartinib
- ravulizumab
- regorafenib
- rilonacept
- risankizumab
- ritlecitinib
- rituximab
- romidepsin
- ropeginterferon alfa-2b
- rozanolixizumab
- ruxolitinib
- ruxolitinib topical
- sarilumab
- satralizumab
- secukinumab
- selinexor
- siltuximab
- siponimod
- sirolimus
- sirolimus albumin-bound
- spesolimab
- sulfasalazine
- sutimlimab
- tacrolimus
- tafasitamab
- talquetamab
- tarlatamab
- teclistamab
- temozolomide
- teplizumab
- teriflunomide
- thioguanine
- thiotepa
- tildrakizumab
- tisagenlecleucel
- tocilizumab
- tofacitinib
- topotecan
- tralokinumab
- triamcinolone
- ublituximab
- upadacitinib
- ustekinumab
- vamorolone
- vedolizumab
- venetoclax
- vilobelimab
- vinblastine
- vincristine
- vinorelbine
- voclosporin
- zanubrutinib
- zilucoplan
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
- glaucoma (long-term use)
- cataracts (long-term use)
- immunosuppression (long-term use)
- hypercorticism (long-term use)
- adrenal suppression (long-term use)
- growth suppression (long-term use in peds pts)
Common Reactions
- headache
- URI sx
- epistaxis
- nasal burning
- nasal irritation
- nausea
- vomiting
- cough
- diarrhea
- abdominal pain
- bronchitis
- dizziness
- candidiasis, nasal or oral
- nasal septal perforation
- nasal ulcer
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; risk of fetal harm not expected based on limited human data and insignificant systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on insignificant systemic absorption in breastfeeding pts
Pharmacology .
Metabolism: liver extensively; CYP450: 3A4 substrate; Info: minimal systemic absorption
Excretion: feces primarily; Half-life: 7.8h
Subclass: Corticosteroids, Intranasal
Mechanism of Action: exact mechanism of anti-inflammatory action unknown; inhibits multiple inflammatory cytokines; produces multiple glucocorticoid and mineralocorticoid effects
Alternatives .
Search for Alternative Products by:
- Other OTCs w/ Same Active Ingredient(s)
- Children's Flonase Allergy Relief: nasal spray
- Same Subclass
- Corticosteroids, Intranasal
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