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Viberzi
eluxadoline
Adult Dosing .
Dosage forms: TAB: 75 mg, 100 mg
IBS, diarrhea-predominant
- [100 mg PO bid]
- Info: may decr. dose to 75 mg PO bid if tolerability concern; give with food
renal dosing
- [see below]
- CrCl <60: 75 mg bid
- HD/PD: not defined
hepatic dosing
- [see below]
- Child-Pugh Class A or B: 75 mg bid; Child-Pugh Class C: contraindicated
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- alcoholism
- alcohol addiction
- alcohol abuse
- alcohol use >3 drinks/day, concurrent
- gallbladder removal history
- pancreatitis history
- pancreatic duct obstruction, known or suspected
- biliary duct obstruction, known or suspected
- sphincter of Oddi dysfunction
- GI obstruction, known or suspected
- constipation history, chronic
- constipation history, severe
- hepatic impairment, Child-Pugh Class C
- caution: hepatic impairment, Child-Pugh Class A-B
- caution: CrCl <60
- caution: elderly patients
Drug Interactions .
Overview
eluxadoline
antidiarrheal; opioid
- OATP1B1 substrate
- BCRP inhibitor
- OATP1B1 inhibitor, weak
- decreases gastrointestinal motility
Contraindicated
- ethanol (alcoholic beverage)
- grazoprevir
Avoid/Use Alternative
- aclidinium inhaled
- alfentanil
- alosetron
- alpelisib
- amantadine
- amitriptyline
- amoxapine
- atrasentan
- atropine
- belladonna alkaloids
- benztropine
- brincidofovir
- brompheniramine
- buprenorphine
- butorphanol
- carbinoxamine
- chlophedianol
- chlorcyclizine
- chlorpheniramine
- chlorpromazine
- cladribine oral
- clemastine
- clidinium
- clomipramine
- clozapine
- codeine
- cyclobenzaprine
- cyproheptadine
- darifenacin
- desipramine
- dexbrompheniramine
- dexchlorpheniramine
- dicyclomine
- difenoxin
- dihydrocodeine
- dimenhydrinate
- diphenhydramine
- disopyramide
- doxepin
- doxepin topical
- doxylamine
- elagolix
- erenumab
- fentanyl
- fesoterodine
- flavoxate
- fluphenazine
- glycopyrrolate
- glycopyrronium topical
- hydrocodone
- hydromorphone
- hydroxyzine
- hyoscyamine
- imipramine
- levorphanol
- loperamide
- loxapine
- meclizine
- meperidine
- methadone
- methscopolamine
- mirtazapine
- molindone
- morphine
- nalbuphine
- nortriptyline
- olanzapine
- oliceridine
- orforglipron
- orphenadrine
- oxybutynin
- oxycodone
- oxymorphone
- pazopanib
- pentazocine
- perphenazine
- pheniramine
- pimozide
- pramlintide
- prochlorperazine
- promethazine
- protriptyline
- pyrilamine
- quetiapine
- remifentanil
- scopolamine
- sofpironium topical
- solifenacin
- sufentanil
- tapentadol
- thioridazine
- thiothixene
- tolterodine
- topotecan
- tramadol
- trifluoperazine
- trihexyphenidyl
- trimipramine
- triprolidine
- trospium
Monitor/Modify Tx
- atazanavir
- atogepant
- atorvastatin
- belumosudil
- bempedoic acid
- ceftobiprole
- clarithromycin
- clopidogrel
- cobicistat
- cyclosporine
- darolutamide
- darunavir
- elexacaftor/tezacaftor/ivacaftor
- eltrombopag
- enasidenib
- encorafenib
- erythromycin
- fluvastatin
- fostemsavir
- gemfibrozil
- glecaprevir
- irbesartan
- lapatinib
- leflunomide
- leniolisib
- letermovir
- lopinavir/ritonavir
- lovastatin
- methotrexate
- midostaurin
- mitoxantrone
- momelotinib
- nateglinide
- pibrentasvir
- pitavastatin
- pravastatin
- red yeast rice
- repaglinide
- resmetirom
- rifampin
- rilzabrutinib
- riociguat
- ritonavir
- rivaroxaban
- rosuvastatin
- sacubitril
- simvastatin
- talazoparib
- tenofovir alafenamide
- tenofovir disoproxil
- teriflunomide
- tipranavir
- ubrogepant
- vadadustat
- velpatasvir
- voclosporin
- voxilaprevir
Caution Advised
- bosentan
- seladelpar
- sulfasalazine
Adverse Reactions .
Serious Reactions
- pancreatitis
- sphincter of Oddi spasm
- hypersensitivity reaction
- anaphylaxis
- angioedema
- constipation, severe
- intestinal obstruction
- intestinal perforation
- fecal impaction
Common Reactions
- constipation
- nausea
- vomiting
- abdominal pain
- ALT incr.
- abdominal distension
- bronchitis
- dizziness
- flatulence
- rash
- somnolence
- sedation
Safety/Monitoring .
Monitoring Parameters
Cr at baseline
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; no known risk of fetal harm based on animal data at 10x and 115x therapeutic exposure
Lactation
Clinical Summary
weigh risk/benefit while breastfeeding; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: for eluxadoline: unknown; CYP450: unknown
Excretion: for eluxadoline: feces 82.2%, urine <1%; Half-life: 3.7-6h
Subclass: Diarrhea ; Irritable Bowel Syndrome (IBS)
Mechanism of Action
for eluxadoline: binds to various opioid receptors, inhibiting peristalsis
Formulary .
No Formulary Selected
Manufacturer/Pricing .
Manufacturer: Allergan, Inc.
DEA/FDA: Schedule IV
Retail Price
Estimated prices only. For current pricing, visit GoodRx.
oral tablet:
- 75 mg (60 ea): $1,421.00
- 100 mg (60 ea): $1,421.00
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