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Shingrix
zoster vaccine (recombinant), adjuvanted (RZV)
Adult Dosing .
Dosage forms: INJ
shingles prevention
- [immunocompromised pts, 18 yo and older]
- Dose: 0.5 mL IM x1 at mo 0 and mo 1-2 for 2 total doses; Info: repeat dose if <4wk between 1st and 2nd dose
- [immunocompetent pts, 50 yo and older]
- Dose: 0.5 mL IM x2 doses 2-6mo apart; Info: repeat dose if <4wk between 1st and 2nd dose; search 'immunization' for epocrates Adult Immunization decision tool incl. links to CDC/ACIP schedules
renal dosing
- [no adjustment]
- renal impairment: no adjustment
- HD/PD: no adjustment; no supplement
hepatic dosing
- [no adjustment]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- caution: illness, acute moderate-severe
- caution: herpes zoster episode, active
Drug Interactions .
Overview
zoster vaccine, recombinant
vaccine
- non-live vaccine
Avoid/Use Alternative
- interferon gamma 1b
Monitor/Modify Tx
- alemtuzumab
- anti-thymocyte globulin
- belimumab
- blinatumomab
- brentuximab vedotin
- daratumumab
- deuruxolitinib
- elranatamab
- epcoritamab
- gemtuzumab ozogamicin
- glofitamab
- ibritumomab tiuxetan
- inebilizumab
- inotuzumab ozogamicin
- isatuximab
- loncastuximab tesirine
- lymphocyte immune globulin, anti-thymocyte globulin
- mosunetuzumab
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- ofatumumab
- polatuzumab vedotin
- rituximab
- tafasitamab
- talquetamab
- teclistamab
- ublituximab
- venetoclax
Adverse Reactions .
Serious Reactions
- hypersensitivity rxn
- anaphylaxis
- lymphadenitis
- fever
- optic neuropathy
- Guillain-Barre syndrome
Common Reactions
- injection site rxn
- myalgia
- fatigue
- headache
- rigors
- fever
- nausea
- vomiting
- diarrhea
- abdominal pain
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy, consider delaying vaccination until pregnancy completed; inadequate human data available; no known risk of fetal harm based on animal data at 0.2x recommended human dose
Lactation
Clinical Summary
may use while breastfeeding, consider delaying vaccination if active herpes zoster episode; no human data available, though risk of infant harm not expected based on vaccine properties; no human data available to assess effects on milk production
Pharmacology .
Metabolism: other; CYP450: unknown
Excretion: other; Half-life: unknown
Subclass: Routine Adult Vaccines ; Varicella/Zoster (VZV) Vaccines
Mechanism of Action
exact mechanism of action unknown; induces antibody formation
Formulary .
No Formulary Selected
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