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Oxervate (cenegermin-bkbj)
cenegermin (recombinant) ophthalmic
Adult Dosing .
Dosage forms: SOL: 0.002%
Special Note
- [drug name clarification]
- Info: nonproprietary name = cenegermin-bkbj
neurotrophic keratitis
- [1 gtt in eye(s) 6x/day x8wk]
- Info: give doses at 2h intervals while awake
Peds Dosing .
- Dosage forms: SOL: 0.002%
Special Note
- [drug name clarification]
- Info: nonproprietary name = cenegermin-bkbj
neurotrophic keratitis
- [2 yo and older]
- Dose: 1 gtt in eye(s) 6x/day x8wk; Info: give doses at 2h intervals while awake
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- ocular infection
Drug Interactions .
Overview
cenegermin ophthalmic
nerve growth factor ophthalmic
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- ocular pain
- corneal deposits
- foreign body sensation
- ocular hyperemia
- ocular inflammation
- lacrimation
- photophobia
- headache
- blepharitis
- corneal neovascularization
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on minimal systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: unknown; CYP450: unknown; Info: minimal systemic absorption
Excretion: tears; Half-life: unknown
Subclass: Neurotrophic Factors, Ophthalmic
Mechanism of Action
binds high affinity (TrkA) and low affinity (p75NTR) nerve growth factor receptors in the anterior segment of the eye, supporting corneal innervation and integrity (recombinant human nerve growth factor)
Formulary .
No Formulary Selected
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