Librium

Overview

chlordiazepoxide

benzodiazepine

• CYP3A4 substrate
• CNS depression
• hypotensive effects

Avoid/Use Alternative

• alfentanil
Librium (chlordiazepoxide)

+

alfentanil

1 interaction

Avoid/Use Alternative

chlordiazepoxide + alfentanil

use alternative or monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, delayed recovery from anesthesia, severe hypotension, incl. orthostasis, syncope (additive effects)

• alprazolam
Librium (chlordiazepoxide)

+

alprazolam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + alprazolam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate benzodiazepine tx)

• aripiprazole lauroxil
Librium (chlordiazepoxide)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

chlordiazepoxide + aripiprazole lauroxil

ARISTADA INITIO: avoid combo; ARISTADA: monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• buprenorphine
Librium (chlordiazepoxide)

+

buprenorphine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + buprenorphine

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• butalbital
Librium (chlordiazepoxide)

+

butalbital

1 interaction

Avoid/Use Alternative

chlordiazepoxide + butalbital

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• butorphanol
Librium (chlordiazepoxide)

+

butorphanol

1 interaction

Avoid/Use Alternative

chlordiazepoxide + butorphanol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• clobazam
Librium (chlordiazepoxide)

+

clobazam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + clobazam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (additive effects, duplicate tx)

• clonazepam
Librium (chlordiazepoxide)

+

clonazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + clonazepam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (additive effects, duplicate tx)

• clonidine
Librium (chlordiazepoxide)

+

clonidine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + clonidine

if ADHD use, avoid combo; otherwise, monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clorazepate
Librium (chlordiazepoxide)

+

clorazepate

1 interaction

Avoid/Use Alternative

chlordiazepoxide + clorazepate

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (additive effects, duplicate tx)

• codeine
Librium (chlordiazepoxide)

+

codeine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• diazepam
Librium (chlordiazepoxide)

+

diazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + diazepam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate tx)

• dihydrocodeine
Librium (chlordiazepoxide)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + dihydrocodeine

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• doxylamine
Librium (chlordiazepoxide)

+

doxylamine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• estazolam
Librium (chlordiazepoxide)

+

estazolam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + estazolam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate benzodiazepine tx)

• ethanol
Librium (chlordiazepoxide)

+

ethanol

1 interaction

Avoid/Use Alternative

chlordiazepoxide + ethanol

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• fentanyl
Librium (chlordiazepoxide)

+

fentanyl

1 interaction

Avoid/Use Alternative

chlordiazepoxide + fentanyl

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (additive effects)

• flurazepam
Librium (chlordiazepoxide)

+

flurazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + flurazepam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate tx)

• hydrocodone
Librium (chlordiazepoxide)

+

hydrocodone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (additive effects)

• hydromorphone
Librium (chlordiazepoxide)

+

hydromorphone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + hydromorphone

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• isocarboxazid
Librium (chlordiazepoxide)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

chlordiazepoxide + isocarboxazid

use alternative during and x10 days after isocarboxazid use: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• kava
Librium (chlordiazepoxide)

+

kava

1 interaction

Avoid/Use Alternative

chlordiazepoxide + kava

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• kratom
Librium (chlordiazepoxide)

+

kratom

1 interaction

Avoid/Use Alternative

chlordiazepoxide + kratom

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levorphanol
Librium (chlordiazepoxide)

+

levorphanol

1 interaction

Avoid/Use Alternative

chlordiazepoxide + levorphanol

use alternative or monitor resp. rate, BP: decr. levorphanol start dose by at least 50%, consider decr. chlordiazepoxide dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• lorazepam
Librium (chlordiazepoxide)

+

lorazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + lorazepam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate benzodiazepine tx)

• meperidine
Librium (chlordiazepoxide)

+

meperidine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + meperidine

use alternative or monitor resp. rate, decr. meperidine dose 25-50%, consider decr. chlordiazepoxide dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (additive effects)

• metaxalone
Librium (chlordiazepoxide)

+

metaxalone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + metaxalone

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methadone
Librium (chlordiazepoxide)

+

methadone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + methadone

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• metoclopramide
Librium (chlordiazepoxide)

+

metoclopramide

1 interaction

Avoid/Use Alternative

chlordiazepoxide + metoclopramide

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• midazolam
Librium (chlordiazepoxide)

+

midazolam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate tx)

• morphine
Librium (chlordiazepoxide)

+

morphine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + morphine

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• nalbuphine
Librium (chlordiazepoxide)

+

nalbuphine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + nalbuphine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• oliceridine
Librium (chlordiazepoxide)

+

oliceridine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + oliceridine

use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• opium
Librium (chlordiazepoxide)

+

opium

1 interaction

Avoid/Use Alternative

chlordiazepoxide + opium

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• oxazepam
Librium (chlordiazepoxide)

+

oxazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + oxazepam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate tx)

• oxybate
Librium (chlordiazepoxide)

+

oxybate

1 interaction

Avoid/Use Alternative

chlordiazepoxide + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Librium (chlordiazepoxide)

+

oxycodone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + oxycodone

use alternative or monitor BP, resp. rate; decr. oxycodone start dose by at least 50%, consider decr. chlordiazepoxide dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• oxymorphone
Librium (chlordiazepoxide)

+

oxymorphone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + oxymorphone

use alternative or monitor resp. rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. chlordiazepoxide dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• pentazocine
Librium (chlordiazepoxide)

+

pentazocine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + pentazocine

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• phenelzine
Librium (chlordiazepoxide)

+

phenelzine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + phenelzine

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• promethazine
Librium (chlordiazepoxide)

+

promethazine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• quazepam
Librium (chlordiazepoxide)

+

quazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + quazepam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate benzodiazepine tx)

• remimazolam
Librium (chlordiazepoxide)

+

remimazolam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + remimazolam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ropeginterferon alfa-2b
Librium (chlordiazepoxide)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

chlordiazepoxide + ropeginterferon alfa-2b

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tapentadol
Librium (chlordiazepoxide)

+

tapentadol

1 interaction

Avoid/Use Alternative

chlordiazepoxide + tapentadol

use alternative or monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• temazepam
Librium (chlordiazepoxide)

+

temazepam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + temazepam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate benzodiazepine tx)

• thalidomide
Librium (chlordiazepoxide)

+

thalidomide

1 interaction

Avoid/Use Alternative

chlordiazepoxide + thalidomide

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tramadol
Librium (chlordiazepoxide)

+

tramadol

1 interaction

Avoid/Use Alternative

chlordiazepoxide + tramadol

use alternative or monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tranylcypromine
Librium (chlordiazepoxide)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

chlordiazepoxide + tranylcypromine

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• triazolam
Librium (chlordiazepoxide)

+

triazolam

1 interaction

Avoid/Use Alternative

chlordiazepoxide + triazolam

use alternative or monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects, duplicate tx)

• trimethobenzamide
Librium (chlordiazepoxide)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

chlordiazepoxide + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• zuranolone
Librium (chlordiazepoxide)

+

zuranolone

1 interaction

Avoid/Use Alternative

chlordiazepoxide + zuranolone

use alternative or monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
Librium (chlordiazepoxide)

+

5-HTP

1 interaction

Monitor/Modify Tx

chlordiazepoxide + 5-HTP

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• adagrasib
Librium (chlordiazepoxide)

+

adagrasib

1 interaction

Monitor/Modify Tx

chlordiazepoxide + adagrasib

monitor resp. rate: combo may incr. chlordiazepoxide levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• aldesleukin
Librium (chlordiazepoxide)

+

aldesleukin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + aldesleukin

monitor resp. rate; withhold aldesleukin if mod-severe somnolence occurs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• allopurinol
Librium (chlordiazepoxide)

+

allopurinol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + allopurinol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• almotriptan
Librium (chlordiazepoxide)

+

almotriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + almotriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amantadine
Librium (chlordiazepoxide)

+

amantadine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + amantadine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amitriptyline
Librium (chlordiazepoxide)

+

amitriptyline

1 interaction

Monitor/Modify Tx

chlordiazepoxide + amitriptyline

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• amoxapine
Librium (chlordiazepoxide)

+

amoxapine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + amoxapine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• apomorphine
Librium (chlordiazepoxide)

+

apomorphine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + apomorphine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Librium (chlordiazepoxide)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

chlordiazepoxide + apraclonidine ophthalmic

monitor resp. rate if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Librium (chlordiazepoxide)

+

aripiprazole bimonthly injection

1 interaction

Monitor/Modify Tx

chlordiazepoxide + aripiprazole bimonthly injection

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole monthly injection
Librium (chlordiazepoxide)

+

aripiprazole monthly injection

1 interaction

Monitor/Modify Tx

chlordiazepoxide + aripiprazole monthly injection

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• aripiprazole oral
Librium (chlordiazepoxide)

+

aripiprazole oral

1 interaction

Monitor/Modify Tx

chlordiazepoxide + aripiprazole oral

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• asenapine
Librium (chlordiazepoxide)

+

asenapine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + asenapine

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• baclofen
Librium (chlordiazepoxide)

+

baclofen

1 interaction

Monitor/Modify Tx

chlordiazepoxide + baclofen

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• brexpiprazole
Librium (chlordiazepoxide)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

chlordiazepoxide + brexpiprazole

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• brimonidine topical
Librium (chlordiazepoxide)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

chlordiazepoxide + brimonidine topical

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• brivaracetam
Librium (chlordiazepoxide)

+

brivaracetam

1 interaction

Monitor/Modify Tx

chlordiazepoxide + brivaracetam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cannabidiol
Librium (chlordiazepoxide)

+

cannabidiol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + cannabidiol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cannabis
Librium (chlordiazepoxide)

+

cannabis

1 interaction

Monitor/Modify Tx

chlordiazepoxide + cannabis

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• carbamazepine
Librium (chlordiazepoxide)

+

carbamazepine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + carbamazepine

monitor BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. syncope (additive effects)

• cariprazine
Librium (chlordiazepoxide)

+

cariprazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + cariprazine

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• carisoprodol
Librium (chlordiazepoxide)

+

carisoprodol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + carisoprodol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cenobamate
Librium (chlordiazepoxide)

+

cenobamate

1 interaction

Monitor/Modify Tx

chlordiazepoxide + cenobamate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cetirizine
Librium (chlordiazepoxide)

+

cetirizine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + cetirizine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chamomile, German
Librium (chlordiazepoxide)

+

chamomile, German

1 interaction

Monitor/Modify Tx

chlordiazepoxide + chamomile, German

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlophedianol
Librium (chlordiazepoxide)

+

chlophedianol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + chlophedianol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlorpromazine
Librium (chlordiazepoxide)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• citalopram
Librium (chlordiazepoxide)

+

citalopram

1 interaction

Monitor/Modify Tx

chlordiazepoxide + citalopram

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clomipramine
Librium (chlordiazepoxide)

+

clomipramine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + clomipramine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clozapine
Librium (chlordiazepoxide)

+

clozapine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + clozapine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• daridorexant
Librium (chlordiazepoxide)

+

daridorexant

1 interaction

Monitor/Modify Tx

chlordiazepoxide + daridorexant

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• darifenacin
Librium (chlordiazepoxide)

+

darifenacin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + darifenacin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desflurane
Librium (chlordiazepoxide)

+

desflurane

1 interaction

Monitor/Modify Tx

chlordiazepoxide + desflurane

monitor resp. rate, consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• desipramine
Librium (chlordiazepoxide)

+

desipramine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + desipramine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• desvenlafaxine
Librium (chlordiazepoxide)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + desvenlafaxine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• deutetrabenazine
Librium (chlordiazepoxide)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + deutetrabenazine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Librium (chlordiazepoxide)

+

dexbrompheniramine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + dexbrompheniramine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Librium (chlordiazepoxide)

+

dexchlorpheniramine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + dexchlorpheniramine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dexmedetomidine
Librium (chlordiazepoxide)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + dexmedetomidine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Librium (chlordiazepoxide)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

chlordiazepoxide + dexmedetomidine injection

monitor resp. rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dichlorphenamide
Librium (chlordiazepoxide)

+

dichlorphenamide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + dichlorphenamide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• difelikefalin
Librium (chlordiazepoxide)

+

difelikefalin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + difelikefalin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• difenoxin
Librium (chlordiazepoxide)

+

difenoxin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + difenoxin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• diphenhydramine
Librium (chlordiazepoxide)

+

diphenhydramine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + diphenhydramine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• domperidone
Librium (chlordiazepoxide)

+

domperidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + domperidone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• doxepin
Librium (chlordiazepoxide)

+

doxepin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + doxepin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• doxepin topical
Librium (chlordiazepoxide)

+

doxepin topical

1 interaction

Monitor/Modify Tx

chlordiazepoxide + doxepin topical

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dronabinol
Librium (chlordiazepoxide)

+

dronabinol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + dronabinol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• droperidol
Librium (chlordiazepoxide)

+

droperidol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + droperidol

monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• duloxetine
Librium (chlordiazepoxide)

+

duloxetine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + duloxetine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• efavirenz
Librium (chlordiazepoxide)

+

efavirenz

1 interaction

Monitor/Modify Tx

chlordiazepoxide + efavirenz

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eletriptan
Librium (chlordiazepoxide)

+

eletriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + eletriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• entacapone
Librium (chlordiazepoxide)

+

entacapone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + entacapone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• entrectinib
Librium (chlordiazepoxide)

+

entrectinib

1 interaction

Monitor/Modify Tx

chlordiazepoxide + entrectinib

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• escitalopram
Librium (chlordiazepoxide)

+

escitalopram

1 interaction

Monitor/Modify Tx

chlordiazepoxide + escitalopram

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• esketamine
Librium (chlordiazepoxide)

+

esketamine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + esketamine

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Librium (chlordiazepoxide)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

chlordiazepoxide + eslicarbazepine acetate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Librium (chlordiazepoxide)

+

eszopiclone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ethanol (in some formulations)
Librium (chlordiazepoxide)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ethanol (in some formulations)

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethosuximide
Librium (chlordiazepoxide)

+

ethosuximide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ethosuximide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etomidate
Librium (chlordiazepoxide)

+

etomidate

1 interaction

Monitor/Modify Tx

chlordiazepoxide + etomidate

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• felbamate
Librium (chlordiazepoxide)

+

felbamate

1 interaction

Monitor/Modify Tx

chlordiazepoxide + felbamate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fenfluramine
Librium (chlordiazepoxide)

+

fenfluramine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + fenfluramine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fesoterodine
Librium (chlordiazepoxide)

+

fesoterodine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + fesoterodine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• flibanserin
Librium (chlordiazepoxide)

+

flibanserin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + flibanserin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fluoxetine
Librium (chlordiazepoxide)

+

fluoxetine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + fluoxetine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fluphenazine
Librium (chlordiazepoxide)

+

fluphenazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + fluphenazine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fluvoxamine
Librium (chlordiazepoxide)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + fluvoxamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• foslevodopa
Librium (chlordiazepoxide)

+

foslevodopa

1 interaction

Monitor/Modify Tx

chlordiazepoxide + foslevodopa

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• frovatriptan
Librium (chlordiazepoxide)

+

frovatriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + frovatriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin
Librium (chlordiazepoxide)

+

gabapentin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + gabapentin

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Librium (chlordiazepoxide)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

chlordiazepoxide + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ganaxolone
Librium (chlordiazepoxide)

+

ganaxolone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ganaxolone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• glofitamab
Librium (chlordiazepoxide)

+

glofitamab

1 interaction

Monitor/Modify Tx

chlordiazepoxide + glofitamab

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• glycopyrrolate
Librium (chlordiazepoxide)

+

glycopyrrolate

1 interaction

Monitor/Modify Tx

chlordiazepoxide + glycopyrrolate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• guanfacine
Librium (chlordiazepoxide)

+

guanfacine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + guanfacine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• haloperidol
Librium (chlordiazepoxide)

+

haloperidol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + haloperidol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• hydroxyzine
Librium (chlordiazepoxide)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + hydroxyzine

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ifosfamide
Librium (chlordiazepoxide)

+

ifosfamide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ifosfamide

monitor resp. rate; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• iloperidone
Librium (chlordiazepoxide)

+

iloperidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + iloperidone

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• isoflurane
Librium (chlordiazepoxide)

+

isoflurane

1 interaction

Monitor/Modify Tx

chlordiazepoxide + isoflurane

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ketamine
Librium (chlordiazepoxide)

+

ketamine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

• lacosamide
Librium (chlordiazepoxide)

+

lacosamide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lacosamide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• lamotrigine
Librium (chlordiazepoxide)

+

lamotrigine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lamotrigine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• lasmiditan
Librium (chlordiazepoxide)

+

lasmiditan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lasmiditan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• lemborexant
Librium (chlordiazepoxide)

+

lemborexant

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• levetiracetam
Librium (chlordiazepoxide)

+

levetiracetam

1 interaction

Monitor/Modify Tx

chlordiazepoxide + levetiracetam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• levocetirizine
Librium (chlordiazepoxide)

+

levocetirizine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + levocetirizine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• levodopa
Librium (chlordiazepoxide)

+

levodopa

1 interaction

Monitor/Modify Tx

chlordiazepoxide + levodopa

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• linvoseltamab
Librium (chlordiazepoxide)

+

linvoseltamab

1 interaction

Monitor/Modify Tx

chlordiazepoxide + linvoseltamab

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• lofexidine
Librium (chlordiazepoxide)

+

lofexidine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lofexidine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• lumateperone
Librium (chlordiazepoxide)

+

lumateperone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lumateperone

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• lurasidone
Librium (chlordiazepoxide)

+

lurasidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + lurasidone

monitor resp. rate, BP; consider lowest lurasidone start dose, titrate slowly: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• melatonin
Librium (chlordiazepoxide)

+

melatonin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + melatonin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methocarbamol
Librium (chlordiazepoxide)

+

methocarbamol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + methocarbamol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methohexital
Librium (chlordiazepoxide)

+

methohexital

1 interaction

Monitor/Modify Tx

chlordiazepoxide + methohexital

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methsuximide
Librium (chlordiazepoxide)

+

methsuximide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + methsuximide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methyldopa
Librium (chlordiazepoxide)

+

methyldopa

1 interaction

Monitor/Modify Tx

chlordiazepoxide + methyldopa

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• metyrapone
Librium (chlordiazepoxide)

+

metyrapone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + metyrapone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• milnacipran
Librium (chlordiazepoxide)

+

milnacipran

1 interaction

Monitor/Modify Tx

chlordiazepoxide + milnacipran

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• mirtazapine
Librium (chlordiazepoxide)

+

mirtazapine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + mirtazapine

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• mitotane
Librium (chlordiazepoxide)

+

mitotane

1 interaction

Monitor/Modify Tx

chlordiazepoxide + mitotane

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• molindone
Librium (chlordiazepoxide)

+

molindone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + molindone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• mosunetuzumab
Librium (chlordiazepoxide)

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

chlordiazepoxide + mosunetuzumab

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Librium (chlordiazepoxide)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

chlordiazepoxide + mycophenolate mofetil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• naltrexone
Librium (chlordiazepoxide)

+

naltrexone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + naltrexone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• naratriptan
Librium (chlordiazepoxide)

+

naratriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + naratriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• nelarabine
Librium (chlordiazepoxide)

+

nelarabine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• nortriptyline
Librium (chlordiazepoxide)

+

nortriptyline

1 interaction

Monitor/Modify Tx

chlordiazepoxide + nortriptyline

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• olanzapine
Librium (chlordiazepoxide)

+

olanzapine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + olanzapine

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• opicapone
Librium (chlordiazepoxide)

+

opicapone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + opicapone

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• orphenadrine
Librium (chlordiazepoxide)

+

orphenadrine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + orphenadrine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxcarbazepine
Librium (chlordiazepoxide)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + oxcarbazepine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxybutynin
Librium (chlordiazepoxide)

+

oxybutynin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + oxybutynin

monitor resp. rate; decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS and resp. depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• paliperidone
Librium (chlordiazepoxide)

+

paliperidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + paliperidone

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• paroxetine
Librium (chlordiazepoxide)

+

paroxetine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + paroxetine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• passion flower
Librium (chlordiazepoxide)

+

passion flower

1 interaction

Monitor/Modify Tx

chlordiazepoxide + passion flower

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• pentobarbital
Librium (chlordiazepoxide)

+

pentobarbital

1 interaction

Monitor/Modify Tx

chlordiazepoxide + pentobarbital

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• perampanel
Librium (chlordiazepoxide)

+

perampanel

1 interaction

Monitor/Modify Tx

chlordiazepoxide + perampanel

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• perphenazine
Librium (chlordiazepoxide)

+

perphenazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + perphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• phenobarbital
Librium (chlordiazepoxide)

+

phenobarbital

1 interaction

Monitor/Modify Tx

chlordiazepoxide + phenobarbital

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• phenylephrine injection
Librium (chlordiazepoxide)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

chlordiazepoxide + phenylephrine injection

monitor BP: combo may decr. phenylephrine efficacy (antagonistic effects)

• phenytoin
Librium (chlordiazepoxide)

+

phenytoin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + phenytoin

monitor phenytoin levels, resp. rate: combo may incr. phenytoin levels, risk of toxicity; may incr. risk of CNS and resp. depression, psychomotor impairment (mechanism unknown; additive effects)

• pimozide
Librium (chlordiazepoxide)

+

pimozide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + pimozide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• pramipexole
Librium (chlordiazepoxide)

+

pramipexole

1 interaction

Monitor/Modify Tx

chlordiazepoxide + pramipexole

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• pregabalin
Librium (chlordiazepoxide)

+

pregabalin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + pregabalin

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• primidone
Librium (chlordiazepoxide)

+

primidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + primidone

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• procarbazine
Librium (chlordiazepoxide)

+

procarbazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + procarbazine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• prochlorperazine
Librium (chlordiazepoxide)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + prochlorperazine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• propofol
Librium (chlordiazepoxide)

+

propofol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + propofol

monitor resp. rate, BP; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (additive effects)

• quetiapine
Librium (chlordiazepoxide)

+

quetiapine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + quetiapine

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• rasagiline
Librium (chlordiazepoxide)

+

rasagiline

1 interaction

Monitor/Modify Tx

chlordiazepoxide + rasagiline

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• remifentanil
Librium (chlordiazepoxide)

+

remifentanil

1 interaction

Monitor/Modify Tx

chlordiazepoxide + remifentanil

monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (additive effects)

• repotrectinib
Librium (chlordiazepoxide)

+

repotrectinib

1 interaction

Monitor/Modify Tx

chlordiazepoxide + repotrectinib

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• risperidone
Librium (chlordiazepoxide)

+

risperidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + risperidone

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• rizatriptan
Librium (chlordiazepoxide)

+

rizatriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + rizatriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ropinirole
Librium (chlordiazepoxide)

+

ropinirole

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ropinirole

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• rufinamide
Librium (chlordiazepoxide)

+

rufinamide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + rufinamide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• safinamide
Librium (chlordiazepoxide)

+

safinamide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + safinamide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• scopolamine
Librium (chlordiazepoxide)

+

scopolamine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + scopolamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• selegiline
Librium (chlordiazepoxide)

+

selegiline

1 interaction

Monitor/Modify Tx

chlordiazepoxide + selegiline

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• selegiline transdermal
Librium (chlordiazepoxide)

+

selegiline transdermal

1 interaction

Monitor/Modify Tx

chlordiazepoxide + selegiline transdermal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• selinexor
Librium (chlordiazepoxide)

+

selinexor

1 interaction

Monitor/Modify Tx

chlordiazepoxide + selinexor

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• sertraline
Librium (chlordiazepoxide)

+

sertraline

1 interaction

Monitor/Modify Tx

chlordiazepoxide + sertraline

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• sevoflurane
Librium (chlordiazepoxide)

+

sevoflurane

1 interaction

Monitor/Modify Tx

chlordiazepoxide + sevoflurane

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• solifenacin
Librium (chlordiazepoxide)

+

solifenacin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + solifenacin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• stiripentol
Librium (chlordiazepoxide)

+

stiripentol

1 interaction

Monitor/Modify Tx

chlordiazepoxide + stiripentol

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• sufentanil
Librium (chlordiazepoxide)

+

sufentanil

1 interaction

Monitor/Modify Tx

chlordiazepoxide + sufentanil

monitor resp. rate, decr. sufentanil start dose, consider decr. chlordiazepoxide dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (additive effects)

• sumatriptan
Librium (chlordiazepoxide)

+

sumatriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + sumatriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• suvorexant
Librium (chlordiazepoxide)

+

suvorexant

1 interaction

Monitor/Modify Tx

chlordiazepoxide + suvorexant

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• thioridazine
Librium (chlordiazepoxide)

+

thioridazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + thioridazine

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• thiotepa
Librium (chlordiazepoxide)

+

thiotepa

1 interaction

Monitor/Modify Tx

chlordiazepoxide + thiotepa

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• thiothixene
Librium (chlordiazepoxide)

+

thiothixene

1 interaction

Monitor/Modify Tx

chlordiazepoxide + thiothixene

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tiagabine
Librium (chlordiazepoxide)

+

tiagabine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + tiagabine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tizanidine
Librium (chlordiazepoxide)

+

tizanidine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + tizanidine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tolcapone
Librium (chlordiazepoxide)

+

tolcapone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + tolcapone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tolterodine
Librium (chlordiazepoxide)

+

tolterodine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + tolterodine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• topiramate
Librium (chlordiazepoxide)

+

topiramate

1 interaction

Monitor/Modify Tx

chlordiazepoxide + topiramate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trazodone
Librium (chlordiazepoxide)

+

trazodone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + trazodone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trihexyphenidyl
Librium (chlordiazepoxide)

+

trihexyphenidyl

1 interaction

Monitor/Modify Tx

chlordiazepoxide + trihexyphenidyl

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trospium
Librium (chlordiazepoxide)

+

trospium

1 interaction

Monitor/Modify Tx

chlordiazepoxide + trospium

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• valbenazine
Librium (chlordiazepoxide)

+

valbenazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + valbenazine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• valerian
Librium (chlordiazepoxide)

+

valerian

1 interaction

Monitor/Modify Tx

chlordiazepoxide + valerian

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• valproic acid
Librium (chlordiazepoxide)

+

valproic acid

1 interaction

Monitor/Modify Tx

chlordiazepoxide + valproic acid

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• vigabatrin
Librium (chlordiazepoxide)

+

vigabatrin

1 interaction

Monitor/Modify Tx

chlordiazepoxide + vigabatrin

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• vilazodone
Librium (chlordiazepoxide)

+

vilazodone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + vilazodone

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• viloxazine
Librium (chlordiazepoxide)

+

viloxazine

1 interaction

Monitor/Modify Tx

chlordiazepoxide + viloxazine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• zaleplon
Librium (chlordiazepoxide)

+

zaleplon

1 interaction

Monitor/Modify Tx

chlordiazepoxide + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ziconotide
Librium (chlordiazepoxide)

+

ziconotide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ziconotide

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ziprasidone
Librium (chlordiazepoxide)

+

ziprasidone

1 interaction

Monitor/Modify Tx

chlordiazepoxide + ziprasidone

monitor BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• zolmitriptan
Librium (chlordiazepoxide)

+

zolmitriptan

1 interaction

Monitor/Modify Tx

chlordiazepoxide + zolmitriptan

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• zolpidem
Librium (chlordiazepoxide)

+

zolpidem

1 interaction

Monitor/Modify Tx

chlordiazepoxide + zolpidem

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• zonisamide
Librium (chlordiazepoxide)

+

zonisamide

1 interaction

Monitor/Modify Tx

chlordiazepoxide + zonisamide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

Therapeutic Advantage

• flumazenil
Librium (chlordiazepoxide)

+

flumazenil

1 interaction

Therapeutic Advantage

chlordiazepoxide + flumazenil

use for therapeutic advantage: combo will reverse sedation, other benzodiazepine effects (antagonistic effects)

Caution Advised

• atazanavir
Librium (chlordiazepoxide)

+

atazanavir

1 interaction

Caution Advised

chlordiazepoxide + atazanavir

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• baclofen intrathecal
Librium (chlordiazepoxide)

+

baclofen intrathecal

1 interaction

Caution Advised

chlordiazepoxide + baclofen intrathecal

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• brimonidine ophthalmic
Librium (chlordiazepoxide)

+

brimonidine ophthalmic

1 interaction

Caution Advised

chlordiazepoxide + brimonidine ophthalmic

caution advised if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• bromocriptine
Librium (chlordiazepoxide)

+

bromocriptine

1 interaction

Caution Advised

chlordiazepoxide + bromocriptine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• brompheniramine
Librium (chlordiazepoxide)

+

brompheniramine

1 interaction

Caution Advised

chlordiazepoxide + brompheniramine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• buspirone
Librium (chlordiazepoxide)

+

buspirone

1 interaction

Caution Advised

chlordiazepoxide + buspirone

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• carbinoxamine
Librium (chlordiazepoxide)

+

carbinoxamine

1 interaction

Caution Advised

chlordiazepoxide + carbinoxamine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ceritinib
Librium (chlordiazepoxide)

+

ceritinib

1 interaction

Caution Advised

chlordiazepoxide + ceritinib

caution advised: combo may incr. chlordiazepoxide levels, risk of adverse effects (hepatic metab. inhibited)

• chloramphenicol
Librium (chlordiazepoxide)

+

chloramphenicol

1 interaction

Caution Advised

chlordiazepoxide + chloramphenicol

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• chlorpheniramine
Librium (chlordiazepoxide)

+

chlorpheniramine

1 interaction

Caution Advised

chlordiazepoxide + chlorpheniramine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chlorzoxazone
Librium (chlordiazepoxide)

+

chlorzoxazone

1 interaction

Caution Advised

chlordiazepoxide + chlorzoxazone

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• clarithromycin
Librium (chlordiazepoxide)

+

clarithromycin

1 interaction

Caution Advised

chlordiazepoxide + clarithromycin

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• clemastine
Librium (chlordiazepoxide)

+

clemastine

1 interaction

Caution Advised

chlordiazepoxide + clemastine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cobicistat
Librium (chlordiazepoxide)

+

cobicistat

1 interaction

Caution Advised

chlordiazepoxide + cobicistat

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment (hepatic metab. inhibited)

• cyclobenzaprine
Librium (chlordiazepoxide)

+

cyclobenzaprine

1 interaction

Caution Advised

chlordiazepoxide + cyclobenzaprine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• cyproheptadine
Librium (chlordiazepoxide)

+

cyproheptadine

1 interaction

Caution Advised

chlordiazepoxide + cyproheptadine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dantrolene
Librium (chlordiazepoxide)

+

dantrolene

1 interaction

Caution Advised

chlordiazepoxide + dantrolene

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• dimenhydrinate
Librium (chlordiazepoxide)

+

dimenhydrinate

1 interaction

Caution Advised

chlordiazepoxide + dimenhydrinate

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• diphenoxylate
Librium (chlordiazepoxide)

+

diphenoxylate

1 interaction

Caution Advised

chlordiazepoxide + diphenoxylate

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• fosphenytoin
Librium (chlordiazepoxide)

+

fosphenytoin

1 interaction

Caution Advised

chlordiazepoxide + fosphenytoin

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• hyoscyamine
Librium (chlordiazepoxide)

+

hyoscyamine

1 interaction

Caution Advised

chlordiazepoxide + hyoscyamine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• idelalisib
Librium (chlordiazepoxide)

+

idelalisib

1 interaction

Caution Advised

chlordiazepoxide + idelalisib

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS and resp. depression, psychomotor impairment (hepatic metab. inhibited)

• imipramine
Librium (chlordiazepoxide)

+

imipramine

1 interaction

Caution Advised

chlordiazepoxide + imipramine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• itraconazole
Librium (chlordiazepoxide)

+

itraconazole

1 interaction

Caution Advised

chlordiazepoxide + itraconazole

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• ketoconazole
Librium (chlordiazepoxide)

+

ketoconazole

1 interaction

Caution Advised

chlordiazepoxide + ketoconazole

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• levoketoconazole
Librium (chlordiazepoxide)

+

levoketoconazole

1 interaction

Caution Advised

chlordiazepoxide + levoketoconazole

caution advised: combo may incr. chlordiazepoxide levels, risk of adverse effects (hepatic metab. inhibited)

• levomilnacipran
Librium (chlordiazepoxide)

+

levomilnacipran

1 interaction

Caution Advised

chlordiazepoxide + levomilnacipran

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• lonafarnib
Librium (chlordiazepoxide)

+

lonafarnib

1 interaction

Caution Advised

chlordiazepoxide + lonafarnib

caution advised: combo may incr. chlordiazepoxide levels, risk of adverse effects (hepatic metab. inhibited)

• lopinavir/ritonavir
Librium (chlordiazepoxide)

+

lopinavir/ ritonavir

1 interaction

Caution Advised

chlordiazepoxide + lopinavir/ ritonavir

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• loxapine
Librium (chlordiazepoxide)

+

loxapine

1 interaction

Caution Advised

chlordiazepoxide + loxapine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• meclizine
Librium (chlordiazepoxide)

+

meclizine

1 interaction

Caution Advised

chlordiazepoxide + meclizine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• meprobamate
Librium (chlordiazepoxide)

+

meprobamate

1 interaction

Caution Advised

chlordiazepoxide + meprobamate

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• metyrosine
Librium (chlordiazepoxide)

+

metyrosine

1 interaction

Caution Advised

chlordiazepoxide + metyrosine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• mifepristone
Librium (chlordiazepoxide)

+

mifepristone

1 interaction

Caution Advised

chlordiazepoxide + mifepristone

caution advised w/in 14 days of daily mifepristone use: combo may incr. chlordiazepoxide levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• nefazodone
Librium (chlordiazepoxide)

+

nefazodone

1 interaction

Caution Advised

chlordiazepoxide + nefazodone

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• nelfinavir
Librium (chlordiazepoxide)

+

nelfinavir

1 interaction

Caution Advised

chlordiazepoxide + nelfinavir

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• pheniramine
Librium (chlordiazepoxide)

+

pheniramine

1 interaction

Caution Advised

chlordiazepoxide + pheniramine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• posaconazole
Librium (chlordiazepoxide)

+

posaconazole

1 interaction

Caution Advised

chlordiazepoxide + posaconazole

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• protriptyline
Librium (chlordiazepoxide)

+

protriptyline

1 interaction

Caution Advised

chlordiazepoxide + protriptyline

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• pyrilamine
Librium (chlordiazepoxide)

+

pyrilamine

1 interaction

Caution Advised

chlordiazepoxide + pyrilamine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ramelteon
Librium (chlordiazepoxide)

+

ramelteon

1 interaction

Caution Advised

chlordiazepoxide + ramelteon

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• ribociclib
Librium (chlordiazepoxide)

+

ribociclib

1 interaction

Caution Advised

chlordiazepoxide + ribociclib

caution advised: combo may incr. chlordiazepoxide levels, risk of adverse effects (hepatic metab. inhibited)

• ritonavir
Librium (chlordiazepoxide)

+

ritonavir

1 interaction

Caution Advised

chlordiazepoxide + ritonavir

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• rotigotine transdermal
Librium (chlordiazepoxide)

+

rotigotine transdermal

1 interaction

Caution Advised

chlordiazepoxide + rotigotine transdermal

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tasimelteon
Librium (chlordiazepoxide)

+

tasimelteon

1 interaction

Caution Advised

chlordiazepoxide + tasimelteon

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tetrabenazine
Librium (chlordiazepoxide)

+

tetrabenazine

1 interaction

Caution Advised

chlordiazepoxide + tetrabenazine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tipranavir
Librium (chlordiazepoxide)

+

tipranavir

1 interaction

Caution Advised

chlordiazepoxide + tipranavir

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• trifluoperazine
Librium (chlordiazepoxide)

+

trifluoperazine

1 interaction

Caution Advised

chlordiazepoxide + trifluoperazine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• trimipramine
Librium (chlordiazepoxide)

+

trimipramine

1 interaction

Caution Advised

chlordiazepoxide + trimipramine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• triprolidine
Librium (chlordiazepoxide)

+

triprolidine

1 interaction

Caution Advised

chlordiazepoxide + triprolidine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tucatinib
Librium (chlordiazepoxide)

+

tucatinib

1 interaction

Caution Advised

chlordiazepoxide + tucatinib

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• venlafaxine
Librium (chlordiazepoxide)

+

venlafaxine

1 interaction

Caution Advised

chlordiazepoxide + venlafaxine

caution advised: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• voriconazole
Librium (chlordiazepoxide)

+

voriconazole

1 interaction

Caution Advised

chlordiazepoxide + voriconazole

caution advised: combo may incr. chlordiazepoxide levels, risk of CNS depression, psychomotor impairment (hepatic metab. inhibited)