Ayvakit

Overview

avapritinib

kinase inhibitor

• CYP3A4 substrate
• antiplatelet/anticoagulant effects
• photosensitivity

Avoid/Use Alternative

• adagrasib
Ayvakit (avapritinib)

+

adagrasib

1 interaction

Avoid/Use Alternative

avapritinib + adagrasib

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• aminolevulinic acid topical
Ayvakit (avapritinib)

+

aminolevulinic acid topical

1 interaction

Avoid/Use Alternative

avapritinib + aminolevulinic acid topical

avoid combo during and x1wk after avapritinib tx: combo may incr. risk of photosensitivity reaction (additive effects)

• apalutamide
Ayvakit (avapritinib)

+

apalutamide

1 interaction

Avoid/Use Alternative

avapritinib + apalutamide

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• aprepitant
Ayvakit (avapritinib)

+

aprepitant

1 interaction

Avoid/Use Alternative

avapritinib + aprepitant

GIST: if aprepitant 3-day regimen, use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: if aprepitant 3-day regimen, use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: if aprepitant 3-day regimen, avoid combo; aprepitant single dose-regimen OK: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• atazanavir
Ayvakit (avapritinib)

+

atazanavir

1 interaction

Avoid/Use Alternative

avapritinib + atazanavir

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• avacopan
Ayvakit (avapritinib)

+

avacopan

1 interaction

Avoid/Use Alternative

avapritinib + avacopan

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• berotralstat
Ayvakit (avapritinib)

+

berotralstat

1 interaction

Avoid/Use Alternative

avapritinib + berotralstat

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• bosentan
Ayvakit (avapritinib)

+

bosentan

1 interaction

Avoid/Use Alternative

avapritinib + bosentan

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• butalbital
Ayvakit (avapritinib)

+

butalbital

1 interaction

Avoid/Use Alternative

avapritinib + butalbital

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• carbamazepine
Ayvakit (avapritinib)

+

carbamazepine

1 interaction

Avoid/Use Alternative

avapritinib + carbamazepine

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• cenobamate
Ayvakit (avapritinib)

+

cenobamate

1 interaction

Avoid/Use Alternative

avapritinib + cenobamate

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• ceritinib
Ayvakit (avapritinib)

+

ceritinib

1 interaction

Avoid/Use Alternative

avapritinib + ceritinib

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• chloramphenicol
Ayvakit (avapritinib)

+

chloramphenicol

1 interaction

Avoid/Use Alternative

avapritinib + chloramphenicol

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ciprofloxacin
Ayvakit (avapritinib)

+

ciprofloxacin

1 interaction

Avoid/Use Alternative

avapritinib + ciprofloxacin

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• clarithromycin
Ayvakit (avapritinib)

+

clarithromycin

1 interaction

Avoid/Use Alternative

avapritinib + clarithromycin

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• clofazimine
Ayvakit (avapritinib)

+

clofazimine

1 interaction

Avoid/Use Alternative

avapritinib + clofazimine

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• cobicistat
Ayvakit (avapritinib)

+

cobicistat

1 interaction

Avoid/Use Alternative

avapritinib + cobicistat

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• conivaptan
Ayvakit (avapritinib)

+

conivaptan

1 interaction

Avoid/Use Alternative

avapritinib + conivaptan

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd during and x7 days after conivaptan tx; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd during and x7 days after conivaptan tx; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo during and x7 days after conivaptan tx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• crizotinib
Ayvakit (avapritinib)

+

crizotinib

1 interaction

Avoid/Use Alternative

avapritinib + crizotinib

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• cyclosporine
Ayvakit (avapritinib)

+

cyclosporine

1 interaction

Avoid/Use Alternative

avapritinib + cyclosporine

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• dabrafenib
Ayvakit (avapritinib)

+

dabrafenib

1 interaction

Avoid/Use Alternative

avapritinib + dabrafenib

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• danazol
Ayvakit (avapritinib)

+

danazol

1 interaction

Avoid/Use Alternative

avapritinib + danazol

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• darunavir
Ayvakit (avapritinib)

+

darunavir

1 interaction

Avoid/Use Alternative

avapritinib + darunavir

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• diltiazem
Ayvakit (avapritinib)

+

diltiazem

1 interaction

Avoid/Use Alternative

avapritinib + diltiazem

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• dronedarone
Ayvakit (avapritinib)

+

dronedarone

1 interaction

Avoid/Use Alternative

avapritinib + dronedarone

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• duvelisib
Ayvakit (avapritinib)

+

duvelisib

1 interaction

Avoid/Use Alternative

avapritinib + duvelisib

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• efavirenz
Ayvakit (avapritinib)

+

efavirenz

1 interaction

Avoid/Use Alternative

avapritinib + efavirenz

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• encorafenib
Ayvakit (avapritinib)

+

encorafenib

1 interaction

Avoid/Use Alternative

avapritinib + encorafenib

avoid combo: combo may decr. avapritinib levels, efficacy; may incr. risk of GI or other bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• enzalutamide
Ayvakit (avapritinib)

+

enzalutamide

1 interaction

Avoid/Use Alternative

avapritinib + enzalutamide

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• erythromycin
Ayvakit (avapritinib)

+

erythromycin

1 interaction

Avoid/Use Alternative

avapritinib + erythromycin

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ethinyl estradiol (contraceptive)
Ayvakit (avapritinib)

+

ethinyl estradiol (contraceptive)

1 interaction

Avoid/Use Alternative

avapritinib + ethinyl estradiol (contraceptive)

monitor bleeding or thrombosis s/sx, especially if ethinyl estradiol dose >20 mcg; if possible, use alternative contraception: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects; may incr. ethinyl estradiol levels, risk of thromboembolism, other adverse effects (hepatic metabolism inhibited; mechanism unknown)

• etravirine
Ayvakit (avapritinib)

+

etravirine

1 interaction

Avoid/Use Alternative

avapritinib + etravirine

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• fedratinib
Ayvakit (avapritinib)

+

fedratinib

1 interaction

Avoid/Use Alternative

avapritinib + fedratinib

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fexinidazole
Ayvakit (avapritinib)

+

fexinidazole

1 interaction

Avoid/Use Alternative

avapritinib + fexinidazole

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• fluconazole
Ayvakit (avapritinib)

+

fluconazole

1 interaction

Avoid/Use Alternative

avapritinib + fluconazole

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fosamprenavir
Ayvakit (avapritinib)

+

fosamprenavir

1 interaction

Avoid/Use Alternative

avapritinib + fosamprenavir

GIST: use alternative or monitor bleeding s/sx; consider avapritinib dose adjustment; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; consider avapritinib dose adjustment; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. or decr. avapritinib levels, incr. risk of bleeding (including life-threatening), other adverse effects or decr. efficacy (hepatic metabolism altered)

• fosphenytoin
Ayvakit (avapritinib)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

avapritinib + fosphenytoin

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• grapefruit
Ayvakit (avapritinib)

+

grapefruit

1 interaction

Avoid/Use Alternative

avapritinib + grapefruit

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (GI metabolism inhibited)

• idelalisib
Ayvakit (avapritinib)

+

idelalisib

1 interaction

Avoid/Use Alternative

avapritinib + idelalisib

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• imatinib
Ayvakit (avapritinib)

+

imatinib

1 interaction

Avoid/Use Alternative

avapritinib + imatinib

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• isavuconazonium
Ayvakit (avapritinib)

+

isavuconazonium

1 interaction

Avoid/Use Alternative

avapritinib + isavuconazonium

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• itraconazole
Ayvakit (avapritinib)

+

itraconazole

1 interaction

Avoid/Use Alternative

avapritinib + itraconazole

avoid combo during and x2wk after itraconazole tx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ivosidenib
Ayvakit (avapritinib)

+

ivosidenib

1 interaction

Avoid/Use Alternative

avapritinib + ivosidenib

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• ketoconazole
Ayvakit (avapritinib)

+

ketoconazole

1 interaction

Avoid/Use Alternative

avapritinib + ketoconazole

avoid combo during and up to 1wk after ketoconazole tx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lefamulin
Ayvakit (avapritinib)

+

lefamulin

1 interaction

Avoid/Use Alternative

avapritinib + lefamulin

GIST: if oral lefamulin, use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: if oral lefamulin, use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: if oral lefamulin, avoid combo; IV lefamulin use OK: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lenacapavir
Ayvakit (avapritinib)

+

lenacapavir

1 interaction

Avoid/Use Alternative

avapritinib + lenacapavir

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd during and x9mo after lenacapavir tx; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd during and x9mo after lenacapavir tx; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo during and x9mo after lenacapavir tx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• letermovir
Ayvakit (avapritinib)

+

letermovir

1 interaction

Avoid/Use Alternative

avapritinib + letermovir

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• levoketoconazole
Ayvakit (avapritinib)

+

levoketoconazole

1 interaction

Avoid/Use Alternative

avapritinib + levoketoconazole

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lonafarnib
Ayvakit (avapritinib)

+

lonafarnib

1 interaction

Avoid/Use Alternative

avapritinib + lonafarnib

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lopinavir/ritonavir
Ayvakit (avapritinib)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

avapritinib + lopinavir/ ritonavir

avoid combo: combo may incr. or decr. avapritinib levels, incr. risk of bleeding (including life-threatening), other adverse effects or decr. efficacy (hepatic metabolism altered)

• lorlatinib
Ayvakit (avapritinib)

+

lorlatinib

1 interaction

Avoid/Use Alternative

avapritinib + lorlatinib

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• lumacaftor/ivacaftor
Ayvakit (avapritinib)

+

lumacaftor/ ivacaftor

1 interaction

Avoid/Use Alternative

avapritinib + lumacaftor/ ivacaftor

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• mavacamten
Ayvakit (avapritinib)

+

mavacamten

1 interaction

Avoid/Use Alternative

avapritinib + mavacamten

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• mifepristone
Ayvakit (avapritinib)

+

mifepristone

1 interaction

Avoid/Use Alternative

avapritinib + mifepristone

avoid combo during and x14 days after daily mifepristone use; caution advised if pregnancy termination use: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• mitapivat
Ayvakit (avapritinib)

+

mitapivat

1 interaction

Avoid/Use Alternative

avapritinib + mitapivat

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• mitotane
Ayvakit (avapritinib)

+

mitotane

1 interaction

Avoid/Use Alternative

avapritinib + mitotane

avoid combo: combo may decr. avapritinib levels, efficacy; may incr. risk of bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• modafinil
Ayvakit (avapritinib)

+

modafinil

1 interaction

Avoid/Use Alternative

avapritinib + modafinil

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• nafcillin
Ayvakit (avapritinib)

+

nafcillin

1 interaction

Avoid/Use Alternative

avapritinib + nafcillin

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• nefazodone
Ayvakit (avapritinib)

+

nefazodone

1 interaction

Avoid/Use Alternative

avapritinib + nefazodone

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• nelfinavir
Ayvakit (avapritinib)

+

nelfinavir

1 interaction

Avoid/Use Alternative

avapritinib + nelfinavir

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• netupitant
Ayvakit (avapritinib)

+

netupitant

1 interaction

Avoid/Use Alternative

avapritinib + netupitant

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd during and x1wk after (fos)netupitant tx; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd during and x1wk after (fos)netupitant tx; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo during and x1wk after (fos)netupitant tx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• nilotinib
Ayvakit (avapritinib)

+

nilotinib

1 interaction

Avoid/Use Alternative

avapritinib + nilotinib

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• nirogacestat
Ayvakit (avapritinib)

+

nirogacestat

1 interaction

Avoid/Use Alternative

avapritinib + nirogacestat

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• pacritinib
Ayvakit (avapritinib)

+

pacritinib

1 interaction

Avoid/Use Alternative

avapritinib + pacritinib

avoid combo: combo may decr. avapritinib levels, efficacy; may incr. risk of bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• pentobarbital
Ayvakit (avapritinib)

+

pentobarbital

1 interaction

Avoid/Use Alternative

avapritinib + pentobarbital

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• pexidartinib
Ayvakit (avapritinib)

+

pexidartinib

1 interaction

Avoid/Use Alternative

avapritinib + pexidartinib

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• phenobarbital
Ayvakit (avapritinib)

+

phenobarbital

1 interaction

Avoid/Use Alternative

avapritinib + phenobarbital

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• phenytoin
Ayvakit (avapritinib)

+

phenytoin

1 interaction

Avoid/Use Alternative

avapritinib + phenytoin

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• porfimer
Ayvakit (avapritinib)

+

porfimer

1 interaction

Avoid/Use Alternative

avapritinib + porfimer

avoid combo during and x1wk after avapritinib tx: combo may incr. risk of GI or other bleeding (including life-threatening), photosensitivity reaction (additive effects)

• posaconazole
Ayvakit (avapritinib)

+

posaconazole

1 interaction

Avoid/Use Alternative

avapritinib + posaconazole

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• primidone
Ayvakit (avapritinib)

+

primidone

1 interaction

Avoid/Use Alternative

avapritinib + primidone

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• repotrectinib
Ayvakit (avapritinib)

+

repotrectinib

1 interaction

Avoid/Use Alternative

avapritinib + repotrectinib

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• ribociclib
Ayvakit (avapritinib)

+

ribociclib

1 interaction

Avoid/Use Alternative

avapritinib + ribociclib

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• rifabutin
Ayvakit (avapritinib)

+

rifabutin

1 interaction

Avoid/Use Alternative

avapritinib + rifabutin

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• rifampin
Ayvakit (avapritinib)

+

rifampin

1 interaction

Avoid/Use Alternative

avapritinib + rifampin

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• rifapentine
Ayvakit (avapritinib)

+

rifapentine

1 interaction

Avoid/Use Alternative

avapritinib + rifapentine

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• rilzabrutinib
Ayvakit (avapritinib)

+

rilzabrutinib

1 interaction

Avoid/Use Alternative

avapritinib + rilzabrutinib

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ritonavir
Ayvakit (avapritinib)

+

ritonavir

1 interaction

Avoid/Use Alternative

avapritinib + ritonavir

avoid combo: combo may incr. or decr. avapritinib levels, incr. risk of bleeding (including life-threatening), other adverse effects or decr. efficacy (hepatic metabolism altered)

• sotorasib
Ayvakit (avapritinib)

+

sotorasib

1 interaction

Avoid/Use Alternative

avapritinib + sotorasib

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• St. John's wort
Ayvakit (avapritinib)

+

St. John's wort

1 interaction

Avoid/Use Alternative

avapritinib + St. John's wort

avoid combo: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• tipranavir
Ayvakit (avapritinib)

+

tipranavir

1 interaction

Avoid/Use Alternative

avapritinib + tipranavir

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• tucatinib
Ayvakit (avapritinib)

+

tucatinib

1 interaction

Avoid/Use Alternative

avapritinib + tucatinib

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• verapamil
Ayvakit (avapritinib)

+

verapamil

1 interaction

Avoid/Use Alternative

avapritinib + verapamil

GIST: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 100 mg qd; ADVANCED SYSTEMIC MASTOCYTOSIS: use alternative or monitor bleeding s/sx; decr. avapritinib start dose to 50 mg qd; INDOLENT SYSTEMIC MASTOCYTOSIS: avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• voriconazole
Ayvakit (avapritinib)

+

voriconazole

1 interaction

Avoid/Use Alternative

avapritinib + voriconazole

avoid combo: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

Monitor/Modify Tx

• acalabrutinib
Ayvakit (avapritinib)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

avapritinib + acalabrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ado-trastuzumab emtansine
Ayvakit (avapritinib)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

avapritinib + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• afatinib
Ayvakit (avapritinib)

+

afatinib

1 interaction

Monitor/Modify Tx

avapritinib + afatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• alpha-tocopherol (vitamin E)
Ayvakit (avapritinib)

+

alpha-tocopherol (vitamin E)

1 interaction

Monitor/Modify Tx

avapritinib + alpha-tocopherol (vitamin E)

monitor bleeding signs/symptoms, especially with alpha-tocopherol doses >800 units/day: combo may increase risk of bleeding, including life-threatening (additive effects)

• alprazolam
Ayvakit (avapritinib)

+

alprazolam

1 interaction

Monitor/Modify Tx

avapritinib + alprazolam

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• alprostadil intracavernous
Ayvakit (avapritinib)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

avapritinib + alprostadil intracavernous

monitor injection site bleeding signs/symptoms: combo may increase risk of localized bleeding (additive effects)

• alprostadil intravenous
Ayvakit (avapritinib)

+

alprostadil intravenous

1 interaction

Monitor/Modify Tx

avapritinib + alprostadil intravenous

monitor bleeding signs/symptoms: combo may increase risk of bleeding, including life-threatening (additive effects)

• alteplase
Ayvakit (avapritinib)

+

alteplase

1 interaction

Monitor/Modify Tx

avapritinib + alteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• amiodarone
Ayvakit (avapritinib)

+

amiodarone

1 interaction

Monitor/Modify Tx

avapritinib + amiodarone

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• amlodipine
Ayvakit (avapritinib)

+

amlodipine

1 interaction

Monitor/Modify Tx

avapritinib + amlodipine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• anacaulase topical
Ayvakit (avapritinib)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

avapritinib + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• anagrelide
Ayvakit (avapritinib)

+

anagrelide

1 interaction

Monitor/Modify Tx

avapritinib + anagrelide

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• antithrombin
Ayvakit (avapritinib)

+

antithrombin

1 interaction

Monitor/Modify Tx

avapritinib + antithrombin

monitor bleeding s/sx: combo may incr. risk of bleeding, including severe or life-threatening (additive effects)

• apixaban
Ayvakit (avapritinib)

+

apixaban

1 interaction

Monitor/Modify Tx

avapritinib + apixaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• argatroban
Ayvakit (avapritinib)

+

argatroban

1 interaction

Monitor/Modify Tx

avapritinib + argatroban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• asciminib
Ayvakit (avapritinib)

+

asciminib

1 interaction

Monitor/Modify Tx

avapritinib + asciminib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• asparaginase
Ayvakit (avapritinib)

+

asparaginase

1 interaction

Monitor/Modify Tx

avapritinib + asparaginase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• aspirin
Ayvakit (avapritinib)

+

aspirin

1 interaction

Monitor/Modify Tx

avapritinib + aspirin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• atorvastatin
Ayvakit (avapritinib)

+

atorvastatin

1 interaction

Monitor/Modify Tx

avapritinib + atorvastatin

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• axitinib
Ayvakit (avapritinib)

+

axitinib

1 interaction

Monitor/Modify Tx

avapritinib + axitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• belumosudil
Ayvakit (avapritinib)

+

belumosudil

1 interaction

Monitor/Modify Tx

avapritinib + belumosudil

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• berberine
Ayvakit (avapritinib)

+

berberine

1 interaction

Monitor/Modify Tx

avapritinib + berberine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• bevacizumab
Ayvakit (avapritinib)

+

bevacizumab

1 interaction

Monitor/Modify Tx

avapritinib + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bicalutamide
Ayvakit (avapritinib)

+

bicalutamide

1 interaction

Monitor/Modify Tx

avapritinib + bicalutamide

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• binimetinib
Ayvakit (avapritinib)

+

binimetinib

1 interaction

Monitor/Modify Tx

avapritinib + binimetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bivalirudin
Ayvakit (avapritinib)

+

bivalirudin

1 interaction

Monitor/Modify Tx

avapritinib + bivalirudin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• brentuximab vedotin
Ayvakit (avapritinib)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

avapritinib + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• bromelain
Ayvakit (avapritinib)

+

bromelain

1 interaction

Monitor/Modify Tx

avapritinib + bromelain

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• bromfenac ophthalmic
Ayvakit (avapritinib)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

avapritinib + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• cabazitaxel
Ayvakit (avapritinib)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

avapritinib + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• cabozantinib
Ayvakit (avapritinib)

+

cabozantinib

1 interaction

Monitor/Modify Tx

avapritinib + cabozantinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• calaspargase
Ayvakit (avapritinib)

+

calaspargase

1 interaction

Monitor/Modify Tx

avapritinib + calaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• cangrelor
Ayvakit (avapritinib)

+

cangrelor

1 interaction

Monitor/Modify Tx

avapritinib + cangrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• capivasertib
Ayvakit (avapritinib)

+

capivasertib

1 interaction

Monitor/Modify Tx

avapritinib + capivasertib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• caplacizumab
Ayvakit (avapritinib)

+

caplacizumab

1 interaction

Monitor/Modify Tx

avapritinib + caplacizumab

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• carfilzomib
Ayvakit (avapritinib)

+

carfilzomib

1 interaction

Monitor/Modify Tx

avapritinib + carfilzomib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• celecoxib
Ayvakit (avapritinib)

+

celecoxib

1 interaction

Monitor/Modify Tx

avapritinib + celecoxib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• chlorzoxazone
Ayvakit (avapritinib)

+

chlorzoxazone

1 interaction

Monitor/Modify Tx

avapritinib + chlorzoxazone

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• cilostazol
Ayvakit (avapritinib)

+

cilostazol

1 interaction

Monitor/Modify Tx

avapritinib + cilostazol

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• cimetidine
Ayvakit (avapritinib)

+

cimetidine

1 interaction

Monitor/Modify Tx

avapritinib + cimetidine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• citalopram
Ayvakit (avapritinib)

+

citalopram

1 interaction

Monitor/Modify Tx

avapritinib + citalopram

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• clopidogrel
Ayvakit (avapritinib)

+

clopidogrel

1 interaction

Monitor/Modify Tx

avapritinib + clopidogrel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• clotrimazole oropharyngeal
Ayvakit (avapritinib)

+

clotrimazole oropharyngeal

1 interaction

Monitor/Modify Tx

avapritinib + clotrimazole oropharyngeal

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• collagenase clostridium histolyticum
Ayvakit (avapritinib)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

avapritinib + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, including severe (additive effects)

• cranberry
Ayvakit (avapritinib)

+

cranberry

1 interaction

Monitor/Modify Tx

avapritinib + cranberry

monitor bleeding s/sx, especially w/ large amounts of cranberry: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (GI metabolism inhibited)

• cysteamine
Ayvakit (avapritinib)

+

cysteamine

1 interaction

Monitor/Modify Tx

avapritinib + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• dabigatran
Ayvakit (avapritinib)

+

dabigatran

1 interaction

Monitor/Modify Tx

avapritinib + dabigatran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• dalteparin
Ayvakit (avapritinib)

+

dalteparin

1 interaction

Monitor/Modify Tx

avapritinib + dalteparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• danshen
Ayvakit (avapritinib)

+

danshen

1 interaction

Monitor/Modify Tx

avapritinib + danshen

monitor bleeding s/sx: combo may decr. avapritinib levels, efficacy; may incr. risk of bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• daridorexant
Ayvakit (avapritinib)

+

daridorexant

1 interaction

Monitor/Modify Tx

avapritinib + daridorexant

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• dasatinib
Ayvakit (avapritinib)

+

dasatinib

1 interaction

Monitor/Modify Tx

avapritinib + dasatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• deferasirox
Ayvakit (avapritinib)

+

deferasirox

1 interaction

Monitor/Modify Tx

avapritinib + deferasirox

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• defibrotide
Ayvakit (avapritinib)

+

defibrotide

1 interaction

Monitor/Modify Tx

avapritinib + defibrotide

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• desvenlafaxine
Ayvakit (avapritinib)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

avapritinib + desvenlafaxine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• deuruxolitinib
Ayvakit (avapritinib)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

avapritinib + deuruxolitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diclofenac
Ayvakit (avapritinib)

+

diclofenac

1 interaction

Monitor/Modify Tx

avapritinib + diclofenac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diclofenac ophthalmic
Ayvakit (avapritinib)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

avapritinib + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• diclofenac topical
Ayvakit (avapritinib)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

avapritinib + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diflunisal
Ayvakit (avapritinib)

+

diflunisal

1 interaction

Monitor/Modify Tx

avapritinib + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• dimethyl fumarate
Ayvakit (avapritinib)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

avapritinib + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• diosmin
Ayvakit (avapritinib)

+

diosmin

1 interaction

Monitor/Modify Tx

avapritinib + diosmin

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• dipyridamole
Ayvakit (avapritinib)

+

dipyridamole

1 interaction

Monitor/Modify Tx

avapritinib + dipyridamole

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• diroximel fumarate
Ayvakit (avapritinib)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

avapritinib + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• duloxetine
Ayvakit (avapritinib)

+

duloxetine

1 interaction

Monitor/Modify Tx

avapritinib + duloxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• edoxaban
Ayvakit (avapritinib)

+

edoxaban

1 interaction

Monitor/Modify Tx

avapritinib + edoxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• elinzanetant
Ayvakit (avapritinib)

+

elinzanetant

1 interaction

Monitor/Modify Tx

avapritinib + elinzanetant

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• enoxaparin
Ayvakit (avapritinib)

+

enoxaparin

1 interaction

Monitor/Modify Tx

avapritinib + enoxaparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• entrectinib
Ayvakit (avapritinib)

+

entrectinib

1 interaction

Monitor/Modify Tx

avapritinib + entrectinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• epoprostenol
Ayvakit (avapritinib)

+

epoprostenol

1 interaction

Monitor/Modify Tx

avapritinib + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• eptifibatide
Ayvakit (avapritinib)

+

eptifibatide

1 interaction

Monitor/Modify Tx

avapritinib + eptifibatide

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• erlotinib
Ayvakit (avapritinib)

+

erlotinib

1 interaction

Monitor/Modify Tx

avapritinib + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• escitalopram
Ayvakit (avapritinib)

+

escitalopram

1 interaction

Monitor/Modify Tx

avapritinib + escitalopram

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ethanol (alcoholic beverage)
Ayvakit (avapritinib)

+

ethanol (alcoholic beverage)

1 interaction

Monitor/Modify Tx

avapritinib + ethanol (alcoholic beverage)

monitor bleeding signs/symptoms: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• etodolac
Ayvakit (avapritinib)

+

etodolac

1 interaction

Monitor/Modify Tx

avapritinib + etodolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• evening primrose oil
Ayvakit (avapritinib)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

avapritinib + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• everolimus
Ayvakit (avapritinib)

+

everolimus

1 interaction

Monitor/Modify Tx

avapritinib + everolimus

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fenoprofen
Ayvakit (avapritinib)

+

fenoprofen

1 interaction

Monitor/Modify Tx

avapritinib + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• fenugreek
Ayvakit (avapritinib)

+

fenugreek

1 interaction

Monitor/Modify Tx

avapritinib + fenugreek

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• finerenone
Ayvakit (avapritinib)

+

finerenone

1 interaction

Monitor/Modify Tx

avapritinib + finerenone

monitor bleeding s/sx if on finerenone 40 mg/day: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• flibanserin
Ayvakit (avapritinib)

+

flibanserin

1 interaction

Monitor/Modify Tx

avapritinib + flibanserin

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fluoxetine
Ayvakit (avapritinib)

+

fluoxetine

1 interaction

Monitor/Modify Tx

avapritinib + fluoxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flurbiprofen
Ayvakit (avapritinib)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

avapritinib + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• flurbiprofen ophthalmic
Ayvakit (avapritinib)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

avapritinib + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• fluvoxamine
Ayvakit (avapritinib)

+

fluvoxamine

1 interaction

Monitor/Modify Tx

avapritinib + fluvoxamine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fondaparinux
Ayvakit (avapritinib)

+

fondaparinux

1 interaction

Monitor/Modify Tx

avapritinib + fondaparinux

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• fosaprepitant
Ayvakit (avapritinib)

+

fosaprepitant

1 interaction

Monitor/Modify Tx

avapritinib + fosaprepitant

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fostamatinib
Ayvakit (avapritinib)

+

fostamatinib

1 interaction

Monitor/Modify Tx

avapritinib + fostamatinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• fruquintinib
Ayvakit (avapritinib)

+

fruquintinib

1 interaction

Monitor/Modify Tx

avapritinib + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• garlic
Ayvakit (avapritinib)

+

garlic

1 interaction

Monitor/Modify Tx

avapritinib + garlic

monitor bleeding s/sx w/ supplemental garlic; dietary intake OK: combo may decr. avapritinib levels, efficacy; may incr. risk of bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• gefitinib
Ayvakit (avapritinib)

+

gefitinib

1 interaction

Monitor/Modify Tx

avapritinib + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• gemtuzumab ozogamicin
Ayvakit (avapritinib)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

avapritinib + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• gepotidacin
Ayvakit (avapritinib)

+

gepotidacin

1 interaction

Monitor/Modify Tx

avapritinib + gepotidacin

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ginkgo
Ayvakit (avapritinib)

+

ginkgo

1 interaction

Monitor/Modify Tx

avapritinib + ginkgo

monitor bleeding s/sx: combo may incr. or decr. avapritinib levels, incr. risk of bleeding (including life-threatening), other adverse effects or decr. efficacy (hepatic metabolism altered, additive effects)

• givinostat
Ayvakit (avapritinib)

+

givinostat

1 interaction

Monitor/Modify Tx

avapritinib + givinostat

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (GI metabolism inhibited)

• givosiran
Ayvakit (avapritinib)

+

givosiran

1 interaction

Monitor/Modify Tx

avapritinib + givosiran

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited; givosiran effects on hepatic heme biosynthesis may reduce CYP450 enzyme activity)

• glecaprevir
Ayvakit (avapritinib)

+

glecaprevir

1 interaction

Monitor/Modify Tx

avapritinib + glecaprevir

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• goldenseal
Ayvakit (avapritinib)

+

goldenseal

1 interaction

Monitor/Modify Tx

avapritinib + goldenseal

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• grazoprevir
Ayvakit (avapritinib)

+

grazoprevir

1 interaction

Monitor/Modify Tx

avapritinib + grazoprevir

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• heparin
Ayvakit (avapritinib)

+

heparin

1 interaction

Monitor/Modify Tx

avapritinib + heparin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• hydrocortisone
Ayvakit (avapritinib)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

avapritinib + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ibrutinib
Ayvakit (avapritinib)

+

ibrutinib

1 interaction

Monitor/Modify Tx

avapritinib + ibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ibuprofen
Ayvakit (avapritinib)

+

ibuprofen

1 interaction

Monitor/Modify Tx

avapritinib + ibuprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ibuprofen lysine
Ayvakit (avapritinib)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

avapritinib + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• icosapent ethyl
Ayvakit (avapritinib)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

avapritinib + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• indomethacin
Ayvakit (avapritinib)

+

indomethacin

1 interaction

Monitor/Modify Tx

avapritinib + indomethacin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• isoniazid
Ayvakit (avapritinib)

+

isoniazid

1 interaction

Monitor/Modify Tx

avapritinib + isoniazid

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• istradefylline
Ayvakit (avapritinib)

+

istradefylline

1 interaction

Monitor/Modify Tx

avapritinib + istradefylline

monitor bleeding s/sx, especially w/ istradefylline 40 mg dose: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ivacaftor
Ayvakit (avapritinib)

+

ivacaftor

1 interaction

Monitor/Modify Tx

avapritinib + ivacaftor

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ketoprofen
Ayvakit (avapritinib)

+

ketoprofen

1 interaction

Monitor/Modify Tx

avapritinib + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ketorolac
Ayvakit (avapritinib)

+

ketorolac

1 interaction

Monitor/Modify Tx

avapritinib + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ketorolac ophthalmic
Ayvakit (avapritinib)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

avapritinib + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• kratom
Ayvakit (avapritinib)

+

kratom

1 interaction

Monitor/Modify Tx

avapritinib + kratom

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lapatinib
Ayvakit (avapritinib)

+

lapatinib

1 interaction

Monitor/Modify Tx

avapritinib + lapatinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• larotrectinib
Ayvakit (avapritinib)

+

larotrectinib

1 interaction

Monitor/Modify Tx

avapritinib + larotrectinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lazertinib
Ayvakit (avapritinib)

+

lazertinib

1 interaction

Monitor/Modify Tx

avapritinib + lazertinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lenvatinib
Ayvakit (avapritinib)

+

lenvatinib

1 interaction

Monitor/Modify Tx

avapritinib + lenvatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• levomilnacipran
Ayvakit (avapritinib)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

avapritinib + levomilnacipran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lifileucel
Ayvakit (avapritinib)

+

lifileucel

1 interaction

Monitor/Modify Tx

avapritinib + lifileucel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• lomitapide
Ayvakit (avapritinib)

+

lomitapide

1 interaction

Monitor/Modify Tx

avapritinib + lomitapide

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lovastatin
Ayvakit (avapritinib)

+

lovastatin

1 interaction

Monitor/Modify Tx

avapritinib + lovastatin

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• lurasidone
Ayvakit (avapritinib)

+

lurasidone

1 interaction

Monitor/Modify Tx

avapritinib + lurasidone

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• magnesium salicylate
Ayvakit (avapritinib)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

avapritinib + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• maribavir
Ayvakit (avapritinib)

+

maribavir

1 interaction

Monitor/Modify Tx

avapritinib + maribavir

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• mavorixafor
Ayvakit (avapritinib)

+

mavorixafor

1 interaction

Monitor/Modify Tx

avapritinib + mavorixafor

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• meclofenamate
Ayvakit (avapritinib)

+

meclofenamate

1 interaction

Monitor/Modify Tx

avapritinib + meclofenamate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• mefenamic acid
Ayvakit (avapritinib)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

avapritinib + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• meloxicam
Ayvakit (avapritinib)

+

meloxicam

1 interaction

Monitor/Modify Tx

avapritinib + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• methotrexate
Ayvakit (avapritinib)

+

methotrexate

1 interaction

Monitor/Modify Tx

avapritinib + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• methyl salicylate topical
Ayvakit (avapritinib)

+

methyl salicylate topical

1 interaction

Monitor/Modify Tx

avapritinib + methyl salicylate topical

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, systemic salicylate absorption may occur from topical use)

• milnacipran
Ayvakit (avapritinib)

+

milnacipran

1 interaction

Monitor/Modify Tx

avapritinib + milnacipran

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• monomethyl fumarate
Ayvakit (avapritinib)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

avapritinib + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• mycophenolate mofetil
Ayvakit (avapritinib)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

avapritinib + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• mycophenolic acid
Ayvakit (avapritinib)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

avapritinib + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nabumetone
Ayvakit (avapritinib)

+

nabumetone

1 interaction

Monitor/Modify Tx

avapritinib + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• naproxen
Ayvakit (avapritinib)

+

naproxen

1 interaction

Monitor/Modify Tx

avapritinib + naproxen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nattokinase
Ayvakit (avapritinib)

+

nattokinase

1 interaction

Monitor/Modify Tx

avapritinib + nattokinase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• nepafenac ophthalmic
Ayvakit (avapritinib)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

avapritinib + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects)

• niacin (vitamin B3)
Ayvakit (avapritinib)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

avapritinib + niacin (vitamin B3)

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• nicardipine
Ayvakit (avapritinib)

+

nicardipine

1 interaction

Monitor/Modify Tx

avapritinib + nicardipine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• nintedanib
Ayvakit (avapritinib)

+

nintedanib

1 interaction

Monitor/Modify Tx

avapritinib + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• nusinersen
Ayvakit (avapritinib)

+

nusinersen

1 interaction

Monitor/Modify Tx

avapritinib + nusinersen

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• obinutuzumab
Ayvakit (avapritinib)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

avapritinib + obinutuzumab

monitor platelets, bleeding s/sx; consider holding avapritinib, especially during first obinutuzumab cycle: combo may incr. risk of severe bleeding, including life-threatening (additive effects)

• omega-3-acid
Ayvakit (avapritinib)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

avapritinib + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• osilodrostat
Ayvakit (avapritinib)

+

osilodrostat

1 interaction

Monitor/Modify Tx

avapritinib + osilodrostat

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• oxaliplatin
Ayvakit (avapritinib)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

avapritinib + oxaliplatin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• oxaprozin
Ayvakit (avapritinib)

+

oxaprozin

1 interaction

Monitor/Modify Tx

avapritinib + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• palbociclib
Ayvakit (avapritinib)

+

palbociclib

1 interaction

Monitor/Modify Tx

avapritinib + palbociclib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• paroxetine
Ayvakit (avapritinib)

+

paroxetine

1 interaction

Monitor/Modify Tx

avapritinib + paroxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pazopanib
Ayvakit (avapritinib)

+

pazopanib

1 interaction

Monitor/Modify Tx

avapritinib + pazopanib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• pegaspargase
Ayvakit (avapritinib)

+

pegaspargase

1 interaction

Monitor/Modify Tx

avapritinib + pegaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• penicillin G
Ayvakit (avapritinib)

+

penicillin G

1 interaction

Monitor/Modify Tx

avapritinib + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• pentosan polysulfate sodium
Ayvakit (avapritinib)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

avapritinib + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• pentoxifylline
Ayvakit (avapritinib)

+

pentoxifylline

1 interaction

Monitor/Modify Tx

avapritinib + pentoxifylline

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• peppermint
Ayvakit (avapritinib)

+

peppermint

1 interaction

Monitor/Modify Tx

avapritinib + peppermint

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• pibrentasvir
Ayvakit (avapritinib)

+

pibrentasvir

1 interaction

Monitor/Modify Tx

avapritinib + pibrentasvir

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• piperacillin
Ayvakit (avapritinib)

+

piperacillin

1 interaction

Monitor/Modify Tx

avapritinib + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding, including life-threatening (additive effects)

• piroxicam
Ayvakit (avapritinib)

+

piroxicam

1 interaction

Monitor/Modify Tx

avapritinib + piroxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pirtobrutinib
Ayvakit (avapritinib)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

avapritinib + pirtobrutinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of GI or other bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• plasminogen, human
Ayvakit (avapritinib)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

avapritinib + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ponatinib
Ayvakit (avapritinib)

+

ponatinib

1 interaction

Monitor/Modify Tx

avapritinib + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• pralsetinib
Ayvakit (avapritinib)

+

pralsetinib

1 interaction

Monitor/Modify Tx

avapritinib + pralsetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• prasugrel
Ayvakit (avapritinib)

+

prasugrel

1 interaction

Monitor/Modify Tx

avapritinib + prasugrel

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• primaquine
Ayvakit (avapritinib)

+

primaquine

1 interaction

Monitor/Modify Tx

avapritinib + primaquine

monitor bleeding signs/symptoms: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism possibly inhibited)

• quercetin
Ayvakit (avapritinib)

+

quercetin

1 interaction

Monitor/Modify Tx

avapritinib + quercetin

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ramucirumab
Ayvakit (avapritinib)

+

ramucirumab

1 interaction

Monitor/Modify Tx

avapritinib + ramucirumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• ranibizumab
Ayvakit (avapritinib)

+

ranibizumab

1 interaction

Monitor/Modify Tx

avapritinib + ranibizumab

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects)

• ranolazine
Ayvakit (avapritinib)

+

ranolazine

1 interaction

Monitor/Modify Tx

avapritinib + ranolazine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• regorafenib
Ayvakit (avapritinib)

+

regorafenib

1 interaction

Monitor/Modify Tx

avapritinib + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• remdesivir
Ayvakit (avapritinib)

+

remdesivir

1 interaction

Monitor/Modify Tx

avapritinib + remdesivir

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• remibrutinib
Ayvakit (avapritinib)

+

remibrutinib

1 interaction

Monitor/Modify Tx

avapritinib + remibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• resveratrol
Ayvakit (avapritinib)

+

resveratrol

1 interaction

Monitor/Modify Tx

avapritinib + resveratrol

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• reteplase
Ayvakit (avapritinib)

+

reteplase

1 interaction

Monitor/Modify Tx

avapritinib + reteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• revakinagene taroretcel
Ayvakit (avapritinib)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

avapritinib + revakinagene taroretcel

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects)

• ritlecitinib
Ayvakit (avapritinib)

+

ritlecitinib

1 interaction

Monitor/Modify Tx

avapritinib + ritlecitinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• rivaroxaban
Ayvakit (avapritinib)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

avapritinib + rivaroxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• rucaparib
Ayvakit (avapritinib)

+

rucaparib

1 interaction

Monitor/Modify Tx

avapritinib + rucaparib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• salsalate
Ayvakit (avapritinib)

+

salsalate

1 interaction

Monitor/Modify Tx

avapritinib + salsalate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• saw palmetto
Ayvakit (avapritinib)

+

saw palmetto

1 interaction

Monitor/Modify Tx

avapritinib + saw palmetto

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• selpercatinib
Ayvakit (avapritinib)

+

selpercatinib

1 interaction

Monitor/Modify Tx

avapritinib + selpercatinib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• selumetinib
Ayvakit (avapritinib)

+

selumetinib

1 interaction

Monitor/Modify Tx

avapritinib + selumetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet and anticoagulant effects augmented by vitamin E content in selumetinib capsules)

• sepiapterin
Ayvakit (avapritinib)

+

sepiapterin

1 interaction

Monitor/Modify Tx

avapritinib + sepiapterin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• sertraline
Ayvakit (avapritinib)

+

sertraline

1 interaction

Monitor/Modify Tx

avapritinib + sertraline

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sevabertinib
Ayvakit (avapritinib)

+

sevabertinib

1 interaction

Monitor/Modify Tx

avapritinib + sevabertinib

monitor bleeding signs/symptoms: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• sirolimus albumin-bound
Ayvakit (avapritinib)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

avapritinib + sirolimus albumin-bound

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• sorafenib
Ayvakit (avapritinib)

+

sorafenib

1 interaction

Monitor/Modify Tx

avapritinib + sorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• sotatercept
Ayvakit (avapritinib)

+

sotatercept

1 interaction

Monitor/Modify Tx

avapritinib + sotatercept

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, including severe or life-threatening (additive effects)

• spironolactone
Ayvakit (avapritinib)

+

spironolactone

1 interaction

Monitor/Modify Tx

avapritinib + spironolactone

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism possibly inhibited)

• stiripentol
Ayvakit (avapritinib)

+

stiripentol

1 interaction

Monitor/Modify Tx

avapritinib + stiripentol

monitor bleeding s/sx: combo may incr. or decr. avapritinib levels, incr. risk of bleeding (including life-threatening), other adverse effects or decr. efficacy (hepatic metabolism altered)

• sulindac
Ayvakit (avapritinib)

+

sulindac

1 interaction

Monitor/Modify Tx

avapritinib + sulindac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• sunitinib
Ayvakit (avapritinib)

+

sunitinib

1 interaction

Monitor/Modify Tx

avapritinib + sunitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tenecteplase
Ayvakit (avapritinib)

+

tenecteplase

1 interaction

Monitor/Modify Tx

avapritinib + tenecteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• ticagrelor
Ayvakit (avapritinib)

+

ticagrelor

1 interaction

Monitor/Modify Tx

avapritinib + ticagrelor

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited, additive effects)

• tirofiban
Ayvakit (avapritinib)

+

tirofiban

1 interaction

Monitor/Modify Tx

avapritinib + tirofiban

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• tisotumab vedotin
Ayvakit (avapritinib)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

avapritinib + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• tivozanib
Ayvakit (avapritinib)

+

tivozanib

1 interaction

Monitor/Modify Tx

avapritinib + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tolmetin
Ayvakit (avapritinib)

+

tolmetin

1 interaction

Monitor/Modify Tx

avapritinib + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• tolvaptan
Ayvakit (avapritinib)

+

tolvaptan

1 interaction

Monitor/Modify Tx

avapritinib + tolvaptan

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• tovorafenib
Ayvakit (avapritinib)

+

tovorafenib

1 interaction

Monitor/Modify Tx

avapritinib + tovorafenib

monitor bleeding s/sx: combo may decr. avapritinib levels, efficacy; may incr. risk of bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• trametinib
Ayvakit (avapritinib)

+

trametinib

1 interaction

Monitor/Modify Tx

avapritinib + trametinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• trazodone
Ayvakit (avapritinib)

+

trazodone

1 interaction

Monitor/Modify Tx

avapritinib + trazodone

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• treosulfan
Ayvakit (avapritinib)

+

treosulfan

1 interaction

Monitor/Modify Tx

avapritinib + treosulfan

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism possibly inhibited)

• treprostinil
Ayvakit (avapritinib)

+

treprostinil

1 interaction

Monitor/Modify Tx

avapritinib + treprostinil

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• trofinetide
Ayvakit (avapritinib)

+

trofinetide

1 interaction

Monitor/Modify Tx

avapritinib + trofinetide

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (GI metabolism inhibited)

• upadacitinib
Ayvakit (avapritinib)

+

upadacitinib

1 interaction

Monitor/Modify Tx

avapritinib + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• vadadustat
Ayvakit (avapritinib)

+

vadadustat

1 interaction

Monitor/Modify Tx

avapritinib + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

• valproic acid
Ayvakit (avapritinib)

+

valproic acid

1 interaction

Monitor/Modify Tx

avapritinib + valproic acid

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• vandetanib
Ayvakit (avapritinib)

+

vandetanib

1 interaction

Monitor/Modify Tx

avapritinib + vandetanib

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• venlafaxine
Ayvakit (avapritinib)

+

venlafaxine

1 interaction

Monitor/Modify Tx

avapritinib + venlafaxine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
Ayvakit (avapritinib)

+

vilazodone

1 interaction

Monitor/Modify Tx

avapritinib + vilazodone

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• viloxazine
Ayvakit (avapritinib)

+

viloxazine

1 interaction

Monitor/Modify Tx

avapritinib + viloxazine

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• vinpocetine
Ayvakit (avapritinib)

+

vinpocetine

1 interaction

Monitor/Modify Tx

avapritinib + vinpocetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• vonoprazan
Ayvakit (avapritinib)

+

vonoprazan

1 interaction

Monitor/Modify Tx

avapritinib + vonoprazan

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• vorapaxar
Ayvakit (avapritinib)

+

vorapaxar

1 interaction

Monitor/Modify Tx

avapritinib + vorapaxar

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects)

• vortioxetine
Ayvakit (avapritinib)

+

vortioxetine

1 interaction

Monitor/Modify Tx

avapritinib + vortioxetine

monitor bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• warfarin
Ayvakit (avapritinib)

+

warfarin

1 interaction

Monitor/Modify Tx

avapritinib + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of bleeding, including life-threatening (synergistic effects)

• willow bark
Ayvakit (avapritinib)

+

willow bark

1 interaction

Monitor/Modify Tx

avapritinib + willow bark

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects, willow bark may contain salicylates)

• xanomeline
Ayvakit (avapritinib)

+

xanomeline

1 interaction

Monitor/Modify Tx

avapritinib + xanomeline

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (GI metabolism possibly inhibited)

• zanubrutinib
Ayvakit (avapritinib)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

avapritinib + zanubrutinib

monitor bleeding s/sx: combo may decr. avapritinib levels, efficacy; may incr. risk of bleeding, including life-threatening (hepatic metabolism induced; additive effects)

• ziftomenib
Ayvakit (avapritinib)

+

ziftomenib

1 interaction

Monitor/Modify Tx

avapritinib + ziftomenib

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• zileuton
Ayvakit (avapritinib)

+

zileuton

1 interaction

Monitor/Modify Tx

avapritinib + zileuton

monitor bleeding s/sx: combo may incr. avapritinib levels, risk of bleeding (including life-threatening), other adverse effects (hepatic metabolism inhibited)

• ziv-aflibercept
Ayvakit (avapritinib)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

avapritinib + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, including life-threatening (additive effects)

Caution Advised

• acitretin
Ayvakit (avapritinib)

+

acitretin

1 interaction

Caution Advised

avapritinib + acitretin

caution advised during and x1wk after avapritinib tx: combo may incr. risk of photosensitivity reaction (additive effects)

• armodafinil
Ayvakit (avapritinib)

+

armodafinil

1 interaction

Caution Advised

avapritinib + armodafinil

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• artemether/lumefantrine
Ayvakit (avapritinib)

+

artemether/ lumefantrine

1 interaction

Caution Advised

avapritinib + artemether/ lumefantrine

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• belzutifan
Ayvakit (avapritinib)

+

belzutifan

1 interaction

Caution Advised

avapritinib + belzutifan

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• bexarotene
Ayvakit (avapritinib)

+

bexarotene

1 interaction

Caution Advised

avapritinib + bexarotene

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• brigatinib
Ayvakit (avapritinib)

+

brigatinib

1 interaction

Caution Advised

avapritinib + brigatinib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• clobazam
Ayvakit (avapritinib)

+

clobazam

1 interaction

Caution Advised

avapritinib + clobazam

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• darolutamide
Ayvakit (avapritinib)

+

darolutamide

1 interaction

Caution Advised

avapritinib + darolutamide

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• dexamethasone
Ayvakit (avapritinib)

+

dexamethasone

1 interaction

Caution Advised

avapritinib + dexamethasone

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• dicloxacillin
Ayvakit (avapritinib)

+

dicloxacillin

1 interaction

Caution Advised

avapritinib + dicloxacillin

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• echinacea
Ayvakit (avapritinib)

+

echinacea

1 interaction

Caution Advised

avapritinib + echinacea

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• elafibranor
Ayvakit (avapritinib)

+

elafibranor

1 interaction

Caution Advised

avapritinib + elafibranor

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• elagolix
Ayvakit (avapritinib)

+

elagolix

1 interaction

Caution Advised

avapritinib + elagolix

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• enasidenib
Ayvakit (avapritinib)

+

enasidenib

1 interaction

Caution Advised

avapritinib + enasidenib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• eslicarbazepine acetate
Ayvakit (avapritinib)

+

eslicarbazepine acetate

1 interaction

Caution Advised

avapritinib + eslicarbazepine acetate

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• felbamate
Ayvakit (avapritinib)

+

felbamate

1 interaction

Caution Advised

avapritinib + felbamate

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• ginseng, Asian
Ayvakit (avapritinib)

+

ginseng, Asian

1 interaction

Caution Advised

avapritinib + ginseng, Asian

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• glycerol phenylbutyrate
Ayvakit (avapritinib)

+

glycerol phenylbutyrate

1 interaction

Caution Advised

avapritinib + glycerol phenylbutyrate

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• griseofulvin
Ayvakit (avapritinib)

+

griseofulvin

1 interaction

Caution Advised

avapritinib + griseofulvin

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• meropenem
Ayvakit (avapritinib)

+

meropenem

1 interaction

Caution Advised

avapritinib + meropenem

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism possibly induced)

• methoxsalen
Ayvakit (avapritinib)

+

methoxsalen

1 interaction

Caution Advised

avapritinib + methoxsalen

caution advised during and x1wk after avapritinib tx: combo may incr. risk of photosensitivity reaction (additive effects)

• mobocertinib
Ayvakit (avapritinib)

+

mobocertinib

1 interaction

Caution Advised

avapritinib + mobocertinib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• nevirapine
Ayvakit (avapritinib)

+

nevirapine

1 interaction

Caution Advised

avapritinib + nevirapine

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• odevixibat
Ayvakit (avapritinib)

+

odevixibat

1 interaction

Caution Advised

avapritinib + odevixibat

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• olutasidenib
Ayvakit (avapritinib)

+

olutasidenib

1 interaction

Caution Advised

avapritinib + olutasidenib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism possibly induced)

• omaveloxolone
Ayvakit (avapritinib)

+

omaveloxolone

1 interaction

Caution Advised

avapritinib + omaveloxolone

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• oxcarbazepine
Ayvakit (avapritinib)

+

oxcarbazepine

1 interaction

Caution Advised

avapritinib + oxcarbazepine

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• perampanel
Ayvakit (avapritinib)

+

perampanel

1 interaction

Caution Advised

avapritinib + perampanel

caution advised if on perampanel 12 mg/day: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• pioglitazone
Ayvakit (avapritinib)

+

pioglitazone

1 interaction

Caution Advised

avapritinib + pioglitazone

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• prednisone
Ayvakit (avapritinib)

+

prednisone

1 interaction

Caution Advised

avapritinib + prednisone

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• rufinamide
Ayvakit (avapritinib)

+

rufinamide

1 interaction

Caution Advised

avapritinib + rufinamide

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• sarilumab
Ayvakit (avapritinib)

+

sarilumab

1 interaction

Caution Advised

avapritinib + sarilumab

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism altered; sarilumab may reverse inflammatory cytokine-induced downregulation of CYP450 enzymes resulting in relative induction of enzymes upon tx start and downregulation upon D/C)

• sunvozertinib
Ayvakit (avapritinib)

+

sunvozertinib

1 interaction

Caution Advised

avapritinib + sunvozertinib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• suzetrigine
Ayvakit (avapritinib)

+

suzetrigine

1 interaction

Caution Advised

avapritinib + suzetrigine

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• tazemetostat
Ayvakit (avapritinib)

+

tazemetostat

1 interaction

Caution Advised

avapritinib + tazemetostat

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• tecovirimat
Ayvakit (avapritinib)

+

tecovirimat

1 interaction

Caution Advised

avapritinib + tecovirimat

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• telotristat ethyl
Ayvakit (avapritinib)

+

telotristat ethyl

1 interaction

Caution Advised

avapritinib + telotristat ethyl

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• tocilizumab
Ayvakit (avapritinib)

+

tocilizumab

1 interaction

Caution Advised

avapritinib + tocilizumab

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism altered; tocilizumab may reverse inflammatory cytokine-induced downregulation of CYP450 enzymes resulting in relative induction of enzymes)

• topiramate
Ayvakit (avapritinib)

+

topiramate

1 interaction

Caution Advised

avapritinib + topiramate

caution advised especially w/ topiramate doses >200 mg/day: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• vaborbactam
Ayvakit (avapritinib)

+

vaborbactam

1 interaction

Caution Advised

avapritinib + vaborbactam

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism possibly induced)

• vamorolone
Ayvakit (avapritinib)

+

vamorolone

1 interaction

Caution Advised

avapritinib + vamorolone

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism possibly induced)

• vemurafenib
Ayvakit (avapritinib)

+

vemurafenib

1 interaction

Caution Advised

avapritinib + vemurafenib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• verteporfin
Ayvakit (avapritinib)

+

verteporfin

1 interaction

Caution Advised

avapritinib + verteporfin

caution advised during and x1wk after avapritinib tx: combo may incr. risk of photosensitivity reaction (additive effects)

• vinblastine
Ayvakit (avapritinib)

+

vinblastine

1 interaction

Caution Advised

avapritinib + vinblastine

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism induced)

• vorasidenib
Ayvakit (avapritinib)

+

vorasidenib

1 interaction

Caution Advised

avapritinib + vorasidenib

caution advised: combo may decr. avapritinib levels, efficacy (hepatic metabolism possibly induced)