Select a medication above to begin.
Barhemsys
amisulpride
Adult Dosing .
Dosage forms: INJ
nausea/vomiting prevention, postop
- [5 mg IV x1]
- Start: with anesthesia induction
nausea/vomiting tx, postop
- [10 mg IV x1]
renal dosing
- [see below]
- renal impairment: no adjustment
- HD/PD: not defined
hepatic dosing
- [not defined]
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- long QT syndrome, congenital
- avoid: breastfeeding during tx and x48h after D/C
- caution: electrolyte abnormalities
- caution: QT prolongation
- caution: QT prolongation family history
- caution: torsades de pointes history
- caution: cardiac conduction disturbance
- caution: ventricular arrhythmia
- caution: bradycardia
- caution: MI, recent
- caution: CHF
Drug Interactions .
Overview
amisulpride
dopamine-2 antagonist
- dopamine antagonist
- hyperprolactinemic effects
- prolongs QT interval (conditional)
Contraindicated
- pimozide
- thioridazine
Avoid/Use Alternative
- apomorphine
- arsenic trioxide
- artemether/lumefantrine
- bedaquiline
- bromocriptine
- cabergoline
- cisapride
- crizotinib
- domperidone
- dronedarone
- droperidol
- ephedra
- fexinidazole
- fosfomycin injection
- foslevodopa
- hydroxychloroquine
- lefamulin
- levodopa
- lonafarnib
- mobocertinib
- pramipexole
- quizartinib
- ropinirole
- rotigotine transdermal
- sotalol
- tetrabenazine
- toremifene
- triptorelin
- vandetanib
- ziprasidone
Monitor/Modify Tx
- adagrasib
- amiodarone
- anagrelide
- apalutamide
- asenapine
- azithromycin
- cabozantinib
- ceritinib
- chloroquine
- citalopram
- clarithromycin
- clofazimine
- degarelix
- desflurane
- desipramine
- dexmedetomidine
- dexmedetomidine injection
- disopyramide
- dofetilide
- donepezil
- dordaviprone
- encorafenib
- epirubicin
- eribulin
- erythromycin
- flecainide
- fluorouracil
- gilteritinib
- glasdegib
- goserelin
- haloperidol
- histrelin
- hydroxyzine
- ibutilide
- inotuzumab ozogamicin
- isoflurane
- ivosidenib
- leuprolide
- levofloxacin
- levoketoconazole
- lofexidine
- macimorelin
- methadone
- moxifloxacin
- nilotinib
- oliceridine
- ondansetron
- osimertinib
- pacritinib
- paliperidone
- palonosetron
- pasireotide
- pentamidine
- procainamide
- propafenone
- quinidine (antiarrhythmic)
- quinidine (CYP2D6 inhibitor)
- quinine
- revumenib
- ribociclib
- romidepsin
- rucaparib
- selpercatinib
- sevoflurane
- taletrectinib
- telavancin
- tramadol
- triclabendazole
- trifluridine
- vemurafenib
- ziftomenib
Caution Advised
- chasteberry
- rasagiline
- safinamide
- selegiline
- solriamfetol
Adverse Reactions .
Serious Reactions
- QT prolongation
Common Reactions
- prolactin elevated
- rigors
- hypokalemia
- procedural hypotension
- abdominal distension
- infusion site pain
- hypersensitivity reaction
Safety/Monitoring .
Monitoring Parameters
electrolytes including Mg at baseline; ECG if QT prolongation risk
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; inadequate human data available; no known risk of fetal harm based on animal data at 43x and 645x recommended human dose
Lactation
Clinical Summary
avoid breastfeeding during tx and x48h after D/C; no known risk of infant harm based on limited human data, though drug excreted into milk; no human data available to assess effects on milk production
Pharmacology .
Metabolism: for amisulpride: unknown; CYP450: none
Excretion: for amisulpride: urine 74% (58% unchanged), feces 23% (20% unchanged); Half-life: 4-5h
Subclass: Antiemetics, Dopamine Antagonists
Mechanism of Action
for amisulpride: selectively antagonizes dopamine D2 and D3 receptors, producing antiemetic effects
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.