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birch triterpenes topical
Adult Dosing .
Dosage forms: GEL: 10%
epidermolysis bullosa, dystrophic or junctional
- [apply 1 mm layer w/ each dressing change until healed]
Peds Dosing .
- Dosage forms: GEL: 10%
epidermolysis bullosa, dystrophic or junctional
- [6 mo and older]
- Dose: apply 1 mm layer w/ each dressing change until healed
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
Drug Interactions .
Overview
birch triterpenes
wound care
-
None
No significant interactions known or found for this drug. Caution always advised with multiple medications.
Adverse Reactions .
Serious Reactions
may occur but none reported
Common Reactions
- application site rxn
Safety/Monitoring .
Monitoring Parameters
no routine tests recommended
Pregnancy/Lactation .
Pregnancy
Clinical Summary
may use during pregnancy; no human data available, though risk of fetal harm not expected based on minimal to no systemic absorption
Lactation
Clinical Summary
may use while breastfeeding; no human data available, though risk of infant harm and adverse effects on milk production not expected based on minimal to no systemic absorption in breastfeeding patients
Pharmacology .
Metabolism: for betulin: minimal; CYP450: 3A (primary) substrate; Info: minimal to no systemic absorption
Excretion: for betulin: unknown; Half-life: unknown
Subclass: Epidermolysis Bullosa
Mechanism of Action
exact mechanism of action unknown
Formulary .
No Formulary Selected
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