Libervant

Overview

diazepam

benzodiazepine

• CYP2C19 substrate
• CYP3A4 substrate
• affected by altered fat absorption
• antiepileptic agent
• CNS depression
• hypotensive effects

Contraindicated

• amifampridine
Libervant (diazepam transmucosal)

+

amifampridine

1 interaction

Contraindicated

diazepam + amifampridine

contraindicated if seizure disorder use; otherwise, caution advised: combo may alter seizure control (antagonistic effects, amifampridine may decr. seizure threshold)

• bupropion
Libervant (diazepam transmucosal)

+

bupropion

1 interaction

Contraindicated

diazepam + bupropion

contraindicated if seizure disorder use; otherwise, consider lower bupropion doses: combo may alter seizure control (antagonistic effects, bupropion may decr. seizure threshold)

• dalfampridine
Libervant (diazepam transmucosal)

+

dalfampridine

1 interaction

Contraindicated

diazepam + dalfampridine

contraindicated if seizure disorder use; otherwise, caution advised: combo may alter seizure control (antagonistic effects, dalfampridine may decr. seizure threshold)

Avoid/Use Alternative

• alfentanil
Libervant (diazepam transmucosal)

+

alfentanil

1 interaction

Avoid/Use Alternative

diazepam + alfentanil

use alternative or monitor BP, respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), delayed recovery from anesthesia; may alter seizure control (additive effects; antagonistic effects, alfentanil may decr. seizure threshold)

• alprazolam
Libervant (diazepam transmucosal)

+

alprazolam

1 interaction

Avoid/Use Alternative

diazepam + alprazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• aripiprazole lauroxil
Libervant (diazepam transmucosal)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

diazepam + aripiprazole lauroxil

ARISTADA INITIO: avoid combo; ARISTADA: monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• baclofen intrathecal
Libervant (diazepam transmucosal)

+

baclofen intrathecal

1 interaction

Avoid/Use Alternative

diazepam + baclofen intrathecal

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, baclofen may decr. seizure threshold)

• buprenorphine
Libervant (diazepam transmucosal)

+

buprenorphine

1 interaction

Avoid/Use Alternative

diazepam + buprenorphine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, buprenorphine may decr. seizure threshold)

• butalbital
Libervant (diazepam transmucosal)

+

butalbital

1 interaction

Avoid/Use Alternative

diazepam + butalbital

avoid combo: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• butorphanol
Libervant (diazepam transmucosal)

+

butorphanol

1 interaction

Avoid/Use Alternative

diazepam + butorphanol

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including syncope; may alter seizure control (additive effects; antagonistic effects, butorphanol may decr. seizure threshold)

• chlordiazepoxide
Libervant (diazepam transmucosal)

+

chlordiazepoxide

1 interaction

Avoid/Use Alternative

diazepam + chlordiazepoxide

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• clobazam
Libervant (diazepam transmucosal)

+

clobazam

1 interaction

Avoid/Use Alternative

diazepam + clobazam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

• clonazepam
Libervant (diazepam transmucosal)

+

clonazepam

1 interaction

Avoid/Use Alternative

diazepam + clonazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

• clonidine
Libervant (diazepam transmucosal)

+

clonidine

1 interaction

Avoid/Use Alternative

diazepam + clonidine

if ADHD use, avoid combo; otherwise, monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• clorazepate
Libervant (diazepam transmucosal)

+

clorazepate

1 interaction

Avoid/Use Alternative

diazepam + clorazepate

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (additive effects, duplicate therapy)

• codeine
Libervant (diazepam transmucosal)

+

codeine

1 interaction

Avoid/Use Alternative

diazepam + codeine

avoid combo if antitussive use; otherwise use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• desflurane
Libervant (diazepam transmucosal)

+

desflurane

1 interaction

Avoid/Use Alternative

diazepam + desflurane

use alternative or monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Libervant (diazepam transmucosal)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

diazepam + dexmedetomidine injection

use alternative or monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• diazepam
Libervant (diazepam transmucosal)

+

diazepam

1 interaction

Avoid/Use Alternative

diazepam + diazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• dihydrocodeine
Libervant (diazepam transmucosal)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

diazepam + dihydrocodeine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, dihydrocodeine may decr. seizure threshold)

• doxylamine
Libervant (diazepam transmucosal)

+

doxylamine

1 interaction

Avoid/Use Alternative

diazepam + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• estazolam
Libervant (diazepam transmucosal)

+

estazolam

1 interaction

Avoid/Use Alternative

diazepam + estazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• ethanol (alcoholic beverage)
Libervant (diazepam transmucosal)

+

ethanol (alcoholic beverage)

1 interaction

Avoid/Use Alternative

diazepam + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ethanol (in some formulations)
Libervant (diazepam transmucosal)

+

ethanol (in some formulations)

1 interaction

Avoid/Use Alternative

diazepam + ethanol (in some formulations)

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ethanol injection
Libervant (diazepam transmucosal)

+

ethanol injection

1 interaction

Avoid/Use Alternative

diazepam + ethanol injection

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant use: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• fentanyl
Libervant (diazepam transmucosal)

+

fentanyl

1 interaction

Avoid/Use Alternative

diazepam + fentanyl

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope); may alter seizure control (additive effects; antagonistic effects, fentanyl may decr. seizure threshold)

• flurazepam
Libervant (diazepam transmucosal)

+

flurazepam

1 interaction

Avoid/Use Alternative

diazepam + flurazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• fluvoxamine
Libervant (diazepam transmucosal)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

diazepam + fluvoxamine

use alternative or monitor respiratory rate; consider decr. diazepam dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metabolism inhibited, additive effects; antagonistic effects, fluvoxamine may decr. seizure threshold)

• gabapentin
Libervant (diazepam transmucosal)

+

gabapentin

1 interaction

Avoid/Use Alternative

diazepam + gabapentin

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• gabapentin enacarbil
Libervant (diazepam transmucosal)

+

gabapentin enacarbil

1 interaction

Avoid/Use Alternative

diazepam + gabapentin enacarbil

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ginkgo
Libervant (diazepam transmucosal)

+

ginkgo

1 interaction

Avoid/Use Alternative

diazepam + ginkgo

if seizure disorder use, avoid consumption of ginkgo seeds; otherwise, caution advised: combo may alter seizure control (antagonistic effects, ginkgotoxin may decr. seizure threshold)

• grapefruit
Libervant (diazepam transmucosal)

+

grapefruit

1 interaction

Avoid/Use Alternative

diazepam + grapefruit

avoid grapefruit juice w/ oral diazepam: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (GI metabolism inhibited)

• haloperidol
Libervant (diazepam transmucosal)

+

haloperidol

1 interaction

Avoid/Use Alternative

diazepam + haloperidol

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, haloperidol may decr. seizure threshold)

• hydrocodone
Libervant (diazepam transmucosal)

+

hydrocodone

1 interaction

Avoid/Use Alternative

diazepam + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope); may alter seizure control (additive effects; antagonistic effects, hydrocodone may decr. seizure threshold)

• hydromorphone
Libervant (diazepam transmucosal)

+

hydromorphone

1 interaction

Avoid/Use Alternative

diazepam + hydromorphone

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope); may alter seizure control (additive effects; antagonistic effects, hydromorphone may decr. seizure threshold)

• isocarboxazid
Libervant (diazepam transmucosal)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

diazepam + isocarboxazid

use alternative during and x10 days after isocarboxazid use: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, isocarboxazid may decr. seizure threshold)

• isoflurane
Libervant (diazepam transmucosal)

+

isoflurane

1 interaction

Avoid/Use Alternative

diazepam + isoflurane

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• kava
Libervant (diazepam transmucosal)

+

kava

1 interaction

Avoid/Use Alternative

diazepam + kava

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ketamine
Libervant (diazepam transmucosal)

+

ketamine

1 interaction

Avoid/Use Alternative

diazepam + ketamine

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ketamine may decr. seizure threshold)

• kratom
Libervant (diazepam transmucosal)

+

kratom

1 interaction

Avoid/Use Alternative

diazepam + kratom

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, kratom may decr. seizure threshold)

• levorphanol
Libervant (diazepam transmucosal)

+

levorphanol

1 interaction

Avoid/Use Alternative

diazepam + levorphanol

use alternative or monitor respiratory rate, BP; decr. levorphanol start dose by at least 50%, consider decr. diazepam dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope); may alter seizure control (additive effects; antagonistic effects, levorphanol may decr. seizure threshold)

• lorazepam
Libervant (diazepam transmucosal)

+

lorazepam

1 interaction

Avoid/Use Alternative

diazepam + lorazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• meperidine
Libervant (diazepam transmucosal)

+

meperidine

1 interaction

Avoid/Use Alternative

diazepam + meperidine

use alternative or monitor respiratory rate, BP; decr. meperidine dose 25-50%, consider decr. diazepam dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis syncope; may alter seizure control (additive effects; antagonistic effects, meperidine may decr. seizure threshold)

• metaxalone
Libervant (diazepam transmucosal)

+

metaxalone

1 interaction

Avoid/Use Alternative

diazepam + metaxalone

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• methadone
Libervant (diazepam transmucosal)

+

methadone

1 interaction

Avoid/Use Alternative

diazepam + methadone

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope), other adverse effects; may alter seizure control (hepatic metabolism inhibited, additive effects; antagonistic effects, methadone may decr. seizure threshold)

• methohexital
Libervant (diazepam transmucosal)

+

methohexital

1 interaction

Avoid/Use Alternative

diazepam + methohexital

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• metoclopramide
Libervant (diazepam transmucosal)

+

metoclopramide

1 interaction

Avoid/Use Alternative

diazepam + metoclopramide

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may alter seizure control; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (antagonistic effects, metoclopramide may decr. seizure threshold; additive effects)

• midazolam
Libervant (diazepam transmucosal)

+

midazolam

1 interaction

Avoid/Use Alternative

diazepam + midazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• morphine
Libervant (diazepam transmucosal)

+

morphine

1 interaction

Avoid/Use Alternative

diazepam + morphine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, morphine may decr. seizure threshold)

• nalbuphine
Libervant (diazepam transmucosal)

+

nalbuphine

1 interaction

Avoid/Use Alternative

diazepam + nalbuphine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, nalbuphine may decr. seizure threshold)

• olanzapine
Libervant (diazepam transmucosal)

+

olanzapine

1 interaction

Avoid/Use Alternative

diazepam + olanzapine

avoid combo w/ parenteral diazepam and IM olanzapine; otherwise, monitor BP, respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, olanzapine may decr. seizure threshold)

• oliceridine
Libervant (diazepam transmucosal)

+

oliceridine

1 interaction

Avoid/Use Alternative

diazepam + oliceridine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, oliceridine may decr. seizure threshold)

• opium
Libervant (diazepam transmucosal)

+

opium

1 interaction

Avoid/Use Alternative

diazepam + opium

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension including orthostasis, syncope; may alter seizure control if seizure disorder use (additive effects; antagonistic effects, morphine in opium may decr. seizure threshold)

• oxazepam
Libervant (diazepam transmucosal)

+

oxazepam

1 interaction

Avoid/Use Alternative

diazepam + oxazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• oxybate
Libervant (diazepam transmucosal)

+

oxybate

1 interaction

Avoid/Use Alternative

diazepam + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Libervant (diazepam transmucosal)

+

oxycodone

1 interaction

Avoid/Use Alternative

diazepam + oxycodone

use alternative or monitor BP, respiratory rate; decr. oxycodone start dose by at least 50%, consider decr. diazepam dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, oxycodone may decr. seizure threshold)

• oxymorphone
Libervant (diazepam transmucosal)

+

oxymorphone

1 interaction

Avoid/Use Alternative

diazepam + oxymorphone

use alternative or monitor respiratory rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. diazepam dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, oxymorphone may decr. seizure threshold)

• paliperidone
Libervant (diazepam transmucosal)

+

paliperidone

1 interaction

Avoid/Use Alternative

diazepam + paliperidone

use alternative or monitor BP, respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• pentazocine
Libervant (diazepam transmucosal)

+

pentazocine

1 interaction

Avoid/Use Alternative

diazepam + pentazocine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, pentazocine may decr. seizure threshold)

• pentobarbital
Libervant (diazepam transmucosal)

+

pentobarbital

1 interaction

Avoid/Use Alternative

diazepam + pentobarbital

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• phenelzine
Libervant (diazepam transmucosal)

+

phenelzine

1 interaction

Avoid/Use Alternative

diazepam + phenelzine

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, phenelzine may decr. seizure threshold)

• phenobarbital
Libervant (diazepam transmucosal)

+

phenobarbital

1 interaction

Avoid/Use Alternative

diazepam + phenobarbital

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• pregabalin
Libervant (diazepam transmucosal)

+

pregabalin

1 interaction

Avoid/Use Alternative

diazepam + pregabalin

use alternative or monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• primidone
Libervant (diazepam transmucosal)

+

primidone

1 interaction

Avoid/Use Alternative

diazepam + primidone

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• promethazine
Libervant (diazepam transmucosal)

+

promethazine

1 interaction

Avoid/Use Alternative

diazepam + promethazine

use alternative or monitor respiratory rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, promethazine may decr. seizure threshold)

• propofol
Libervant (diazepam transmucosal)

+

propofol

1 interaction

Avoid/Use Alternative

diazepam + propofol

use alternative or monitor respiratory rate, BP; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension; may alter seizure control (additive effects; antagonistic effects, propofol may decr. seizure threshold)

• quazepam
Libervant (diazepam transmucosal)

+

quazepam

1 interaction

Avoid/Use Alternative

diazepam + quazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• remifentanil
Libervant (diazepam transmucosal)

+

remifentanil

1 interaction

Avoid/Use Alternative

diazepam + remifentanil

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, remifentanil may decr. seizure threshold)

• remimazolam
Libervant (diazepam transmucosal)

+

remimazolam

1 interaction

Avoid/Use Alternative

diazepam + remimazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• ropeginterferon alfa-2b
Libervant (diazepam transmucosal)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

diazepam + ropeginterferon alfa-2b

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• scopolamine
Libervant (diazepam transmucosal)

+

scopolamine

1 interaction

Avoid/Use Alternative

diazepam + scopolamine

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, scopolamine may decrease seizure threshold)

• sufentanil
Libervant (diazepam transmucosal)

+

sufentanil

1 interaction

Avoid/Use Alternative

diazepam + sufentanil

use alternative or monitor respiratory rate, BP; decr. sufentanil start dose, consider decr. diazepam dose; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension (including orthostasis, syncope); may alter seizure control (additive effects; antagonistic effects, sufentanil may decr. seizure threshold)

• tapentadol
Libervant (diazepam transmucosal)

+

tapentadol

1 interaction

Avoid/Use Alternative

diazepam + tapentadol

use alternative or monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, tapentadol may decrease seizure threshold)

• temazepam
Libervant (diazepam transmucosal)

+

temazepam

1 interaction

Avoid/Use Alternative

diazepam + temazepam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• thalidomide
Libervant (diazepam transmucosal)

+

thalidomide

1 interaction

Avoid/Use Alternative

diazepam + thalidomide

use alternative or monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thalidomide may decr. seizure threshold)

• tradipitant
Libervant (diazepam transmucosal)

+

tradipitant

1 interaction

Avoid/Use Alternative

diazepam + tradipitant

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tramadol
Libervant (diazepam transmucosal)

+

tramadol

1 interaction

Avoid/Use Alternative

diazepam + tramadol

use alternative or monitor respiratory rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, tramadol may decr. seizure threshold)

• tranylcypromine
Libervant (diazepam transmucosal)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

diazepam + tranylcypromine

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, tranylcypromine may decr. seizure threshold)

• triazolam
Libervant (diazepam transmucosal)

+

triazolam

1 interaction

Avoid/Use Alternative

diazepam + triazolam

use alternative or monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects, duplicate therapy)

• zuranolone
Libervant (diazepam transmucosal)

+

zuranolone

1 interaction

Avoid/Use Alternative

diazepam + zuranolone

use alternative or monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• 5-HTP
Libervant (diazepam transmucosal)

+

5-HTP

1 interaction

Monitor/Modify Tx

diazepam + 5-HTP

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• adagrasib
Libervant (diazepam transmucosal)

+

adagrasib

1 interaction

Monitor/Modify Tx

diazepam + adagrasib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• aldesleukin
Libervant (diazepam transmucosal)

+

aldesleukin

1 interaction

Monitor/Modify Tx

diazepam + aldesleukin

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx; withhold aldesleukin if mod-severe somnolence occurs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, aldesleukin may decr. seizure threshold)

• allopurinol
Libervant (diazepam transmucosal)

+

allopurinol

1 interaction

Monitor/Modify Tx

diazepam + allopurinol

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• almotriptan
Libervant (diazepam transmucosal)

+

almotriptan

1 interaction

Monitor/Modify Tx

diazepam + almotriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• amantadine
Libervant (diazepam transmucosal)

+

amantadine

1 interaction

Monitor/Modify Tx

diazepam + amantadine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• amitriptyline
Libervant (diazepam transmucosal)

+

amitriptyline

1 interaction

Monitor/Modify Tx

diazepam + amitriptyline

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, amitriptyline may decr. seizure threshold)

• amoxapine
Libervant (diazepam transmucosal)

+

amoxapine

1 interaction

Monitor/Modify Tx

diazepam + amoxapine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, amoxapine may decr. seizure threshold)

• apomorphine
Libervant (diazepam transmucosal)

+

apomorphine

1 interaction

Monitor/Modify Tx

diazepam + apomorphine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• apraclonidine ophthalmic
Libervant (diazepam transmucosal)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

diazepam + apraclonidine ophthalmic

monitor respiratory rate if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• aripiprazole bimonthly injection
Libervant (diazepam transmucosal)

+

aripiprazole bimonthly injection

1 interaction

Monitor/Modify Tx

diazepam + aripiprazole bimonthly injection

monitor BP, respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• aripiprazole monthly injection
Libervant (diazepam transmucosal)

+

aripiprazole monthly injection

1 interaction

Monitor/Modify Tx

diazepam + aripiprazole monthly injection

monitor BP, respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• aripiprazole oral
Libervant (diazepam transmucosal)

+

aripiprazole oral

1 interaction

Monitor/Modify Tx

diazepam + aripiprazole oral

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis; may alter seizure control (additive effects; antagonistic effects, aripiprazole may decr. seizure threshold)

• armodafinil
Libervant (diazepam transmucosal)

+

armodafinil

1 interaction

Monitor/Modify Tx

diazepam + armodafinil

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• asenapine
Libervant (diazepam transmucosal)

+

asenapine

1 interaction

Monitor/Modify Tx

diazepam + asenapine

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, asenapine may decr. seizure threshold)

• atazanavir
Libervant (diazepam transmucosal)

+

atazanavir

1 interaction

Monitor/Modify Tx

diazepam + atazanavir

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• baclofen
Libervant (diazepam transmucosal)

+

baclofen

1 interaction

Monitor/Modify Tx

diazepam + baclofen

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, baclofen may decr. seizure threshold)

• brexpiprazole
Libervant (diazepam transmucosal)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

diazepam + brexpiprazole

monitor BP, respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, brexpiprazole may decr. seizure threshold)

• brimonidine topical
Libervant (diazepam transmucosal)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

diazepam + brimonidine topical

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• brivaracetam
Libervant (diazepam transmucosal)

+

brivaracetam

1 interaction

Monitor/Modify Tx

diazepam + brivaracetam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• bromocriptine
Libervant (diazepam transmucosal)

+

bromocriptine

1 interaction

Monitor/Modify Tx

diazepam + bromocriptine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• brompheniramine
Libervant (diazepam transmucosal)

+

brompheniramine

1 interaction

Monitor/Modify Tx

diazepam + brompheniramine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• buspirone
Libervant (diazepam transmucosal)

+

buspirone

1 interaction

Monitor/Modify Tx

diazepam + buspirone

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• cannabidiol
Libervant (diazepam transmucosal)

+

cannabidiol

1 interaction

Monitor/Modify Tx

diazepam + cannabidiol

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• cannabis
Libervant (diazepam transmucosal)

+

cannabis

1 interaction

Monitor/Modify Tx

diazepam + cannabis

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metabolism inhibited, additive effects; antagonistic effects, cannabis may decr. seizure threshold)

• carbamazepine
Libervant (diazepam transmucosal)

+

carbamazepine

1 interaction

Monitor/Modify Tx

diazepam + carbamazepine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• carbinoxamine
Libervant (diazepam transmucosal)

+

carbinoxamine

1 interaction

Monitor/Modify Tx

diazepam + carbinoxamine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• cariprazine
Libervant (diazepam transmucosal)

+

cariprazine

1 interaction

Monitor/Modify Tx

diazepam + cariprazine

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may alter seizure control; may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (antagonistic effects, cariprazine may decr. seizure threshold; additive effects)

• carisoprodol
Libervant (diazepam transmucosal)

+

carisoprodol

1 interaction

Monitor/Modify Tx

diazepam + carisoprodol

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• cenobamate
Libervant (diazepam transmucosal)

+

cenobamate

1 interaction

Monitor/Modify Tx

diazepam + cenobamate

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. diazepam levels, incr. risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism altered; additive effects)

• ceritinib
Libervant (diazepam transmucosal)

+

ceritinib

1 interaction

Monitor/Modify Tx

diazepam + ceritinib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• cetirizine
Libervant (diazepam transmucosal)

+

cetirizine

1 interaction

Monitor/Modify Tx

diazepam + cetirizine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• chamomile, German
Libervant (diazepam transmucosal)

+

chamomile, German

1 interaction

Monitor/Modify Tx

diazepam + chamomile, German

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• chlophedianol
Libervant (diazepam transmucosal)

+

chlophedianol

1 interaction

Monitor/Modify Tx

diazepam + chlophedianol

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• chloramphenicol
Libervant (diazepam transmucosal)

+

chloramphenicol

1 interaction

Monitor/Modify Tx

diazepam + chloramphenicol

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• chlorcyclizine
Libervant (diazepam transmucosal)

+

chlorcyclizine

1 interaction

Monitor/Modify Tx

diazepam + chlorcyclizine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorpheniramine
Libervant (diazepam transmucosal)

+

chlorpheniramine

1 interaction

Monitor/Modify Tx

diazepam + chlorpheniramine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• chlorpromazine
Libervant (diazepam transmucosal)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

diazepam + chlorpromazine

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, chlorpromazine may decr. seizure threshold)

• chlorzoxazone
Libervant (diazepam transmucosal)

+

chlorzoxazone

1 interaction

Monitor/Modify Tx

diazepam + chlorzoxazone

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• cimetidine
Libervant (diazepam transmucosal)

+

cimetidine

1 interaction

Monitor/Modify Tx

diazepam + cimetidine

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• citalopram
Libervant (diazepam transmucosal)

+

citalopram

1 interaction

Monitor/Modify Tx

diazepam + citalopram

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, citalopram may decr. seizure threshold)

• clarithromycin
Libervant (diazepam transmucosal)

+

clarithromycin

1 interaction

Monitor/Modify Tx

diazepam + clarithromycin

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• clemastine
Libervant (diazepam transmucosal)

+

clemastine

1 interaction

Monitor/Modify Tx

diazepam + clemastine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• clomipramine
Libervant (diazepam transmucosal)

+

clomipramine

1 interaction

Monitor/Modify Tx

diazepam + clomipramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, clomipramine may decr. seizure threshold)

• clopidogrel
Libervant (diazepam transmucosal)

+

clopidogrel

1 interaction

Monitor/Modify Tx

diazepam + clopidogrel

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• clozapine
Libervant (diazepam transmucosal)

+

clozapine

1 interaction

Monitor/Modify Tx

diazepam + clozapine

monitor respiratory rate, BP, HR; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, clozapine may decr. seizure threshold)

• cobicistat
Libervant (diazepam transmucosal)

+

cobicistat

1 interaction

Monitor/Modify Tx

diazepam + cobicistat

monitor respiratory rate; consider decr. diazepam dose: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• cyclobenzaprine
Libervant (diazepam transmucosal)

+

cyclobenzaprine

1 interaction

Monitor/Modify Tx

diazepam + cyclobenzaprine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, cyclobenzaprine may decr. seizure threshold)

• cyproheptadine
Libervant (diazepam transmucosal)

+

cyproheptadine

1 interaction

Monitor/Modify Tx

diazepam + cyproheptadine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dantrolene
Libervant (diazepam transmucosal)

+

dantrolene

1 interaction

Monitor/Modify Tx

diazepam + dantrolene

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• daridorexant
Libervant (diazepam transmucosal)

+

daridorexant

1 interaction

Monitor/Modify Tx

diazepam + daridorexant

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• darifenacin
Libervant (diazepam transmucosal)

+

darifenacin

1 interaction

Monitor/Modify Tx

diazepam + darifenacin

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• darunavir
Libervant (diazepam transmucosal)

+

darunavir

1 interaction

Monitor/Modify Tx

diazepam + darunavir

monitor respiratory rate; consider diazepam dose decr.: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• desipramine
Libervant (diazepam transmucosal)

+

desipramine

1 interaction

Monitor/Modify Tx

diazepam + desipramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, desipramine may decr. seizure threshold)

• desvenlafaxine
Libervant (diazepam transmucosal)

+

desvenlafaxine

1 interaction

Monitor/Modify Tx

diazepam + desvenlafaxine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, desvenlafaxine may decr. seizure threshold)

• deutetrabenazine
Libervant (diazepam transmucosal)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

diazepam + deutetrabenazine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dexbrompheniramine
Libervant (diazepam transmucosal)

+

dexbrompheniramine

1 interaction

Monitor/Modify Tx

diazepam + dexbrompheniramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dexchlorpheniramine
Libervant (diazepam transmucosal)

+

dexchlorpheniramine

1 interaction

Monitor/Modify Tx

diazepam + dexchlorpheniramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dexmedetomidine
Libervant (diazepam transmucosal)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

diazepam + dexmedetomidine

monitor respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• dichlorphenamide
Libervant (diazepam transmucosal)

+

dichlorphenamide

1 interaction

Monitor/Modify Tx

diazepam + dichlorphenamide

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• difelikefalin
Libervant (diazepam transmucosal)

+

difelikefalin

1 interaction

Monitor/Modify Tx

diazepam + difelikefalin

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• difenoxin
Libervant (diazepam transmucosal)

+

difenoxin

1 interaction

Monitor/Modify Tx

diazepam + difenoxin

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dimenhydrinate
Libervant (diazepam transmucosal)

+

dimenhydrinate

1 interaction

Monitor/Modify Tx

diazepam + dimenhydrinate

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• diphenhydramine
Libervant (diazepam transmucosal)

+

diphenhydramine

1 interaction

Monitor/Modify Tx

diazepam + diphenhydramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• diphenoxylate
Libervant (diazepam transmucosal)

+

diphenoxylate

1 interaction

Monitor/Modify Tx

diazepam + diphenoxylate

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• domperidone
Libervant (diazepam transmucosal)

+

domperidone

1 interaction

Monitor/Modify Tx

diazepam + domperidone

monitor respiratory rate use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• doxepin
Libervant (diazepam transmucosal)

+

doxepin

1 interaction

Monitor/Modify Tx

diazepam + doxepin

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, doxepin may decr. seizure threshold)

• doxepin topical
Libervant (diazepam transmucosal)

+

doxepin topical

1 interaction

Monitor/Modify Tx

diazepam + doxepin topical

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• dronabinol
Libervant (diazepam transmucosal)

+

dronabinol

1 interaction

Monitor/Modify Tx

diazepam + dronabinol

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, dronabinol may decr. seizure threshold)

• droperidol
Libervant (diazepam transmucosal)

+

droperidol

1 interaction

Monitor/Modify Tx

diazepam + droperidol

monitor respiratory rate; decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• duloxetine
Libervant (diazepam transmucosal)

+

duloxetine

1 interaction

Monitor/Modify Tx

diazepam + duloxetine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, duloxetine may decr. seizure threshold)

• efavirenz
Libervant (diazepam transmucosal)

+

efavirenz

1 interaction

Monitor/Modify Tx

diazepam + efavirenz

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. diazepam levels, incr. risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism altered, additive effects)

• elagolix
Libervant (diazepam transmucosal)

+

elagolix

1 interaction

Monitor/Modify Tx

diazepam + elagolix

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• eletriptan
Libervant (diazepam transmucosal)

+

eletriptan

1 interaction

Monitor/Modify Tx

diazepam + eletriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• elinzanetant
Libervant (diazepam transmucosal)

+

elinzanetant

1 interaction

Monitor/Modify Tx

diazepam + elinzanetant

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx; caution advised if seizure disorder use: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, elinzanetant may decr. seizure threshold)

• enasidenib
Libervant (diazepam transmucosal)

+

enasidenib

1 interaction

Monitor/Modify Tx

diazepam + enasidenib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• entacapone
Libervant (diazepam transmucosal)

+

entacapone

1 interaction

Monitor/Modify Tx

diazepam + entacapone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• entrectinib
Libervant (diazepam transmucosal)

+

entrectinib

1 interaction

Monitor/Modify Tx

diazepam + entrectinib

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• escitalopram
Libervant (diazepam transmucosal)

+

escitalopram

1 interaction

Monitor/Modify Tx

diazepam + escitalopram

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• esketamine
Libervant (diazepam transmucosal)

+

esketamine

1 interaction

Monitor/Modify Tx

diazepam + esketamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Libervant (diazepam transmucosal)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

diazepam + eslicarbazepine acetate

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• esomeprazole
Libervant (diazepam transmucosal)

+

esomeprazole

1 interaction

Monitor/Modify Tx

diazepam + esomeprazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• estradiol (contraceptive)
Libervant (diazepam transmucosal)

+

estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

diazepam + estradiol (contraceptive)

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• eszopiclone
Libervant (diazepam transmucosal)

+

eszopiclone

1 interaction

Monitor/Modify Tx

diazepam + eszopiclone

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
Libervant (diazepam transmucosal)

+

ethinyl estradiol (contraceptive)

1 interaction

Monitor/Modify Tx

diazepam + ethinyl estradiol (contraceptive)

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• ethosuximide
Libervant (diazepam transmucosal)

+

ethosuximide

1 interaction

Monitor/Modify Tx

diazepam + ethosuximide

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• etomidate
Libervant (diazepam transmucosal)

+

etomidate

1 interaction

Monitor/Modify Tx

diazepam + etomidate

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• etravirine
Libervant (diazepam transmucosal)

+

etravirine

1 interaction

Monitor/Modify Tx

diazepam + etravirine

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• fedratinib
Libervant (diazepam transmucosal)

+

fedratinib

1 interaction

Monitor/Modify Tx

diazepam + fedratinib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• felbamate
Libervant (diazepam transmucosal)

+

felbamate

1 interaction

Monitor/Modify Tx

diazepam + felbamate

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• fenfluramine
Libervant (diazepam transmucosal)

+

fenfluramine

1 interaction

Monitor/Modify Tx

diazepam + fenfluramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• fesoterodine
Libervant (diazepam transmucosal)

+

fesoterodine

1 interaction

Monitor/Modify Tx

diazepam + fesoterodine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• fexinidazole
Libervant (diazepam transmucosal)

+

fexinidazole

1 interaction

Monitor/Modify Tx

diazepam + fexinidazole

monitor respiratory rate: combo may incr. or decr. diazepam levels, incr. risk of CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism altered)

• flibanserin
Libervant (diazepam transmucosal)

+

flibanserin

1 interaction

Monitor/Modify Tx

diazepam + flibanserin

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• fluconazole
Libervant (diazepam transmucosal)

+

fluconazole

1 interaction

Monitor/Modify Tx

diazepam + fluconazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• fluoxetine
Libervant (diazepam transmucosal)

+

fluoxetine

1 interaction

Monitor/Modify Tx

diazepam + fluoxetine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metabolism inhibited, additive effects; antagonistic effects, fluoxetine may decr. seizure threshold)

• fluphenazine
Libervant (diazepam transmucosal)

+

fluphenazine

1 interaction

Monitor/Modify Tx

diazepam + fluphenazine

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, fluphenazine may decr. seizure threshold)

• foslevodopa
Libervant (diazepam transmucosal)

+

foslevodopa

1 interaction

Monitor/Modify Tx

diazepam + foslevodopa

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• fosphenytoin
Libervant (diazepam transmucosal)

+

fosphenytoin

1 interaction

Monitor/Modify Tx

diazepam + fosphenytoin

monitor respiratory rate, phenytoin levels; use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. phenytoin levels, incr. risk of adverse effects or decr. efficacy; may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (mechanism unknown, hepatic metabolism possibly altered; hepatic metabolism induced; additive effects)

• frovatriptan
Libervant (diazepam transmucosal)

+

frovatriptan

1 interaction

Monitor/Modify Tx

diazepam + frovatriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ganaxolone
Libervant (diazepam transmucosal)

+

ganaxolone

1 interaction

Monitor/Modify Tx

diazepam + ganaxolone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• garlic
Libervant (diazepam transmucosal)

+

garlic

1 interaction

Monitor/Modify Tx

diazepam + garlic

monitor respiratory rate w/ supplemental garlic; dietary intake OK: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• givosiran
Libervant (diazepam transmucosal)

+

givosiran

1 interaction

Monitor/Modify Tx

diazepam + givosiran

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited; givosiran effects on hepatic heme biosynthesis may reduce CYP450 enzyme activity)

• glofitamab
Libervant (diazepam transmucosal)

+

glofitamab

1 interaction

Monitor/Modify Tx

diazepam + glofitamab

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• glycopyrrolate
Libervant (diazepam transmucosal)

+

glycopyrrolate

1 interaction

Monitor/Modify Tx

diazepam + glycopyrrolate

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• guanfacine
Libervant (diazepam transmucosal)

+

guanfacine

1 interaction

Monitor/Modify Tx

diazepam + guanfacine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• hydroxyzine
Libervant (diazepam transmucosal)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

diazepam + hydroxyzine

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• hyoscyamine
Libervant (diazepam transmucosal)

+

hyoscyamine

1 interaction

Monitor/Modify Tx

diazepam + hyoscyamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• idelalisib
Libervant (diazepam transmucosal)

+

idelalisib

1 interaction

Monitor/Modify Tx

diazepam + idelalisib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• ifosfamide
Libervant (diazepam transmucosal)

+

ifosfamide

1 interaction

Monitor/Modify Tx

diazepam + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, ifosfamide may decr. seizure threshold)

• iloperidone
Libervant (diazepam transmucosal)

+

iloperidone

1 interaction

Monitor/Modify Tx

diazepam + iloperidone

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• imipramine
Libervant (diazepam transmucosal)

+

imipramine

1 interaction

Monitor/Modify Tx

diazepam + imipramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, imipramine may decr. seizure threshold)

• isoniazid
Libervant (diazepam transmucosal)

+

isoniazid

1 interaction

Monitor/Modify Tx

diazepam + isoniazid

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metabolism inhibited; antagonistic effects, isoniazid may decr. seizure threshold)

• itraconazole
Libervant (diazepam transmucosal)

+

itraconazole

1 interaction

Monitor/Modify Tx

diazepam + itraconazole

monitor respiratory rate; consider decr. diazepam dose during and x2wk after itraconazole tx: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• ketoconazole
Libervant (diazepam transmucosal)

+

ketoconazole

1 interaction

Monitor/Modify Tx

diazepam + ketoconazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• lacosamide
Libervant (diazepam transmucosal)

+

lacosamide

1 interaction

Monitor/Modify Tx

diazepam + lacosamide

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lamotrigine
Libervant (diazepam transmucosal)

+

lamotrigine

1 interaction

Monitor/Modify Tx

diazepam + lamotrigine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lemborexant
Libervant (diazepam transmucosal)

+

lemborexant

1 interaction

Monitor/Modify Tx

diazepam + lemborexant

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• levetiracetam
Libervant (diazepam transmucosal)

+

levetiracetam

1 interaction

Monitor/Modify Tx

diazepam + levetiracetam

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• levocetirizine
Libervant (diazepam transmucosal)

+

levocetirizine

1 interaction

Monitor/Modify Tx

diazepam + levocetirizine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• levodopa
Libervant (diazepam transmucosal)

+

levodopa

1 interaction

Monitor/Modify Tx

diazepam + levodopa

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• levoketoconazole
Libervant (diazepam transmucosal)

+

levoketoconazole

1 interaction

Monitor/Modify Tx

diazepam + levoketoconazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• levomilnacipran
Libervant (diazepam transmucosal)

+

levomilnacipran

1 interaction

Monitor/Modify Tx

diazepam + levomilnacipran

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, levomilnacipran may decr. seizure threshold)

• linvoseltamab
Libervant (diazepam transmucosal)

+

linvoseltamab

1 interaction

Monitor/Modify Tx

diazepam + linvoseltamab

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lofexidine
Libervant (diazepam transmucosal)

+

lofexidine

1 interaction

Monitor/Modify Tx

diazepam + lofexidine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lonafarnib
Libervant (diazepam transmucosal)

+

lonafarnib

1 interaction

Monitor/Modify Tx

diazepam + lonafarnib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• lopinavir/ritonavir
Libervant (diazepam transmucosal)

+

lopinavir/ ritonavir

1 interaction

Monitor/Modify Tx

diazepam + lopinavir/ ritonavir

monitor respiratory rate: combo may incr. or decr. diazepam levels, incr. risk of CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism altered)

• loxapine
Libervant (diazepam transmucosal)

+

loxapine

1 interaction

Monitor/Modify Tx

diazepam + loxapine

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, loxapine may decr. seizure threshold)

• luliconazole topical
Libervant (diazepam transmucosal)

+

luliconazole topical

1 interaction

Monitor/Modify Tx

diazepam + luliconazole topical

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• lumateperone
Libervant (diazepam transmucosal)

+

lumateperone

1 interaction

Monitor/Modify Tx

diazepam + lumateperone

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, lumateperone may decr. seizure threshold)

• lurasidone
Libervant (diazepam transmucosal)

+

lurasidone

1 interaction

Monitor/Modify Tx

diazepam + lurasidone

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, lurasidone may decr. seizure threshold)

• meclizine
Libervant (diazepam transmucosal)

+

meclizine

1 interaction

Monitor/Modify Tx

diazepam + meclizine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• melatonin
Libervant (diazepam transmucosal)

+

melatonin

1 interaction

Monitor/Modify Tx

diazepam + melatonin

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, melatonin may decr. seizure threshold)

• meprobamate
Libervant (diazepam transmucosal)

+

meprobamate

1 interaction

Monitor/Modify Tx

diazepam + meprobamate

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• methocarbamol
Libervant (diazepam transmucosal)

+

methocarbamol

1 interaction

Monitor/Modify Tx

diazepam + methocarbamol

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, methocarbamol may decr. seizure threshold)

• methsuximide
Libervant (diazepam transmucosal)

+

methsuximide

1 interaction

Monitor/Modify Tx

diazepam + methsuximide

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• methyldopa
Libervant (diazepam transmucosal)

+

methyldopa

1 interaction

Monitor/Modify Tx

diazepam + methyldopa

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• metyrapone
Libervant (diazepam transmucosal)

+

metyrapone

1 interaction

Monitor/Modify Tx

diazepam + metyrapone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• metyrosine
Libervant (diazepam transmucosal)

+

metyrosine

1 interaction

Monitor/Modify Tx

diazepam + metyrosine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• mifepristone
Libervant (diazepam transmucosal)

+

mifepristone

1 interaction

Monitor/Modify Tx

diazepam + mifepristone

monitor respiratory rate w/in 14 days of daily mifepristone use: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• milnacipran
Libervant (diazepam transmucosal)

+

milnacipran

1 interaction

Monitor/Modify Tx

diazepam + milnacipran

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, milnacipran may decr. seizure threshold)

• milsaperidone
Libervant (diazepam transmucosal)

+

milsaperidone

1 interaction

Monitor/Modify Tx

diazepam + milsaperidone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, milsaperidone may lower seizure threshold)

• mirtazapine
Libervant (diazepam transmucosal)

+

mirtazapine

1 interaction

Monitor/Modify Tx

diazepam + mirtazapine

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, mirtazapine may decr. seizure threshold)

• mitotane
Libervant (diazepam transmucosal)

+

mitotane

1 interaction

Monitor/Modify Tx

diazepam + mitotane

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• modafinil
Libervant (diazepam transmucosal)

+

modafinil

1 interaction

Monitor/Modify Tx

diazepam + modafinil

monitor respiratory rate: combo may incr. or decr. diazepam levels, incr. risk of CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism altered)

• molindone
Libervant (diazepam transmucosal)

+

molindone

1 interaction

Monitor/Modify Tx

diazepam + molindone

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may alter seizure control; may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis (antagonistic effects, molindone may decr. seizure threshold; additive effects)

• mosunetuzumab
Libervant (diazepam transmucosal)

+

mosunetuzumab

1 interaction

Monitor/Modify Tx

diazepam + mosunetuzumab

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
Libervant (diazepam transmucosal)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

diazepam + mycophenolate mofetil

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• naltrexone
Libervant (diazepam transmucosal)

+

naltrexone

1 interaction

Monitor/Modify Tx

diazepam + naltrexone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• naratriptan
Libervant (diazepam transmucosal)

+

naratriptan

1 interaction

Monitor/Modify Tx

diazepam + naratriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• nefazodone
Libervant (diazepam transmucosal)

+

nefazodone

1 interaction

Monitor/Modify Tx

diazepam + nefazodone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metabolism inhibited, additive effects; antagonistic effects, nefazodone may decr. seizure threshold)

• nelarabine
Libervant (diazepam transmucosal)

+

nelarabine

1 interaction

Monitor/Modify Tx

diazepam + nelarabine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx; withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nelarabine may decr. seizure threshold)

• nelfinavir
Libervant (diazepam transmucosal)

+

nelfinavir

1 interaction

Monitor/Modify Tx

diazepam + nelfinavir

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• nortriptyline
Libervant (diazepam transmucosal)

+

nortriptyline

1 interaction

Monitor/Modify Tx

diazepam + nortriptyline

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, nortriptyline may decr. seizure threshold)

• omeprazole
Libervant (diazepam transmucosal)

+

omeprazole

1 interaction

Monitor/Modify Tx

diazepam + omeprazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• opicapone
Libervant (diazepam transmucosal)

+

opicapone

1 interaction

Monitor/Modify Tx

diazepam + opicapone

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• orphenadrine
Libervant (diazepam transmucosal)

+

orphenadrine

1 interaction

Monitor/Modify Tx

diazepam + orphenadrine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• osilodrostat
Libervant (diazepam transmucosal)

+

osilodrostat

1 interaction

Monitor/Modify Tx

diazepam + osilodrostat

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• oxcarbazepine
Libervant (diazepam transmucosal)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

diazepam + oxcarbazepine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• oxybutynin
Libervant (diazepam transmucosal)

+

oxybutynin

1 interaction

Monitor/Modify Tx

diazepam + oxybutynin

monitor respiratory rate; decr. dose of one or both drugs or consider oxybutynin transdermal patch, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; somnolence less likely with oxybutynin transdermal patch (additive effects)

• paroxetine
Libervant (diazepam transmucosal)

+

paroxetine

1 interaction

Monitor/Modify Tx

diazepam + paroxetine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, paroxetine may decr. seizure threshold)

• passion flower
Libervant (diazepam transmucosal)

+

passion flower

1 interaction

Monitor/Modify Tx

diazepam + passion flower

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• perampanel
Libervant (diazepam transmucosal)

+

perampanel

1 interaction

Monitor/Modify Tx

diazepam + perampanel

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• perphenazine
Libervant (diazepam transmucosal)

+

perphenazine

1 interaction

Monitor/Modify Tx

diazepam + perphenazine

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, perphenazine may decr. seizure threshold)

• pheniramine
Libervant (diazepam transmucosal)

+

pheniramine

1 interaction

Monitor/Modify Tx

diazepam + pheniramine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• phenylephrine injection
Libervant (diazepam transmucosal)

+

phenylephrine injection

1 interaction

Monitor/Modify Tx

diazepam + phenylephrine injection

monitor BP: combo may decr. phenylephrine efficacy (antagonistic effects)

• phenytoin
Libervant (diazepam transmucosal)

+

phenytoin

1 interaction

Monitor/Modify Tx

diazepam + phenytoin

monitor respiratory rate, phenytoin levels; use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. phenytoin levels, incr. risk of adverse effects or decr. efficacy; may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (mechanism unknown, hepatic metabolism possibly altered; hepatic metabolism induced; additive effects)

• pimozide
Libervant (diazepam transmucosal)

+

pimozide

1 interaction

Monitor/Modify Tx

diazepam + pimozide

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, pimozide may decr. seizure threshold)

• pirtobrutinib
Libervant (diazepam transmucosal)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

diazepam + pirtobrutinib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• posaconazole
Libervant (diazepam transmucosal)

+

posaconazole

1 interaction

Monitor/Modify Tx

diazepam + posaconazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• pramipexole
Libervant (diazepam transmucosal)

+

pramipexole

1 interaction

Monitor/Modify Tx

diazepam + pramipexole

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• procarbazine
Libervant (diazepam transmucosal)

+

procarbazine

1 interaction

Monitor/Modify Tx

diazepam + procarbazine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, procarbazine may decr. seizure threshold)

• prochlorperazine
Libervant (diazepam transmucosal)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

diazepam + prochlorperazine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, prochlorperazine may decr. seizure threshold)

• propranolol
Libervant (diazepam transmucosal)

+

propranolol

1 interaction

Monitor/Modify Tx

diazepam + propranolol

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (mechanism unknown, hepatic metabolism possibly inhibited)

• protriptyline
Libervant (diazepam transmucosal)

+

protriptyline

1 interaction

Monitor/Modify Tx

diazepam + protriptyline

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, protriptyline may decr. seizure threshold)

• pyrilamine
Libervant (diazepam transmucosal)

+

pyrilamine

1 interaction

Monitor/Modify Tx

diazepam + pyrilamine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• quetiapine
Libervant (diazepam transmucosal)

+

quetiapine

1 interaction

Monitor/Modify Tx

diazepam + quetiapine

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, quetiapine may decr. seizure threshold)

• ramelteon
Libervant (diazepam transmucosal)

+

ramelteon

1 interaction

Monitor/Modify Tx

diazepam + ramelteon

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• rasagiline
Libervant (diazepam transmucosal)

+

rasagiline

1 interaction

Monitor/Modify Tx

diazepam + rasagiline

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repotrectinib
Libervant (diazepam transmucosal)

+

repotrectinib

1 interaction

Monitor/Modify Tx

diazepam + repotrectinib

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. diazepam levels, efficacy; may incr. risk of profound CNS and respiratory depression, psychomotor impairment (hepatic metabolism induced; additive effects)

• ribociclib
Libervant (diazepam transmucosal)

+

ribociclib

1 interaction

Monitor/Modify Tx

diazepam + ribociclib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• risperidone
Libervant (diazepam transmucosal)

+

risperidone

1 interaction

Monitor/Modify Tx

diazepam + risperidone

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, risperidone may decr. seizure threshold)

• ritonavir
Libervant (diazepam transmucosal)

+

ritonavir

1 interaction

Monitor/Modify Tx

diazepam + ritonavir

monitor respiratory rate; consider decr. diazepam dose: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• rizatriptan
Libervant (diazepam transmucosal)

+

rizatriptan

1 interaction

Monitor/Modify Tx

diazepam + rizatriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ropinirole
Libervant (diazepam transmucosal)

+

ropinirole

1 interaction

Monitor/Modify Tx

diazepam + ropinirole

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• rotigotine transdermal
Libervant (diazepam transmucosal)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

diazepam + rotigotine transdermal

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• rucaparib
Libervant (diazepam transmucosal)

+

rucaparib

1 interaction

Monitor/Modify Tx

diazepam + rucaparib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• rufinamide
Libervant (diazepam transmucosal)

+

rufinamide

1 interaction

Monitor/Modify Tx

diazepam + rufinamide

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• safinamide
Libervant (diazepam transmucosal)

+

safinamide

1 interaction

Monitor/Modify Tx

diazepam + safinamide

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• selegiline
Libervant (diazepam transmucosal)

+

selegiline

1 interaction

Monitor/Modify Tx

diazepam + selegiline

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• selegiline transdermal
Libervant (diazepam transmucosal)

+

selegiline transdermal

1 interaction

Monitor/Modify Tx

diazepam + selegiline transdermal

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, selegiline transdermal may decr. seizure threshold)

• selinexor
Libervant (diazepam transmucosal)

+

selinexor

1 interaction

Monitor/Modify Tx

diazepam + selinexor

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• sertraline
Libervant (diazepam transmucosal)

+

sertraline

1 interaction

Monitor/Modify Tx

diazepam + sertraline

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sertraline may decr. seizure threshold)

• sevoflurane
Libervant (diazepam transmucosal)

+

sevoflurane

1 interaction

Monitor/Modify Tx

diazepam + sevoflurane

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sevoflurane may decr. seizure threshold)

• solifenacin
Libervant (diazepam transmucosal)

+

solifenacin

1 interaction

Monitor/Modify Tx

diazepam + solifenacin

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• stiripentol
Libervant (diazepam transmucosal)

+

stiripentol

1 interaction

Monitor/Modify Tx

diazepam + stiripentol

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• sumatriptan
Libervant (diazepam transmucosal)

+

sumatriptan

1 interaction

Monitor/Modify Tx

diazepam + sumatriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, sumatriptan may decr. seizure threshold)

• suvorexant
Libervant (diazepam transmucosal)

+

suvorexant

1 interaction

Monitor/Modify Tx

diazepam + suvorexant

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tasimelteon
Libervant (diazepam transmucosal)

+

tasimelteon

1 interaction

Monitor/Modify Tx

diazepam + tasimelteon

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tecovirimat
Libervant (diazepam transmucosal)

+

tecovirimat

1 interaction

Monitor/Modify Tx

diazepam + tecovirimat

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• tetrabenazine
Libervant (diazepam transmucosal)

+

tetrabenazine

1 interaction

Monitor/Modify Tx

diazepam + tetrabenazine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• thioridazine
Libervant (diazepam transmucosal)

+

thioridazine

1 interaction

Monitor/Modify Tx

diazepam + thioridazine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thioridazine may decr. seizure threshold)

• thiotepa
Libervant (diazepam transmucosal)

+

thiotepa

1 interaction

Monitor/Modify Tx

diazepam + thiotepa

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thiotepa may decr. seizure threshold)

• thiothixene
Libervant (diazepam transmucosal)

+

thiothixene

1 interaction

Monitor/Modify Tx

diazepam + thiothixene

monitor respiratory rate; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, thiothixene may decr. seizure threshold)

• tiagabine
Libervant (diazepam transmucosal)

+

tiagabine

1 interaction

Monitor/Modify Tx

diazepam + tiagabine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tipranavir
Libervant (diazepam transmucosal)

+

tipranavir

1 interaction

Monitor/Modify Tx

diazepam + tipranavir

monitor respiratory rate: combo may incr. or decr. diazepam levels, incr. risk of CNS and respiratory depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metabolism altered)

• tizanidine
Libervant (diazepam transmucosal)

+

tizanidine

1 interaction

Monitor/Modify Tx

diazepam + tizanidine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tolcapone
Libervant (diazepam transmucosal)

+

tolcapone

1 interaction

Monitor/Modify Tx

diazepam + tolcapone

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tolterodine
Libervant (diazepam transmucosal)

+

tolterodine

1 interaction

Monitor/Modify Tx

diazepam + tolterodine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• topiramate
Libervant (diazepam transmucosal)

+

topiramate

1 interaction

Monitor/Modify Tx

diazepam + topiramate

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. diazepam levels, risk of profound CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• trazodone
Libervant (diazepam transmucosal)

+

trazodone

1 interaction

Monitor/Modify Tx

diazepam + trazodone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• treosulfan
Libervant (diazepam transmucosal)

+

treosulfan

1 interaction

Monitor/Modify Tx

diazepam + treosulfan

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects; may alter seizure control (hepatic metabolism possibly inhibited; antagonistic effects, treosulfan may decr. seizure threshold)

• triclabendazole
Libervant (diazepam transmucosal)

+

triclabendazole

1 interaction

Monitor/Modify Tx

diazepam + triclabendazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism possibly inhibited)

• trifluoperazine
Libervant (diazepam transmucosal)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

diazepam + trifluoperazine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, trifluoperazine may decr. seizure threshold)

• trihexyphenidyl
Libervant (diazepam transmucosal)

+

trihexyphenidyl

1 interaction

Monitor/Modify Tx

diazepam + trihexyphenidyl

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• trimethobenzamide
Libervant (diazepam transmucosal)

+

trimethobenzamide

1 interaction

Monitor/Modify Tx

diazepam + trimethobenzamide

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• trimipramine
Libervant (diazepam transmucosal)

+

trimipramine

1 interaction

Monitor/Modify Tx

diazepam + trimipramine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, trimipramine may decr. seizure threshold)

• triprolidine
Libervant (diazepam transmucosal)

+

triprolidine

1 interaction

Monitor/Modify Tx

diazepam + triprolidine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• trospium
Libervant (diazepam transmucosal)

+

trospium

1 interaction

Monitor/Modify Tx

diazepam + trospium

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• tucatinib
Libervant (diazepam transmucosal)

+

tucatinib

1 interaction

Monitor/Modify Tx

diazepam + tucatinib

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• valbenazine
Libervant (diazepam transmucosal)

+

valbenazine

1 interaction

Monitor/Modify Tx

diazepam + valbenazine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• valerian
Libervant (diazepam transmucosal)

+

valerian

1 interaction

Monitor/Modify Tx

diazepam + valerian

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• valproic acid
Libervant (diazepam transmucosal)

+

valproic acid

1 interaction

Monitor/Modify Tx

diazepam + valproic acid

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• venlafaxine
Libervant (diazepam transmucosal)

+

venlafaxine

1 interaction

Monitor/Modify Tx

diazepam + venlafaxine

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, venlafaxine may decr. seizure threshold)

• vigabatrin
Libervant (diazepam transmucosal)

+

vigabatrin

1 interaction

Monitor/Modify Tx

diazepam + vigabatrin

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• vilazodone
Libervant (diazepam transmucosal)

+

vilazodone

1 interaction

Monitor/Modify Tx

diazepam + vilazodone

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, vilazodone may decr. seizure threshold)

• viloxazine
Libervant (diazepam transmucosal)

+

viloxazine

1 interaction

Monitor/Modify Tx

diazepam + viloxazine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• vonoprazan
Libervant (diazepam transmucosal)

+

vonoprazan

1 interaction

Monitor/Modify Tx

diazepam + vonoprazan

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• voriconazole
Libervant (diazepam transmucosal)

+

voriconazole

1 interaction

Monitor/Modify Tx

diazepam + voriconazole

monitor respiratory rate: combo may incr. diazepam levels, risk of CNS and respiratory depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited)

• zaleplon
Libervant (diazepam transmucosal)

+

zaleplon

1 interaction

Monitor/Modify Tx

diazepam + zaleplon

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ziconotide
Libervant (diazepam transmucosal)

+

ziconotide

1 interaction

Monitor/Modify Tx

diazepam + ziconotide

monitor respiratory rate; consider decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• ziprasidone
Libervant (diazepam transmucosal)

+

ziprasidone

1 interaction

Monitor/Modify Tx

diazepam + ziprasidone

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, ziprasidone may decr. seizure threshold)

• zolmitriptan
Libervant (diazepam transmucosal)

+

zolmitriptan

1 interaction

Monitor/Modify Tx

diazepam + zolmitriptan

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• zolpidem
Libervant (diazepam transmucosal)

+

zolpidem

1 interaction

Monitor/Modify Tx

diazepam + zolpidem

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• zonisamide
Libervant (diazepam transmucosal)

+

zonisamide

1 interaction

Monitor/Modify Tx

diazepam + zonisamide

monitor respiratory rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

Therapeutic Advantage

• flumazenil
Libervant (diazepam transmucosal)

+

flumazenil

1 interaction

Therapeutic Advantage

diazepam + flumazenil

use for therapeutic advantage: combo will reverse sedation, other benzodiazepine effects (antagonistic effects)

Caution Advised

• acyclovir
Libervant (diazepam transmucosal)

+

acyclovir

1 interaction

Caution Advised

diazepam + acyclovir

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, acyclovir may decr. seizure threshold)

• aminophylline
Libervant (diazepam transmucosal)

+

aminophylline

1 interaction

Caution Advised

diazepam + aminophylline

caution advised: combo may decr. diazepam efficacy; may alter seizure control (aminophylline converted to theophylline; antagonistic effects, theophylline may decr. seizure threshold)

• amoxicillin
Libervant (diazepam transmucosal)

+

amoxicillin

1 interaction

Caution Advised

diazepam + amoxicillin

caution advised if seizure disorder use, especially w/ high amoxicillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, amoxicillin may decr. seizure threshold)

• amphetamine
Libervant (diazepam transmucosal)

+

amphetamine

1 interaction

Caution Advised

diazepam + amphetamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, amphetamine may decr. seizure threshold)

• ampicillin
Libervant (diazepam transmucosal)

+

ampicillin

1 interaction

Caution Advised

diazepam + ampicillin

caution advised if seizure disorder use, especially w/ high ampicillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, ampicillin may decr. seizure threshold)

• apalutamide
Libervant (diazepam transmucosal)

+

apalutamide

1 interaction

Caution Advised

diazepam + apalutamide

caution advised: combo may decr. diazepam levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, apalutamide may decr. seizure threshold)

• axicabtagene ciloleucel
Libervant (diazepam transmucosal)

+

axicabtagene ciloleucel

1 interaction

Caution Advised

diazepam + axicabtagene ciloleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, axicabtagene ciloleucel may decr. seizure threshold)

• benzphetamine
Libervant (diazepam transmucosal)

+

benzphetamine

1 interaction

Caution Advised

diazepam + benzphetamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, benzphetamine may decr. seizure threshold)

• betamethasone
Libervant (diazepam transmucosal)

+

betamethasone

1 interaction

Caution Advised

diazepam + betamethasone

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, betamethasone may decr. seizure threshold)

• bosentan
Libervant (diazepam transmucosal)

+

bosentan

1 interaction

Caution Advised

diazepam + bosentan

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• brexucabtagene autoleucel
Libervant (diazepam transmucosal)

+

brexucabtagene autoleucel

1 interaction

Caution Advised

diazepam + brexucabtagene autoleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, brexucabtagene autoleucel may decr. seizure threshold)

• brimonidine ophthalmic
Libervant (diazepam transmucosal)

+

brimonidine ophthalmic

1 interaction

Caution Advised

diazepam + brimonidine ophthalmic

caution advised if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• busulfan
Libervant (diazepam transmucosal)

+

busulfan

1 interaction

Caution Advised

diazepam + busulfan

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, busulfan may decr. seizure threshold)

• cefazolin
Libervant (diazepam transmucosal)

+

cefazolin

1 interaction

Caution Advised

diazepam + cefazolin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cefazolin may decr. seizure threshold)

• cefepime
Libervant (diazepam transmucosal)

+

cefepime

1 interaction

Caution Advised

diazepam + cefepime

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cefepime may decr. seizure threshold)

• cefiderocol
Libervant (diazepam transmucosal)

+

cefiderocol

1 interaction

Caution Advised

diazepam + cefiderocol

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cefiderocol may decr. seizure threshold)

• ceftaroline
Libervant (diazepam transmucosal)

+

ceftaroline

1 interaction

Caution Advised

diazepam + ceftaroline

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ceftaroline may decr. seizure threshold)

• ceftazidime
Libervant (diazepam transmucosal)

+

ceftazidime

1 interaction

Caution Advised

diazepam + ceftazidime

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ceftazidime may decr. seizure threshold)

• ceftobiprole
Libervant (diazepam transmucosal)

+

ceftobiprole

1 interaction

Caution Advised

diazepam + ceftobiprole

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ceftobiprole may decr. seizure threshold)

• chlorambucil
Libervant (diazepam transmucosal)

+

chlorambucil

1 interaction

Caution Advised

diazepam + chlorambucil

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, chlorambucil may decr. seizure threshold)

• chloroquine
Libervant (diazepam transmucosal)

+

chloroquine

1 interaction

Caution Advised

diazepam + chloroquine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, chloroquine may decr. seizure threshold)

• ciltacabtagene autoleucel
Libervant (diazepam transmucosal)

+

ciltacabtagene autoleucel

1 interaction

Caution Advised

diazepam + ciltacabtagene autoleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ciltacabtagene autoleucel may decr. seizure threshold)

• ciprofloxacin
Libervant (diazepam transmucosal)

+

ciprofloxacin

1 interaction

Caution Advised

diazepam + ciprofloxacin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ciprofloxacin may decr. seizure threshold)

• cisatracurium
Libervant (diazepam transmucosal)

+

cisatracurium

1 interaction

Caution Advised

diazepam + cisatracurium

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cisatracurium active metabolite may decr. seizure threshold)

• cocaine
Libervant (diazepam transmucosal)

+

cocaine

1 interaction

Caution Advised

diazepam + cocaine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cocaine may decr. seizure threshold)

• cortisone
Libervant (diazepam transmucosal)

+

cortisone

1 interaction

Caution Advised

diazepam + cortisone

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cortisone may decr. seizure threshold)

• cycloserine
Libervant (diazepam transmucosal)

+

cycloserine

1 interaction

Caution Advised

diazepam + cycloserine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cycloserine may decr. seizure threshold)

• cyclosporine
Libervant (diazepam transmucosal)

+

cyclosporine

1 interaction

Caution Advised

diazepam + cyclosporine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, cyclosporine may decr. seizure threshold)

• dabrafenib
Libervant (diazepam transmucosal)

+

dabrafenib

1 interaction

Caution Advised

diazepam + dabrafenib

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• darbepoetin alfa
Libervant (diazepam transmucosal)

+

darbepoetin alfa

1 interaction

Caution Advised

diazepam + darbepoetin alfa

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, darbepoetin alfa may decr. seizure threshold)

• darolutamide
Libervant (diazepam transmucosal)

+

darolutamide

1 interaction

Caution Advised

diazepam + darolutamide

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, darolutamide may decr. seizure threshold)

• deflazacort
Libervant (diazepam transmucosal)

+

deflazacort

1 interaction

Caution Advised

diazepam + deflazacort

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, deflazacort may decr. seizure threshold)

• delafloxacin
Libervant (diazepam transmucosal)

+

delafloxacin

1 interaction

Caution Advised

diazepam + delafloxacin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, delafloxacin may decr. seizure threshold)

• dexamethasone
Libervant (diazepam transmucosal)

+

dexamethasone

1 interaction

Caution Advised

diazepam + dexamethasone

caution advised: combo may decr. diazepam levels, efficacy; may alter seizure control (hepatic metabolism possibly induced; antagonistic effects, dexamethasone may decr. seizure threshold)

• dexmethylphenidate
Libervant (diazepam transmucosal)

+

dexmethylphenidate

1 interaction

Caution Advised

diazepam + dexmethylphenidate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, (ser)dexmethylphenidate may decr. seizure threshold)

• dextroamphetamine
Libervant (diazepam transmucosal)

+

dextroamphetamine

1 interaction

Caution Advised

diazepam + dextroamphetamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, dextroamphetamine may decr. seizure threshold)

• dicloxacillin
Libervant (diazepam transmucosal)

+

dicloxacillin

1 interaction

Caution Advised

diazepam + dicloxacillin

caution advised: combo may decr. diazepam levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, dicloxacillin may decr. seizure threshold)

• diethylpropion
Libervant (diazepam transmucosal)

+

diethylpropion

1 interaction

Caution Advised

diazepam + diethylpropion

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, diethylpropion may decr. seizure threshold)

• donepezil
Libervant (diazepam transmucosal)

+

donepezil

1 interaction

Caution Advised

diazepam + donepezil

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, donepezil may decr. seizure threshold)

• elivaldogene autotemcel
Libervant (diazepam transmucosal)

+

elivaldogene autotemcel

1 interaction

Caution Advised

diazepam + elivaldogene autotemcel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, elivaldogene autotemcel may decr. seizure threshold)

• encorafenib
Libervant (diazepam transmucosal)

+

encorafenib

1 interaction

Caution Advised

diazepam + encorafenib

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• enzalutamide
Libervant (diazepam transmucosal)

+

enzalutamide

1 interaction

Caution Advised

diazepam + enzalutamide

caution advised: combo may decr. diazepam levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, enzalutamide may decr. seizure threshold)

• ephedra
Libervant (diazepam transmucosal)

+

ephedra

1 interaction

Caution Advised

diazepam + ephedra

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ephedra may decr. seizure threshold)

• epoetin alfa
Libervant (diazepam transmucosal)

+

epoetin alfa

1 interaction

Caution Advised

diazepam + epoetin alfa

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, epoetin alfa may decr. seizure threshold)

• ertapenem
Libervant (diazepam transmucosal)

+

ertapenem

1 interaction

Caution Advised

diazepam + ertapenem

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ertapenem may decr. seizure threshold)

• foscarnet
Libervant (diazepam transmucosal)

+

foscarnet

1 interaction

Caution Advised

diazepam + foscarnet

caution advised if diazepam seizure disorder use: combo may alter seizure control (antagonistic effects, foscarnet may decr. seizure threshold)

• galantamine
Libervant (diazepam transmucosal)

+

galantamine

1 interaction

Caution Advised

diazepam + galantamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, galantamine may decr. seizure threshold)

• ganciclovir
Libervant (diazepam transmucosal)

+

ganciclovir

1 interaction

Caution Advised

diazepam + ganciclovir

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ganciclovir may decr. seizure threshold)

• goserelin
Libervant (diazepam transmucosal)

+

goserelin

1 interaction

Caution Advised

diazepam + goserelin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, goserelin may decr. seizure threshold)

• histrelin
Libervant (diazepam transmucosal)

+

histrelin

1 interaction

Caution Advised

diazepam + histrelin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, histrelin may decr. seizure threshold)

• hydroxychloroquine
Libervant (diazepam transmucosal)

+

hydroxychloroquine

1 interaction

Caution Advised

diazepam + hydroxychloroquine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, hydroxychloroquine may decr. seizure threshold)

• idecabtagene vicleucel
Libervant (diazepam transmucosal)

+

idecabtagene vicleucel

1 interaction

Caution Advised

diazepam + idecabtagene vicleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, idecabtagene vicleucel may decr. seizure threshold)

• imipenem
Libervant (diazepam transmucosal)

+

imipenem

1 interaction

Caution Advised

diazepam + imipenem

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, imipenem may decr. seizure threshold)

• interferon beta 1a
Libervant (diazepam transmucosal)

+

interferon beta 1a

1 interaction

Caution Advised

diazepam + interferon beta 1a

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, interferon beta 1a may decr. seizure threshold)

• interferon beta 1b
Libervant (diazepam transmucosal)

+

interferon beta 1b

1 interaction

Caution Advised

diazepam + interferon beta 1b

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, interferon beta 1b may decr. seizure threshold)

• iohexol
Libervant (diazepam transmucosal)

+

iohexol

1 interaction

Caution Advised

diazepam + iohexol

if seizure disorder use, caution advised w/ intrathecal iohexol: combo may alter seizure control (antagonistic effects, intrathecal iohexol may decr. seizure threshold)

• iopamidol
Libervant (diazepam transmucosal)

+

iopamidol

1 interaction

Caution Advised

diazepam + iopamidol

caution advised w/ intrathecal iopamidol if seizure disorder use: combo may alter seizure control (antagonistic effects, intrathecal iopamidol may decr. seizure threshold)

• ivosidenib
Libervant (diazepam transmucosal)

+

ivosidenib

1 interaction

Caution Advised

diazepam + ivosidenib

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• ketorolac
Libervant (diazepam transmucosal)

+

ketorolac

1 interaction

Caution Advised

diazepam + ketorolac

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ketorolac may decr. seizure threshold)

• leuprolide
Libervant (diazepam transmucosal)

+

leuprolide

1 interaction

Caution Advised

diazepam + leuprolide

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, leuprolide may decr. seizure threshold)

• levocarnitine
Libervant (diazepam transmucosal)

+

levocarnitine

1 interaction

Caution Advised

diazepam + levocarnitine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, levocarnitine may decr. seizure threshold)

• levofloxacin
Libervant (diazepam transmucosal)

+

levofloxacin

1 interaction

Caution Advised

diazepam + levofloxacin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, levofloxacin may decr. seizure threshold)

• lidocaine
Libervant (diazepam transmucosal)

+

lidocaine

1 interaction

Caution Advised

diazepam + lidocaine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• lidocaine topical
Libervant (diazepam transmucosal)

+

lidocaine topical

1 interaction

Caution Advised

diazepam + lidocaine topical

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lidocaine may decr. seizure threshold)

• linezolid
Libervant (diazepam transmucosal)

+

linezolid

1 interaction

Caution Advised

diazepam + linezolid

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, linezolid may decr. seizure threshold)

• lisdexamfetamine
Libervant (diazepam transmucosal)

+

lisdexamfetamine

1 interaction

Caution Advised

diazepam + lisdexamfetamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, dextroamphetamine may decr. seizure threshold)

• lisocabtagene maraleucel
Libervant (diazepam transmucosal)

+

lisocabtagene maraleucel

1 interaction

Caution Advised

diazepam + lisocabtagene maraleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lisocabtagene maraleucel may decr. seizure threshold)

• lithium
Libervant (diazepam transmucosal)

+

lithium

1 interaction

Caution Advised

diazepam + lithium

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, lithium may decr. seizure threshold)

• lorlatinib
Libervant (diazepam transmucosal)

+

lorlatinib

1 interaction

Caution Advised

diazepam + lorlatinib

caution advised: combo may decr. diazepam levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, lorlatinib may decr. seizure threshold)

• lumacaftor/ivacaftor
Libervant (diazepam transmucosal)

+

lumacaftor/ ivacaftor

1 interaction

Caution Advised

diazepam + lumacaftor/ ivacaftor

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• magnesium citrate
Libervant (diazepam transmucosal)

+

magnesium citrate

1 interaction

Caution Advised

diazepam + magnesium citrate

caution advised if diazepam seizure disorder use and magnesium citrate bowel prep use: combo may alter seizure control (antagonistic effects, magnesium citrate may decr. seizure threshold)

• mavacamten
Libervant (diazepam transmucosal)

+

mavacamten

1 interaction

Caution Advised

diazepam + mavacamten

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• mefloquine
Libervant (diazepam transmucosal)

+

mefloquine

1 interaction

Caution Advised

diazepam + mefloquine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, mefloquine may decr. seizure threshold)

• meropenem
Libervant (diazepam transmucosal)

+

meropenem

1 interaction

Caution Advised

diazepam + meropenem

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, meropenem may decr. seizure threshold)

• methamphetamine
Libervant (diazepam transmucosal)

+

methamphetamine

1 interaction

Caution Advised

diazepam + methamphetamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, methamphetamine may decr. seizure threshold)

• methotrexate
Libervant (diazepam transmucosal)

+

methotrexate

1 interaction

Caution Advised

diazepam + methotrexate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, methotrexate may decr. seizure threshold)

• methoxy polyethylene glycol-epoetin beta
Libervant (diazepam transmucosal)

+

methoxy polyethylene glycol-epoetin beta

1 interaction

Caution Advised

diazepam + methoxy polyethylene glycol-epoetin beta

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, methoxy polyethylene glycol-epoetin beta may decr. seizure threshold)

• metronidazole
Libervant (diazepam transmucosal)

+

metronidazole

1 interaction

Caution Advised

diazepam + metronidazole

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, metronidazole may decr. seizure threshold)

• mexiletine
Libervant (diazepam transmucosal)

+

mexiletine

1 interaction

Caution Advised

diazepam + mexiletine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, mexiletine may decr. seizure threshold)

• mitapivat
Libervant (diazepam transmucosal)

+

mitapivat

1 interaction

Caution Advised

diazepam + mitapivat

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• moxifloxacin
Libervant (diazepam transmucosal)

+

moxifloxacin

1 interaction

Caution Advised

diazepam + moxifloxacin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, moxifloxacin may decr. seizure threshold)

• nafarelin nasal
Libervant (diazepam transmucosal)

+

nafarelin nasal

1 interaction

Caution Advised

diazepam + nafarelin nasal

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, nafarelin may decr. seizure threshold)

• nafcillin
Libervant (diazepam transmucosal)

+

nafcillin

1 interaction

Caution Advised

diazepam + nafcillin

caution advised: combo may decr. diazepam levels, efficacy; may alter seizure control (hepatic metabolism induced; antagonistic effects, nafcillin may decr. seizure threshold)

• obecabtagene autoleucel
Libervant (diazepam transmucosal)

+

obecabtagene autoleucel

1 interaction

Caution Advised

diazepam + obecabtagene autoleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, obecabtagene autoleucel may decr. seizure threshold)

• ofloxacin
Libervant (diazepam transmucosal)

+

ofloxacin

1 interaction

Caution Advised

diazepam + ofloxacin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ofloxacin may decr. seizure threshold)

• oxacillin
Libervant (diazepam transmucosal)

+

oxacillin

1 interaction

Caution Advised

diazepam + oxacillin

caution advised if seizure disorder use, especially w/ high oxacillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, oxacillin may decr. seizure threshold)

• pacritinib
Libervant (diazepam transmucosal)

+

pacritinib

1 interaction

Caution Advised

diazepam + pacritinib

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• peginterferon beta 1a
Libervant (diazepam transmucosal)

+

peginterferon beta 1a

1 interaction

Caution Advised

diazepam + peginterferon beta 1a

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, peginterferon beta 1a may decr. seizure threshold)

• penicillin G
Libervant (diazepam transmucosal)

+

penicillin G

1 interaction

Caution Advised

diazepam + penicillin G

caution advised if seizure disorder use, especially w/ high penicillin G doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin G may decr. seizure threshold)

• penicillin V
Libervant (diazepam transmucosal)

+

penicillin V

1 interaction

Caution Advised

diazepam + penicillin V

caution advised if seizure disorder use, especially w/ high penicillin V doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, penicillin V may decr. seizure threshold)

• pexidartinib
Libervant (diazepam transmucosal)

+

pexidartinib

1 interaction

Caution Advised

diazepam + pexidartinib

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• phendimetrazine
Libervant (diazepam transmucosal)

+

phendimetrazine

1 interaction

Caution Advised

diazepam + phendimetrazine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, phendimetrazine may decr. seizure threshold)

• phentermine
Libervant (diazepam transmucosal)

+

phentermine

1 interaction

Caution Advised

diazepam + phentermine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, phentermine may decr. seizure threshold)

• piperacillin
Libervant (diazepam transmucosal)

+

piperacillin

1 interaction

Caution Advised

diazepam + piperacillin

caution advised if seizure disorder use, especially w/ high piperacillin doses or concomitant renal impairment: combo may alter seizure control (antagonistic effects, piperacillin may decr. seizure threshold)

• polyethylene glycol
Libervant (diazepam transmucosal)

+

polyethylene glycol

1 interaction

Caution Advised

diazepam + polyethylene glycol

caution advised if diazepam seizure disorder use and polyethylene glycol bowel prep use: combo may alter seizure control (antagonistic effects, polyethylene glycol may decr. seizure threshold)

• polyethylene glycol/electrolytes
Libervant (diazepam transmucosal)

+

polyethylene glycol/ electrolytes

1 interaction

Caution Advised

diazepam + polyethylene glycol/ electrolytes

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, polyethylene glycol/electrolytes may decr. seizure threshold)

• pyridostigmine
Libervant (diazepam transmucosal)

+

pyridostigmine

1 interaction

Caution Advised

diazepam + pyridostigmine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, pyridostigmine may decr. seizure threshold)

• pyrimethamine
Libervant (diazepam transmucosal)

+

pyrimethamine

1 interaction

Caution Advised

diazepam + pyrimethamine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, pyrimethamine may decr. seizure threshold)

• quinine
Libervant (diazepam transmucosal)

+

quinine

1 interaction

Caution Advised

diazepam + quinine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, quinine may decr. seizure threshold)

• raloxifene
Libervant (diazepam transmucosal)

+

raloxifene

1 interaction

Caution Advised

diazepam + raloxifene

caution advised: combo may incr. or decr. levels of both drugs, incr. risk of adverse effects or decr. efficacy (mechanism unknown)

• regadenoson
Libervant (diazepam transmucosal)

+

regadenoson

1 interaction

Caution Advised

diazepam + regadenoson

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, regadenoson may decr. seizure threshold)

• rifabutin
Libervant (diazepam transmucosal)

+

rifabutin

1 interaction

Caution Advised

diazepam + rifabutin

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• rifampin
Libervant (diazepam transmucosal)

+

rifampin

1 interaction

Caution Advised

diazepam + rifampin

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• rifapentine
Libervant (diazepam transmucosal)

+

rifapentine

1 interaction

Caution Advised

diazepam + rifapentine

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• rivastigmine
Libervant (diazepam transmucosal)

+

rivastigmine

1 interaction

Caution Advised

diazepam + rivastigmine

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, rivastigmine may decr. seizure threshold)

• sodium picosulfate
Libervant (diazepam transmucosal)

+

sodium picosulfate

1 interaction

Caution Advised

diazepam + sodium picosulfate

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, sodium picosulfate may decr. seizure threshold)

• sotorasib
Libervant (diazepam transmucosal)

+

sotorasib

1 interaction

Caution Advised

diazepam + sotorasib

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• St. John's wort
Libervant (diazepam transmucosal)

+

St. John's wort

1 interaction

Caution Advised

diazepam + St. John's wort

caution advised: combo may decr. diazepam levels, efficacy (hepatic metabolism induced)

• sulfate bowel prep
Libervant (diazepam transmucosal)

+

sulfate bowel prep

1 interaction

Caution Advised

diazepam + sulfate bowel prep

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, sulfate bowel prep may decr. seizure threshold)

• tacrolimus
Libervant (diazepam transmucosal)

+

tacrolimus

1 interaction

Caution Advised

diazepam + tacrolimus

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, tacrolimus may decr. seizure threshold)

• teclistamab
Libervant (diazepam transmucosal)

+

teclistamab

1 interaction

Caution Advised

diazepam + teclistamab

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, teclistamab may decr. seizure threshold)

• terbutaline
Libervant (diazepam transmucosal)

+

terbutaline

1 interaction

Caution Advised

diazepam + terbutaline

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, terbutaline may decr. seizure threshold)

• theophylline
Libervant (diazepam transmucosal)

+

theophylline

1 interaction

Caution Advised

diazepam + theophylline

caution advised: combo may decr. diazepam efficacy; may alter seizure control (antagonistic effects, theophylline may decr. seizure threshold)

• tinidazole
Libervant (diazepam transmucosal)

+

tinidazole

1 interaction

Caution Advised

diazepam + tinidazole

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, tinidazole may decr. seizure threshold)

• tisagenlecleucel
Libervant (diazepam transmucosal)

+

tisagenlecleucel

1 interaction

Caution Advised

diazepam + tisagenlecleucel

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, tisagenlecleucel may decr. seizure threshold)

• tranexamic acid
Libervant (diazepam transmucosal)

+

tranexamic acid

1 interaction

Caution Advised

diazepam + tranexamic acid

if seizure disorder use, caution advised w/ high-dose IV tranexamic acid: combo may alter seizure control (antagonistic effects, tranexamic acid may decr. seizure threshold)

• triamcinolone
Libervant (diazepam transmucosal)

+

triamcinolone

1 interaction

Caution Advised

diazepam + triamcinolone

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, triamcinolone may decr. seizure threshold)

• triptorelin
Libervant (diazepam transmucosal)

+

triptorelin

1 interaction

Caution Advised

diazepam + triptorelin

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, triptorelin may decr. seizure threshold)

• vadadustat
Libervant (diazepam transmucosal)

+

vadadustat

1 interaction

Caution Advised

diazepam + vadadustat

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, vadadustat may decr. seizure threshold)

• valacyclovir
Libervant (diazepam transmucosal)

+

valacyclovir

1 interaction

Caution Advised

diazepam + valacyclovir

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, acyclovir may decr. seizure threshold)

• valganciclovir
Libervant (diazepam transmucosal)

+

valganciclovir

1 interaction

Caution Advised

diazepam + valganciclovir

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, ganciclovir may decr. seizure threshold)

• varenicline
Libervant (diazepam transmucosal)

+

varenicline

1 interaction

Caution Advised

diazepam + varenicline

caution advised if seizure disorder use: combo may alter seizure control (antagonistic effects, varenicline may decr. seizure threshold)