Nemluvio (nemolizumab-ilto)

Overview

nemolizumab

IL-31 antagonist

• immunomodulatory effects (other)

Contraindicated

• adenovirus vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

adenovirus vaccine, live

1 interaction

Contraindicated

nemolizumab + adenovirus vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• chikungunya vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

chikungunya vaccine, live

1 interaction

Contraindicated

nemolizumab + chikungunya vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• cholera vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

cholera vaccine, live

1 interaction

Contraindicated

nemolizumab + cholera vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• dengue vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

dengue vaccine, live

1 interaction

Contraindicated

nemolizumab + dengue vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• influenza nasal vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

influenza nasal vaccine, live

1 interaction

Contraindicated

nemolizumab + influenza nasal vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• measles/mumps/rubella vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

measles/ mumps/ rubella vaccine, live

1 interaction

Contraindicated

nemolizumab + measles/ mumps/ rubella vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• rotavirus vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

rotavirus vaccine, live

1 interaction

Contraindicated

nemolizumab + rotavirus vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• smallpox vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

smallpox vaccine, live

1 interaction

Contraindicated

nemolizumab + smallpox vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• typhoid vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

typhoid vaccine, live

1 interaction

Contraindicated

nemolizumab + typhoid vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• varicella vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

varicella vaccine, live

1 interaction

Contraindicated

nemolizumab + varicella vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

• yellow fever vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

yellow fever vaccine, live

1 interaction

Contraindicated

nemolizumab + yellow fever vaccine, live

contraindicated; vaccinate at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response, incr. risk of disseminated infection (immunosuppressive effects)

Avoid/Use Alternative

• rabies vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

rabies vaccine

1 interaction

Avoid/Use Alternative

nemolizumab + rabies vaccine

if possible, avoid immunomodulating tx or vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

Monitor/Modify Tx

• anthrax vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

anthrax vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + anthrax vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• chikungunya vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

chikungunya vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + chikungunya vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• COVID-19 vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

COVID-19 vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + COVID-19 vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• diphtheria/tetanus vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

diphtheria/ tetanus vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + diphtheria/ tetanus vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• diphtheria/tetanus/pertussis vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

diphtheria/ tetanus/ pertussis vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + diphtheria/ tetanus/ pertussis vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• ebola vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

ebola vaccine, live

1 interaction

Monitor/Modify Tx

nemolizumab + ebola vaccine, live

consider vaccinating at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response; may incr. risk of mild vesicular stomatitis virus infection (immunosuppressive effects, recombinant vaccine w/ vesicular stomatitis virus vector)

• Haemophilus b vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

Haemophilus b vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + Haemophilus b vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• hepatitis A vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

hepatitis A vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + hepatitis A vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• hepatitis B vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

hepatitis B vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + hepatitis B vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• human papillomavirus vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

human papillomavirus vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + human papillomavirus vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• influenza H5N1 vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

influenza H5N1 vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + influenza H5N1 vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• influenza vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

influenza vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + influenza vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider vaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• Japanese encephalitis vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

Japanese encephalitis vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + Japanese encephalitis vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• meningococcal vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

meningococcal vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + meningococcal vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• pneumococcal vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

pneumococcal vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + pneumococcal vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• poliovirus vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

poliovirus vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + poliovirus vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• respiratory syncytial virus vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

respiratory syncytial virus vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + respiratory syncytial virus vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• smallpox/mpox vaccine, live
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

smallpox/ mpox vaccine, live

1 interaction

Monitor/Modify Tx

nemolizumab + smallpox/ mpox vaccine, live

consider vaccinating at least 4wk before or 3mo after nemolizumab tx: combo may result in inadequate vaccine response (immunosuppressive effects)

• tick-borne encephalitis vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

tick-borne encephalitis vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + tick-borne encephalitis vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)

• typhoid vaccine
Nemluvio (nemolizumab-ilto) (nemolizumab)

+

typhoid vaccine

1 interaction

Monitor/Modify Tx

nemolizumab + typhoid vaccine

if possible, vaccinate at least 2wk before starting nemolizumab tx; otherwise, consider post-immunization titer check or revaccination after immunocompetence restored: combo may result in inadequate vaccine response (immunosuppressive effects)