codeine sulfate

Overview

codeine

opioid

• CYP2D6 substrate
• CYP3A4 substrate
• antidiuretic hormone effects
• CNS depression
• decreases gastrointestinal motility
• hyponatremia
• hypotensive effects
• lowers seizure threshold
• opioid agonist
• potentiates neuromuscular blockade
• serotonergic effects
• urinary retention

• consider prescribing an opioid overdose reversal agent, especially w/ concomitant CNS depressant use
• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• isocarboxazid
codeine sulfate (generic)

+

isocarboxazid

1 interaction

Contraindicated

codeine + isocarboxazid

contraindicated w/in 14 days of isocarboxazid use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• isoniazid
codeine sulfate (generic)

+

isoniazid

1 interaction

Contraindicated

codeine + isoniazid

contraindicated w/in 14 days of isoniazid use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects, isoniazid inhibits monoamine oxidase)

• linezolid
codeine sulfate (generic)

+

linezolid

1 interaction

Contraindicated

codeine + linezolid

contraindicated w/in 14 days of linezolid use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of resp. depression, serotonin syndrome (additive effects, linezolid reversibly inhibits monoamine oxidase)

• methylene blue injection
codeine sulfate (generic)

+

methylene blue injection

1 interaction

Contraindicated

codeine + methylene blue injection

contraindicated w/in 14 days of methylene blue use; hold codeine if emergency use; monitor resp. rate, BP, serotonin syndrome sx up to 4h after last methylene blue dose; may resume codeine 72h after last methylene blue dose: combo may incr. risk of resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylene blue oral
codeine sulfate (generic)

+

methylene blue oral

1 interaction

Contraindicated

codeine + methylene blue oral

contraindicated w/in 14 days of methylene blue use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of resp. depression, serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• naltrexone
codeine sulfate (generic)

+

naltrexone

1 interaction

Contraindicated

codeine + naltrexone

contraindicated; D/C codeine at least 7-10 days before naltrexone start: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent patients (antagonistic effects)

• phenelzine
codeine sulfate (generic)

+

phenelzine

1 interaction

Contraindicated

codeine + phenelzine

contraindicated w/in 14 days of phenelzine use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• potassium chloride
codeine sulfate (generic)

+

potassium chloride

1 interaction

Contraindicated

codeine + potassium chloride

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• potassium citrate
codeine sulfate (generic)

+

potassium citrate

1 interaction

Contraindicated

codeine + potassium citrate

contraindicated w/ solid potassium formulations; consider alternative, incl. liquid potassium formulations: combo may incr. risk of GI ulcerative, stenotic lesions (GI transit delayed, increased local exposure to high potassium concentration)

• procarbazine
codeine sulfate (generic)

+

procarbazine

1 interaction

Contraindicated

codeine + procarbazine

contraindicated w/in 14 days of procarbazine use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects, procarbazine inhibits monoamine oxidase)

• rasagiline
codeine sulfate (generic)

+

rasagiline

1 interaction

Contraindicated

codeine + rasagiline

contraindicated w/in 14 days of rasagiline use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• safinamide
codeine sulfate (generic)

+

safinamide

1 interaction

Contraindicated

codeine + safinamide

contraindicated w/in 14 days of safinamide use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• samidorphan
codeine sulfate (generic)

+

samidorphan

1 interaction

Contraindicated

codeine + samidorphan

contraindicated; D/C codeine at least 7 days before samidorphan start; D/C samidorphan at least 5 days before non-urgent codeine use: combo may decr. codeine efficacy, precipitate severe withdrawal in opioid dependent patients (antagonistic effects)

• selegiline
codeine sulfate (generic)

+

selegiline

1 interaction

Contraindicated

codeine + selegiline

contraindicated w/in 14 days of selegiline use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• selegiline transdermal
codeine sulfate (generic)

+

selegiline transdermal

1 interaction

Contraindicated

codeine + selegiline transdermal

contraindicated w/in 14 days of selegiline use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• tranylcypromine
codeine sulfate (generic)

+

tranylcypromine

1 interaction

Contraindicated

codeine + tranylcypromine

contraindicated w/in 14 days of tranylcypromine use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• yohimbe
codeine sulfate (generic)

+

yohimbe

1 interaction

Contraindicated

codeine + yohimbe

contraindicated w/in 14 days of yohimbe use; if urgent use, consider alternative, incl. buprenorphine or oxymorphone: combo may incr. risk of resp. depression, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects, yohimbe inhibits monoamine oxidase)

Avoid/Use Alternative

• 5-HTP
codeine sulfate (generic)

+

5-HTP

1 interaction

Avoid/Use Alternative

codeine + 5-HTP

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• abiraterone acetate
codeine sulfate (generic)

+

abiraterone acetate

1 interaction

Avoid/Use Alternative

codeine + abiraterone acetate

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• adagrasib
codeine sulfate (generic)

+

adagrasib

1 interaction

Avoid/Use Alternative

codeine + adagrasib

consider alternative: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• aldesleukin
codeine sulfate (generic)

+

aldesleukin

1 interaction

Avoid/Use Alternative

codeine + aldesleukin

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe or life-threatening hypotension (incl. orthostasis, syncope), seizures (additive effects)

• alfentanil
codeine sulfate (generic)

+

alfentanil

1 interaction

Avoid/Use Alternative

codeine + alfentanil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus (additive effects)

• allopurinol
codeine sulfate (generic)

+

allopurinol

1 interaction

Avoid/Use Alternative

codeine + allopurinol

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• almotriptan
codeine sulfate (generic)

+

almotriptan

1 interaction

Avoid/Use Alternative

codeine + almotriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment (additive effects)

• alprazolam
codeine sulfate (generic)

+

alprazolam

1 interaction

Avoid/Use Alternative

codeine + alprazolam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, vasodilation, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• amantadine
codeine sulfate (generic)

+

amantadine

1 interaction

Avoid/Use Alternative

codeine + amantadine

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• amifampridine
codeine sulfate (generic)

+

amifampridine

1 interaction

Avoid/Use Alternative

codeine + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amiodarone
codeine sulfate (generic)

+

amiodarone

1 interaction

Avoid/Use Alternative

codeine + amiodarone

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• amitriptyline
codeine sulfate (generic)

+

amitriptyline

1 interaction

Avoid/Use Alternative

codeine + amitriptyline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• amlodipine
codeine sulfate (generic)

+

amlodipine

1 interaction

Avoid/Use Alternative

codeine + amlodipine

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• amoxapine
codeine sulfate (generic)

+

amoxapine

1 interaction

Avoid/Use Alternative

codeine + amoxapine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• amphetamine
codeine sulfate (generic)

+

amphetamine

1 interaction

Avoid/Use Alternative

codeine + amphetamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. amphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

• apalutamide
codeine sulfate (generic)

+

apalutamide

1 interaction

Avoid/Use Alternative

codeine + apalutamide

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• apomorphine
codeine sulfate (generic)

+

apomorphine

1 interaction

Avoid/Use Alternative

codeine + apomorphine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
codeine sulfate (generic)

+

apraclonidine ophthalmic

1 interaction

Avoid/Use Alternative

codeine + apraclonidine ophthalmic

avoid combo if antitussive use; otherwise, monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aprepitant
codeine sulfate (generic)

+

aprepitant

1 interaction

Avoid/Use Alternative

codeine + aprepitant

if aprepitant 3-day regimen, use alternative or monitor resp. rate; consider decr. codeine dose; aprepitant single dose-regimen OK: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• aripiprazole bimonthly injection
codeine sulfate (generic)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

codeine + aripiprazole bimonthly injection

avoid combo if antitussive use; otherwise monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole lauroxil
codeine sulfate (generic)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

codeine + aripiprazole lauroxil

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole monthly injection
codeine sulfate (generic)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

codeine + aripiprazole monthly injection

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• aripiprazole oral
codeine sulfate (generic)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

codeine + aripiprazole oral

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• armodafinil
codeine sulfate (generic)

+

armodafinil

1 interaction

Avoid/Use Alternative

codeine + armodafinil

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• artemether/lumefantrine
codeine sulfate (generic)

+

artemether/ lumefantrine

1 interaction

Avoid/Use Alternative

codeine + artemether/ lumefantrine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. or decr. codeine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy; may decr. active metabolite morphine levels, efficacy (hepatic metab. altered, decr. conversion to morphine)

• asciminib
codeine sulfate (generic)

+

asciminib

1 interaction

Avoid/Use Alternative

codeine + asciminib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• asenapine
codeine sulfate (generic)

+

asenapine

1 interaction

Avoid/Use Alternative

codeine + asenapine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• atazanavir
codeine sulfate (generic)

+

atazanavir

1 interaction

Avoid/Use Alternative

codeine + atazanavir

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• atorvastatin
codeine sulfate (generic)

+

atorvastatin

1 interaction

Avoid/Use Alternative

codeine + atorvastatin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• avacopan
codeine sulfate (generic)

+

avacopan

1 interaction

Avoid/Use Alternative

codeine + avacopan

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• baclofen
codeine sulfate (generic)

+

baclofen

1 interaction

Avoid/Use Alternative

codeine + baclofen

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• baclofen intrathecal
codeine sulfate (generic)

+

baclofen intrathecal

1 interaction

Avoid/Use Alternative

codeine + baclofen intrathecal

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• belumosudil
codeine sulfate (generic)

+

belumosudil

1 interaction

Avoid/Use Alternative

codeine + belumosudil

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• belzutifan
codeine sulfate (generic)

+

belzutifan

1 interaction

Avoid/Use Alternative

codeine + belzutifan

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• berberine
codeine sulfate (generic)

+

berberine

1 interaction

Avoid/Use Alternative

codeine + berberine

use alternative or monitor resp. rate, BP, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• berotralstat
codeine sulfate (generic)

+

berotralstat

1 interaction

Avoid/Use Alternative

codeine + berotralstat

use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, conversion to morphine altered)

• bexarotene
codeine sulfate (generic)

+

bexarotene

1 interaction

Avoid/Use Alternative

codeine + bexarotene

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• bicalutamide
codeine sulfate (generic)

+

bicalutamide

1 interaction

Avoid/Use Alternative

codeine + bicalutamide

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• black cohosh
codeine sulfate (generic)

+

black cohosh

1 interaction

Avoid/Use Alternative

codeine + black cohosh

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• bosentan
codeine sulfate (generic)

+

bosentan

1 interaction

Avoid/Use Alternative

codeine + bosentan

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• brexpiprazole
codeine sulfate (generic)

+

brexpiprazole

1 interaction

Avoid/Use Alternative

codeine + brexpiprazole

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• brigatinib
codeine sulfate (generic)

+

brigatinib

1 interaction

Avoid/Use Alternative

codeine + brigatinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• brimonidine ophthalmic
codeine sulfate (generic)

+

brimonidine ophthalmic

1 interaction

Avoid/Use Alternative

codeine + brimonidine ophthalmic

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• brimonidine topical
codeine sulfate (generic)

+

brimonidine topical

1 interaction

Avoid/Use Alternative

codeine + brimonidine topical

avoid combo if antitussive use; otherwise monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• brivaracetam
codeine sulfate (generic)

+

brivaracetam

1 interaction

Avoid/Use Alternative

codeine + brivaracetam

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• bromocriptine
codeine sulfate (generic)

+

bromocriptine

1 interaction

Avoid/Use Alternative

codeine + bromocriptine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension, incl. orthostasis, syncope (additive effects)

• brompheniramine
codeine sulfate (generic)

+

brompheniramine

1 interaction

Avoid/Use Alternative

codeine + brompheniramine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• buprenorphine
codeine sulfate (generic)

+

buprenorphine

1 interaction

Avoid/Use Alternative

codeine + buprenorphine

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent patients; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (antagonistic effects; additive effects)

• bupropion
codeine sulfate (generic)

+

bupropion

1 interaction

Avoid/Use Alternative

codeine + bupropion

use alternative or monitor resp. rate, withdrawal sx; consider lower bupropion doses: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, seizures, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• buspirone
codeine sulfate (generic)

+

buspirone

1 interaction

Avoid/Use Alternative

codeine + buspirone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• butalbital
codeine sulfate (generic)

+

butalbital

1 interaction

Avoid/Use Alternative

codeine + butalbital

avoid combo: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• butorphanol
codeine sulfate (generic)

+

butorphanol

1 interaction

Avoid/Use Alternative

codeine + butorphanol

avoid combo if antitussive use; otherwise use alternative or monitor for withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent patients; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (antagonistic effects; additive effects)

• cannabidiol
codeine sulfate (generic)

+

cannabidiol

1 interaction

Avoid/Use Alternative

codeine + cannabidiol

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• cannabis
codeine sulfate (generic)

+

cannabis

1 interaction

Avoid/Use Alternative

codeine + cannabis

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• capivasertib
codeine sulfate (generic)

+

capivasertib

1 interaction

Avoid/Use Alternative

codeine + capivasertib

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may incr. or decr. active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may incr. or decr. production of active metabolite morphine)

• carbamazepine
codeine sulfate (generic)

+

carbamazepine

1 interaction

Avoid/Use Alternative

codeine + carbamazepine

avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension (incl. syncope), serotonin syndrome; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• carbinoxamine
codeine sulfate (generic)

+

carbinoxamine

1 interaction

Avoid/Use Alternative

codeine + carbinoxamine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• cariprazine
codeine sulfate (generic)

+

cariprazine

1 interaction

Avoid/Use Alternative

codeine + cariprazine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• carisoprodol
codeine sulfate (generic)

+

carisoprodol

1 interaction

Avoid/Use Alternative

codeine + carisoprodol

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• celecoxib
codeine sulfate (generic)

+

celecoxib

1 interaction

Avoid/Use Alternative

codeine + celecoxib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• cenobamate
codeine sulfate (generic)

+

cenobamate

1 interaction

Avoid/Use Alternative

codeine + cenobamate

avoid combo if antitussive use, otherwise use alternative or monitor withdrawal sx, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• ceritinib
codeine sulfate (generic)

+

ceritinib

1 interaction

Avoid/Use Alternative

codeine + ceritinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cetirizine
codeine sulfate (generic)

+

cetirizine

1 interaction

Avoid/Use Alternative

codeine + cetirizine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chamomile, German
codeine sulfate (generic)

+

chamomile, German

1 interaction

Avoid/Use Alternative

codeine + chamomile, German

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• chlophedianol
codeine sulfate (generic)

+

chlophedianol

1 interaction

Avoid/Use Alternative

codeine + chlophedianol

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• chloramphenicol
codeine sulfate (generic)

+

chloramphenicol

1 interaction

Avoid/Use Alternative

codeine + chloramphenicol

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• chlorcyclizine
codeine sulfate (generic)

+

chlorcyclizine

1 interaction

Avoid/Use Alternative

codeine + chlorcyclizine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• chlordiazepoxide
codeine sulfate (generic)

+

chlordiazepoxide

1 interaction

Avoid/Use Alternative

codeine + chlordiazepoxide

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• chlorpheniramine
codeine sulfate (generic)

+

chlorpheniramine

1 interaction

Avoid/Use Alternative

codeine + chlorpheniramine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• chlorpromazine
codeine sulfate (generic)

+

chlorpromazine

1 interaction

Avoid/Use Alternative

codeine + chlorpromazine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. codeine conversion to morphine; additive effects)

• chlorzoxazone
codeine sulfate (generic)

+

chlorzoxazone

1 interaction

Avoid/Use Alternative

codeine + chlorzoxazone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• cilostazol
codeine sulfate (generic)

+

cilostazol

1 interaction

Avoid/Use Alternative

codeine + cilostazol

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• cimetidine
codeine sulfate (generic)

+

cimetidine

1 interaction

Avoid/Use Alternative

codeine + cimetidine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• cinacalcet
codeine sulfate (generic)

+

cinacalcet

1 interaction

Avoid/Use Alternative

codeine + cinacalcet

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• ciprofloxacin
codeine sulfate (generic)

+

ciprofloxacin

1 interaction

Avoid/Use Alternative

codeine + ciprofloxacin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• citalopram
codeine sulfate (generic)

+

citalopram

1 interaction

Avoid/Use Alternative

codeine + citalopram

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• clarithromycin
codeine sulfate (generic)

+

clarithromycin

1 interaction

Avoid/Use Alternative

codeine + clarithromycin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• clemastine
codeine sulfate (generic)

+

clemastine

1 interaction

Avoid/Use Alternative

codeine + clemastine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• clobazam
codeine sulfate (generic)

+

clobazam

1 interaction

Avoid/Use Alternative

codeine + clobazam

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx, BP; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may alter codeine or decr. active metabolite morphine levels, incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy; may alter seizure control (hepatic metab. altered, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• clofazimine
codeine sulfate (generic)

+

clofazimine

1 interaction

Avoid/Use Alternative

codeine + clofazimine

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• clomipramine
codeine sulfate (generic)

+

clomipramine

1 interaction

Avoid/Use Alternative

codeine + clomipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), seizures, serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• clonazepam
codeine sulfate (generic)

+

clonazepam

1 interaction

Avoid/Use Alternative

codeine + clonazepam

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• clonidine
codeine sulfate (generic)

+

clonidine

1 interaction

Avoid/Use Alternative

codeine + clonidine

avoid combo if ADHD or antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• clopidogrel
codeine sulfate (generic)

+

clopidogrel

1 interaction

Avoid/Use Alternative

codeine + clopidogrel

consider alternative parenteral antiplatelet agent for acute tx of ACS; otherwise, caution advised: combo may decr. clopidogrel and active metabolite levels, efficacy (absorption of clopidogrel possibly affected by delayed gastric emptying)

• clorazepate
codeine sulfate (generic)

+

clorazepate

1 interaction

Avoid/Use Alternative

codeine + clorazepate

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• clotrimazole oropharyngeal
codeine sulfate (generic)

+

clotrimazole oropharyngeal

1 interaction

Avoid/Use Alternative

codeine + clotrimazole oropharyngeal

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• clozapine
codeine sulfate (generic)

+

clozapine

1 interaction

Avoid/Use Alternative

codeine + clozapine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, HR, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), seizures, severe constipation, paralytic ileus (incl. life-threatening), other anticholinergic adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. possibly inhibited, decr. conversion to morphine, additive effects)

• cobicistat
codeine sulfate (generic)

+

cobicistat

1 interaction

Avoid/Use Alternative

codeine + cobicistat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• cocaine
codeine sulfate (generic)

+

cocaine

1 interaction

Avoid/Use Alternative

codeine + cocaine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
codeine sulfate (generic)

+

codeine

1 interaction

Avoid/Use Alternative

codeine + codeine

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, other adverse effects (additive effects, duplicate tx)

• conivaptan
codeine sulfate (generic)

+

conivaptan

1 interaction

Avoid/Use Alternative

codeine + conivaptan

use alternative or monitor resp. rate; consider decr. codeine dose during and x7 days after conivaptan tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cranberry
codeine sulfate (generic)

+

cranberry

1 interaction

Avoid/Use Alternative

codeine + cranberry

use alternative or monitor resp. rate, consider decr. codeine dose, especially w/ large amounts of cranberry: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• crizotinib
codeine sulfate (generic)

+

crizotinib

1 interaction

Avoid/Use Alternative

codeine + crizotinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cyclobenzaprine
codeine sulfate (generic)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

codeine + cyclobenzaprine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects)

• cyclosporine
codeine sulfate (generic)

+

cyclosporine

1 interaction

Avoid/Use Alternative

codeine + cyclosporine

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• cyproheptadine
codeine sulfate (generic)

+

cyproheptadine

1 interaction

Avoid/Use Alternative

codeine + cyproheptadine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• dabrafenib
codeine sulfate (generic)

+

dabrafenib

1 interaction

Avoid/Use Alternative

codeine + dabrafenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• dacomitinib
codeine sulfate (generic)

+

dacomitinib

1 interaction

Avoid/Use Alternative

codeine + dacomitinib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• danazol
codeine sulfate (generic)

+

danazol

1 interaction

Avoid/Use Alternative

codeine + danazol

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• danshen
codeine sulfate (generic)

+

danshen

1 interaction

Avoid/Use Alternative

codeine + danshen

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• dantrolene
codeine sulfate (generic)

+

dantrolene

1 interaction

Avoid/Use Alternative

codeine + dantrolene

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• daridorexant
codeine sulfate (generic)

+

daridorexant

1 interaction

Avoid/Use Alternative

codeine + daridorexant

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• darifenacin
codeine sulfate (generic)

+

darifenacin

1 interaction

Avoid/Use Alternative

codeine + darifenacin

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• darolutamide
codeine sulfate (generic)

+

darolutamide

1 interaction

Avoid/Use Alternative

codeine + darolutamide

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• darunavir
codeine sulfate (generic)

+

darunavir

1 interaction

Avoid/Use Alternative

codeine + darunavir

use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, conversion to morphine altered)

• desflurane
codeine sulfate (generic)

+

desflurane

1 interaction

Avoid/Use Alternative

codeine + desflurane

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• desipramine
codeine sulfate (generic)

+

desipramine

1 interaction

Avoid/Use Alternative

codeine + desipramine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects)

• desvenlafaxine
codeine sulfate (generic)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

codeine + desvenlafaxine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• deutetrabenazine
codeine sulfate (generic)

+

deutetrabenazine

1 interaction

Avoid/Use Alternative

codeine + deutetrabenazine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dexamethasone
codeine sulfate (generic)

+

dexamethasone

1 interaction

Avoid/Use Alternative

codeine + dexamethasone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• dexbrompheniramine
codeine sulfate (generic)

+

dexbrompheniramine

1 interaction

Avoid/Use Alternative

codeine + dexbrompheniramine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• dexchlorpheniramine
codeine sulfate (generic)

+

dexchlorpheniramine

1 interaction

Avoid/Use Alternative

codeine + dexchlorpheniramine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• dexmedetomidine
codeine sulfate (generic)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

codeine + dexmedetomidine

avoid combo if antitussive use; otherwise monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• dexmedetomidine injection
codeine sulfate (generic)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

codeine + dexmedetomidine injection

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe or life-threatening hypotension (incl. orthostasis, syncope), bradycardia, AV block (additive effects)

• dexmethylphenidate
codeine sulfate (generic)

+

dexmethylphenidate

1 interaction

Avoid/Use Alternative

codeine + dexmethylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
codeine sulfate (generic)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

codeine + dextroamphetamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration; decr. dextroamphetamine start dose: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
codeine sulfate (generic)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

codeine + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diazepam
codeine sulfate (generic)

+

diazepam

1 interaction

Avoid/Use Alternative

codeine + diazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• dichlorphenamide
codeine sulfate (generic)

+

dichlorphenamide

1 interaction

Avoid/Use Alternative

codeine + dichlorphenamide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• dicloxacillin
codeine sulfate (generic)

+

dicloxacillin

1 interaction

Avoid/Use Alternative

codeine + dicloxacillin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• difelikefalin
codeine sulfate (generic)

+

difelikefalin

1 interaction

Avoid/Use Alternative

codeine + difelikefalin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• difenoxin
codeine sulfate (generic)

+

difenoxin

1 interaction

Avoid/Use Alternative

codeine + difenoxin

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus (additive effects)

• dihydrocodeine
codeine sulfate (generic)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

codeine + dihydrocodeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• dihydroergotamine
codeine sulfate (generic)

+

dihydroergotamine

1 interaction

Avoid/Use Alternative

codeine + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• diltiazem
codeine sulfate (generic)

+

diltiazem

1 interaction

Avoid/Use Alternative

codeine + diltiazem

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• dimenhydrinate
codeine sulfate (generic)

+

dimenhydrinate

1 interaction

Avoid/Use Alternative

codeine + dimenhydrinate

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• diosmin
codeine sulfate (generic)

+

diosmin

1 interaction

Avoid/Use Alternative

codeine + diosmin

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• diphenhydramine
codeine sulfate (generic)

+

diphenhydramine

1 interaction

Avoid/Use Alternative

codeine + diphenhydramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. codeine conversion to morphine; additive effects)

• diphenoxylate
codeine sulfate (generic)

+

diphenoxylate

1 interaction

Avoid/Use Alternative

codeine + diphenoxylate

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• domperidone
codeine sulfate (generic)

+

domperidone

1 interaction

Avoid/Use Alternative

codeine + domperidone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may decr. domperidone efficacy (additive effects; antagonistic effects)

• doxepin
codeine sulfate (generic)

+

doxepin

1 interaction

Avoid/Use Alternative

codeine + doxepin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• doxepin topical
codeine sulfate (generic)

+

doxepin topical

1 interaction

Avoid/Use Alternative

codeine + doxepin topical

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe constipation, paralytic ileus, urinary retention (additive effects)

• doxylamine
codeine sulfate (generic)

+

doxylamine

1 interaction

Avoid/Use Alternative

codeine + doxylamine

avoid combo if antitussive use or doxylamine use for pregnancy-related nausea/vomiting; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• dronabinol
codeine sulfate (generic)

+

dronabinol

1 interaction

Avoid/Use Alternative

codeine + dronabinol

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• dronedarone
codeine sulfate (generic)

+

dronedarone

1 interaction

Avoid/Use Alternative

codeine + dronedarone

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• droperidol
codeine sulfate (generic)

+

droperidol

1 interaction

Avoid/Use Alternative

codeine + droperidol

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• duloxetine
codeine sulfate (generic)

+

duloxetine

1 interaction

Avoid/Use Alternative

codeine + duloxetine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• duvelisib
codeine sulfate (generic)

+

duvelisib

1 interaction

Avoid/Use Alternative

codeine + duvelisib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• echinacea
codeine sulfate (generic)

+

echinacea

1 interaction

Avoid/Use Alternative

codeine + echinacea

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• efavirenz
codeine sulfate (generic)

+

efavirenz

1 interaction

Avoid/Use Alternative

codeine + efavirenz

avoid combo if antitussive use; otherwise monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• elafibranor
codeine sulfate (generic)

+

elafibranor

1 interaction

Avoid/Use Alternative

codeine + elafibranor

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• elagolix
codeine sulfate (generic)

+

elagolix

1 interaction

Avoid/Use Alternative

codeine + elagolix

use alternative or monitor withdrawal sx: combo may decr. codeine levels, efficacy (hepatic metab. induced)

• eletriptan
codeine sulfate (generic)

+

eletriptan

1 interaction

Avoid/Use Alternative

codeine + eletriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• eliglustat
codeine sulfate (generic)

+

eliglustat

1 interaction

Avoid/Use Alternative

codeine + eliglustat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• elinzanetant
codeine sulfate (generic)

+

elinzanetant

1 interaction

Avoid/Use Alternative

codeine + elinzanetant

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine, additive effects)

• eluxadoline
codeine sulfate (generic)

+

eluxadoline

1 interaction

Avoid/Use Alternative

codeine + eluxadoline

avoid combo: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• enasidenib
codeine sulfate (generic)

+

enasidenib

1 interaction

Avoid/Use Alternative

codeine + enasidenib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. altered, decr. conversion to morphine)

• encorafenib
codeine sulfate (generic)

+

encorafenib

1 interaction

Avoid/Use Alternative

codeine + encorafenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• entacapone
codeine sulfate (generic)

+

entacapone

1 interaction

Avoid/Use Alternative

codeine + entacapone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• entrectinib
codeine sulfate (generic)

+

entrectinib

1 interaction

Avoid/Use Alternative

codeine + entrectinib

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• enzalutamide
codeine sulfate (generic)

+

enzalutamide

1 interaction

Avoid/Use Alternative

codeine + enzalutamide

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• ergotamine
codeine sulfate (generic)

+

ergotamine

1 interaction

Avoid/Use Alternative

codeine + ergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• erythromycin
codeine sulfate (generic)

+

erythromycin

1 interaction

Avoid/Use Alternative

codeine + erythromycin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. erythromycin efficacy when used for GI promotility (hepatic metab. inhibited, may incr. production of active metabolite morphine; antagonistic effects)

• escitalopram
codeine sulfate (generic)

+

escitalopram

1 interaction

Avoid/Use Alternative

codeine + escitalopram

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• esketamine
codeine sulfate (generic)

+

esketamine

1 interaction

Avoid/Use Alternative

codeine + esketamine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
codeine sulfate (generic)

+

eslicarbazepine acetate

1 interaction

Avoid/Use Alternative

codeine + eslicarbazepine acetate

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• estazolam
codeine sulfate (generic)

+

estazolam

1 interaction

Avoid/Use Alternative

codeine + estazolam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• eszopiclone
codeine sulfate (generic)

+

eszopiclone

1 interaction

Avoid/Use Alternative

codeine + eszopiclone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethanol
codeine sulfate (generic)

+

ethanol

1 interaction

Avoid/Use Alternative

codeine + ethanol

ORAL ETHANOL: avoid combo; IV ETHANOL: avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: coingestion of oral ethanol or combo of IV ethanol w/ codeine may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ethanol (in some formulations)
codeine sulfate (generic)

+

ethanol (in some formulations)

1 interaction

Avoid/Use Alternative

codeine + ethanol (in some formulations)

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ethinyl estradiol (contraceptive)
codeine sulfate (generic)

+

ethinyl estradiol (contraceptive)

1 interaction

Avoid/Use Alternative

codeine + ethinyl estradiol (contraceptive)

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• ethosuximide
codeine sulfate (generic)

+

ethosuximide

1 interaction

Avoid/Use Alternative

codeine + ethosuximide

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• etomidate
codeine sulfate (generic)

+

etomidate

1 interaction

Avoid/Use Alternative

codeine + etomidate

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension (additive effects)

• etravirine
codeine sulfate (generic)

+

etravirine

1 interaction

Avoid/Use Alternative

codeine + etravirine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• everolimus
codeine sulfate (generic)

+

everolimus

1 interaction

Avoid/Use Alternative

codeine + everolimus

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• fedratinib
codeine sulfate (generic)

+

fedratinib

1 interaction

Avoid/Use Alternative

codeine + fedratinib

use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, conversion to morphine altered)

• felbamate
codeine sulfate (generic)

+

felbamate

1 interaction

Avoid/Use Alternative

codeine + felbamate

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• felodipine
codeine sulfate (generic)

+

felodipine

1 interaction

Avoid/Use Alternative

codeine + felodipine

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• fenfluramine
codeine sulfate (generic)

+

fenfluramine

1 interaction

Avoid/Use Alternative

codeine + fenfluramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• fentanyl
codeine sulfate (generic)

+

fentanyl

1 interaction

Avoid/Use Alternative

codeine + fentanyl

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• fesoterodine
codeine sulfate (generic)

+

fesoterodine

1 interaction

Avoid/Use Alternative

codeine + fesoterodine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• fexinidazole
codeine sulfate (generic)

+

fexinidazole

1 interaction

Avoid/Use Alternative

codeine + fexinidazole

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• finerenone
codeine sulfate (generic)

+

finerenone

1 interaction

Avoid/Use Alternative

codeine + finerenone

use alternative or monitor resp. rate if on finerenone 40 mg/day; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• flibanserin
codeine sulfate (generic)

+

flibanserin

1 interaction

Avoid/Use Alternative

codeine + flibanserin

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• fluconazole
codeine sulfate (generic)

+

fluconazole

1 interaction

Avoid/Use Alternative

codeine + fluconazole

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• fluoxetine
codeine sulfate (generic)

+

fluoxetine

1 interaction

Avoid/Use Alternative

codeine + fluoxetine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• fluphenazine
codeine sulfate (generic)

+

fluphenazine

1 interaction

Avoid/Use Alternative

codeine + fluphenazine

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• flurazepam
codeine sulfate (generic)

+

flurazepam

1 interaction

Avoid/Use Alternative

codeine + flurazepam

avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fluvoxamine
codeine sulfate (generic)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

codeine + fluvoxamine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• fosamprenavir
codeine sulfate (generic)

+

fosamprenavir

1 interaction

Avoid/Use Alternative

codeine + fosamprenavir

use alternative or monitor resp. rate, withdrawal sx: combo may alter codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may alter production of active metabolite morphine)

• fosaprepitant
codeine sulfate (generic)

+

fosaprepitant

1 interaction

Avoid/Use Alternative

codeine + fosaprepitant

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may alter production of active metabolite morphine)

• foslevodopa
codeine sulfate (generic)

+

foslevodopa

1 interaction

Avoid/Use Alternative

codeine + foslevodopa

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fosphenytoin
codeine sulfate (generic)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

codeine + fosphenytoin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• fostamatinib
codeine sulfate (generic)

+

fostamatinib

1 interaction

Avoid/Use Alternative

codeine + fostamatinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• frovatriptan
codeine sulfate (generic)

+

frovatriptan

1 interaction

Avoid/Use Alternative

codeine + frovatriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• gabapentin
codeine sulfate (generic)

+

gabapentin

1 interaction

Avoid/Use Alternative

codeine + gabapentin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• gabapentin enacarbil
codeine sulfate (generic)

+

gabapentin enacarbil

1 interaction

Avoid/Use Alternative

codeine + gabapentin enacarbil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ganaxolone
codeine sulfate (generic)

+

ganaxolone

1 interaction

Avoid/Use Alternative

codeine + ganaxolone

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• garlic
codeine sulfate (generic)

+

garlic

1 interaction

Avoid/Use Alternative

codeine + garlic

use alternative or monitor withdrawal sx, BP w/ supplemental garlic; dietary intake OK: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of severe hypotension, incl. orthostasis, syncope (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• gefitinib
codeine sulfate (generic)

+

gefitinib

1 interaction

Avoid/Use Alternative

codeine + gefitinib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• gepirone
codeine sulfate (generic)

+

gepirone

1 interaction

Avoid/Use Alternative

codeine + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• gepotidacin
codeine sulfate (generic)

+

gepotidacin

1 interaction

Avoid/Use Alternative

codeine + gepotidacin

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ginkgo
codeine sulfate (generic)

+

ginkgo

1 interaction

Avoid/Use Alternative

codeine + ginkgo

avoid combo: combo may alter codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may alter production of active metabolite morphine)

• ginseng, Asian
codeine sulfate (generic)

+

ginseng, Asian

1 interaction

Avoid/Use Alternative

codeine + ginseng, Asian

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• givinostat
codeine sulfate (generic)

+

givinostat

1 interaction

Avoid/Use Alternative

codeine + givinostat

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• givosiran
codeine sulfate (generic)

+

givosiran

1 interaction

Avoid/Use Alternative

codeine + givosiran

use alternative or monitor resp. rate, withdrawal sx, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, may incr. or decr. conversion to active metabolite morphine; givosiran effects on hepatic heme biosynthesis may reduce CYP450 enzyme activity)

• glecaprevir
codeine sulfate (generic)

+

glecaprevir

1 interaction

Avoid/Use Alternative

codeine + glecaprevir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• glofitamab
codeine sulfate (generic)

+

glofitamab

1 interaction

Avoid/Use Alternative

codeine + glofitamab

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• glycerol phenylbutyrate
codeine sulfate (generic)

+

glycerol phenylbutyrate

1 interaction

Avoid/Use Alternative

codeine + glycerol phenylbutyrate

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• glycopyrrolate
codeine sulfate (generic)

+

glycopyrrolate

1 interaction

Avoid/Use Alternative

codeine + glycopyrrolate

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• goldenseal
codeine sulfate (generic)

+

goldenseal

1 interaction

Avoid/Use Alternative

codeine + goldenseal

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• granisetron
codeine sulfate (generic)

+

granisetron

1 interaction

Avoid/Use Alternative

codeine + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• grapefruit
codeine sulfate (generic)

+

grapefruit

1 interaction

Avoid/Use Alternative

codeine + grapefruit

avoid grapefruit juice: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• grazoprevir
codeine sulfate (generic)

+

grazoprevir

1 interaction

Avoid/Use Alternative

codeine + grazoprevir

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• griseofulvin
codeine sulfate (generic)

+

griseofulvin

1 interaction

Avoid/Use Alternative

codeine + griseofulvin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• guanfacine
codeine sulfate (generic)

+

guanfacine

1 interaction

Avoid/Use Alternative

codeine + guanfacine

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• haloperidol
codeine sulfate (generic)

+

haloperidol

1 interaction

Avoid/Use Alternative

codeine + haloperidol

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hydralazine
codeine sulfate (generic)

+

hydralazine

1 interaction

Avoid/Use Alternative

codeine + hydralazine

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• hydrocodone
codeine sulfate (generic)

+

hydrocodone

1 interaction

Avoid/Use Alternative

codeine + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• hydromorphone
codeine sulfate (generic)

+

hydromorphone

1 interaction

Avoid/Use Alternative

codeine + hydromorphone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus (additive effects)

• hydroxychloroquine
codeine sulfate (generic)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

codeine + hydroxychloroquine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy; may incr. risk of seizures (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• hydroxyzine
codeine sulfate (generic)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

codeine + hydroxyzine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• hyoscyamine
codeine sulfate (generic)

+

hyoscyamine

1 interaction

Avoid/Use Alternative

codeine + hyoscyamine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• idelalisib
codeine sulfate (generic)

+

idelalisib

1 interaction

Avoid/Use Alternative

codeine + idelalisib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ifosfamide
codeine sulfate (generic)

+

ifosfamide

1 interaction

Avoid/Use Alternative

codeine + ifosfamide

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• iloperidone
codeine sulfate (generic)

+

iloperidone

1 interaction

Avoid/Use Alternative

codeine + iloperidone

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• imatinib
codeine sulfate (generic)

+

imatinib

1 interaction

Avoid/Use Alternative

codeine + imatinib

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• imipramine
codeine sulfate (generic)

+

imipramine

1 interaction

Avoid/Use Alternative

codeine + imipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• iohexol
codeine sulfate (generic)

+

iohexol

1 interaction

Avoid/Use Alternative

codeine + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isavuconazonium
codeine sulfate (generic)

+

isavuconazonium

1 interaction

Avoid/Use Alternative

codeine + isavuconazonium

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• isoflurane
codeine sulfate (generic)

+

isoflurane

1 interaction

Avoid/Use Alternative

codeine + isoflurane

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• istradefylline
codeine sulfate (generic)

+

istradefylline

1 interaction

Avoid/Use Alternative

codeine + istradefylline

use alternative or monitor resp. rate, consider decr. codeine dose, especially w/ istradefylline 40 mg dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• itraconazole
codeine sulfate (generic)

+

itraconazole

1 interaction

Avoid/Use Alternative

codeine + itraconazole

use alternative or monitor resp. rate; consider decr. codeine dose during and x2wk after itraconazole tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ivacaftor
codeine sulfate (generic)

+

ivacaftor

1 interaction

Avoid/Use Alternative

codeine + ivacaftor

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ivosidenib
codeine sulfate (generic)

+

ivosidenib

1 interaction

Avoid/Use Alternative

codeine + ivosidenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• kava
codeine sulfate (generic)

+

kava

1 interaction

Avoid/Use Alternative

codeine + kava

avoid combo: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ketamine
codeine sulfate (generic)

+

ketamine

1 interaction

Avoid/Use Alternative

codeine + ketamine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment, delayed recovery from anesthesia (additive effects)

• ketoconazole
codeine sulfate (generic)

+

ketoconazole

1 interaction

Avoid/Use Alternative

codeine + ketoconazole

use alternative or monitor resp. rate; consider decr. codeine dose during and up to 1wk after ketoconazole tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• kratom
codeine sulfate (generic)

+

kratom

1 interaction

Avoid/Use Alternative

codeine + kratom

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine, additive effects)

• labetalol
codeine sulfate (generic)

+

labetalol

1 interaction

Avoid/Use Alternative

codeine + labetalol

use alternative or monitor resp. rate, withdrawal sx, BP: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• lacosamide
codeine sulfate (generic)

+

lacosamide

1 interaction

Avoid/Use Alternative

codeine + lacosamide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• lamotrigine
codeine sulfate (generic)

+

lamotrigine

1 interaction

Avoid/Use Alternative

codeine + lamotrigine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• lapatinib
codeine sulfate (generic)

+

lapatinib

1 interaction

Avoid/Use Alternative

codeine + lapatinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• larotrectinib
codeine sulfate (generic)

+

larotrectinib

1 interaction

Avoid/Use Alternative

codeine + larotrectinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lasmiditan
codeine sulfate (generic)

+

lasmiditan

1 interaction

Avoid/Use Alternative

codeine + lasmiditan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• lazertinib
codeine sulfate (generic)

+

lazertinib

1 interaction

Avoid/Use Alternative

codeine + lazertinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lefamulin
codeine sulfate (generic)

+

lefamulin

1 interaction

Avoid/Use Alternative

codeine + lefamulin

ORAL LEFAMULIN: use alternative or monitor resp. rate, consider decr. codeine dose; IV lefamulin use OK: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lemborexant
codeine sulfate (generic)

+

lemborexant

1 interaction

Avoid/Use Alternative

codeine + lemborexant

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lenacapavir
codeine sulfate (generic)

+

lenacapavir

1 interaction

Avoid/Use Alternative

codeine + lenacapavir

use alternative or monitor resp. rate, consider decr. codeine dose during and x9mo after lenacapavir tx: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• letermovir
codeine sulfate (generic)

+

letermovir

1 interaction

Avoid/Use Alternative

codeine + letermovir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• levetiracetam
codeine sulfate (generic)

+

levetiracetam

1 interaction

Avoid/Use Alternative

codeine + levetiracetam

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• levocetirizine
codeine sulfate (generic)

+

levocetirizine

1 interaction

Avoid/Use Alternative

codeine + levocetirizine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• levodopa
codeine sulfate (generic)

+

levodopa

1 interaction

Avoid/Use Alternative

codeine + levodopa

avoid combo if antitussive use; otherwise, monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• levoketoconazole
codeine sulfate (generic)

+

levoketoconazole

1 interaction

Avoid/Use Alternative

codeine + levoketoconazole

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• levomilnacipran
codeine sulfate (generic)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

codeine + levomilnacipran

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• levorphanol
codeine sulfate (generic)

+

levorphanol

1 interaction

Avoid/Use Alternative

codeine + levorphanol

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. levorphanol start dose by at least 50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• linvoseltamab
codeine sulfate (generic)

+

linvoseltamab

1 interaction

Avoid/Use Alternative

codeine + linvoseltamab

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lisdexamfetamine
codeine sulfate (generic)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

codeine + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
codeine sulfate (generic)

+

lithium

1 interaction

Avoid/Use Alternative

codeine + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lofexidine
codeine sulfate (generic)

+

lofexidine

1 interaction

Avoid/Use Alternative

codeine + lofexidine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• lomitapide
codeine sulfate (generic)

+

lomitapide

1 interaction

Avoid/Use Alternative

codeine + lomitapide

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lonafarnib
codeine sulfate (generic)

+

lonafarnib

1 interaction

Avoid/Use Alternative

codeine + lonafarnib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• lopinavir/ritonavir
codeine sulfate (generic)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

codeine + lopinavir/ ritonavir

use alternative or monitor resp. rate, withdrawal sx: combo may alter codeine and active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may alter production of active metabolite morphine)

• lorazepam
codeine sulfate (generic)

+

lorazepam

1 interaction

Avoid/Use Alternative

codeine + lorazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• lorlatinib
codeine sulfate (generic)

+

lorlatinib

1 interaction

Avoid/Use Alternative

codeine + lorlatinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• lovastatin
codeine sulfate (generic)

+

lovastatin

1 interaction

Avoid/Use Alternative

codeine + lovastatin

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• loxapine
codeine sulfate (generic)

+

loxapine

1 interaction

Avoid/Use Alternative

codeine + loxapine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• lumacaftor/ivacaftor
codeine sulfate (generic)

+

lumacaftor/ ivacaftor

1 interaction

Avoid/Use Alternative

codeine + lumacaftor/ ivacaftor

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• lumateperone
codeine sulfate (generic)

+

lumateperone

1 interaction

Avoid/Use Alternative

codeine + lumateperone

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• lurasidone
codeine sulfate (generic)

+

lurasidone

1 interaction

Avoid/Use Alternative

codeine + lurasidone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• maribavir
codeine sulfate (generic)

+

maribavir

1 interaction

Avoid/Use Alternative

codeine + maribavir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• mavacamten
codeine sulfate (generic)

+

mavacamten

1 interaction

Avoid/Use Alternative

codeine + mavacamten

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• mavorixafor
codeine sulfate (generic)

+

mavorixafor

1 interaction

Avoid/Use Alternative

codeine + mavorixafor

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• meclizine
codeine sulfate (generic)

+

meclizine

1 interaction

Avoid/Use Alternative

codeine + meclizine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• melatonin
codeine sulfate (generic)

+

melatonin

1 interaction

Avoid/Use Alternative

codeine + melatonin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meperidine
codeine sulfate (generic)

+

meperidine

1 interaction

Avoid/Use Alternative

codeine + meperidine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. meperidine dose 25-50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• meprobamate
codeine sulfate (generic)

+

meprobamate

1 interaction

Avoid/Use Alternative

codeine + meprobamate

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• meropenem
codeine sulfate (generic)

+

meropenem

1 interaction

Avoid/Use Alternative

codeine + meropenem

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• metaxalone
codeine sulfate (generic)

+

metaxalone

1 interaction

Avoid/Use Alternative

codeine + metaxalone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
codeine sulfate (generic)

+

methadone

1 interaction

Avoid/Use Alternative

codeine + methadone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• methamphetamine
codeine sulfate (generic)

+

methamphetamine

1 interaction

Avoid/Use Alternative

codeine + methamphetamine

use alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methocarbamol
codeine sulfate (generic)

+

methocarbamol

1 interaction

Avoid/Use Alternative

codeine + methocarbamol

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• methohexital
codeine sulfate (generic)

+

methohexital

1 interaction

Avoid/Use Alternative

codeine + methohexital

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• methsuximide
codeine sulfate (generic)

+

methsuximide

1 interaction

Avoid/Use Alternative

codeine + methsuximide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• methyldopa
codeine sulfate (generic)

+

methyldopa

1 interaction

Avoid/Use Alternative

codeine + methyldopa

avoid combo if antitussive use; otherwise, monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• methylergonovine
codeine sulfate (generic)

+

methylergonovine

1 interaction

Avoid/Use Alternative

codeine + methylergonovine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylphenidate
codeine sulfate (generic)

+

methylphenidate

1 interaction

Avoid/Use Alternative

codeine + methylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• metoclopramide
codeine sulfate (generic)

+

metoclopramide

1 interaction

Avoid/Use Alternative

codeine + metoclopramide

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome; may decr. metoclopramide efficacy (additive effects; antagonistic effects; absorption of oral metoclopramide affected by delayed gastric emptying)

• metyrapone
codeine sulfate (generic)

+

metyrapone

1 interaction

Avoid/Use Alternative

codeine + metyrapone

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• metyrosine
codeine sulfate (generic)

+

metyrosine

1 interaction

Avoid/Use Alternative

codeine + metyrosine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• midazolam
codeine sulfate (generic)

+

midazolam

1 interaction

Avoid/Use Alternative

codeine + midazolam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• mifepristone
codeine sulfate (generic)

+

mifepristone

1 interaction

Avoid/Use Alternative

codeine + mifepristone

use alternative or monitor resp. rate; consider decr. codeine dose during and x14 days after daily mifepristone use; caution advised if pregnancy termination use: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited)

• milnacipran
codeine sulfate (generic)

+

milnacipran

1 interaction

Avoid/Use Alternative

codeine + milnacipran

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• mirabegron
codeine sulfate (generic)

+

mirabegron

1 interaction

Avoid/Use Alternative

codeine + mirabegron

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• mirtazapine
codeine sulfate (generic)

+

mirtazapine

1 interaction

Avoid/Use Alternative

codeine + mirtazapine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• mitapivat
codeine sulfate (generic)

+

mitapivat

1 interaction

Avoid/Use Alternative

codeine + mitapivat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• mitotane
codeine sulfate (generic)

+

mitotane

1 interaction

Avoid/Use Alternative

codeine + mitotane

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• mobocertinib
codeine sulfate (generic)

+

mobocertinib

1 interaction

Avoid/Use Alternative

codeine + mobocertinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• modafinil
codeine sulfate (generic)

+

modafinil

1 interaction

Avoid/Use Alternative

codeine + modafinil

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• molindone
codeine sulfate (generic)

+

molindone

1 interaction

Avoid/Use Alternative

codeine + molindone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• morphine
codeine sulfate (generic)

+

morphine

1 interaction

Avoid/Use Alternative

codeine + morphine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• mosunetuzumab
codeine sulfate (generic)

+

mosunetuzumab

1 interaction

Avoid/Use Alternative

codeine + mosunetuzumab

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• mycophenolate mofetil
codeine sulfate (generic)

+

mycophenolate mofetil

1 interaction

Avoid/Use Alternative

codeine + mycophenolate mofetil

avoid combo if antitussive use; otherwise monitor resp. rate, decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• nafcillin
codeine sulfate (generic)

+

nafcillin

1 interaction

Avoid/Use Alternative

codeine + nafcillin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• nalbuphine
codeine sulfate (generic)

+

nalbuphine

1 interaction

Avoid/Use Alternative

codeine + nalbuphine

avoid combo if antitussive use; otherwise use alternative or monitor for withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent patients; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (antagonistic effects; additive effects)

• naratriptan
codeine sulfate (generic)

+

naratriptan

1 interaction

Avoid/Use Alternative

codeine + naratriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• nefazodone
codeine sulfate (generic)

+

nefazodone

1 interaction

Avoid/Use Alternative

codeine + nefazodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• nelarabine
codeine sulfate (generic)

+

nelarabine

1 interaction

Avoid/Use Alternative

codeine + nelarabine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx; withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• nelfinavir
codeine sulfate (generic)

+

nelfinavir

1 interaction

Avoid/Use Alternative

codeine + nelfinavir

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• netupitant
codeine sulfate (generic)

+

netupitant

1 interaction

Avoid/Use Alternative

codeine + netupitant

use alternative or monitor resp. rate, consider decr. codeine dose during and x1wk after (fos)netupitant tx: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• nevirapine
codeine sulfate (generic)

+

nevirapine

1 interaction

Avoid/Use Alternative

codeine + nevirapine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• nicardipine
codeine sulfate (generic)

+

nicardipine

1 interaction

Avoid/Use Alternative

codeine + nicardipine

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine; additive effects)

• nilotinib
codeine sulfate (generic)

+

nilotinib

1 interaction

Avoid/Use Alternative

codeine + nilotinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• nirogacestat
codeine sulfate (generic)

+

nirogacestat

1 interaction

Avoid/Use Alternative

codeine + nirogacestat

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• nortriptyline
codeine sulfate (generic)

+

nortriptyline

1 interaction

Avoid/Use Alternative

codeine + nortriptyline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• odevixibat
codeine sulfate (generic)

+

odevixibat

1 interaction

Avoid/Use Alternative

codeine + odevixibat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• olanzapine
codeine sulfate (generic)

+

olanzapine

1 interaction

Avoid/Use Alternative

codeine + olanzapine

avoid combo if antitussive use; otherwise, consider alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus (incl. life-threatening), urinary retention (additive effects)

• oliceridine
codeine sulfate (generic)

+

oliceridine

1 interaction

Avoid/Use Alternative

codeine + oliceridine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• olutasidenib
codeine sulfate (generic)

+

olutasidenib

1 interaction

Avoid/Use Alternative

codeine + olutasidenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• omaveloxolone
codeine sulfate (generic)

+

omaveloxolone

1 interaction

Avoid/Use Alternative

codeine + omaveloxolone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• ondansetron
codeine sulfate (generic)

+

ondansetron

1 interaction

Avoid/Use Alternative

codeine + ondansetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• opicapone
codeine sulfate (generic)

+

opicapone

1 interaction

Avoid/Use Alternative

codeine + opicapone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• opium
codeine sulfate (generic)

+

opium

1 interaction

Avoid/Use Alternative

codeine + opium

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome (additive effects)

• orphenadrine
codeine sulfate (generic)

+

orphenadrine

1 interaction

Avoid/Use Alternative

codeine + orphenadrine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• osilodrostat
codeine sulfate (generic)

+

osilodrostat

1 interaction

Avoid/Use Alternative

codeine + osilodrostat

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• oxazepam
codeine sulfate (generic)

+

oxazepam

1 interaction

Avoid/Use Alternative

codeine + oxazepam

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• oxcarbazepine
codeine sulfate (generic)

+

oxcarbazepine

1 interaction

Avoid/Use Alternative

codeine + oxcarbazepine

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• oxybate
codeine sulfate (generic)

+

oxybate

1 interaction

Avoid/Use Alternative

codeine + oxybate

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; consider holding oxybate, especially if peri- or post-operative opioid analgesia required: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxybutynin
codeine sulfate (generic)

+

oxybutynin

1 interaction

Avoid/Use Alternative

codeine + oxybutynin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs or consider oxybutynin transdermal patch, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxycodone
codeine sulfate (generic)

+

oxycodone

1 interaction

Avoid/Use Alternative

codeine + oxycodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• oxymorphone
codeine sulfate (generic)

+

oxymorphone

1 interaction

Avoid/Use Alternative

codeine + oxymorphone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• pacritinib
codeine sulfate (generic)

+

pacritinib

1 interaction

Avoid/Use Alternative

codeine + pacritinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• palbociclib
codeine sulfate (generic)

+

palbociclib

1 interaction

Avoid/Use Alternative

codeine + palbociclib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• paliperidone
codeine sulfate (generic)

+

paliperidone

1 interaction

Avoid/Use Alternative

codeine + paliperidone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• palonosetron
codeine sulfate (generic)

+

palonosetron

1 interaction

Avoid/Use Alternative

codeine + palonosetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• paroxetine
codeine sulfate (generic)

+

paroxetine

1 interaction

Avoid/Use Alternative

codeine + paroxetine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• passion flower
codeine sulfate (generic)

+

passion flower

1 interaction

Avoid/Use Alternative

codeine + passion flower

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• pazopanib
codeine sulfate (generic)

+

pazopanib

1 interaction

Avoid/Use Alternative

codeine + pazopanib

use alternative or monitor resp. rate, withdrawal sx; consider decr. codeine dose: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• pentazocine
codeine sulfate (generic)

+

pentazocine

1 interaction

Avoid/Use Alternative

codeine + pentazocine

avoid combo if antitussive use; otherwise use alternative or monitor for withdrawal sx, resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine efficacy, precipitate withdrawal in opioid dependent patients; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (antagonistic effects; additive effects)

• pentobarbital
codeine sulfate (generic)

+

pentobarbital

1 interaction

Avoid/Use Alternative

codeine + pentobarbital

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, BP; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• peppermint
codeine sulfate (generic)

+

peppermint

1 interaction

Avoid/Use Alternative

codeine + peppermint

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• perampanel
codeine sulfate (generic)

+

perampanel

1 interaction

Avoid/Use Alternative

codeine + perampanel

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; consider decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy if on perampanel 12 mg/day; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• perphenazine
codeine sulfate (generic)

+

perphenazine

1 interaction

Avoid/Use Alternative

codeine + perphenazine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• pexidartinib
codeine sulfate (generic)

+

pexidartinib

1 interaction

Avoid/Use Alternative

codeine + pexidartinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• pheniramine
codeine sulfate (generic)

+

pheniramine

1 interaction

Avoid/Use Alternative

codeine + pheniramine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• phenobarbital
codeine sulfate (generic)

+

phenobarbital

1 interaction

Avoid/Use Alternative

codeine + phenobarbital

avoid combo if antitussive use; otherwise, use alternative or monitor BP, resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• phenytoin
codeine sulfate (generic)

+

phenytoin

1 interaction

Avoid/Use Alternative

codeine + phenytoin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• pibrentasvir
codeine sulfate (generic)

+

pibrentasvir

1 interaction

Avoid/Use Alternative

codeine + pibrentasvir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• pimozide
codeine sulfate (generic)

+

pimozide

1 interaction

Avoid/Use Alternative

codeine + pimozide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• pioglitazone
codeine sulfate (generic)

+

pioglitazone

1 interaction

Avoid/Use Alternative

codeine + pioglitazone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• pirtobrutinib
codeine sulfate (generic)

+

pirtobrutinib

1 interaction

Avoid/Use Alternative

codeine + pirtobrutinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• posaconazole
codeine sulfate (generic)

+

posaconazole

1 interaction

Avoid/Use Alternative

codeine + posaconazole

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• pramipexole
codeine sulfate (generic)

+

pramipexole

1 interaction

Avoid/Use Alternative

codeine + pramipexole

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• pramlintide
codeine sulfate (generic)

+

pramlintide

1 interaction

Avoid/Use Alternative

codeine + pramlintide

consider alternative: combo may incr. risk of severe constipation, paralytic ileus (additive effects)

• prasugrel
codeine sulfate (generic)

+

prasugrel

1 interaction

Avoid/Use Alternative

codeine + prasugrel

consider alternative parenteral antiplatelet agent for acute tx of ACS; otherwise, caution advised: combo may decr. prasugrel active metabolite levels, efficacy (absorption of prasugrel possibly affected by delayed gastric emptying)

• prednisone
codeine sulfate (generic)

+

prednisone

1 interaction

Avoid/Use Alternative

codeine + prednisone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• pregabalin
codeine sulfate (generic)

+

pregabalin

1 interaction

Avoid/Use Alternative

codeine + pregabalin

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• primidone
codeine sulfate (generic)

+

primidone

1 interaction

Avoid/Use Alternative

codeine + primidone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• prochlorperazine
codeine sulfate (generic)

+

prochlorperazine

1 interaction

Avoid/Use Alternative

codeine + prochlorperazine

avoid combo if antitussive use; otherwise consider alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• promethazine
codeine sulfate (generic)

+

promethazine

1 interaction

Avoid/Use Alternative

codeine + promethazine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. codeine dose by at least 25-50%, consider decr. promethazine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, seizures, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• propafenone
codeine sulfate (generic)

+

propafenone

1 interaction

Avoid/Use Alternative

codeine + propafenone

use alternative or monitor resp. rate, withdrawal sx, BP: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine, additive effects)

• propofol
codeine sulfate (generic)

+

propofol

1 interaction

Avoid/Use Alternative

codeine + propofol

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• propranolol
codeine sulfate (generic)

+

propranolol

1 interaction

Avoid/Use Alternative

codeine + propranolol

use alternative or monitor resp. rate, withdrawal sx, BP: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• protriptyline
codeine sulfate (generic)

+

protriptyline

1 interaction

Avoid/Use Alternative

codeine + protriptyline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• pyrilamine
codeine sulfate (generic)

+

pyrilamine

1 interaction

Avoid/Use Alternative

codeine + pyrilamine

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• quazepam
codeine sulfate (generic)

+

quazepam

1 interaction

Avoid/Use Alternative

codeine + quazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• quercetin
codeine sulfate (generic)

+

quercetin

1 interaction

Avoid/Use Alternative

codeine + quercetin

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• quetiapine
codeine sulfate (generic)

+

quetiapine

1 interaction

Avoid/Use Alternative

codeine + quetiapine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• quinidine (antiarrhythmic)
codeine sulfate (generic)

+

quinidine (antiarrhythmic)

1 interaction

Avoid/Use Alternative

codeine + quinidine (antiarrhythmic)

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• quinidine (CYP2D6 inhibitor)
codeine sulfate (generic)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Avoid/Use Alternative

codeine + quinidine (CYP2D6 inhibitor)

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• ramelteon
codeine sulfate (generic)

+

ramelteon

1 interaction

Avoid/Use Alternative

codeine + ramelteon

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ranolazine
codeine sulfate (generic)

+

ranolazine

1 interaction

Avoid/Use Alternative

codeine + ranolazine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• remdesivir
codeine sulfate (generic)

+

remdesivir

1 interaction

Avoid/Use Alternative

codeine + remdesivir

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• remifentanil
codeine sulfate (generic)

+

remifentanil

1 interaction

Avoid/Use Alternative

codeine + remifentanil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• remimazolam
codeine sulfate (generic)

+

remimazolam

1 interaction

Avoid/Use Alternative

codeine + remimazolam

avoid combo if antitussive use; otherwise use alternative or monitor BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of severe hypotension (incl. orthostasis, syncope), profound CNS and resp. depression, psychomotor impairment (additive effects)

• repotrectinib
codeine sulfate (generic)

+

repotrectinib

1 interaction

Avoid/Use Alternative

codeine + repotrectinib

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• resveratrol
codeine sulfate (generic)

+

resveratrol

1 interaction

Avoid/Use Alternative

codeine + resveratrol

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• revefenacin inhaled
codeine sulfate (generic)

+

revefenacin inhaled

1 interaction

Avoid/Use Alternative

codeine + revefenacin inhaled

consider alternative: combo may incr. risk of severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• ribociclib
codeine sulfate (generic)

+

ribociclib

1 interaction

Avoid/Use Alternative

codeine + ribociclib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• rifabutin
codeine sulfate (generic)

+

rifabutin

1 interaction

Avoid/Use Alternative

codeine + rifabutin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• rifampin
codeine sulfate (generic)

+

rifampin

1 interaction

Avoid/Use Alternative

codeine + rifampin

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• rifapentine
codeine sulfate (generic)

+

rifapentine

1 interaction

Avoid/Use Alternative

codeine + rifapentine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• rilzabrutinib
codeine sulfate (generic)

+

rilzabrutinib

1 interaction

Avoid/Use Alternative

codeine + rilzabrutinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• risperidone
codeine sulfate (generic)

+

risperidone

1 interaction

Avoid/Use Alternative

codeine + risperidone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ritlecitinib
codeine sulfate (generic)

+

ritlecitinib

1 interaction

Avoid/Use Alternative

codeine + ritlecitinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ritonavir
codeine sulfate (generic)

+

ritonavir

1 interaction

Avoid/Use Alternative

codeine + ritonavir

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• rizatriptan
codeine sulfate (generic)

+

rizatriptan

1 interaction

Avoid/Use Alternative

codeine + rizatriptan

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• rolapitant
codeine sulfate (generic)

+

rolapitant

1 interaction

Avoid/Use Alternative

codeine + rolapitant

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• ropeginterferon alfa-2b
codeine sulfate (generic)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

codeine + ropeginterferon alfa-2b

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ropinirole
codeine sulfate (generic)

+

ropinirole

1 interaction

Avoid/Use Alternative

codeine + ropinirole

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• rotigotine transdermal
codeine sulfate (generic)

+

rotigotine transdermal

1 interaction

Avoid/Use Alternative

codeine + rotigotine transdermal

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• rucaparib
codeine sulfate (generic)

+

rucaparib

1 interaction

Avoid/Use Alternative

codeine + rucaparib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• rufinamide
codeine sulfate (generic)

+

rufinamide

1 interaction

Avoid/Use Alternative

codeine + rufinamide

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• SAMe
codeine sulfate (generic)

+

SAMe

1 interaction

Avoid/Use Alternative

codeine + SAMe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• sarilumab
codeine sulfate (generic)

+

sarilumab

1 interaction

Avoid/Use Alternative

codeine + sarilumab

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. altered; sarilumab may reverse inflammatory cytokine-induced downregulation of CYP450 enzymes resulting in relative induction of enzymes upon tx start and downregulation upon D/C)

• scopolamine
codeine sulfate (generic)

+

scopolamine

1 interaction

Avoid/Use Alternative

codeine + scopolamine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• selinexor
codeine sulfate (generic)

+

selinexor

1 interaction

Avoid/Use Alternative

codeine + selinexor

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• selpercatinib
codeine sulfate (generic)

+

selpercatinib

1 interaction

Avoid/Use Alternative

codeine + selpercatinib

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• sertraline
codeine sulfate (generic)

+

sertraline

1 interaction

Avoid/Use Alternative

codeine + sertraline

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• sevabertinib
codeine sulfate (generic)

+

sevabertinib

1 interaction

Avoid/Use Alternative

codeine + sevabertinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, incr. risk of, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• sevoflurane
codeine sulfate (generic)

+

sevoflurane

1 interaction

Avoid/Use Alternative

codeine + sevoflurane

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• solifenacin
codeine sulfate (generic)

+

solifenacin

1 interaction

Avoid/Use Alternative

codeine + solifenacin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of severe constipation, paralytic ileus, urinary retention, profound CNS and resp. depression, psychomotor impairment (additive effects)

• sotorasib
codeine sulfate (generic)

+

sotorasib

1 interaction

Avoid/Use Alternative

codeine + sotorasib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of active metabolite morphine)

• spironolactone
codeine sulfate (generic)

+

spironolactone

1 interaction

Avoid/Use Alternative

codeine + spironolactone

use alternative or monitor resp. rate, BP; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects; may decr. spironolactone efficacy (hepatic metab. possibly inhibited, may incr. production of active metabolite morphine; additive effects; antagonistic effects, opioids may induce antidiuretic hormone release)

• St. John's wort
codeine sulfate (generic)

+

St. John's wort

1 interaction

Avoid/Use Alternative

codeine + St. John's wort

use alternative or monitor withdrawal sx, serotonin syndrome sx, especially during initiation/titration: combo may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of serotonin syndrome (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects)

• stiripentol
codeine sulfate (generic)

+

stiripentol

1 interaction

Avoid/Use Alternative

codeine + stiripentol

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. or decr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy; may alter seizure control (hepatic metab. possibly altered, may incr. or decr. production of morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• sufentanil
codeine sulfate (generic)

+

sufentanil

1 interaction

Avoid/Use Alternative

codeine + sufentanil

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. sufentanil start dose, consider decr. codeine dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• sumatriptan
codeine sulfate (generic)

+

sumatriptan

1 interaction

Avoid/Use Alternative

codeine + sumatriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• sunvozertinib
codeine sulfate (generic)

+

sunvozertinib

1 interaction

Avoid/Use Alternative

codeine + sunvozertinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• suvorexant
codeine sulfate (generic)

+

suvorexant

1 interaction

Avoid/Use Alternative

codeine + suvorexant

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• suzetrigine
codeine sulfate (generic)

+

suzetrigine

1 interaction

Avoid/Use Alternative

codeine + suzetrigine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• tapentadol
codeine sulfate (generic)

+

tapentadol

1 interaction

Avoid/Use Alternative

codeine + tapentadol

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• tasimelteon
codeine sulfate (generic)

+

tasimelteon

1 interaction

Avoid/Use Alternative

codeine + tasimelteon

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• tazemetostat
codeine sulfate (generic)

+

tazemetostat

1 interaction

Avoid/Use Alternative

codeine + tazemetostat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• tecovirimat
codeine sulfate (generic)

+

tecovirimat

1 interaction

Avoid/Use Alternative

codeine + tecovirimat

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• telotristat ethyl
codeine sulfate (generic)

+

telotristat ethyl

1 interaction

Avoid/Use Alternative

codeine + telotristat ethyl

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• temazepam
codeine sulfate (generic)

+

temazepam

1 interaction

Avoid/Use Alternative

codeine + temazepam

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• terbinafine
codeine sulfate (generic)

+

terbinafine

1 interaction

Avoid/Use Alternative

codeine + terbinafine

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• tetrabenazine
codeine sulfate (generic)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

codeine + tetrabenazine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• thalidomide
codeine sulfate (generic)

+

thalidomide

1 interaction

Avoid/Use Alternative

codeine + thalidomide

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• thioridazine
codeine sulfate (generic)

+

thioridazine

1 interaction

Avoid/Use Alternative

codeine + thioridazine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, withdrawal sx; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• thiotepa
codeine sulfate (generic)

+

thiotepa

1 interaction

Avoid/Use Alternative

codeine + thiotepa

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• thiothixene
codeine sulfate (generic)

+

thiothixene

1 interaction

Avoid/Use Alternative

codeine + thiothixene

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation, paralytic ileus, urinary retention (additive effects)

• tiagabine
codeine sulfate (generic)

+

tiagabine

1 interaction

Avoid/Use Alternative

codeine + tiagabine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• ticagrelor
codeine sulfate (generic)

+

ticagrelor

1 interaction

Avoid/Use Alternative

codeine + ticagrelor

use alternative or monitor resp. rate, consider decr. codeine dose; consider alternative parenteral antiplatelet agent for acute tx of ACS: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. ticagrelor and active metabolite levels, efficacy (hepatic metab. inhibited, may incr. production of active metabolite morphine; absorption of ticagrelor possibly affected by delayed gastric emptying)

• tipranavir
codeine sulfate (generic)

+

tipranavir

1 interaction

Avoid/Use Alternative

codeine + tipranavir

use alternative or monitor resp. rate, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine)

• tizanidine
codeine sulfate (generic)

+

tizanidine

1 interaction

Avoid/Use Alternative

codeine + tizanidine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tocilizumab
codeine sulfate (generic)

+

tocilizumab

1 interaction

Avoid/Use Alternative

codeine + tocilizumab

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. altered; tocilizumab may reverse inflammatory cytokine-induced downregulation of CYP450 enzymes resulting in relative induction of enzymes)

• tolcapone
codeine sulfate (generic)

+

tolcapone

1 interaction

Avoid/Use Alternative

codeine + tolcapone

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• tolterodine
codeine sulfate (generic)

+

tolterodine

1 interaction

Avoid/Use Alternative

codeine + tolterodine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• tolvaptan
codeine sulfate (generic)

+

tolvaptan

1 interaction

Avoid/Use Alternative

codeine + tolvaptan

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• topiramate
codeine sulfate (generic)

+

topiramate

1 interaction

Avoid/Use Alternative

codeine + topiramate

avoid combo if antitussive use; otherwise, use alternative or monitor withdrawal sx, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo w/ topiramate doses >200 mg/day may decr. codeine and active metabolite morphine levels, efficacy; may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, may decr. production of active metabolite morphine; additive effects; antagonistic effects, codeine may decr. seizure threshold)

• tovorafenib
codeine sulfate (generic)

+

tovorafenib

1 interaction

Avoid/Use Alternative

codeine + tovorafenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• tramadol
codeine sulfate (generic)

+

tramadol

1 interaction

Avoid/Use Alternative

codeine + tramadol

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), seizures, serotonin syndrome, severe constipation, paralytic ileus (additive effects)

• trazodone
codeine sulfate (generic)

+

trazodone

1 interaction

Avoid/Use Alternative

codeine + trazodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome (additive effects)

• treosulfan
codeine sulfate (generic)

+

treosulfan

1 interaction

Avoid/Use Alternative

codeine + treosulfan

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, seizures, other adverse effects (hepatic metab. possibly inhibited, may incr. production of active metabolite morphine; additive effects)

• triazolam
codeine sulfate (generic)

+

triazolam

1 interaction

Avoid/Use Alternative

codeine + triazolam

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• trifluoperazine
codeine sulfate (generic)

+

trifluoperazine

1 interaction

Avoid/Use Alternative

codeine + trifluoperazine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• trihexyphenidyl
codeine sulfate (generic)

+

trihexyphenidyl

1 interaction

Avoid/Use Alternative

codeine + trihexyphenidyl

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• trimethobenzamide
codeine sulfate (generic)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

codeine + trimethobenzamide

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• trimipramine
codeine sulfate (generic)

+

trimipramine

1 interaction

Avoid/Use Alternative

codeine + trimipramine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), serotonin syndrome, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• triprolidine
codeine sulfate (generic)

+

triprolidine

1 interaction

Avoid/Use Alternative

codeine + triprolidine

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• trofinetide
codeine sulfate (generic)

+

trofinetide

1 interaction

Avoid/Use Alternative

codeine + trofinetide

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. inhibited, may incr. production of active metabolite morphine)

• trospium
codeine sulfate (generic)

+

trospium

1 interaction

Avoid/Use Alternative

codeine + trospium

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe constipation, paralytic ileus, urinary retention (additive effects)

• tucatinib
codeine sulfate (generic)

+

tucatinib

1 interaction

Avoid/Use Alternative

codeine + tucatinib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• upadacitinib
codeine sulfate (generic)

+

upadacitinib

1 interaction

Avoid/Use Alternative

codeine + upadacitinib

use alternative or monitor resp. rate, withdrawal sx if taking upadacitinib dose 45 mg qd: combo may incr. codeine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine)

• vaborbactam
codeine sulfate (generic)

+

vaborbactam

1 interaction

Avoid/Use Alternative

codeine + vaborbactam

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• valbenazine
codeine sulfate (generic)

+

valbenazine

1 interaction

Avoid/Use Alternative

codeine + valbenazine

avoid combo if antitussive use; otherwise monitor resp. rate, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valerian
codeine sulfate (generic)

+

valerian

1 interaction

Avoid/Use Alternative

codeine + valerian

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• valproic acid
codeine sulfate (generic)

+

valproic acid

1 interaction

Avoid/Use Alternative

codeine + valproic acid

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• vamorolone
codeine sulfate (generic)

+

vamorolone

1 interaction

Avoid/Use Alternative

codeine + vamorolone

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• vemurafenib
codeine sulfate (generic)

+

vemurafenib

1 interaction

Avoid/Use Alternative

codeine + vemurafenib

use alternative or monitor resp. rate, withdrawal sx: combo may alter codeine and decr. active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, other adverse effects or decr. efficacy (hepatic metab. altered, may decr. production of active metabolite morphine)

• venlafaxine
codeine sulfate (generic)

+

venlafaxine

1 interaction

Avoid/Use Alternative

codeine + venlafaxine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• verapamil
codeine sulfate (generic)

+

verapamil

1 interaction

Avoid/Use Alternative

codeine + verapamil

use alternative or monitor resp. rate, BP, withdrawal sx: combo may incr. codeine, alter active metabolite morphine levels, incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension (incl. orthostasis, syncope), other adverse effects or decr. efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• vigabatrin
codeine sulfate (generic)

+

vigabatrin

1 interaction

Avoid/Use Alternative

codeine + vigabatrin

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• vilazodone
codeine sulfate (generic)

+

vilazodone

1 interaction

Avoid/Use Alternative

codeine + vilazodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• viloxazine
codeine sulfate (generic)

+

viloxazine

1 interaction

Avoid/Use Alternative

codeine + viloxazine

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, withdrawal sx; consider codeine dose adjustment: combo may incr. codeine and active metabolite morphine levels, risk of profound CNS and resp. depression, psychomotor impairment, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, may alter production of active metabolite morphine; additive effects)

• vinblastine
codeine sulfate (generic)

+

vinblastine

1 interaction

Avoid/Use Alternative

codeine + vinblastine

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• vonoprazan
codeine sulfate (generic)

+

vonoprazan

1 interaction

Avoid/Use Alternative

codeine + vonoprazan

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• vorasidenib
codeine sulfate (generic)

+

vorasidenib

1 interaction

Avoid/Use Alternative

codeine + vorasidenib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. possibly induced, may decr. production of morphine)

• voriconazole
codeine sulfate (generic)

+

voriconazole

1 interaction

Avoid/Use Alternative

codeine + voriconazole

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• vortioxetine
codeine sulfate (generic)

+

vortioxetine

1 interaction

Avoid/Use Alternative

codeine + vortioxetine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• xanomeline
codeine sulfate (generic)

+

xanomeline

1 interaction

Avoid/Use Alternative

codeine + xanomeline

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (GI metab. possibly inhibited, may incr. production of active metabolite morphine)

• zaleplon
codeine sulfate (generic)

+

zaleplon

1 interaction

Avoid/Use Alternative

codeine + zaleplon

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zanubrutinib
codeine sulfate (generic)

+

zanubrutinib

1 interaction

Avoid/Use Alternative

codeine + zanubrutinib

use alternative or monitor withdrawal sx: combo may decr. codeine and active metabolite morphine levels, efficacy (hepatic metab. induced, may decr. production of morphine)

• ziconotide
codeine sulfate (generic)

+

ziconotide

1 interaction

Avoid/Use Alternative

codeine + ziconotide

avoid combo if antitussive use; otherwise, monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• ziftomenib
codeine sulfate (generic)

+

ziftomenib

1 interaction

Avoid/Use Alternative

codeine + ziftomenib

use alternative or monitor resp. rate, consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• zileuton
codeine sulfate (generic)

+

zileuton

1 interaction

Avoid/Use Alternative

codeine + zileuton

use alternative or monitor resp. rate; consider decr. codeine dose: combo may incr. codeine and active metabolite morphine levels, risk of CNS and resp. depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, may incr. production of active metabolite morphine)

• ziprasidone
codeine sulfate (generic)

+

ziprasidone

1 interaction

Avoid/Use Alternative

codeine + ziprasidone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, severe hypotension (incl. orthostasis, syncope), severe constipation/paralytic ileus, other anticholinergic adverse effects (additive effects)

• zolmitriptan
codeine sulfate (generic)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

codeine + zolmitriptan

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• zolpidem
codeine sulfate (generic)

+

zolpidem

1 interaction

Avoid/Use Alternative

codeine + zolpidem

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• zonisamide
codeine sulfate (generic)

+

zonisamide

1 interaction

Avoid/Use Alternative

codeine + zonisamide

avoid combo if antitussive use; otherwise monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, codeine may decr. seizure threshold)

• zuranolone
codeine sulfate (generic)

+

zuranolone

1 interaction

Avoid/Use Alternative

codeine + zuranolone

avoid combo if antitussive use; otherwise, use alternative or monitor resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)