Lexapro

Overview

escitalopram

SSRI

• CYP2C19 substrate
• CYP3A4 substrate
• CYP2D6 inhibitor, weak
• antiplatelet effects
• CNS depression
• hyponatremia
• lowers seizure threshold
• prolongs QT interval (conditional)
• serotonergic effects

• add MAO inhibitor to Interaction Check if recent (14 days) use

Contraindicated

• eliglustat
Lexapro (escitalopram)

+

eliglustat

1 interaction

Contraindicated

escitalopram + eliglustat

CYP2D6 EM: if Child-Pugh Class A, decr. eliglustat dose to 84 mg qd; otherwise, monitor ECG; CYP2D6 IM: contraindicated if also combined w/ strong CYP3A4 inhibitor; avoid combo if also combined w/ moderate CYP3A4 inhibitor; otherwise, monitor ECG; CYP2D6 PM: contraindicated if also combined w/ strong CYP3A4 inhibitor; avoid combo if also combined w/ weak or moderate CYP3A4 inhibitor; otherwise, monitor ECG: combo may incr. eliglustat levels, risk of PR or QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• isocarboxazid
Lexapro (escitalopram)

+

isocarboxazid

1 interaction

Contraindicated

escitalopram + isocarboxazid

contraindicated w/in 14 days of isocarboxazid or escitalopram use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• linezolid
Lexapro (escitalopram)

+

linezolid

1 interaction

Contraindicated

escitalopram + linezolid

contraindicated; hold escitalopram if urgent use; monitor sodium, serotonin syndrome sx x2wk after escitalopram D/C or 24h after last linezolid dose; may resume escitalopram 24h after last linezolid dose: combo may incr. risk of serotonin syndrome, hyponatremia (additive effects, linezolid reversibly inhibits monoamine oxidase)

• methylene blue injection
Lexapro (escitalopram)

+

methylene blue injection

1 interaction

Contraindicated

escitalopram + methylene blue injection

contraindicated; hold escitalopram if emergency use; monitor serotonin syndrome sx x2wk after escitalopram D/C or 24h after last methylene blue dose; may resume escitalopram 24h after last methylene blue dose: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• phenelzine
Lexapro (escitalopram)

+

phenelzine

1 interaction

Contraindicated

escitalopram + phenelzine

contraindicated w/in 14 days of phenelzine or escitalopram use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• pimozide
Lexapro (escitalopram)

+

pimozide

1 interaction

Contraindicated

escitalopram + pimozide

contraindicated: combo may incr. pimozide levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• selegiline transdermal
Lexapro (escitalopram)

+

selegiline transdermal

1 interaction

Contraindicated

escitalopram + selegiline transdermal

contraindicated w/in 14 days of selegiline transdermal or escitalopram use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• thioridazine
Lexapro (escitalopram)

+

thioridazine

1 interaction

Contraindicated

escitalopram + thioridazine

contraindicated: combo may incr. thioridazine levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (hepatic metab. inhibited, additive effects)

• tranylcypromine
Lexapro (escitalopram)

+

tranylcypromine

1 interaction

Contraindicated

escitalopram + tranylcypromine

contraindicated w/in 14 days of tranylcypromine or escitalopram use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Avoid/Use Alternative

• 5-HTP
Lexapro (escitalopram)

+

5-HTP

1 interaction

Avoid/Use Alternative

escitalopram + 5-HTP

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• aldesleukin
Lexapro (escitalopram)

+

aldesleukin

1 interaction

Avoid/Use Alternative

escitalopram + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, seizures (additive effects)

• alfentanil
Lexapro (escitalopram)

+

alfentanil

1 interaction

Avoid/Use Alternative

escitalopram + alfentanil

use alternative or monitor BP, resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, hypotension (additive effects)

• almotriptan
Lexapro (escitalopram)

+

almotriptan

1 interaction

Avoid/Use Alternative

escitalopram + almotriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amifampridine
Lexapro (escitalopram)

+

amifampridine

1 interaction

Avoid/Use Alternative

escitalopram + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amitriptyline
Lexapro (escitalopram)

+

amitriptyline

1 interaction

Avoid/Use Alternative

escitalopram + amitriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amoxapine
Lexapro (escitalopram)

+

amoxapine

1 interaction

Avoid/Use Alternative

escitalopram + amoxapine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• amphetamine
Lexapro (escitalopram)

+

amphetamine

1 interaction

Avoid/Use Alternative

escitalopram + amphetamine

use alternative or decr. amphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• arsenic trioxide
Lexapro (escitalopram)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

escitalopram + arsenic trioxide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• artemether/lumefantrine
Lexapro (escitalopram)

+

artemether/ lumefantrine

1 interaction

Avoid/Use Alternative

escitalopram + artemether/ lumefantrine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bedaquiline
Lexapro (escitalopram)

+

bedaquiline

1 interaction

Avoid/Use Alternative

escitalopram + bedaquiline

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bromocriptine
Lexapro (escitalopram)

+

bromocriptine

1 interaction

Avoid/Use Alternative

escitalopram + bromocriptine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• buprenorphine
Lexapro (escitalopram)

+

buprenorphine

1 interaction

Avoid/Use Alternative

escitalopram + buprenorphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• buspirone
Lexapro (escitalopram)

+

buspirone

1 interaction

Avoid/Use Alternative

escitalopram + buspirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• butalbital
Lexapro (escitalopram)

+

butalbital

1 interaction

Avoid/Use Alternative

escitalopram + butalbital

avoid combo: combo may decr. escitalopram levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• butorphanol
Lexapro (escitalopram)

+

butorphanol

1 interaction

Avoid/Use Alternative

escitalopram + butorphanol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• carbamazepine
Lexapro (escitalopram)

+

carbamazepine

1 interaction

Avoid/Use Alternative

escitalopram + carbamazepine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may decr. escitalopram levels, efficacy; may incr. risk of hyponatremia, seizures, serotonin syndrome, CNS depression, psychomotor impairment (hepatic metab. induced; additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• cisapride
Lexapro (escitalopram)

+

cisapride

1 interaction

Avoid/Use Alternative

escitalopram + cisapride

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• citalopram
Lexapro (escitalopram)

+

citalopram

1 interaction

Avoid/Use Alternative

escitalopram + citalopram

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, hyponatremia, bleeding (incl. life-threatening), CNS depression, psychomotor impairment, serotonin syndrome (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• clomipramine
Lexapro (escitalopram)

+

clomipramine

1 interaction

Avoid/Use Alternative

escitalopram + clomipramine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia, serotonin syndrome, seizures (additive effects)

• clonidine
Lexapro (escitalopram)

+

clonidine

1 interaction

Avoid/Use Alternative

escitalopram + clonidine

if ADHD use, avoid combo; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• cocaine
Lexapro (escitalopram)

+

cocaine

1 interaction

Avoid/Use Alternative

escitalopram + cocaine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• codeine
Lexapro (escitalopram)

+

codeine

1 interaction

Avoid/Use Alternative

escitalopram + codeine

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. codeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite morphine levels, efficacy (hepatic metab. inhibited, decr. conversion to morphine; additive effects)

• crizotinib
Lexapro (escitalopram)

+

crizotinib

1 interaction

Avoid/Use Alternative

escitalopram + crizotinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• cyclobenzaprine
Lexapro (escitalopram)

+

cyclobenzaprine

1 interaction

Avoid/Use Alternative

escitalopram + cyclobenzaprine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• desipramine
Lexapro (escitalopram)

+

desipramine

1 interaction

Avoid/Use Alternative

escitalopram + desipramine

use alternative or monitor desipramine levels, ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. desipramine levels, risk of QT prolongation, cardiac arrhythmias, serotonin syndrome, CNS depression, psychomotor impairment (hepatic metab. inhibited; additive effects)

• desvenlafaxine
Lexapro (escitalopram)

+

desvenlafaxine

1 interaction

Avoid/Use Alternative

escitalopram + desvenlafaxine

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dexmethylphenidate
Lexapro (escitalopram)

+

dexmethylphenidate

1 interaction

Avoid/Use Alternative

escitalopram + dexmethylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextroamphetamine
Lexapro (escitalopram)

+

dextroamphetamine

1 interaction

Avoid/Use Alternative

escitalopram + dextroamphetamine

use alternative or decr. dextroamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dextromethorphan
Lexapro (escitalopram)

+

dextromethorphan

1 interaction

Avoid/Use Alternative

escitalopram + dextromethorphan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• dihydrocodeine
Lexapro (escitalopram)

+

dihydrocodeine

1 interaction

Avoid/Use Alternative

escitalopram + dihydrocodeine

use alternative or monitor resp. rate, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. dihydrocodeine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, other adverse effects; may decr. active metabolite dihydromorphine levels, efficacy (hepatic metab. inhibited, decr. conversion to dihydromorphine, additive effects)

• dihydroergotamine
Lexapro (escitalopram)

+

dihydroergotamine

1 interaction

Avoid/Use Alternative

escitalopram + dihydroergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• domperidone
Lexapro (escitalopram)

+

domperidone

1 interaction

Avoid/Use Alternative

escitalopram + domperidone

use alternative or monitor ECG, HR, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• doxepin
Lexapro (escitalopram)

+

doxepin

1 interaction

Avoid/Use Alternative

escitalopram + doxepin

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• doxepin topical
Lexapro (escitalopram)

+

doxepin topical

1 interaction

Avoid/Use Alternative

escitalopram + doxepin topical

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• doxylamine
Lexapro (escitalopram)

+

doxylamine

1 interaction

Avoid/Use Alternative

escitalopram + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dronedarone
Lexapro (escitalopram)

+

dronedarone

1 interaction

Avoid/Use Alternative

escitalopram + dronedarone

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• duloxetine
Lexapro (escitalopram)

+

duloxetine

1 interaction

Avoid/Use Alternative

escitalopram + duloxetine

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• edoxaban
Lexapro (escitalopram)

+

edoxaban

1 interaction

Avoid/Use Alternative

escitalopram + edoxaban

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eletriptan
Lexapro (escitalopram)

+

eletriptan

1 interaction

Avoid/Use Alternative

escitalopram + eletriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• enoxaparin
Lexapro (escitalopram)

+

enoxaparin

1 interaction

Avoid/Use Alternative

escitalopram + enoxaparin

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ephedra
Lexapro (escitalopram)

+

ephedra

1 interaction

Avoid/Use Alternative

escitalopram + ephedra

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ergotamine
Lexapro (escitalopram)

+

ergotamine

1 interaction

Avoid/Use Alternative

escitalopram + ergotamine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• escitalopram
Lexapro (escitalopram)

+

escitalopram

1 interaction

Avoid/Use Alternative

escitalopram + escitalopram

avoid combo: combo may incr. risk of serotonin syndrome, bleeding (incl. life-threatening), hyponatremia, CNS depression, psychomotor impairment, other adverse effects (additive effects, duplicate tx)

• ethanol
Lexapro (escitalopram)

+

ethanol

1 interaction

Avoid/Use Alternative

escitalopram + ethanol

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenfluramine
Lexapro (escitalopram)

+

fenfluramine

1 interaction

Avoid/Use Alternative

escitalopram + fenfluramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• fentanyl
Lexapro (escitalopram)

+

fentanyl

1 interaction

Avoid/Use Alternative

escitalopram + fentanyl

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• fexinidazole
Lexapro (escitalopram)

+

fexinidazole

1 interaction

Avoid/Use Alternative

escitalopram + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after escitalopram D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx: combo may decr. escitalopram levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• fluoxetine
Lexapro (escitalopram)

+

fluoxetine

1 interaction

Avoid/Use Alternative

escitalopram + fluoxetine

avoid combo: combo may incr. escitalopram levels, risk of serotonin syndrome, bleeding (incl. life-threatening), hyponatremia, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• fluvoxamine
Lexapro (escitalopram)

+

fluvoxamine

1 interaction

Avoid/Use Alternative

escitalopram + fluvoxamine

avoid combo: combo may incr. escitalopram levels, risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• fondaparinux
Lexapro (escitalopram)

+

fondaparinux

1 interaction

Avoid/Use Alternative

escitalopram + fondaparinux

use alternative or monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• frovatriptan
Lexapro (escitalopram)

+

frovatriptan

1 interaction

Avoid/Use Alternative

escitalopram + frovatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• gepirone
Lexapro (escitalopram)

+

gepirone

1 interaction

Avoid/Use Alternative

escitalopram + gepirone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• granisetron
Lexapro (escitalopram)

+

granisetron

1 interaction

Avoid/Use Alternative

escitalopram + granisetron

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• hydrocodone
Lexapro (escitalopram)

+

hydrocodone

1 interaction

Avoid/Use Alternative

escitalopram + hydrocodone

avoid combo if antitussive use; otherwise use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• hydromorphone
Lexapro (escitalopram)

+

hydromorphone

1 interaction

Avoid/Use Alternative

escitalopram + hydromorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• hydroxychloroquine
Lexapro (escitalopram)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

escitalopram + hydroxychloroquine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

• imipramine
Lexapro (escitalopram)

+

imipramine

1 interaction

Avoid/Use Alternative

escitalopram + imipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• iohexol
Lexapro (escitalopram)

+

iohexol

1 interaction

Avoid/Use Alternative

escitalopram + iohexol

avoid combo if intrathecal iohexol use: combo may incr. risk of seizures (additive effects)

• isoniazid
Lexapro (escitalopram)

+

isoniazid

1 interaction

Avoid/Use Alternative

escitalopram + isoniazid

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, isoniazid inhibits monoamine oxidase)

• kava
Lexapro (escitalopram)

+

kava

1 interaction

Avoid/Use Alternative

escitalopram + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• kratom
Lexapro (escitalopram)

+

kratom

1 interaction

Avoid/Use Alternative

escitalopram + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lasmiditan
Lexapro (escitalopram)

+

lasmiditan

1 interaction

Avoid/Use Alternative

escitalopram + lasmiditan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• lefamulin
Lexapro (escitalopram)

+

lefamulin

1 interaction

Avoid/Use Alternative

escitalopram + lefamulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levomilnacipran
Lexapro (escitalopram)

+

levomilnacipran

1 interaction

Avoid/Use Alternative

escitalopram + levomilnacipran

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• levorphanol
Lexapro (escitalopram)

+

levorphanol

1 interaction

Avoid/Use Alternative

escitalopram + levorphanol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• lisdexamfetamine
Lexapro (escitalopram)

+

lisdexamfetamine

1 interaction

Avoid/Use Alternative

escitalopram + lisdexamfetamine

use alternative or decr. lisdexamfetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lithium
Lexapro (escitalopram)

+

lithium

1 interaction

Avoid/Use Alternative

escitalopram + lithium

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• lonafarnib
Lexapro (escitalopram)

+

lonafarnib

1 interaction

Avoid/Use Alternative

escitalopram + lonafarnib

use alternative or monitor HR, ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• meperidine
Lexapro (escitalopram)

+

meperidine

1 interaction

Avoid/Use Alternative

escitalopram + meperidine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• metaxalone
Lexapro (escitalopram)

+

metaxalone

1 interaction

Avoid/Use Alternative

escitalopram + metaxalone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• methadone
Lexapro (escitalopram)

+

methadone

1 interaction

Avoid/Use Alternative

escitalopram + methadone

use alternative or monitor resp. rate, ECG, serotonin syndrome sx, especially during initiation/titration; consider decr. methadone dose: combo may incr. methadone levels, risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, serotonin syndrome, other adverse effects (hepatic metab. inhibited, additive effects)

• methamphetamine
Lexapro (escitalopram)

+

methamphetamine

1 interaction

Avoid/Use Alternative

escitalopram + methamphetamine

use alternative or decr. methamphetamine start dose; monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylene blue oral
Lexapro (escitalopram)

+

methylene blue oral

1 interaction

Avoid/Use Alternative

escitalopram + methylene blue oral

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, methylene blue reversibly inhibits monoamine oxidase)

• methylergonovine
Lexapro (escitalopram)

+

methylergonovine

1 interaction

Avoid/Use Alternative

escitalopram + methylergonovine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• methylphenidate
Lexapro (escitalopram)

+

methylphenidate

1 interaction

Avoid/Use Alternative

escitalopram + methylphenidate

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. escitalopram levels, risk of serotonin syndrome, other adverse effects (mechanism unknown, hepatic metab. possibly inhibited, additive effects)

• metoclopramide
Lexapro (escitalopram)

+

metoclopramide

1 interaction

Avoid/Use Alternative

escitalopram + metoclopramide

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• midazolam
Lexapro (escitalopram)

+

midazolam

1 interaction

Avoid/Use Alternative

escitalopram + midazolam

use alternative or monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• milnacipran
Lexapro (escitalopram)

+

milnacipran

1 interaction

Avoid/Use Alternative

escitalopram + milnacipran

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mirtazapine
Lexapro (escitalopram)

+

mirtazapine

1 interaction

Avoid/Use Alternative

escitalopram + mirtazapine

use alternative or monitor sodium, serotonin syndrome sx, especially during initiation/titration; consider decr. dose of one or both drugs: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment, hyponatremia (additive effects)

• mobocertinib
Lexapro (escitalopram)

+

mobocertinib

1 interaction

Avoid/Use Alternative

escitalopram + mobocertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• morphine
Lexapro (escitalopram)

+

morphine

1 interaction

Avoid/Use Alternative

escitalopram + morphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• nalbuphine
Lexapro (escitalopram)

+

nalbuphine

1 interaction

Avoid/Use Alternative

escitalopram + nalbuphine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• naratriptan
Lexapro (escitalopram)

+

naratriptan

1 interaction

Avoid/Use Alternative

escitalopram + naratriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nefazodone
Lexapro (escitalopram)

+

nefazodone

1 interaction

Avoid/Use Alternative

escitalopram + nefazodone

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• nilotinib
Lexapro (escitalopram)

+

nilotinib

1 interaction

Avoid/Use Alternative

escitalopram + nilotinib

use alternative or monitor ECG, electrolytes, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI or other bleeding (incl. life-threatening), hyponatremia (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nortriptyline
Lexapro (escitalopram)

+

nortriptyline

1 interaction

Avoid/Use Alternative

escitalopram + nortriptyline

use alternative or monitor nortriptyline levels, serotonin syndrome sx, especially during initiation/titration: combo may incr. nortriptyline levels, risk of serotonin syndrome, CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• oliceridine
Lexapro (escitalopram)

+

oliceridine

1 interaction

Avoid/Use Alternative

escitalopram + oliceridine

use alternative or monitor resp. rate, ECG, BP, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. oliceridine levels, risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome, QT prolongation, cardiac arrhythmias, hypotension, other adverse effects (hepatic metab. inhibited, additive effects)

• ondansetron
Lexapro (escitalopram)

+

ondansetron

1 interaction

Avoid/Use Alternative

escitalopram + ondansetron

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

• opium
Lexapro (escitalopram)

+

opium

1 interaction

Avoid/Use Alternative

escitalopram + opium

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of serotonin syndrome, profound CNS and resp. depression, psychomotor impairment (additive effects)

• oxybate
Lexapro (escitalopram)

+

oxybate

1 interaction

Avoid/Use Alternative

escitalopram + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• oxycodone
Lexapro (escitalopram)

+

oxycodone

1 interaction

Avoid/Use Alternative

escitalopram + oxycodone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. oxycodone start dose by at least 50%, consider decr. escitalopram dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• oxymorphone
Lexapro (escitalopram)

+

oxymorphone

1 interaction

Avoid/Use Alternative

escitalopram + oxymorphone

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration; decr. oxymorphone start dose by at least 50%, consider decr. escitalopram dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• palonosetron
Lexapro (escitalopram)

+

palonosetron

1 interaction

Avoid/Use Alternative

escitalopram + palonosetron

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, serotonin syndrome (additive effects)

• paroxetine
Lexapro (escitalopram)

+

paroxetine

1 interaction

Avoid/Use Alternative

escitalopram + paroxetine

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• pentazocine
Lexapro (escitalopram)

+

pentazocine

1 interaction

Avoid/Use Alternative

escitalopram + pentazocine

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• phentermine
Lexapro (escitalopram)

+

phentermine

1 interaction

Avoid/Use Alternative

escitalopram + phentermine

avoid combo, especially w/ phentermine dose >15 mg: combo may incr. risk of cardiovascular and CNS stimulatory effects (mechanism unknown)

• procarbazine
Lexapro (escitalopram)

+

procarbazine

1 interaction

Avoid/Use Alternative

escitalopram + procarbazine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects, procarbazine inhibits monoamine oxidase)

• promethazine
Lexapro (escitalopram)

+

promethazine

1 interaction

Avoid/Use Alternative

escitalopram + promethazine

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, seizures (additive effects)

• propafenone
Lexapro (escitalopram)

+

propafenone

1 interaction

Avoid/Use Alternative

escitalopram + propafenone

if also combined w/ CYP3A4 inhibitor, avoid use; otherwise, monitor ECG, BP: combo may incr. propafenone levels, risk of QT prolongation, cardiac arrhythmias, hypotension, other adverse effects (hepatic metab. inhibited, additive effects)

• protriptyline
Lexapro (escitalopram)

+

protriptyline

1 interaction

Avoid/Use Alternative

escitalopram + protriptyline

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• quizartinib
Lexapro (escitalopram)

+

quizartinib

1 interaction

Avoid/Use Alternative

escitalopram + quizartinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rasagiline
Lexapro (escitalopram)

+

rasagiline

1 interaction

Avoid/Use Alternative

escitalopram + rasagiline

avoid combo w/in 14 days of rasagiline use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• remifentanil
Lexapro (escitalopram)

+

remifentanil

1 interaction

Avoid/Use Alternative

escitalopram + remifentanil

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• rizatriptan
Lexapro (escitalopram)

+

rizatriptan

1 interaction

Avoid/Use Alternative

escitalopram + rizatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• ropeginterferon alfa-2b
Lexapro (escitalopram)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

escitalopram + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• SAMe
Lexapro (escitalopram)

+

SAMe

1 interaction

Avoid/Use Alternative

escitalopram + SAMe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects)

• selegiline
Lexapro (escitalopram)

+

selegiline

1 interaction

Avoid/Use Alternative

escitalopram + selegiline

avoid combo w/in 14 days of selegiline use: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• sertraline
Lexapro (escitalopram)

+

sertraline

1 interaction

Avoid/Use Alternative

escitalopram + sertraline

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• sotalol
Lexapro (escitalopram)

+

sotalol

1 interaction

Avoid/Use Alternative

escitalopram + sotalol

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• St. John's wort
Lexapro (escitalopram)

+

St. John's wort

1 interaction

Avoid/Use Alternative

escitalopram + St. John's wort

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may decr. escitalopram levels, efficacy; may incr. risk of serotonin syndrome (hepatic metab. induced; additive effects)

• sufentanil
Lexapro (escitalopram)

+

sufentanil

1 interaction

Avoid/Use Alternative

escitalopram + sufentanil

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. sufentanil start dose, consider decr. escitalopram dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• sumatriptan
Lexapro (escitalopram)

+

sumatriptan

1 interaction

Avoid/Use Alternative

escitalopram + sumatriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• tapentadol
Lexapro (escitalopram)

+

tapentadol

1 interaction

Avoid/Use Alternative

escitalopram + tapentadol

use alternative or monitor resp. rate, serotonin syndrome sx, especially during initiation/titration, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, serotonin syndrome (additive effects)

• thalidomide
Lexapro (escitalopram)

+

thalidomide

1 interaction

Avoid/Use Alternative

escitalopram + thalidomide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• toremifene
Lexapro (escitalopram)

+

toremifene

1 interaction

Avoid/Use Alternative

escitalopram + toremifene

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tramadol
Lexapro (escitalopram)

+

tramadol

1 interaction

Avoid/Use Alternative

escitalopram + tramadol

use alternative or monitor sodium, resp. rate, ECG, withdrawal sx, serotonin syndrome sx, especially during initiation/titration; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. tramadol levels, risk of profound CNS and resp. depression, psychomotor impairment, seizures, serotonin syndrome, QT prolongation, cardiac arrhythmias, severe hyponatremia, other adverse effects; may decr. tramadol active metabolite levels, efficacy (hepatic metab. inhibited, decr. conversion to active metabolite; additive effects)

• trazodone
Lexapro (escitalopram)

+

trazodone

1 interaction

Avoid/Use Alternative

escitalopram + trazodone

use alternative or monitor sodium, bleeding s/sx, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, hyponatremia, CNS depression, psychomotor impairment, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• trimethobenzamide
Lexapro (escitalopram)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

escitalopram + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• trimipramine
Lexapro (escitalopram)

+

trimipramine

1 interaction

Avoid/Use Alternative

escitalopram + trimipramine

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• vandetanib
Lexapro (escitalopram)

+

vandetanib

1 interaction

Avoid/Use Alternative

escitalopram + vandetanib

use alternative or monitor ECG, electrolytes, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• venlafaxine
Lexapro (escitalopram)

+

venlafaxine

1 interaction

Avoid/Use Alternative

escitalopram + venlafaxine

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vilazodone
Lexapro (escitalopram)

+

vilazodone

1 interaction

Avoid/Use Alternative

escitalopram + vilazodone

avoid combo: combo may incr. risk of hyponatremia, serotonin syndrome, bleeding (incl. life-threatening), CNS depression, psychomotor impairment (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; duplicate tx)

• vortioxetine
Lexapro (escitalopram)

+

vortioxetine

1 interaction

Avoid/Use Alternative

escitalopram + vortioxetine

avoid combo: combo may incr. risk of serotonin syndrome, hyponatremia, bleeding (incl. life-threatening), other adverse effects (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake, duplicate tx)

• yohimbe
Lexapro (escitalopram)

+

yohimbe

1 interaction

Avoid/Use Alternative

escitalopram + yohimbe

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome (additive effects, yohimbe inhibits monoamine oxidase)

• ziprasidone
Lexapro (escitalopram)

+

ziprasidone

1 interaction

Avoid/Use Alternative

escitalopram + ziprasidone

use alternative or monitor ECG, serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• zolmitriptan
Lexapro (escitalopram)

+

zolmitriptan

1 interaction

Avoid/Use Alternative

escitalopram + zolmitriptan

use alternative or monitor serotonin syndrome sx, especially during initiation/titration: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• abrocitinib
Lexapro (escitalopram)

+

abrocitinib

1 interaction

Monitor/Modify Tx

escitalopram + abrocitinib

monitor platelets, bleeding s/sx, especially during abrocitinib tx initiation or if abrocitinib 200 mg/day: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• acalabrutinib
Lexapro (escitalopram)

+

acalabrutinib

1 interaction

Monitor/Modify Tx

escitalopram + acalabrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• adagrasib
Lexapro (escitalopram)

+

adagrasib

1 interaction

Monitor/Modify Tx

escitalopram + adagrasib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ado-trastuzumab emtansine
Lexapro (escitalopram)

+

ado-trastuzumab emtansine

1 interaction

Monitor/Modify Tx

escitalopram + ado-trastuzumab emtansine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• afatinib
Lexapro (escitalopram)

+

afatinib

1 interaction

Monitor/Modify Tx

escitalopram + afatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• alprazolam
Lexapro (escitalopram)

+

alprazolam

1 interaction

Monitor/Modify Tx

escitalopram + alprazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• alteplase
Lexapro (escitalopram)

+

alteplase

1 interaction

Monitor/Modify Tx

escitalopram + alteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• amiloride
Lexapro (escitalopram)

+

amiloride

1 interaction

Monitor/Modify Tx

escitalopram + amiloride

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• amiodarone
Lexapro (escitalopram)

+

amiodarone

1 interaction

Monitor/Modify Tx

escitalopram + amiodarone

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• anacaulase topical
Lexapro (escitalopram)

+

anacaulase topical

1 interaction

Monitor/Modify Tx

escitalopram + anacaulase topical

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• anagrelide
Lexapro (escitalopram)

+

anagrelide

1 interaction

Monitor/Modify Tx

escitalopram + anagrelide

monitor ECG, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• antithrombin
Lexapro (escitalopram)

+

antithrombin

1 interaction

Monitor/Modify Tx

escitalopram + antithrombin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• apalutamide
Lexapro (escitalopram)

+

apalutamide

1 interaction

Monitor/Modify Tx

escitalopram + apalutamide

monitor ECG: combo may decr. escitalopram levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• apixaban
Lexapro (escitalopram)

+

apixaban

1 interaction

Monitor/Modify Tx

escitalopram + apixaban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• apomorphine
Lexapro (escitalopram)

+

apomorphine

1 interaction

Monitor/Modify Tx

escitalopram + apomorphine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• argatroban
Lexapro (escitalopram)

+

argatroban

1 interaction

Monitor/Modify Tx

escitalopram + argatroban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• asenapine
Lexapro (escitalopram)

+

asenapine

1 interaction

Monitor/Modify Tx

escitalopram + asenapine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• asparaginase
Lexapro (escitalopram)

+

asparaginase

1 interaction

Monitor/Modify Tx

escitalopram + asparaginase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• aspirin
Lexapro (escitalopram)

+

aspirin

1 interaction

Monitor/Modify Tx

escitalopram + aspirin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• avapritinib
Lexapro (escitalopram)

+

avapritinib

1 interaction

Monitor/Modify Tx

escitalopram + avapritinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• axitinib
Lexapro (escitalopram)

+

axitinib

1 interaction

Monitor/Modify Tx

escitalopram + axitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• azithromycin
Lexapro (escitalopram)

+

azithromycin

1 interaction

Monitor/Modify Tx

escitalopram + azithromycin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• baclofen intrathecal
Lexapro (escitalopram)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

escitalopram + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• bevacizumab
Lexapro (escitalopram)

+

bevacizumab

1 interaction

Monitor/Modify Tx

escitalopram + bevacizumab

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• binimetinib
Lexapro (escitalopram)

+

binimetinib

1 interaction

Monitor/Modify Tx

escitalopram + binimetinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bivalirudin
Lexapro (escitalopram)

+

bivalirudin

1 interaction

Monitor/Modify Tx

escitalopram + bivalirudin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• brentuximab vedotin
Lexapro (escitalopram)

+

brentuximab vedotin

1 interaction

Monitor/Modify Tx

escitalopram + brentuximab vedotin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bromelain
Lexapro (escitalopram)

+

bromelain

1 interaction

Monitor/Modify Tx

escitalopram + bromelain

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bromfenac ophthalmic
Lexapro (escitalopram)

+

bromfenac ophthalmic

1 interaction

Monitor/Modify Tx

escitalopram + bromfenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• bumetanide
Lexapro (escitalopram)

+

bumetanide

1 interaction

Monitor/Modify Tx

escitalopram + bumetanide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• bupropion
Lexapro (escitalopram)

+

bupropion

1 interaction

Monitor/Modify Tx

escitalopram + bupropion

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• cabazitaxel
Lexapro (escitalopram)

+

cabazitaxel

1 interaction

Monitor/Modify Tx

escitalopram + cabazitaxel

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cabozantinib
Lexapro (escitalopram)

+

cabozantinib

1 interaction

Monitor/Modify Tx

escitalopram + cabozantinib

monitor ECG, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• calaspargase
Lexapro (escitalopram)

+

calaspargase

1 interaction

Monitor/Modify Tx

escitalopram + calaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cangrelor
Lexapro (escitalopram)

+

cangrelor

1 interaction

Monitor/Modify Tx

escitalopram + cangrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• caplacizumab
Lexapro (escitalopram)

+

caplacizumab

1 interaction

Monitor/Modify Tx

escitalopram + caplacizumab

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• carfilzomib
Lexapro (escitalopram)

+

carfilzomib

1 interaction

Monitor/Modify Tx

escitalopram + carfilzomib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• celecoxib
Lexapro (escitalopram)

+

celecoxib

1 interaction

Monitor/Modify Tx

escitalopram + celecoxib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ceritinib
Lexapro (escitalopram)

+

ceritinib

1 interaction

Monitor/Modify Tx

escitalopram + ceritinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• chlordiazepoxide
Lexapro (escitalopram)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

escitalopram + chlordiazepoxide

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• chloroquine
Lexapro (escitalopram)

+

chloroquine

1 interaction

Monitor/Modify Tx

escitalopram + chloroquine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• chlorothiazide
Lexapro (escitalopram)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

escitalopram + chlorothiazide

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• chlorpromazine
Lexapro (escitalopram)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

escitalopram + chlorpromazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• chlorthalidone
Lexapro (escitalopram)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

escitalopram + chlorthalidone

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• cilostazol
Lexapro (escitalopram)

+

cilostazol

1 interaction

Monitor/Modify Tx

escitalopram + cilostazol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cisplatin
Lexapro (escitalopram)

+

cisplatin

1 interaction

Monitor/Modify Tx

escitalopram + cisplatin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• clarithromycin
Lexapro (escitalopram)

+

clarithromycin

1 interaction

Monitor/Modify Tx

escitalopram + clarithromycin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clobazam
Lexapro (escitalopram)

+

clobazam

1 interaction

Monitor/Modify Tx

escitalopram + clobazam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• clofazimine
Lexapro (escitalopram)

+

clofazimine

1 interaction

Monitor/Modify Tx

escitalopram + clofazimine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clonazepam
Lexapro (escitalopram)

+

clonazepam

1 interaction

Monitor/Modify Tx

escitalopram + clonazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• clopidogrel
Lexapro (escitalopram)

+

clopidogrel

1 interaction

Monitor/Modify Tx

escitalopram + clopidogrel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• clorazepate
Lexapro (escitalopram)

+

clorazepate

1 interaction

Monitor/Modify Tx

escitalopram + clorazepate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• clozapine
Lexapro (escitalopram)

+

clozapine

1 interaction

Monitor/Modify Tx

escitalopram + clozapine

monitor ECG, BP, HR; consider decr. clozapine dose: combo may incr. clozapine levels, risk of QT prolongation, cardiac arrhythmias, hypotension, bradycardia, CNS depression, psychomotor impairment, seizures, other adverse effects (hepatic metab. inhibited, additive effects)

• collagenase clostridium histolyticum
Lexapro (escitalopram)

+

collagenase clostridium histolyticum

1 interaction

Monitor/Modify Tx

escitalopram + collagenase clostridium histolyticum

monitor injection site bleeding s/sx: combo may incr. risk of localized bleeding, incl. severe (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• cyclophosphamide
Lexapro (escitalopram)

+

cyclophosphamide

1 interaction

Monitor/Modify Tx

escitalopram + cyclophosphamide

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• cysteamine
Lexapro (escitalopram)

+

cysteamine

1 interaction

Monitor/Modify Tx

escitalopram + cysteamine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dabigatran
Lexapro (escitalopram)

+

dabigatran

1 interaction

Monitor/Modify Tx

escitalopram + dabigatran

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dalteparin
Lexapro (escitalopram)

+

dalteparin

1 interaction

Monitor/Modify Tx

escitalopram + dalteparin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• danshen
Lexapro (escitalopram)

+

danshen

1 interaction

Monitor/Modify Tx

escitalopram + danshen

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• daridorexant
Lexapro (escitalopram)

+

daridorexant

1 interaction

Monitor/Modify Tx

escitalopram + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dasatinib
Lexapro (escitalopram)

+

dasatinib

1 interaction

Monitor/Modify Tx

escitalopram + dasatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• deferasirox
Lexapro (escitalopram)

+

deferasirox

1 interaction

Monitor/Modify Tx

escitalopram + deferasirox

monitor bleeding s/sx: combo may incr. risk of GI ulceration, perforation, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• defibrotide
Lexapro (escitalopram)

+

defibrotide

1 interaction

Monitor/Modify Tx

escitalopram + defibrotide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• degarelix
Lexapro (escitalopram)

+

degarelix

1 interaction

Monitor/Modify Tx

escitalopram + degarelix

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• desflurane
Lexapro (escitalopram)

+

desflurane

1 interaction

Monitor/Modify Tx

escitalopram + desflurane

monitor ECG, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment (additive effects)

• desmopressin
Lexapro (escitalopram)

+

desmopressin

1 interaction

Monitor/Modify Tx

escitalopram + desmopressin

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• deuruxolitinib
Lexapro (escitalopram)

+

deuruxolitinib

1 interaction

Monitor/Modify Tx

escitalopram + deuruxolitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dexmedetomidine
Lexapro (escitalopram)

+

dexmedetomidine

1 interaction

Monitor/Modify Tx

escitalopram + dexmedetomidine

monitor HR, ECG, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Lexapro (escitalopram)

+

dexmedetomidine injection

1 interaction

Monitor/Modify Tx

escitalopram + dexmedetomidine injection

monitor ECG, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment (additive effects)

• diazepam
Lexapro (escitalopram)

+

diazepam

1 interaction

Monitor/Modify Tx

escitalopram + diazepam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• diclofenac
Lexapro (escitalopram)

+

diclofenac

1 interaction

Monitor/Modify Tx

escitalopram + diclofenac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac ophthalmic
Lexapro (escitalopram)

+

diclofenac ophthalmic

1 interaction

Monitor/Modify Tx

escitalopram + diclofenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diclofenac topical
Lexapro (escitalopram)

+

diclofenac topical

1 interaction

Monitor/Modify Tx

escitalopram + diclofenac topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diflunisal
Lexapro (escitalopram)

+

diflunisal

1 interaction

Monitor/Modify Tx

escitalopram + diflunisal

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dimethyl fumarate
Lexapro (escitalopram)

+

dimethyl fumarate

1 interaction

Monitor/Modify Tx

escitalopram + dimethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dinutuximab
Lexapro (escitalopram)

+

dinutuximab

1 interaction

Monitor/Modify Tx

escitalopram + dinutuximab

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• diosmin
Lexapro (escitalopram)

+

diosmin

1 interaction

Monitor/Modify Tx

escitalopram + diosmin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• dipyridamole
Lexapro (escitalopram)

+

dipyridamole

1 interaction

Monitor/Modify Tx

escitalopram + dipyridamole

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• diroximel fumarate
Lexapro (escitalopram)

+

diroximel fumarate

1 interaction

Monitor/Modify Tx

escitalopram + diroximel fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• disopyramide
Lexapro (escitalopram)

+

disopyramide

1 interaction

Monitor/Modify Tx

escitalopram + disopyramide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• dofetilide
Lexapro (escitalopram)

+

dofetilide

1 interaction

Monitor/Modify Tx

escitalopram + dofetilide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• donepezil
Lexapro (escitalopram)

+

donepezil

1 interaction

Monitor/Modify Tx

escitalopram + donepezil

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• droperidol
Lexapro (escitalopram)

+

droperidol

1 interaction

Monitor/Modify Tx

escitalopram + droperidol

monitor ECG, decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• encorafenib
Lexapro (escitalopram)

+

encorafenib

1 interaction

Monitor/Modify Tx

escitalopram + encorafenib

monitor ECG, electrolytes, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, GI or other bleeding, incl. life-threatening; may decr. escitalopram levels, efficacy (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; hepatic metab. induced)

• epirubicin
Lexapro (escitalopram)

+

epirubicin

1 interaction

Monitor/Modify Tx

escitalopram + epirubicin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• epoprostenol
Lexapro (escitalopram)

+

epoprostenol

1 interaction

Monitor/Modify Tx

escitalopram + epoprostenol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eptifibatide
Lexapro (escitalopram)

+

eptifibatide

1 interaction

Monitor/Modify Tx

escitalopram + eptifibatide

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• eribulin
Lexapro (escitalopram)

+

eribulin

1 interaction

Monitor/Modify Tx

escitalopram + eribulin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• erlotinib
Lexapro (escitalopram)

+

erlotinib

1 interaction

Monitor/Modify Tx

escitalopram + erlotinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• erythromycin
Lexapro (escitalopram)

+

erythromycin

1 interaction

Monitor/Modify Tx

escitalopram + erythromycin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• esketamine
Lexapro (escitalopram)

+

esketamine

1 interaction

Monitor/Modify Tx

escitalopram + esketamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eslicarbazepine acetate
Lexapro (escitalopram)

+

eslicarbazepine acetate

1 interaction

Monitor/Modify Tx

escitalopram + eslicarbazepine acetate

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures, CNS depression, psychomotor impairment (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• esomeprazole
Lexapro (escitalopram)

+

esomeprazole

1 interaction

Monitor/Modify Tx

escitalopram + esomeprazole

consider monitoring ECG: combo may incr. escitalopram levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. possibly inhibited)

• estazolam
Lexapro (escitalopram)

+

estazolam

1 interaction

Monitor/Modify Tx

escitalopram + estazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• eszopiclone
Lexapro (escitalopram)

+

eszopiclone

1 interaction

Monitor/Modify Tx

escitalopram + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Lexapro (escitalopram)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

escitalopram + ethacrynic acid

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• ethanol (in some formulations)
Lexapro (escitalopram)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

escitalopram + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etodolac
Lexapro (escitalopram)

+

etodolac

1 interaction

Monitor/Modify Tx

escitalopram + etodolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• etomidate
Lexapro (escitalopram)

+

etomidate

1 interaction

Monitor/Modify Tx

escitalopram + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• evening primrose oil
Lexapro (escitalopram)

+

evening primrose oil

1 interaction

Monitor/Modify Tx

escitalopram + evening primrose oil

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenoprofen
Lexapro (escitalopram)

+

fenoprofen

1 interaction

Monitor/Modify Tx

escitalopram + fenoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fenugreek
Lexapro (escitalopram)

+

fenugreek

1 interaction

Monitor/Modify Tx

escitalopram + fenugreek

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flecainide
Lexapro (escitalopram)

+

flecainide

1 interaction

Monitor/Modify Tx

escitalopram + flecainide

monitor flecainide levels, ECG: combo may incr. flecainide levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited, additive effects)

• fluconazole
Lexapro (escitalopram)

+

fluconazole

1 interaction

Monitor/Modify Tx

escitalopram + fluconazole

monitor ECG: combo may incr. escitalopram levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. inhibited)

• fluorouracil
Lexapro (escitalopram)

+

fluorouracil

1 interaction

Monitor/Modify Tx

escitalopram + fluorouracil

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fluphenazine
Lexapro (escitalopram)

+

fluphenazine

1 interaction

Monitor/Modify Tx

escitalopram + fluphenazine

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• flurazepam
Lexapro (escitalopram)

+

flurazepam

1 interaction

Monitor/Modify Tx

escitalopram + flurazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• flurbiprofen
Lexapro (escitalopram)

+

flurbiprofen

1 interaction

Monitor/Modify Tx

escitalopram + flurbiprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• flurbiprofen ophthalmic
Lexapro (escitalopram)

+

flurbiprofen ophthalmic

1 interaction

Monitor/Modify Tx

escitalopram + flurbiprofen ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• fruquintinib
Lexapro (escitalopram)

+

fruquintinib

1 interaction

Monitor/Modify Tx

escitalopram + fruquintinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• furosemide
Lexapro (escitalopram)

+

furosemide

1 interaction

Monitor/Modify Tx

escitalopram + furosemide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• gabapentin
Lexapro (escitalopram)

+

gabapentin

1 interaction

Monitor/Modify Tx

escitalopram + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• gabapentin enacarbil
Lexapro (escitalopram)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

escitalopram + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• garlic
Lexapro (escitalopram)

+

garlic

1 interaction

Monitor/Modify Tx

escitalopram + garlic

monitor bleeding s/sx, especially w/ supplemental garlic; dietary intake OK: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gefitinib
Lexapro (escitalopram)

+

gefitinib

1 interaction

Monitor/Modify Tx

escitalopram + gefitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gemtuzumab ozogamicin
Lexapro (escitalopram)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

escitalopram + gemtuzumab ozogamicin

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• gilteritinib
Lexapro (escitalopram)

+

gilteritinib

1 interaction

Monitor/Modify Tx

escitalopram + gilteritinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. escitalopram efficacy (additive effects; mechanism unknown)

• ginkgo
Lexapro (escitalopram)

+

ginkgo

1 interaction

Monitor/Modify Tx

escitalopram + ginkgo

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• glasdegib
Lexapro (escitalopram)

+

glasdegib

1 interaction

Monitor/Modify Tx

escitalopram + glasdegib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• goserelin
Lexapro (escitalopram)

+

goserelin

1 interaction

Monitor/Modify Tx

escitalopram + goserelin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• haloperidol
Lexapro (escitalopram)

+

haloperidol

1 interaction

Monitor/Modify Tx

escitalopram + haloperidol

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, serotonin syndrome (additive effects)

• heparin
Lexapro (escitalopram)

+

heparin

1 interaction

Monitor/Modify Tx

escitalopram + heparin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• histrelin
Lexapro (escitalopram)

+

histrelin

1 interaction

Monitor/Modify Tx

escitalopram + histrelin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects, androgen deprivation prolongs QT)

• hydrochlorothiazide
Lexapro (escitalopram)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

escitalopram + hydrochlorothiazide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• hydrocortisone
Lexapro (escitalopram)

+

hydrocortisone

1 interaction

Monitor/Modify Tx

escitalopram + hydrocortisone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• hydroxyzine
Lexapro (escitalopram)

+

hydroxyzine

1 interaction

Monitor/Modify Tx

escitalopram + hydroxyzine

monitor ECG; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• ibrutinib
Lexapro (escitalopram)

+

ibrutinib

1 interaction

Monitor/Modify Tx

escitalopram + ibrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibuprofen
Lexapro (escitalopram)

+

ibuprofen

1 interaction

Monitor/Modify Tx

escitalopram + ibuprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibuprofen lysine
Lexapro (escitalopram)

+

ibuprofen lysine

1 interaction

Monitor/Modify Tx

escitalopram + ibuprofen lysine

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ibutilide
Lexapro (escitalopram)

+

ibutilide

1 interaction

Monitor/Modify Tx

escitalopram + ibutilide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• icosapent ethyl
Lexapro (escitalopram)

+

icosapent ethyl

1 interaction

Monitor/Modify Tx

escitalopram + icosapent ethyl

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ifosfamide
Lexapro (escitalopram)

+

ifosfamide

1 interaction

Monitor/Modify Tx

escitalopram + ifosfamide

monitor sodium; D/C one or both drugs if encephalopathy occurs: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia (additive effects)

• iloprost inhaled
Lexapro (escitalopram)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

escitalopram + iloprost inhaled

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• imatinib
Lexapro (escitalopram)

+

imatinib

1 interaction

Monitor/Modify Tx

escitalopram + imatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• indapamide
Lexapro (escitalopram)

+

indapamide

1 interaction

Monitor/Modify Tx

escitalopram + indapamide

monitor sodium: combo may incr. risk of severe hyponatremia (additive effects)

• indomethacin
Lexapro (escitalopram)

+

indomethacin

1 interaction

Monitor/Modify Tx

escitalopram + indomethacin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• inotuzumab ozogamicin
Lexapro (escitalopram)

+

inotuzumab ozogamicin

1 interaction

Monitor/Modify Tx

escitalopram + inotuzumab ozogamicin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• iopamidol
Lexapro (escitalopram)

+

iopamidol

1 interaction

Monitor/Modify Tx

escitalopram + iopamidol

caution advised if intrathecal iopamidol use; consider holding escitalopram at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• isoflurane
Lexapro (escitalopram)

+

isoflurane

1 interaction

Monitor/Modify Tx

escitalopram + isoflurane

monitor ECG, resp. rate: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment (additive effects)

• ivosidenib
Lexapro (escitalopram)

+

ivosidenib

1 interaction

Monitor/Modify Tx

escitalopram + ivosidenib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. escitalopram levels, efficacy (additive effects; hepatic metab. induced)

• ketamine
Lexapro (escitalopram)

+

ketamine

1 interaction

Monitor/Modify Tx

escitalopram + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

• ketoprofen
Lexapro (escitalopram)

+

ketoprofen

1 interaction

Monitor/Modify Tx

escitalopram + ketoprofen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ketorolac
Lexapro (escitalopram)

+

ketorolac

1 interaction

Monitor/Modify Tx

escitalopram + ketorolac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ketorolac ophthalmic
Lexapro (escitalopram)

+

ketorolac ophthalmic

1 interaction

Monitor/Modify Tx

escitalopram + ketorolac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lemborexant
Lexapro (escitalopram)

+

lemborexant

1 interaction

Monitor/Modify Tx

escitalopram + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenvatinib
Lexapro (escitalopram)

+

lenvatinib

1 interaction

Monitor/Modify Tx

escitalopram + lenvatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• leuprolide
Lexapro (escitalopram)

+

leuprolide

1 interaction

Monitor/Modify Tx

escitalopram + leuprolide

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects, androgen deprivation may prolong QT)

• levofloxacin
Lexapro (escitalopram)

+

levofloxacin

1 interaction

Monitor/Modify Tx

escitalopram + levofloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levoketoconazole
Lexapro (escitalopram)

+

levoketoconazole

1 interaction

Monitor/Modify Tx

escitalopram + levoketoconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lifileucel
Lexapro (escitalopram)

+

lifileucel

1 interaction

Monitor/Modify Tx

escitalopram + lifileucel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• lofexidine
Lexapro (escitalopram)

+

lofexidine

1 interaction

Monitor/Modify Tx

escitalopram + lofexidine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• lorazepam
Lexapro (escitalopram)

+

lorazepam

1 interaction

Monitor/Modify Tx

escitalopram + lorazepam

monitor resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• macimorelin
Lexapro (escitalopram)

+

macimorelin

1 interaction

Monitor/Modify Tx

escitalopram + macimorelin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• magnesium citrate
Lexapro (escitalopram)

+

magnesium citrate

1 interaction

Monitor/Modify Tx

escitalopram + magnesium citrate

monitor sodium, especially if magnesium citrate bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• magnesium salicylate
Lexapro (escitalopram)

+

magnesium salicylate

1 interaction

Monitor/Modify Tx

escitalopram + magnesium salicylate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mannitol
Lexapro (escitalopram)

+

mannitol

1 interaction

Monitor/Modify Tx

escitalopram + mannitol

monitor sodium: combo may incr. risk of hyponatremia (incl. life-threatening), seizures (additive effects)

• meclofenamate
Lexapro (escitalopram)

+

meclofenamate

1 interaction

Monitor/Modify Tx

escitalopram + meclofenamate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mefenamic acid
Lexapro (escitalopram)

+

mefenamic acid

1 interaction

Monitor/Modify Tx

escitalopram + mefenamic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• meloxicam
Lexapro (escitalopram)

+

meloxicam

1 interaction

Monitor/Modify Tx

escitalopram + meloxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• methohexital
Lexapro (escitalopram)

+

methohexital

1 interaction

Monitor/Modify Tx

escitalopram + methohexital

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methotrexate
Lexapro (escitalopram)

+

methotrexate

1 interaction

Monitor/Modify Tx

escitalopram + methotrexate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• methyl salicylate topical
Lexapro (escitalopram)

+

methyl salicylate topical

1 interaction

Monitor/Modify Tx

escitalopram + methyl salicylate topical

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• metolazone
Lexapro (escitalopram)

+

metolazone

1 interaction

Monitor/Modify Tx

escitalopram + metolazone

monitor sodium: combo may incr. risk of hyponatremia, incl. life-threatening (additive effects)

• mitotane
Lexapro (escitalopram)

+

mitotane

1 interaction

Monitor/Modify Tx

escitalopram + mitotane

monitor bleeding s/sx: combo may decr. escitalopram levels, efficacy; may incr. risk of CNS depression, psychomotor impairment, bleeding, incl. life-threatening (hepatic metab. induced; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• monomethyl fumarate
Lexapro (escitalopram)

+

monomethyl fumarate

1 interaction

Monitor/Modify Tx

escitalopram + monomethyl fumarate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• moxifloxacin
Lexapro (escitalopram)

+

moxifloxacin

1 interaction

Monitor/Modify Tx

escitalopram + moxifloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mycophenolate mofetil
Lexapro (escitalopram)

+

mycophenolate mofetil

1 interaction

Monitor/Modify Tx

escitalopram + mycophenolate mofetil

monitor bleeding s/sx: combo may incr. risk of CNS depression, psychomotor impairment, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• mycophenolic acid
Lexapro (escitalopram)

+

mycophenolic acid

1 interaction

Monitor/Modify Tx

escitalopram + mycophenolic acid

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nabumetone
Lexapro (escitalopram)

+

nabumetone

1 interaction

Monitor/Modify Tx

escitalopram + nabumetone

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• naproxen
Lexapro (escitalopram)

+

naproxen

1 interaction

Monitor/Modify Tx

escitalopram + naproxen

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nattokinase
Lexapro (escitalopram)

+

nattokinase

1 interaction

Monitor/Modify Tx

escitalopram + nattokinase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nelarabine
Lexapro (escitalopram)

+

nelarabine

1 interaction

Monitor/Modify Tx

escitalopram + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nepafenac ophthalmic
Lexapro (escitalopram)

+

nepafenac ophthalmic

1 interaction

Monitor/Modify Tx

escitalopram + nepafenac ophthalmic

monitor bleeding s/sx: combo may incr. risk of postop ocular bleeding (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• niacin (vitamin B3)
Lexapro (escitalopram)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

escitalopram + niacin (vitamin B3)

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nintedanib
Lexapro (escitalopram)

+

nintedanib

1 interaction

Monitor/Modify Tx

escitalopram + nintedanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• nusinersen
Lexapro (escitalopram)

+

nusinersen

1 interaction

Monitor/Modify Tx

escitalopram + nusinersen

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• olanzapine
Lexapro (escitalopram)

+

olanzapine

1 interaction

Monitor/Modify Tx

escitalopram + olanzapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis (additive effects)

• omega-3-acid
Lexapro (escitalopram)

+

omega-3-acid

1 interaction

Monitor/Modify Tx

escitalopram + omega-3-acid

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• omeprazole
Lexapro (escitalopram)

+

omeprazole

1 interaction

Monitor/Modify Tx

escitalopram + omeprazole

consider monitoring ECG: combo may incr. escitalopram levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metab. possibly inhibited)

• opicapone
Lexapro (escitalopram)

+

opicapone

1 interaction

Monitor/Modify Tx

escitalopram + opicapone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• osimertinib
Lexapro (escitalopram)

+

osimertinib

1 interaction

Monitor/Modify Tx

escitalopram + osimertinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxaliplatin
Lexapro (escitalopram)

+

oxaliplatin

1 interaction

Monitor/Modify Tx

escitalopram + oxaliplatin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxaprozin
Lexapro (escitalopram)

+

oxaprozin

1 interaction

Monitor/Modify Tx

escitalopram + oxaprozin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• oxazepam
Lexapro (escitalopram)

+

oxazepam

1 interaction

Monitor/Modify Tx

escitalopram + oxazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• oxcarbazepine
Lexapro (escitalopram)

+

oxcarbazepine

1 interaction

Monitor/Modify Tx

escitalopram + oxcarbazepine

monitor sodium: combo may incr. risk of hyponatremia, seizures, CNS depression, psychomotor impairment (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• oxybutynin
Lexapro (escitalopram)

+

oxybutynin

1 interaction

Monitor/Modify Tx

escitalopram + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxytocin
Lexapro (escitalopram)

+

oxytocin

1 interaction

Monitor/Modify Tx

escitalopram + oxytocin

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• pacritinib
Lexapro (escitalopram)

+

pacritinib

1 interaction

Monitor/Modify Tx

escitalopram + pacritinib

monitor ECG, electrolytes, platelets, bleeding s/sx: combo may decr. escitalopram levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias, bleeding, incl. life-threatening (hepatic metab. induced; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• paliperidone
Lexapro (escitalopram)

+

paliperidone

1 interaction

Monitor/Modify Tx

escitalopram + paliperidone

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• panobinostat
Lexapro (escitalopram)

+

panobinostat

1 interaction

Monitor/Modify Tx

escitalopram + panobinostat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pasireotide
Lexapro (escitalopram)

+

pasireotide

1 interaction

Monitor/Modify Tx

escitalopram + pasireotide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pazopanib
Lexapro (escitalopram)

+

pazopanib

1 interaction

Monitor/Modify Tx

escitalopram + pazopanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pegaspargase
Lexapro (escitalopram)

+

pegaspargase

1 interaction

Monitor/Modify Tx

escitalopram + pegaspargase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• penicillin G
Lexapro (escitalopram)

+

penicillin G

1 interaction

Monitor/Modify Tx

escitalopram + penicillin G

monitor bleeding s/sx, especially w/ large penicillin G doses and/or concomitant renal impairment: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pentamidine
Lexapro (escitalopram)

+

pentamidine

1 interaction

Monitor/Modify Tx

escitalopram + pentamidine

monitor ECG; risk may be lower w/ nebulized pentamidine: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pentobarbital
Lexapro (escitalopram)

+

pentobarbital

1 interaction

Monitor/Modify Tx

escitalopram + pentobarbital

monitor resp. rate: combo may decr. escitalopram levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• pentosan polysulfate sodium
Lexapro (escitalopram)

+

pentosan polysulfate sodium

1 interaction

Monitor/Modify Tx

escitalopram + pentosan polysulfate sodium

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pentoxifylline
Lexapro (escitalopram)

+

pentoxifylline

1 interaction

Monitor/Modify Tx

escitalopram + pentoxifylline

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• perphenazine
Lexapro (escitalopram)

+

perphenazine

1 interaction

Monitor/Modify Tx

escitalopram + perphenazine

consider decr. dose of one or both drugs: combo may incr. perphenazine levels, risk of CNS depression, psychomotor impairment, other adverse effects (hepatic metab. inhibited, additive effects)

• phenobarbital
Lexapro (escitalopram)

+

phenobarbital

1 interaction

Monitor/Modify Tx

escitalopram + phenobarbital

monitor resp. rate: combo may decr. escitalopram levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• piperacillin
Lexapro (escitalopram)

+

piperacillin

1 interaction

Monitor/Modify Tx

escitalopram + piperacillin

monitor bleeding s/sx, especially w/ prolonged piperacillin tx and/or concomitant renal impairment: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• piroxicam
Lexapro (escitalopram)

+

piroxicam

1 interaction

Monitor/Modify Tx

escitalopram + piroxicam

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pirtobrutinib
Lexapro (escitalopram)

+

pirtobrutinib

1 interaction

Monitor/Modify Tx

escitalopram + pirtobrutinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• plasminogen, human
Lexapro (escitalopram)

+

plasminogen, human

1 interaction

Monitor/Modify Tx

escitalopram + plasminogen, human

monitor bleeding s/sx, especially during and x4h after plasminogen infusion: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• polyethylene glycol
Lexapro (escitalopram)

+

polyethylene glycol

1 interaction

Monitor/Modify Tx

escitalopram + polyethylene glycol

monitor sodium, especially if polyethylene glycol bowel prep use: combo may incr. risk of hyponatremia, seizures (additive effects)

• polyethylene glycol/electrolytes
Lexapro (escitalopram)

+

polyethylene glycol/ electrolytes

1 interaction

Monitor/Modify Tx

escitalopram + polyethylene glycol/ electrolytes

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• ponatinib
Lexapro (escitalopram)

+

ponatinib

1 interaction

Monitor/Modify Tx

escitalopram + ponatinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• porfimer
Lexapro (escitalopram)

+

porfimer

1 interaction

Monitor/Modify Tx

escitalopram + porfimer

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pralsetinib
Lexapro (escitalopram)

+

pralsetinib

1 interaction

Monitor/Modify Tx

escitalopram + pralsetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• prasugrel
Lexapro (escitalopram)

+

prasugrel

1 interaction

Monitor/Modify Tx

escitalopram + prasugrel

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• pregabalin
Lexapro (escitalopram)

+

pregabalin

1 interaction

Monitor/Modify Tx

escitalopram + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• primidone
Lexapro (escitalopram)

+

primidone

1 interaction

Monitor/Modify Tx

escitalopram + primidone

monitor resp. rate: combo may decr. escitalopram levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; additive effects; antagonistic effects, escitalopram may decr. seizure threshold)

• procainamide
Lexapro (escitalopram)

+

procainamide

1 interaction

Monitor/Modify Tx

escitalopram + procainamide

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• propofol
Lexapro (escitalopram)

+

propofol

1 interaction

Monitor/Modify Tx

escitalopram + propofol

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• propranolol
Lexapro (escitalopram)

+

propranolol

1 interaction

Monitor/Modify Tx

escitalopram + propranolol

monitor BP, HR: combo may incr. propranolol levels, risk of hypotension, bradycardia, AV block, other adverse effects (hepatic metab. inhibited)

• quazepam
Lexapro (escitalopram)

+

quazepam

1 interaction

Monitor/Modify Tx

escitalopram + quazepam

monitor resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• quinidine (antiarrhythmic)
Lexapro (escitalopram)

+

quinidine (antiarrhythmic)

1 interaction

Monitor/Modify Tx

escitalopram + quinidine (antiarrhythmic)

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• quinidine (CYP2D6 inhibitor)
Lexapro (escitalopram)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Monitor/Modify Tx

escitalopram + quinidine (CYP2D6 inhibitor)

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• quinine
Lexapro (escitalopram)

+

quinine

1 interaction

Monitor/Modify Tx

escitalopram + quinine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ramucirumab
Lexapro (escitalopram)

+

ramucirumab

1 interaction

Monitor/Modify Tx

escitalopram + ramucirumab

monitor sodium, bleeding s/sx: combo may incr. risk of hyponatremia, GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ranibizumab
Lexapro (escitalopram)

+

ranibizumab

1 interaction

Monitor/Modify Tx

escitalopram + ranibizumab

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• regorafenib
Lexapro (escitalopram)

+

regorafenib

1 interaction

Monitor/Modify Tx

escitalopram + regorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• remimazolam
Lexapro (escitalopram)

+

remimazolam

1 interaction

Monitor/Modify Tx

escitalopram + remimazolam

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• resveratrol
Lexapro (escitalopram)

+

resveratrol

1 interaction

Monitor/Modify Tx

escitalopram + resveratrol

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• reteplase
Lexapro (escitalopram)

+

reteplase

1 interaction

Monitor/Modify Tx

escitalopram + reteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• revakinagene taroretcel
Lexapro (escitalopram)

+

revakinagene taroretcel

1 interaction

Monitor/Modify Tx

escitalopram + revakinagene taroretcel

monitor bleeding s/sx: combo may incr. risk of ocular hemorrhage (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• revumenib
Lexapro (escitalopram)

+

revumenib

1 interaction

Monitor/Modify Tx

escitalopram + revumenib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ribociclib
Lexapro (escitalopram)

+

ribociclib

1 interaction

Monitor/Modify Tx

escitalopram + ribociclib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rivaroxaban
Lexapro (escitalopram)

+

rivaroxaban

1 interaction

Monitor/Modify Tx

escitalopram + rivaroxaban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• romidepsin
Lexapro (escitalopram)

+

romidepsin

1 interaction

Monitor/Modify Tx

escitalopram + romidepsin

monitor ECG, sodium: combo may incr. risk of QT prolongation, cardiac arrhythmias, hyponatremia (additive effects)

• rucaparib
Lexapro (escitalopram)

+

rucaparib

1 interaction

Monitor/Modify Tx

escitalopram + rucaparib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• safinamide
Lexapro (escitalopram)

+

safinamide

1 interaction

Monitor/Modify Tx

escitalopram + safinamide

monitor serotonin syndrome sx, especially during initiation/titration; use lowest effective doses: combo may incr. risk of serotonin syndrome, CNS depression, psychomotor impairment (additive effects)

• salsalate
Lexapro (escitalopram)

+

salsalate

1 interaction

Monitor/Modify Tx

escitalopram + salsalate

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• saw palmetto
Lexapro (escitalopram)

+

saw palmetto

1 interaction

Monitor/Modify Tx

escitalopram + saw palmetto

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• selinexor
Lexapro (escitalopram)

+

selinexor

1 interaction

Monitor/Modify Tx

escitalopram + selinexor

monitor sodium: combo may incr. risk of CNS depression, psychomotor impairment, hyponatremia, incl. life-threatening (additive effects)

• selpercatinib
Lexapro (escitalopram)

+

selpercatinib

1 interaction

Monitor/Modify Tx

escitalopram + selpercatinib

monitor ECG, electrolytes, bleeding s/sx: combo may incr. risk of QT prolongation, cardiac arrhythmias, bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• selumetinib
Lexapro (escitalopram)

+

selumetinib

1 interaction

Monitor/Modify Tx

escitalopram + selumetinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet and anticoagulant effects augmented by SSRI inhibition of platelet serotonin uptake and vitamin E content in selumetinib capsules)

• sevoflurane
Lexapro (escitalopram)

+

sevoflurane

1 interaction

Monitor/Modify Tx

escitalopram + sevoflurane

monitor ECG, resp. rate: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment (additive effects)

• sirolimus albumin-bound
Lexapro (escitalopram)

+

sirolimus albumin-bound

1 interaction

Monitor/Modify Tx

escitalopram + sirolimus albumin-bound

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sorafenib
Lexapro (escitalopram)

+

sorafenib

1 interaction

Monitor/Modify Tx

escitalopram + sorafenib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sotatercept
Lexapro (escitalopram)

+

sotatercept

1 interaction

Monitor/Modify Tx

escitalopram + sotatercept

monitor platelets, bleeding s/sx: combo may incr. risk of bleeding, incl. severe or life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• spironolactone
Lexapro (escitalopram)

+

spironolactone

1 interaction

Monitor/Modify Tx

escitalopram + spironolactone

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• sulfate bowel prep
Lexapro (escitalopram)

+

sulfate bowel prep

1 interaction

Monitor/Modify Tx

escitalopram + sulfate bowel prep

monitor sodium: combo may incr. risk of hyponatremia, seizures (additive effects)

• sulindac
Lexapro (escitalopram)

+

sulindac

1 interaction

Monitor/Modify Tx

escitalopram + sulindac

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• sunitinib
Lexapro (escitalopram)

+

sunitinib

1 interaction

Monitor/Modify Tx

escitalopram + sunitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• suvorexant
Lexapro (escitalopram)

+

suvorexant

1 interaction

Monitor/Modify Tx

escitalopram + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• telavancin
Lexapro (escitalopram)

+

telavancin

1 interaction

Monitor/Modify Tx

escitalopram + telavancin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• temazepam
Lexapro (escitalopram)

+

temazepam

1 interaction

Monitor/Modify Tx

escitalopram + temazepam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• tenecteplase
Lexapro (escitalopram)

+

tenecteplase

1 interaction

Monitor/Modify Tx

escitalopram + tenecteplase

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tetrabenazine
Lexapro (escitalopram)

+

tetrabenazine

1 interaction

Monitor/Modify Tx

escitalopram + tetrabenazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• thiothixene
Lexapro (escitalopram)

+

thiothixene

1 interaction

Monitor/Modify Tx

escitalopram + thiothixene

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ticagrelor
Lexapro (escitalopram)

+

ticagrelor

1 interaction

Monitor/Modify Tx

escitalopram + ticagrelor

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tipranavir
Lexapro (escitalopram)

+

tipranavir

1 interaction

Monitor/Modify Tx

escitalopram + tipranavir

monitor bleeding s/sx: combo may decr. escitalopram levels, efficacy; may incr. risk of bleeding, incl. life-threatening (hepatic metab. induced; additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tirofiban
Lexapro (escitalopram)

+

tirofiban

1 interaction

Monitor/Modify Tx

escitalopram + tirofiban

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tisotumab vedotin
Lexapro (escitalopram)

+

tisotumab vedotin

1 interaction

Monitor/Modify Tx

escitalopram + tisotumab vedotin

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tivozanib
Lexapro (escitalopram)

+

tivozanib

1 interaction

Monitor/Modify Tx

escitalopram + tivozanib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• tolmetin
Lexapro (escitalopram)

+

tolmetin

1 interaction

Monitor/Modify Tx

escitalopram + tolmetin

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• torsemide
Lexapro (escitalopram)

+

torsemide

1 interaction

Monitor/Modify Tx

escitalopram + torsemide

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• tovorafenib
Lexapro (escitalopram)

+

tovorafenib

1 interaction

Monitor/Modify Tx

escitalopram + tovorafenib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• trametinib
Lexapro (escitalopram)

+

trametinib

1 interaction

Monitor/Modify Tx

escitalopram + trametinib

monitor bleeding s/sx, especially w/ concomitant dabrafenib use: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• treprostinil
Lexapro (escitalopram)

+

treprostinil

1 interaction

Monitor/Modify Tx

escitalopram + treprostinil

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• triamterene
Lexapro (escitalopram)

+

triamterene

1 interaction

Monitor/Modify Tx

escitalopram + triamterene

monitor sodium: combo may incr. risk of hyponatremia (additive effects)

• triazolam
Lexapro (escitalopram)

+

triazolam

1 interaction

Monitor/Modify Tx

escitalopram + triazolam

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• triclabendazole
Lexapro (escitalopram)

+

triclabendazole

1 interaction

Monitor/Modify Tx

escitalopram + triclabendazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trifluridine
Lexapro (escitalopram)

+

trifluridine

1 interaction

Monitor/Modify Tx

escitalopram + trifluridine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• triptorelin
Lexapro (escitalopram)

+

triptorelin

1 interaction

Monitor/Modify Tx

escitalopram + triptorelin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects, androgen deprivation prolongs QT)

• upadacitinib
Lexapro (escitalopram)

+

upadacitinib

1 interaction

Monitor/Modify Tx

escitalopram + upadacitinib

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vadadustat
Lexapro (escitalopram)

+

vadadustat

1 interaction

Monitor/Modify Tx

escitalopram + vadadustat

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• valproic acid
Lexapro (escitalopram)

+

valproic acid

1 interaction

Monitor/Modify Tx

escitalopram + valproic acid

monitor bleeding s/sx: combo may incr. risk of bleeding (incl. life-threatening), CNS depression, psychomotor impairment; may alter seizure control (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; antagonistic effects, escitalopram may decr. seizure threshold)

• vasopressin
Lexapro (escitalopram)

+

vasopressin

1 interaction

Monitor/Modify Tx

escitalopram + vasopressin

monitor BP, sodium: combo may incr. pressor response, risk of hyponatremia (additive effects)

• vemurafenib
Lexapro (escitalopram)

+

vemurafenib

1 interaction

Monitor/Modify Tx

escitalopram + vemurafenib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• vinpocetine
Lexapro (escitalopram)

+

vinpocetine

1 interaction

Monitor/Modify Tx

escitalopram + vinpocetine

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• vorapaxar
Lexapro (escitalopram)

+

vorapaxar

1 interaction

Monitor/Modify Tx

escitalopram + vorapaxar

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• warfarin
Lexapro (escitalopram)

+

warfarin

1 interaction

Monitor/Modify Tx

escitalopram + warfarin

monitor INR, bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (synergistic effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• willow bark
Lexapro (escitalopram)

+

willow bark

1 interaction

Monitor/Modify Tx

escitalopram + willow bark

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake; willow bark may contain salicylates)

• zaleplon
Lexapro (escitalopram)

+

zaleplon

1 interaction

Monitor/Modify Tx

escitalopram + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zanubrutinib
Lexapro (escitalopram)

+

zanubrutinib

1 interaction

Monitor/Modify Tx

escitalopram + zanubrutinib

monitor bleeding s/sx: combo may incr. risk of bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• ziconotide
Lexapro (escitalopram)

+

ziconotide

1 interaction

Monitor/Modify Tx

escitalopram + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziv-aflibercept
Lexapro (escitalopram)

+

ziv-aflibercept

1 interaction

Monitor/Modify Tx

escitalopram + ziv-aflibercept

monitor bleeding s/sx: combo may incr. risk of GI or other bleeding, incl. life-threatening (additive effects, antiplatelet effects augmented by inhibition of platelet serotonin uptake)

• zolpidem
Lexapro (escitalopram)

+

zolpidem

1 interaction

Monitor/Modify Tx

escitalopram + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)