Fanapt

Overview

iloperidone

atypical antipsychotic

• CYP2D6 substrate
• CYP3A4 substrate
• CNS depression
• decreases central histamine effects
• dopamine antagonist
• extrapyramidal effects
• hyperglycemic effects
• hyperprolactinemic effects
• hyperthermia
• hypotensive effects
• lowers seizure threshold
• prolongs QT interval (conditional)

Contraindicated

• pimozide
Fanapt (iloperidone)

+

pimozide

1 interaction

Contraindicated

iloperidone + pimozide

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia (additive effects)

• quinidine (CYP2D6 inhibitor)
Fanapt (iloperidone)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Contraindicated

iloperidone + quinidine (CYP2D6 inhibitor)

contraindicated: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• thioridazine
Fanapt (iloperidone)

+

thioridazine

1 interaction

Contraindicated

iloperidone + thioridazine

contraindicated: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, additive effects)

Avoid/Use Alternative

• adagrasib
Fanapt (iloperidone)

+

adagrasib

1 interaction

Avoid/Use Alternative

iloperidone + adagrasib

use alternative or monitor ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• aldesleukin
Fanapt (iloperidone)

+

aldesleukin

1 interaction

Avoid/Use Alternative

iloperidone + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, severe or life-threatening hypotension (including orthostasis, syncope), seizures (additive effects)

• alfuzosin
Fanapt (iloperidone)

+

alfuzosin

1 interaction

Avoid/Use Alternative

iloperidone + alfuzosin

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• amifampridine
Fanapt (iloperidone)

+

amifampridine

1 interaction

Avoid/Use Alternative

iloperidone + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amiodarone
Fanapt (iloperidone)

+

amiodarone

1 interaction

Avoid/Use Alternative

iloperidone + amiodarone

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• anagrelide
Fanapt (iloperidone)

+

anagrelide

1 interaction

Avoid/Use Alternative

iloperidone + anagrelide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• apalutamide
Fanapt (iloperidone)

+

apalutamide

1 interaction

Avoid/Use Alternative

iloperidone + apalutamide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• apomorphine
Fanapt (iloperidone)

+

apomorphine

1 interaction

Avoid/Use Alternative

iloperidone + apomorphine

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• aripiprazole bimonthly injection
Fanapt (iloperidone)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

iloperidone + aripiprazole bimonthly injection

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• aripiprazole lauroxil
Fanapt (iloperidone)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

iloperidone + aripiprazole lauroxil

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• aripiprazole monthly injection
Fanapt (iloperidone)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

iloperidone + aripiprazole monthly injection

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• aripiprazole oral
Fanapt (iloperidone)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

iloperidone + aripiprazole oral

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• arsenic trioxide
Fanapt (iloperidone)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

iloperidone + arsenic trioxide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• artemether/lumefantrine
Fanapt (iloperidone)

+

artemether/ lumefantrine

1 interaction

Avoid/Use Alternative

iloperidone + artemether/ lumefantrine

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• asenapine
Fanapt (iloperidone)

+

asenapine

1 interaction

Avoid/Use Alternative

iloperidone + asenapine

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• azithromycin
Fanapt (iloperidone)

+

azithromycin

1 interaction

Avoid/Use Alternative

iloperidone + azithromycin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bedaquiline
Fanapt (iloperidone)

+

bedaquiline

1 interaction

Avoid/Use Alternative

iloperidone + bedaquiline

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• benztropine
Fanapt (iloperidone)

+

benztropine

1 interaction

Avoid/Use Alternative

iloperidone + benztropine

consider alternative: combo may incr. risk of hyperthermia, including life-threatening (additive effects)

• brexpiprazole
Fanapt (iloperidone)

+

brexpiprazole

1 interaction

Avoid/Use Alternative

iloperidone + brexpiprazole

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, extrapyramidal symptoms, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• bromocriptine
Fanapt (iloperidone)

+

bromocriptine

1 interaction

Avoid/Use Alternative

iloperidone + bromocriptine

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• butalbital
Fanapt (iloperidone)

+

butalbital

1 interaction

Avoid/Use Alternative

iloperidone + butalbital

avoid combo: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• cabergoline
Fanapt (iloperidone)

+

cabergoline

1 interaction

Avoid/Use Alternative

iloperidone + cabergoline

use alternative: combo may incr. risk of hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• cabozantinib
Fanapt (iloperidone)

+

cabozantinib

1 interaction

Avoid/Use Alternative

iloperidone + cabozantinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• cariprazine
Fanapt (iloperidone)

+

cariprazine

1 interaction

Avoid/Use Alternative

iloperidone + cariprazine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• ceritinib
Fanapt (iloperidone)

+

ceritinib

1 interaction

Avoid/Use Alternative

iloperidone + ceritinib

use alternative or monitor ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• chloroquine
Fanapt (iloperidone)

+

chloroquine

1 interaction

Avoid/Use Alternative

iloperidone + chloroquine

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, extrapyramidal symptoms (additive effects)

• cisapride
Fanapt (iloperidone)

+

cisapride

1 interaction

Avoid/Use Alternative

iloperidone + cisapride

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• citalopram
Fanapt (iloperidone)

+

citalopram

1 interaction

Avoid/Use Alternative

iloperidone + citalopram

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• clarithromycin
Fanapt (iloperidone)

+

clarithromycin

1 interaction

Avoid/Use Alternative

iloperidone + clarithromycin

use alternative or monitor ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• clofazimine
Fanapt (iloperidone)

+

clofazimine

1 interaction

Avoid/Use Alternative

iloperidone + clofazimine

use alternative or monitor ECG, electrolytes: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• clonidine
Fanapt (iloperidone)

+

clonidine

1 interaction

Avoid/Use Alternative

iloperidone + clonidine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• clozapine
Fanapt (iloperidone)

+

clozapine

1 interaction

Avoid/Use Alternative

iloperidone + clozapine

use alternative or monitor BP, HR: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, seizures, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• codeine
Fanapt (iloperidone)

+

codeine

1 interaction

Avoid/Use Alternative

iloperidone + codeine

avoid combo if antitussive use; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• crizotinib
Fanapt (iloperidone)

+

crizotinib

1 interaction

Avoid/Use Alternative

iloperidone + crizotinib

use alternative or monitor ECG, electrolytes: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• degarelix
Fanapt (iloperidone)

+

degarelix

1 interaction

Avoid/Use Alternative

iloperidone + degarelix

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• desflurane
Fanapt (iloperidone)

+

desflurane

1 interaction

Avoid/Use Alternative

iloperidone + desflurane

use alternative or monitor ECG, BP, respiratory rate, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• desipramine
Fanapt (iloperidone)

+

desipramine

1 interaction

Avoid/Use Alternative

iloperidone + desipramine

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• dexmedetomidine
Fanapt (iloperidone)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

iloperidone + dexmedetomidine

use alternative or monitor BP, HR, ECG, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), CNS depression, psychomotor impairment (additive effects)

• dexmedetomidine injection
Fanapt (iloperidone)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

iloperidone + dexmedetomidine injection

use alternative or monitor ECG, BP, respiratory rate, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and respiratory depression, psychomotor impairment, severe or life-threatening hypotension, including orthostasis, syncope (additive effects)

• disopyramide
Fanapt (iloperidone)

+

disopyramide

1 interaction

Avoid/Use Alternative

iloperidone + disopyramide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hyperthermia (additive effects)

• dofetilide
Fanapt (iloperidone)

+

dofetilide

1 interaction

Avoid/Use Alternative

iloperidone + dofetilide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• domperidone
Fanapt (iloperidone)

+

domperidone

1 interaction

Avoid/Use Alternative

iloperidone + domperidone

use alternative or monitor ECG, HR, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• donepezil
Fanapt (iloperidone)

+

donepezil

1 interaction

Avoid/Use Alternative

iloperidone + donepezil

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• dordaviprone
Fanapt (iloperidone)

+

dordaviprone

1 interaction

Avoid/Use Alternative

iloperidone + dordaviprone

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• doxazosin
Fanapt (iloperidone)

+

doxazosin

1 interaction

Avoid/Use Alternative

iloperidone + doxazosin

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• doxylamine
Fanapt (iloperidone)

+

doxylamine

1 interaction

Avoid/Use Alternative

iloperidone + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• dronedarone
Fanapt (iloperidone)

+

dronedarone

1 interaction

Avoid/Use Alternative

iloperidone + dronedarone

use alternative or monitor ECG, electrolytes: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• droperidol
Fanapt (iloperidone)

+

droperidol

1 interaction

Avoid/Use Alternative

iloperidone + droperidol

use alternative or monitor ECG, electrolytes; decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• encorafenib
Fanapt (iloperidone)

+

encorafenib

1 interaction

Avoid/Use Alternative

iloperidone + encorafenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ephedra
Fanapt (iloperidone)

+

ephedra

1 interaction

Avoid/Use Alternative

iloperidone + ephedra

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• epirubicin
Fanapt (iloperidone)

+

epirubicin

1 interaction

Avoid/Use Alternative

iloperidone + epirubicin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• eribulin
Fanapt (iloperidone)

+

eribulin

1 interaction

Avoid/Use Alternative

iloperidone + eribulin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• erythromycin
Fanapt (iloperidone)

+

erythromycin

1 interaction

Avoid/Use Alternative

iloperidone + erythromycin

use alternative or monitor ECG, electrolytes: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• ethanol (alcoholic beverage)
Fanapt (iloperidone)

+

ethanol (alcoholic beverage)

1 interaction

Avoid/Use Alternative

iloperidone + ethanol (alcoholic beverage)

avoid combo: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• ethanol injection
Fanapt (iloperidone)

+

ethanol injection

1 interaction

Avoid/Use Alternative

iloperidone + ethanol injection

use alternative or monitor respiratory rate, BP: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• fexinidazole
Fanapt (iloperidone)

+

fexinidazole

1 interaction

Avoid/Use Alternative

iloperidone + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after iloperidone D/C; use alternative or monitor ECG, electrolytes during and x7 days after fexinidazole tx: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• flecainide
Fanapt (iloperidone)

+

flecainide

1 interaction

Avoid/Use Alternative

iloperidone + flecainide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fluorouracil
Fanapt (iloperidone)

+

fluorouracil

1 interaction

Avoid/Use Alternative

iloperidone + fluorouracil

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fosfomycin injection
Fanapt (iloperidone)

+

fosfomycin injection

1 interaction

Avoid/Use Alternative

iloperidone + fosfomycin injection

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• gilteritinib
Fanapt (iloperidone)

+

gilteritinib

1 interaction

Avoid/Use Alternative

iloperidone + gilteritinib

use alternative or monitor ECG, electrolytes, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, including orthostasis, syncope (additive effects)

• glasdegib
Fanapt (iloperidone)

+

glasdegib

1 interaction

Avoid/Use Alternative

iloperidone + glasdegib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• goserelin
Fanapt (iloperidone)

+

goserelin

1 interaction

Avoid/Use Alternative

iloperidone + goserelin

PROSTATE CANCER: use alternative or monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. goserelin efficacy (additive effects, androgen deprivation may prolong QT; iloperidone may cause hyperprolactinemia, decr. GnRH receptors)

• haloperidol
Fanapt (iloperidone)

+

haloperidol

1 interaction

Avoid/Use Alternative

iloperidone + haloperidol

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• hydrocodone
Fanapt (iloperidone)

+

hydrocodone

1 interaction

Avoid/Use Alternative

iloperidone + hydrocodone

avoid combo if antitussive use; otherwise, monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• hydroxychloroquine
Fanapt (iloperidone)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

iloperidone + hydroxychloroquine

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

• hydroxyzine
Fanapt (iloperidone)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

iloperidone + hydroxyzine

use alternative or monitor ECG, electrolytes; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia (additive effects)

• ibutilide
Fanapt (iloperidone)

+

ibutilide

1 interaction

Avoid/Use Alternative

iloperidone + ibutilide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• iloperidone
Fanapt (iloperidone)

+

iloperidone

1 interaction

Avoid/Use Alternative

iloperidone + iloperidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• inotuzumab ozogamicin
Fanapt (iloperidone)

+

inotuzumab ozogamicin

1 interaction

Avoid/Use Alternative

iloperidone + inotuzumab ozogamicin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• isocarboxazid
Fanapt (iloperidone)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

iloperidone + isocarboxazid

use alternative during and x10 days after isocarboxazid use: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• isoflurane
Fanapt (iloperidone)

+

isoflurane

1 interaction

Avoid/Use Alternative

iloperidone + isoflurane

use alternative or monitor BP, ECG, respiratory rate, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• ivosidenib
Fanapt (iloperidone)

+

ivosidenib

1 interaction

Avoid/Use Alternative

iloperidone + ivosidenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• kava
Fanapt (iloperidone)

+

kava

1 interaction

Avoid/Use Alternative

iloperidone + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• kratom
Fanapt (iloperidone)

+

kratom

1 interaction

Avoid/Use Alternative

iloperidone + kratom

use alternative or monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment (additive effects)

• lefamulin
Fanapt (iloperidone)

+

lefamulin

1 interaction

Avoid/Use Alternative

iloperidone + lefamulin

use alternative or monitor ECG, electrolytes: combo with oral lefamulin may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects; combo with IV lefamulin may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metabolism inhibited, additive effects)

• leuprolide
Fanapt (iloperidone)

+

leuprolide

1 interaction

Avoid/Use Alternative

iloperidone + leuprolide

PROSTATE CANCER: use alternative or monitor ECG, electrolytes; ALL OTHER INDICATIONS: consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. leuprolide efficacy (additive effects, androgen deprivation may prolong QT; iloperidone may cause hyperprolactinemia, decr. GnRH receptors)

• levofloxacin
Fanapt (iloperidone)

+

levofloxacin

1 interaction

Avoid/Use Alternative

iloperidone + levofloxacin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levoketoconazole
Fanapt (iloperidone)

+

levoketoconazole

1 interaction

Avoid/Use Alternative

iloperidone + levoketoconazole

use alternative or monitor ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• lofexidine
Fanapt (iloperidone)

+

lofexidine

1 interaction

Avoid/Use Alternative

iloperidone + lofexidine

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• lonafarnib
Fanapt (iloperidone)

+

lonafarnib

1 interaction

Avoid/Use Alternative

iloperidone + lonafarnib

use alternative or monitor HR, ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• lumateperone
Fanapt (iloperidone)

+

lumateperone

1 interaction

Avoid/Use Alternative

iloperidone + lumateperone

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• lurasidone
Fanapt (iloperidone)

+

lurasidone

1 interaction

Avoid/Use Alternative

iloperidone + lurasidone

use alternative or monitor BP; consider lowest lurasidone start dose, titrate slowly: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, extrapyramidal symptoms, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• macimorelin
Fanapt (iloperidone)

+

macimorelin

1 interaction

Avoid/Use Alternative

iloperidone + macimorelin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• metaxalone
Fanapt (iloperidone)

+

metaxalone

1 interaction

Avoid/Use Alternative

iloperidone + metaxalone

use alternative or monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• methadone
Fanapt (iloperidone)

+

methadone

1 interaction

Avoid/Use Alternative

iloperidone + methadone

use alternative or monitor respiratory rate, BP, ECG, electrolytes; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, including orthostasis, syncope (additive effects)

• metoclopramide
Fanapt (iloperidone)

+

metoclopramide

1 interaction

Avoid/Use Alternative

iloperidone + metoclopramide

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal symptoms (additive effects)

• midazolam
Fanapt (iloperidone)

+

midazolam

1 interaction

Avoid/Use Alternative

iloperidone + midazolam

use alternative or monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• milsaperidone
Fanapt (iloperidone)

+

milsaperidone

1 interaction

Avoid/Use Alternative

iloperidone + milsaperidone

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• mobocertinib
Fanapt (iloperidone)

+

mobocertinib

1 interaction

Avoid/Use Alternative

iloperidone + mobocertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• moxifloxacin
Fanapt (iloperidone)

+

moxifloxacin

1 interaction

Avoid/Use Alternative

iloperidone + moxifloxacin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• netupitant
Fanapt (iloperidone)

+

netupitant

1 interaction

Avoid/Use Alternative

iloperidone + netupitant

use alternative or monitor ECG, consider decr. iloperidone dose during and x1wk after (fos)netupitant tx: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• nilotinib
Fanapt (iloperidone)

+

nilotinib

1 interaction

Avoid/Use Alternative

iloperidone + nilotinib

use alternative or monitor ECG, electrolytes: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• olanzapine
Fanapt (iloperidone)

+

olanzapine

1 interaction

Avoid/Use Alternative

iloperidone + olanzapine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• oliceridine
Fanapt (iloperidone)

+

oliceridine

1 interaction

Avoid/Use Alternative

iloperidone + oliceridine

use alternative or monitor respiratory rate, ECG, BP, electrolytes; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, including orthostasis, syncope (additive effects)

• ondansetron
Fanapt (iloperidone)

+

ondansetron

1 interaction

Avoid/Use Alternative

iloperidone + ondansetron

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• osimertinib
Fanapt (iloperidone)

+

osimertinib

1 interaction

Avoid/Use Alternative

iloperidone + osimertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxybate
Fanapt (iloperidone)

+

oxybate

1 interaction

Avoid/Use Alternative

iloperidone + oxybate

use alternative or monitor respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, syncope (additive effects)

• pacritinib
Fanapt (iloperidone)

+

pacritinib

1 interaction

Avoid/Use Alternative

iloperidone + pacritinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• paliperidone
Fanapt (iloperidone)

+

paliperidone

1 interaction

Avoid/Use Alternative

iloperidone + paliperidone

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• palonosetron
Fanapt (iloperidone)

+

palonosetron

1 interaction

Avoid/Use Alternative

iloperidone + palonosetron

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pasireotide
Fanapt (iloperidone)

+

pasireotide

1 interaction

Avoid/Use Alternative

iloperidone + pasireotide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pentamidine
Fanapt (iloperidone)

+

pentamidine

1 interaction

Avoid/Use Alternative

iloperidone + pentamidine

use alternative or monitor ECG, BP, electrolytes; risk may be lower w/ nebulized pentamidine: combo may incr. risk of QT prolongation, cardiac arrhythmias, severe or life-threatening hypotension, including orthostasis, syncope (additive effects)

• phenelzine
Fanapt (iloperidone)

+

phenelzine

1 interaction

Avoid/Use Alternative

iloperidone + phenelzine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• phenoxybenzamine
Fanapt (iloperidone)

+

phenoxybenzamine

1 interaction

Avoid/Use Alternative

iloperidone + phenoxybenzamine

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• phentolamine
Fanapt (iloperidone)

+

phentolamine

1 interaction

Avoid/Use Alternative

iloperidone + phentolamine

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• pitolisant
Fanapt (iloperidone)

+

pitolisant

1 interaction

Avoid/Use Alternative

iloperidone + pitolisant

avoid combo: combo may decr. pitolisant efficacy (antagonistic effects)

• prazosin
Fanapt (iloperidone)

+

prazosin

1 interaction

Avoid/Use Alternative

iloperidone + prazosin

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• procainamide
Fanapt (iloperidone)

+

procainamide

1 interaction

Avoid/Use Alternative

iloperidone + procainamide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• promethazine
Fanapt (iloperidone)

+

promethazine

1 interaction

Avoid/Use Alternative

iloperidone + promethazine

use alternative or monitor respiratory rate, BP; decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, seizures, hypotension, including orthostasis, syncope (additive effects)

• propafenone
Fanapt (iloperidone)

+

propafenone

1 interaction

Avoid/Use Alternative

iloperidone + propafenone

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, including orthostasis, syncope (additive effects)

• quetiapine
Fanapt (iloperidone)

+

quetiapine

1 interaction

Avoid/Use Alternative

iloperidone + quetiapine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• quinidine (antiarrhythmic)
Fanapt (iloperidone)

+

quinidine (antiarrhythmic)

1 interaction

Avoid/Use Alternative

iloperidone + quinidine (antiarrhythmic)

use alternative or monitor ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• quinine
Fanapt (iloperidone)

+

quinine

1 interaction

Avoid/Use Alternative

iloperidone + quinine

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• quizartinib
Fanapt (iloperidone)

+

quizartinib

1 interaction

Avoid/Use Alternative

iloperidone + quizartinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rasagiline
Fanapt (iloperidone)

+

rasagiline

1 interaction

Avoid/Use Alternative

iloperidone + rasagiline

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• revumenib
Fanapt (iloperidone)

+

revumenib

1 interaction

Avoid/Use Alternative

iloperidone + revumenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ribociclib
Fanapt (iloperidone)

+

ribociclib

1 interaction

Avoid/Use Alternative

iloperidone + ribociclib

use alternative or monitor ECG, electrolytes; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited, additive effects)

• risperidone
Fanapt (iloperidone)

+

risperidone

1 interaction

Avoid/Use Alternative

iloperidone + risperidone

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension (including orthostasis, syncope), other adverse effects (additive effects, duplicate therapy)

• romidepsin
Fanapt (iloperidone)

+

romidepsin

1 interaction

Avoid/Use Alternative

iloperidone + romidepsin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ropeginterferon alfa-2b
Fanapt (iloperidone)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

iloperidone + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rucaparib
Fanapt (iloperidone)

+

rucaparib

1 interaction

Avoid/Use Alternative

iloperidone + rucaparib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• safinamide
Fanapt (iloperidone)

+

safinamide

1 interaction

Avoid/Use Alternative

iloperidone + safinamide

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• scopolamine
Fanapt (iloperidone)

+

scopolamine

1 interaction

Avoid/Use Alternative

iloperidone + scopolamine

use alternative: combo may increase risk of CNS depression, psychomotor impairment, hyperthermia, including life-threatening (additive effects)

• selegiline
Fanapt (iloperidone)

+

selegiline

1 interaction

Avoid/Use Alternative

iloperidone + selegiline

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selegiline transdermal
Fanapt (iloperidone)

+

selegiline transdermal

1 interaction

Avoid/Use Alternative

iloperidone + selegiline transdermal

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selpercatinib
Fanapt (iloperidone)

+

selpercatinib

1 interaction

Avoid/Use Alternative

iloperidone + selpercatinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sevoflurane
Fanapt (iloperidone)

+

sevoflurane

1 interaction

Avoid/Use Alternative

iloperidone + sevoflurane

use alternative or monitor ECG, BP, respiratory rate, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), CNS and respiratory depression, psychomotor impairment (additive effects)

• silodosin
Fanapt (iloperidone)

+

silodosin

1 interaction

Avoid/Use Alternative

iloperidone + silodosin

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sotalol
Fanapt (iloperidone)

+

sotalol

1 interaction

Avoid/Use Alternative

iloperidone + sotalol

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, including orthostasis, syncope (additive effects)

• tamsulosin
Fanapt (iloperidone)

+

tamsulosin

1 interaction

Avoid/Use Alternative

iloperidone + tamsulosin

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• telavancin
Fanapt (iloperidone)

+

telavancin

1 interaction

Avoid/Use Alternative

iloperidone + telavancin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• terazosin
Fanapt (iloperidone)

+

terazosin

1 interaction

Avoid/Use Alternative

iloperidone + terazosin

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• tetrabenazine
Fanapt (iloperidone)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

iloperidone + tetrabenazine

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, neuroleptic malignant syndrome, extrapyramidal symptoms, CNS depression, psychomotor impairment (additive effects)

• thalidomide
Fanapt (iloperidone)

+

thalidomide

1 interaction

Avoid/Use Alternative

iloperidone + thalidomide

use alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• toremifene
Fanapt (iloperidone)

+

toremifene

1 interaction

Avoid/Use Alternative

iloperidone + toremifene

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tradipitant
Fanapt (iloperidone)

+

tradipitant

1 interaction

Avoid/Use Alternative

iloperidone + tradipitant

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tramadol
Fanapt (iloperidone)

+

tramadol

1 interaction

Avoid/Use Alternative

iloperidone + tramadol

use alternative or monitor respiratory rate, ECG, BP, electrolytes; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, seizures, QT prolongation, cardiac arrhythmias, severe hypotension, including orthostasis, syncope (additive effects)

• tranylcypromine
Fanapt (iloperidone)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

iloperidone + tranylcypromine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• triclabendazole
Fanapt (iloperidone)

+

triclabendazole

1 interaction

Avoid/Use Alternative

iloperidone + triclabendazole

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trifluridine
Fanapt (iloperidone)

+

trifluridine

1 interaction

Avoid/Use Alternative

iloperidone + trifluridine

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trimethobenzamide
Fanapt (iloperidone)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

iloperidone + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms (additive effects)

• triptorelin
Fanapt (iloperidone)

+

triptorelin

1 interaction

Avoid/Use Alternative

iloperidone + triptorelin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. triptorelin efficacy (additive effects, androgen deprivation may prolong QT; iloperidone may cause hyperprolactinemia, decr. GnRH receptors)

• vandetanib
Fanapt (iloperidone)

+

vandetanib

1 interaction

Avoid/Use Alternative

iloperidone + vandetanib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• vemurafenib
Fanapt (iloperidone)

+

vemurafenib

1 interaction

Avoid/Use Alternative

iloperidone + vemurafenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• yohimbe
Fanapt (iloperidone)

+

yohimbe

1 interaction

Avoid/Use Alternative

iloperidone + yohimbe

avoid combo: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• ziftomenib
Fanapt (iloperidone)

+

ziftomenib

1 interaction

Avoid/Use Alternative

iloperidone + ziftomenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ziprasidone
Fanapt (iloperidone)

+

ziprasidone

1 interaction

Avoid/Use Alternative

iloperidone + ziprasidone

use alternative or monitor ECG, BP, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, other adverse effects (additive effects, duplicate therapy)

• zuranolone
Fanapt (iloperidone)

+

zuranolone

1 interaction

Avoid/Use Alternative

iloperidone + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• abiraterone acetate
Fanapt (iloperidone)

+

abiraterone acetate

1 interaction

Monitor/Modify Tx

iloperidone + abiraterone acetate

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• acarbose
Fanapt (iloperidone)

+

acarbose

1 interaction

Monitor/Modify Tx

iloperidone + acarbose

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• acebutolol
Fanapt (iloperidone)

+

acebutolol

1 interaction

Monitor/Modify Tx

iloperidone + acebutolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• alfentanil
Fanapt (iloperidone)

+

alfentanil

1 interaction

Monitor/Modify Tx

iloperidone + alfentanil

monitor BP, respiratory rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• aliskiren
Fanapt (iloperidone)

+

aliskiren

1 interaction

Monitor/Modify Tx

iloperidone + aliskiren

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• alogliptin
Fanapt (iloperidone)

+

alogliptin

1 interaction

Monitor/Modify Tx

iloperidone + alogliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• alprazolam
Fanapt (iloperidone)

+

alprazolam

1 interaction

Monitor/Modify Tx

iloperidone + alprazolam

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• alprostadil intracavernous
Fanapt (iloperidone)

+

alprostadil intracavernous

1 interaction

Monitor/Modify Tx

iloperidone + alprostadil intracavernous

monitor BP: combo may increase risk of hypotension, including orthostasis, syncope (additive effects)

• amantadine
Fanapt (iloperidone)

+

amantadine

1 interaction

Monitor/Modify Tx

iloperidone + amantadine

monitor BP: combo may incr. risk of hyperthermia, CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• amifostine
Fanapt (iloperidone)

+

amifostine

1 interaction

Monitor/Modify Tx

iloperidone + amifostine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• amiloride
Fanapt (iloperidone)

+

amiloride

1 interaction

Monitor/Modify Tx

iloperidone + amiloride

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• amitriptyline
Fanapt (iloperidone)

+

amitriptyline

1 interaction

Monitor/Modify Tx

iloperidone + amitriptyline

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• amlodipine
Fanapt (iloperidone)

+

amlodipine

1 interaction

Monitor/Modify Tx

iloperidone + amlodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• amoxapine
Fanapt (iloperidone)

+

amoxapine

1 interaction

Monitor/Modify Tx

iloperidone + amoxapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
Fanapt (iloperidone)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

iloperidone + apraclonidine ophthalmic

monitor BP if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• aprepitant
Fanapt (iloperidone)

+

aprepitant

1 interaction

Monitor/Modify Tx

iloperidone + aprepitant

if aprepitant 3-day regimen, monitor ECG; aprepitant single dose-regimen OK: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• aprocitentan
Fanapt (iloperidone)

+

aprocitentan

1 interaction

Monitor/Modify Tx

iloperidone + aprocitentan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• articaine
Fanapt (iloperidone)

+

articaine

1 interaction

Monitor/Modify Tx

iloperidone + articaine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• atazanavir
Fanapt (iloperidone)

+

atazanavir

1 interaction

Monitor/Modify Tx

iloperidone + atazanavir

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• atenolol
Fanapt (iloperidone)

+

atenolol

1 interaction

Monitor/Modify Tx

iloperidone + atenolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• avacopan
Fanapt (iloperidone)

+

avacopan

1 interaction

Monitor/Modify Tx

iloperidone + avacopan

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• avanafil
Fanapt (iloperidone)

+

avanafil

1 interaction

Monitor/Modify Tx

iloperidone + avanafil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• azilsartan medoxomil
Fanapt (iloperidone)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

iloperidone + azilsartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• baclofen intrathecal
Fanapt (iloperidone)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

iloperidone + baclofen intrathecal

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• benazepril
Fanapt (iloperidone)

+

benazepril

1 interaction

Monitor/Modify Tx

iloperidone + benazepril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• berberine
Fanapt (iloperidone)

+

berberine

1 interaction

Monitor/Modify Tx

iloperidone + berberine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• berotralstat
Fanapt (iloperidone)

+

berotralstat

1 interaction

Monitor/Modify Tx

iloperidone + berotralstat

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• betaxolol
Fanapt (iloperidone)

+

betaxolol

1 interaction

Monitor/Modify Tx

iloperidone + betaxolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• betaxolol ophthalmic
Fanapt (iloperidone)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

iloperidone + betaxolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• bethanechol
Fanapt (iloperidone)

+

bethanechol

1 interaction

Monitor/Modify Tx

iloperidone + bethanechol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• bexagliflozin
Fanapt (iloperidone)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

iloperidone + bexagliflozin

monitor glucose, BP: combo may incr. risk of hypotension, including orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• bisoprolol
Fanapt (iloperidone)

+

bisoprolol

1 interaction

Monitor/Modify Tx

iloperidone + bisoprolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• bortezomib
Fanapt (iloperidone)

+

bortezomib

1 interaction

Monitor/Modify Tx

iloperidone + bortezomib

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• brimonidine ophthalmic
Fanapt (iloperidone)

+

brimonidine ophthalmic

1 interaction

Monitor/Modify Tx

iloperidone + brimonidine ophthalmic

monitor BP if elevated IOP or presbyopia use; OTC ocular redness use OK: combo may increase risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• brimonidine topical
Fanapt (iloperidone)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

iloperidone + brimonidine topical

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• bumetanide
Fanapt (iloperidone)

+

bumetanide

1 interaction

Monitor/Modify Tx

iloperidone + bumetanide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• bupivacaine
Fanapt (iloperidone)

+

bupivacaine

1 interaction

Monitor/Modify Tx

iloperidone + bupivacaine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• bupivacaine liposomal
Fanapt (iloperidone)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

iloperidone + bupivacaine liposomal

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• buprenorphine
Fanapt (iloperidone)

+

buprenorphine

1 interaction

Monitor/Modify Tx

iloperidone + buprenorphine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• bupropion
Fanapt (iloperidone)

+

bupropion

1 interaction

Monitor/Modify Tx

iloperidone + bupropion

monitor ECG; decr. iloperidone dose 50%, consider lower bupropion doses: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, seizures, other adverse effects (hepatic metabolism inhibited, additive effects)

• butorphanol
Fanapt (iloperidone)

+

butorphanol

1 interaction

Monitor/Modify Tx

iloperidone + butorphanol

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• canagliflozin
Fanapt (iloperidone)

+

canagliflozin

1 interaction

Monitor/Modify Tx

iloperidone + canagliflozin

monitor BP, glucose: combo may incr. risk of hypotension, including orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• candesartan cilexetil
Fanapt (iloperidone)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

iloperidone + candesartan cilexetil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• cannabis
Fanapt (iloperidone)

+

cannabis

1 interaction

Monitor/Modify Tx

iloperidone + cannabis

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• capivasertib
Fanapt (iloperidone)

+

capivasertib

1 interaction

Monitor/Modify Tx

iloperidone + capivasertib

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• captopril
Fanapt (iloperidone)

+

captopril

1 interaction

Monitor/Modify Tx

iloperidone + captopril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• carbamazepine
Fanapt (iloperidone)

+

carbamazepine

1 interaction

Monitor/Modify Tx

iloperidone + carbamazepine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• carteolol ophthalmic
Fanapt (iloperidone)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

iloperidone + carteolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• carvedilol
Fanapt (iloperidone)

+

carvedilol

1 interaction

Monitor/Modify Tx

iloperidone + carvedilol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• chloramphenicol
Fanapt (iloperidone)

+

chloramphenicol

1 interaction

Monitor/Modify Tx

iloperidone + chloramphenicol

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• chlordiazepoxide
Fanapt (iloperidone)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

iloperidone + chlordiazepoxide

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• chloroprocaine
Fanapt (iloperidone)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

iloperidone + chloroprocaine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• chlorothiazide
Fanapt (iloperidone)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

iloperidone + chlorothiazide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• chlorpromazine
Fanapt (iloperidone)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

iloperidone + chlorpromazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• chlorthalidone
Fanapt (iloperidone)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

iloperidone + chlorthalidone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• cilostazol
Fanapt (iloperidone)

+

cilostazol

1 interaction

Monitor/Modify Tx

iloperidone + cilostazol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• cinacalcet
Fanapt (iloperidone)

+

cinacalcet

1 interaction

Monitor/Modify Tx

iloperidone + cinacalcet

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• ciprofloxacin
Fanapt (iloperidone)

+

ciprofloxacin

1 interaction

Monitor/Modify Tx

iloperidone + ciprofloxacin

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• clevidipine
Fanapt (iloperidone)

+

clevidipine

1 interaction

Monitor/Modify Tx

iloperidone + clevidipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• clobazam
Fanapt (iloperidone)

+

clobazam

1 interaction

Monitor/Modify Tx

iloperidone + clobazam

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• clofarabine
Fanapt (iloperidone)

+

clofarabine

1 interaction

Monitor/Modify Tx

iloperidone + clofarabine

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• clomipramine
Fanapt (iloperidone)

+

clomipramine

1 interaction

Monitor/Modify Tx

iloperidone + clomipramine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, seizures, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• clonazepam
Fanapt (iloperidone)

+

clonazepam

1 interaction

Monitor/Modify Tx

iloperidone + clonazepam

monitor respiratory rate, BP: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• clorazepate
Fanapt (iloperidone)

+

clorazepate

1 interaction

Monitor/Modify Tx

iloperidone + clorazepate

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• cobicistat
Fanapt (iloperidone)

+

cobicistat

1 interaction

Monitor/Modify Tx

iloperidone + cobicistat

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• coenzyme Q-10
Fanapt (iloperidone)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

iloperidone + coenzyme Q-10

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• colesevelam
Fanapt (iloperidone)

+

colesevelam

1 interaction

Monitor/Modify Tx

iloperidone + colesevelam

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• conivaptan
Fanapt (iloperidone)

+

conivaptan

1 interaction

Monitor/Modify Tx

iloperidone + conivaptan

monitor ECG during and x7 days after conivaptan tx: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• cyclosporine
Fanapt (iloperidone)

+

cyclosporine

1 interaction

Monitor/Modify Tx

iloperidone + cyclosporine

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• dacomitinib
Fanapt (iloperidone)

+

dacomitinib

1 interaction

Monitor/Modify Tx

iloperidone + dacomitinib

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• danazol
Fanapt (iloperidone)

+

danazol

1 interaction

Monitor/Modify Tx

iloperidone + danazol

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• dapagliflozin
Fanapt (iloperidone)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

iloperidone + dapagliflozin

monitor glucose, BP: combo may decr. antidiabetic agent efficacy; may incr. risk of hypotension, including orthostasis, syncope (antagonistic effects; additive effects)

• daridorexant
Fanapt (iloperidone)

+

daridorexant

1 interaction

Monitor/Modify Tx

iloperidone + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• darunavir
Fanapt (iloperidone)

+

darunavir

1 interaction

Monitor/Modify Tx

iloperidone + darunavir

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• denileukin diftitox
Fanapt (iloperidone)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

iloperidone + denileukin diftitox

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• diazepam
Fanapt (iloperidone)

+

diazepam

1 interaction

Monitor/Modify Tx

iloperidone + diazepam

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• dihydrocodeine
Fanapt (iloperidone)

+

dihydrocodeine

1 interaction

Monitor/Modify Tx

iloperidone + dihydrocodeine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• diltiazem
Fanapt (iloperidone)

+

diltiazem

1 interaction

Monitor/Modify Tx

iloperidone + diltiazem

monitor ECG, BP: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, additive effects)

• dinutuximab
Fanapt (iloperidone)

+

dinutuximab

1 interaction

Monitor/Modify Tx

iloperidone + dinutuximab

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• dipyridamole
Fanapt (iloperidone)

+

dipyridamole

1 interaction

Monitor/Modify Tx

iloperidone + dipyridamole

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• doxepin
Fanapt (iloperidone)

+

doxepin

1 interaction

Monitor/Modify Tx

iloperidone + doxepin

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• dronabinol
Fanapt (iloperidone)

+

dronabinol

1 interaction

Monitor/Modify Tx

iloperidone + dronabinol

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• dulaglutide
Fanapt (iloperidone)

+

dulaglutide

1 interaction

Monitor/Modify Tx

iloperidone + dulaglutide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• duloxetine
Fanapt (iloperidone)

+

duloxetine

1 interaction

Monitor/Modify Tx

iloperidone + duloxetine

monitor ECG, BP: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• duvelisib
Fanapt (iloperidone)

+

duvelisib

1 interaction

Monitor/Modify Tx

iloperidone + duvelisib

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• eliglustat
Fanapt (iloperidone)

+

eliglustat

1 interaction

Monitor/Modify Tx

iloperidone + eliglustat

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• empagliflozin
Fanapt (iloperidone)

+

empagliflozin

1 interaction

Monitor/Modify Tx

iloperidone + empagliflozin

monitor BP, glucose: combo may incr. risk of hypotension, including orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• enalapril
Fanapt (iloperidone)

+

enalapril

1 interaction

Monitor/Modify Tx

iloperidone + enalapril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• enalaprilat
Fanapt (iloperidone)

+

enalaprilat

1 interaction

Monitor/Modify Tx

iloperidone + enalaprilat

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• entacapone
Fanapt (iloperidone)

+

entacapone

1 interaction

Monitor/Modify Tx

iloperidone + entacapone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• entrectinib
Fanapt (iloperidone)

+

entrectinib

1 interaction

Monitor/Modify Tx

iloperidone + entrectinib

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• eplerenone
Fanapt (iloperidone)

+

eplerenone

1 interaction

Monitor/Modify Tx

iloperidone + eplerenone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• epoprostenol
Fanapt (iloperidone)

+

epoprostenol

1 interaction

Monitor/Modify Tx

iloperidone + epoprostenol

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• ertugliflozin
Fanapt (iloperidone)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

iloperidone + ertugliflozin

monitor BP, glucose: combo may incr. risk of hypotension, including orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• esketamine
Fanapt (iloperidone)

+

esketamine

1 interaction

Monitor/Modify Tx

iloperidone + esketamine

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• esmolol
Fanapt (iloperidone)

+

esmolol

1 interaction

Monitor/Modify Tx

iloperidone + esmolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• estazolam
Fanapt (iloperidone)

+

estazolam

1 interaction

Monitor/Modify Tx

iloperidone + estazolam

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• eszopiclone
Fanapt (iloperidone)

+

eszopiclone

1 interaction

Monitor/Modify Tx

iloperidone + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Fanapt (iloperidone)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

iloperidone + ethacrynic acid

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• ethanol (in some formulations)
Fanapt (iloperidone)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

iloperidone + ethanol (in some formulations)

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etomidate
Fanapt (iloperidone)

+

etomidate

1 interaction

Monitor/Modify Tx

iloperidone + etomidate

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• etripamil nasal
Fanapt (iloperidone)

+

etripamil nasal

1 interaction

Monitor/Modify Tx

iloperidone + etripamil nasal

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• exenatide
Fanapt (iloperidone)

+

exenatide

1 interaction

Monitor/Modify Tx

iloperidone + exenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• fedratinib
Fanapt (iloperidone)

+

fedratinib

1 interaction

Monitor/Modify Tx

iloperidone + fedratinib

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• felodipine
Fanapt (iloperidone)

+

felodipine

1 interaction

Monitor/Modify Tx

iloperidone + felodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• fenoldopam
Fanapt (iloperidone)

+

fenoldopam

1 interaction

Monitor/Modify Tx

iloperidone + fenoldopam

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• fentanyl
Fanapt (iloperidone)

+

fentanyl

1 interaction

Monitor/Modify Tx

iloperidone + fentanyl

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• ferumoxytol
Fanapt (iloperidone)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

iloperidone + ferumoxytol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• flaxseed
Fanapt (iloperidone)

+

flaxseed

1 interaction

Monitor/Modify Tx

iloperidone + flaxseed

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• flibanserin
Fanapt (iloperidone)

+

flibanserin

1 interaction

Monitor/Modify Tx

iloperidone + flibanserin

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• fluconazole
Fanapt (iloperidone)

+

fluconazole

1 interaction

Monitor/Modify Tx

iloperidone + fluconazole

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• fluoxetine
Fanapt (iloperidone)

+

fluoxetine

1 interaction

Monitor/Modify Tx

iloperidone + fluoxetine

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• fluphenazine
Fanapt (iloperidone)

+

fluphenazine

1 interaction

Monitor/Modify Tx

iloperidone + fluphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• flurazepam
Fanapt (iloperidone)

+

flurazepam

1 interaction

Monitor/Modify Tx

iloperidone + flurazepam

monitor BP, respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• fosamprenavir
Fanapt (iloperidone)

+

fosamprenavir

1 interaction

Monitor/Modify Tx

iloperidone + fosamprenavir

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• fosinopril
Fanapt (iloperidone)

+

fosinopril

1 interaction

Monitor/Modify Tx

iloperidone + fosinopril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• foslevodopa
Fanapt (iloperidone)

+

foslevodopa

1 interaction

Monitor/Modify Tx

iloperidone + foslevodopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• furosemide
Fanapt (iloperidone)

+

furosemide

1 interaction

Monitor/Modify Tx

iloperidone + furosemide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• gabapentin
Fanapt (iloperidone)

+

gabapentin

1 interaction

Monitor/Modify Tx

iloperidone + gabapentin

monitor respiratory rate; consider decreasing gabapentin dose: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, iloperidone may decrease seizure threshold)

• gabapentin enacarbil
Fanapt (iloperidone)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

iloperidone + gabapentin enacarbil

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment (additive effects)

• garlic
Fanapt (iloperidone)

+

garlic

1 interaction

Monitor/Modify Tx

iloperidone + garlic

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• givosiran
Fanapt (iloperidone)

+

givosiran

1 interaction

Monitor/Modify Tx

iloperidone + givosiran

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited; givosiran effects on hepatic heme biosynthesis may reduce CYP450 enzyme activity)

• glimepiride
Fanapt (iloperidone)

+

glimepiride

1 interaction

Monitor/Modify Tx

iloperidone + glimepiride

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glipizide
Fanapt (iloperidone)

+

glipizide

1 interaction

Monitor/Modify Tx

iloperidone + glipizide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glyburide
Fanapt (iloperidone)

+

glyburide

1 interaction

Monitor/Modify Tx

iloperidone + glyburide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• grapefruit
Fanapt (iloperidone)

+

grapefruit

1 interaction

Monitor/Modify Tx

iloperidone + grapefruit

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (GI metabolism inhibited)

• guanfacine
Fanapt (iloperidone)

+

guanfacine

1 interaction

Monitor/Modify Tx

iloperidone + guanfacine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• histrelin
Fanapt (iloperidone)

+

histrelin

1 interaction

Monitor/Modify Tx

iloperidone + histrelin

consider monitoring ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. histrelin efficacy (additive effects, androgen deprivation may prolong QT; iloperidone may cause hyperprolactinemia, decr. GnRH receptors)

• hydralazine
Fanapt (iloperidone)

+

hydralazine

1 interaction

Monitor/Modify Tx

iloperidone + hydralazine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• hydrochlorothiazide
Fanapt (iloperidone)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

iloperidone + hydrochlorothiazide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• hydromorphone
Fanapt (iloperidone)

+

hydromorphone

1 interaction

Monitor/Modify Tx

iloperidone + hydromorphone

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• idelalisib
Fanapt (iloperidone)

+

idelalisib

1 interaction

Monitor/Modify Tx

iloperidone + idelalisib

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• ifosfamide
Fanapt (iloperidone)

+

ifosfamide

1 interaction

Monitor/Modify Tx

iloperidone + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloprost
Fanapt (iloperidone)

+

iloprost

1 interaction

Monitor/Modify Tx

iloperidone + iloprost

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• imatinib
Fanapt (iloperidone)

+

imatinib

1 interaction

Monitor/Modify Tx

iloperidone + imatinib

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• imipramine
Fanapt (iloperidone)

+

imipramine

1 interaction

Monitor/Modify Tx

iloperidone + imipramine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• indapamide
Fanapt (iloperidone)

+

indapamide

1 interaction

Monitor/Modify Tx

iloperidone + indapamide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• insulin
Fanapt (iloperidone)

+

insulin

1 interaction

Monitor/Modify Tx

iloperidone + insulin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• iohexol
Fanapt (iloperidone)

+

iohexol

1 interaction

Monitor/Modify Tx

iloperidone + iohexol

if intrathecal iohexol use, D/C iloperidone at least 48h before myelography, may resume at least 24h after procedure: combo may incr. risk of seizures (additive effects)

• iopamidol
Fanapt (iloperidone)

+

iopamidol

1 interaction

Monitor/Modify Tx

iloperidone + iopamidol

caution advised if intrathecal iopamidol use; consider holding iloperidone at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• irbesartan
Fanapt (iloperidone)

+

irbesartan

1 interaction

Monitor/Modify Tx

iloperidone + irbesartan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• iron sucrose
Fanapt (iloperidone)

+

iron sucrose

1 interaction

Monitor/Modify Tx

iloperidone + iron sucrose

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• isavuconazonium
Fanapt (iloperidone)

+

isavuconazonium

1 interaction

Monitor/Modify Tx

iloperidone + isavuconazonium

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• isosorbide dinitrate
Fanapt (iloperidone)

+

isosorbide dinitrate

1 interaction

Monitor/Modify Tx

iloperidone + isosorbide dinitrate

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• isosorbide mononitrate
Fanapt (iloperidone)

+

isosorbide mononitrate

1 interaction

Monitor/Modify Tx

iloperidone + isosorbide mononitrate

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• isradipine
Fanapt (iloperidone)

+

isradipine

1 interaction

Monitor/Modify Tx

iloperidone + isradipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• itraconazole
Fanapt (iloperidone)

+

itraconazole

1 interaction

Monitor/Modify Tx

iloperidone + itraconazole

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• ketamine
Fanapt (iloperidone)

+

ketamine

1 interaction

Monitor/Modify Tx

iloperidone + ketamine

monitor respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression (including life-threatening), psychomotor impairment (additive effects)

• ketoconazole
Fanapt (iloperidone)

+

ketoconazole

1 interaction

Monitor/Modify Tx

iloperidone + ketoconazole

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• labetalol
Fanapt (iloperidone)

+

labetalol

1 interaction

Monitor/Modify Tx

iloperidone + labetalol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• landiolol
Fanapt (iloperidone)

+

landiolol

1 interaction

Monitor/Modify Tx

iloperidone + landiolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• lemborexant
Fanapt (iloperidone)

+

lemborexant

1 interaction

Monitor/Modify Tx

iloperidone + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenacapavir
Fanapt (iloperidone)

+

lenacapavir

1 interaction

Monitor/Modify Tx

iloperidone + lenacapavir

monitor ECG during and x9mo after lenacapavir tx: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• letermovir
Fanapt (iloperidone)

+

letermovir

1 interaction

Monitor/Modify Tx

iloperidone + letermovir

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• levobunolol ophthalmic
Fanapt (iloperidone)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

iloperidone + levobunolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• levodopa
Fanapt (iloperidone)

+

levodopa

1 interaction

Monitor/Modify Tx

iloperidone + levodopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• levorphanol
Fanapt (iloperidone)

+

levorphanol

1 interaction

Monitor/Modify Tx

iloperidone + levorphanol

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• lidocaine
Fanapt (iloperidone)

+

lidocaine

1 interaction

Monitor/Modify Tx

iloperidone + lidocaine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• linagliptin
Fanapt (iloperidone)

+

linagliptin

1 interaction

Monitor/Modify Tx

iloperidone + linagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• liraglutide
Fanapt (iloperidone)

+

liraglutide

1 interaction

Monitor/Modify Tx

iloperidone + liraglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lisinopril
Fanapt (iloperidone)

+

lisinopril

1 interaction

Monitor/Modify Tx

iloperidone + lisinopril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• lithium
Fanapt (iloperidone)

+

lithium

1 interaction

Monitor/Modify Tx

iloperidone + lithium

D/C one or both drugs if encephalopathy occurs: combo may incr. risk of encephalopathic syndrome, extrapyramidal symptoms (additive effects)

• lixisenatide
Fanapt (iloperidone)

+

lixisenatide

1 interaction

Monitor/Modify Tx

iloperidone + lixisenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lopinavir/ritonavir
Fanapt (iloperidone)

+

lopinavir/ ritonavir

1 interaction

Monitor/Modify Tx

iloperidone + lopinavir/ ritonavir

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• lorazepam
Fanapt (iloperidone)

+

lorazepam

1 interaction

Monitor/Modify Tx

iloperidone + lorazepam

monitor respiratory rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• losartan
Fanapt (iloperidone)

+

losartan

1 interaction

Monitor/Modify Tx

iloperidone + losartan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• loxapine
Fanapt (iloperidone)

+

loxapine

1 interaction

Monitor/Modify Tx

iloperidone + loxapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• lubiprostone
Fanapt (iloperidone)

+

lubiprostone

1 interaction

Monitor/Modify Tx

iloperidone + lubiprostone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• magnesium sulfate
Fanapt (iloperidone)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

iloperidone + magnesium sulfate

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• maraviroc
Fanapt (iloperidone)

+

maraviroc

1 interaction

Monitor/Modify Tx

iloperidone + maraviroc

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• mavorixafor
Fanapt (iloperidone)

+

mavorixafor

1 interaction

Monitor/Modify Tx

iloperidone + mavorixafor

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• meperidine
Fanapt (iloperidone)

+

meperidine

1 interaction

Monitor/Modify Tx

iloperidone + meperidine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• mepivacaine
Fanapt (iloperidone)

+

mepivacaine

1 interaction

Monitor/Modify Tx

iloperidone + mepivacaine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• metformin
Fanapt (iloperidone)

+

metformin

1 interaction

Monitor/Modify Tx

iloperidone + metformin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• methohexital
Fanapt (iloperidone)

+

methohexital

1 interaction

Monitor/Modify Tx

iloperidone + methohexital

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• methyldopa
Fanapt (iloperidone)

+

methyldopa

1 interaction

Monitor/Modify Tx

iloperidone + methyldopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• methylene blue injection
Fanapt (iloperidone)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

iloperidone + methylene blue injection

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• metolazone
Fanapt (iloperidone)

+

metolazone

1 interaction

Monitor/Modify Tx

iloperidone + metolazone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• metoprolol
Fanapt (iloperidone)

+

metoprolol

1 interaction

Monitor/Modify Tx

iloperidone + metoprolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• mifepristone
Fanapt (iloperidone)

+

mifepristone

1 interaction

Monitor/Modify Tx

iloperidone + mifepristone

monitor ECG; decr. iloperidone dose 50% during and x14 days after daily mifepristone use; caution advised if pregnancy termination use: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• miglitol
Fanapt (iloperidone)

+

miglitol

1 interaction

Monitor/Modify Tx

iloperidone + miglitol

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• milrinone
Fanapt (iloperidone)

+

milrinone

1 interaction

Monitor/Modify Tx

iloperidone + milrinone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• minoxidil
Fanapt (iloperidone)

+

minoxidil

1 interaction

Monitor/Modify Tx

iloperidone + minoxidil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• mirabegron
Fanapt (iloperidone)

+

mirabegron

1 interaction

Monitor/Modify Tx

iloperidone + mirabegron

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• mirtazapine
Fanapt (iloperidone)

+

mirtazapine

1 interaction

Monitor/Modify Tx

iloperidone + mirtazapine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• moexipril
Fanapt (iloperidone)

+

moexipril

1 interaction

Monitor/Modify Tx

iloperidone + moexipril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• molindone
Fanapt (iloperidone)

+

molindone

1 interaction

Monitor/Modify Tx

iloperidone + molindone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• morphine
Fanapt (iloperidone)

+

morphine

1 interaction

Monitor/Modify Tx

iloperidone + morphine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• nadolol
Fanapt (iloperidone)

+

nadolol

1 interaction

Monitor/Modify Tx

iloperidone + nadolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nalbuphine
Fanapt (iloperidone)

+

nalbuphine

1 interaction

Monitor/Modify Tx

iloperidone + nalbuphine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• nateglinide
Fanapt (iloperidone)

+

nateglinide

1 interaction

Monitor/Modify Tx

iloperidone + nateglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• nattokinase
Fanapt (iloperidone)

+

nattokinase

1 interaction

Monitor/Modify Tx

iloperidone + nattokinase

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• naxitamab
Fanapt (iloperidone)

+

naxitamab

1 interaction

Monitor/Modify Tx

iloperidone + naxitamab

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nebivolol
Fanapt (iloperidone)

+

nebivolol

1 interaction

Monitor/Modify Tx

iloperidone + nebivolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nefazodone
Fanapt (iloperidone)

+

nefazodone

1 interaction

Monitor/Modify Tx

iloperidone + nefazodone

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• nelarabine
Fanapt (iloperidone)

+

nelarabine

1 interaction

Monitor/Modify Tx

iloperidone + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• nelfinavir
Fanapt (iloperidone)

+

nelfinavir

1 interaction

Monitor/Modify Tx

iloperidone + nelfinavir

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• niacin (vitamin B3)
Fanapt (iloperidone)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

iloperidone + niacin (vitamin B3)

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nicardipine
Fanapt (iloperidone)

+

nicardipine

1 interaction

Monitor/Modify Tx

iloperidone + nicardipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nifedipine
Fanapt (iloperidone)

+

nifedipine

1 interaction

Monitor/Modify Tx

iloperidone + nifedipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nimodipine
Fanapt (iloperidone)

+

nimodipine

1 interaction

Monitor/Modify Tx

iloperidone + nimodipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nirogacestat
Fanapt (iloperidone)

+

nirogacestat

1 interaction

Monitor/Modify Tx

iloperidone + nirogacestat

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• nisoldipine
Fanapt (iloperidone)

+

nisoldipine

1 interaction

Monitor/Modify Tx

iloperidone + nisoldipine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nitric oxide
Fanapt (iloperidone)

+

nitric oxide

1 interaction

Monitor/Modify Tx

iloperidone + nitric oxide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• nitrite
Fanapt (iloperidone)

+

nitrite

1 interaction

Monitor/Modify Tx

iloperidone + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis, syncope (additive effects)

• nitroglycerin
Fanapt (iloperidone)

+

nitroglycerin

1 interaction

Monitor/Modify Tx

iloperidone + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• nitroprusside
Fanapt (iloperidone)

+

nitroprusside

1 interaction

Monitor/Modify Tx

iloperidone + nitroprusside

monitor BP: combo may incr. risk of severe or life-threatening hypotension, including orthostasis, syncope (additive effects)

• nortriptyline
Fanapt (iloperidone)

+

nortriptyline

1 interaction

Monitor/Modify Tx

iloperidone + nortriptyline

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), hyperthermia (additive effects)

• obinutuzumab
Fanapt (iloperidone)

+

obinutuzumab

1 interaction

Monitor/Modify Tx

iloperidone + obinutuzumab

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• olmesartan medoxomil
Fanapt (iloperidone)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

iloperidone + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• opicapone
Fanapt (iloperidone)

+

opicapone

1 interaction

Monitor/Modify Tx

iloperidone + opicapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• opium
Fanapt (iloperidone)

+

opium

1 interaction

Monitor/Modify Tx

iloperidone + opium

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• oxazepam
Fanapt (iloperidone)

+

oxazepam

1 interaction

Monitor/Modify Tx

iloperidone + oxazepam

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• oxybutynin
Fanapt (iloperidone)

+

oxybutynin

1 interaction

Monitor/Modify Tx

iloperidone + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of hyperthermia, CNS depression, psychomotor impairment; somnolence less likely with oxybutynin transdermal patch (additive effects)

• oxycodone
Fanapt (iloperidone)

+

oxycodone

1 interaction

Monitor/Modify Tx

iloperidone + oxycodone

monitor respiratory rate, BP; decr. oxycodone start dose by at least 50%, consider decr. iloperidone dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• oxymorphone
Fanapt (iloperidone)

+

oxymorphone

1 interaction

Monitor/Modify Tx

iloperidone + oxymorphone

monitor respiratory rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. iloperidone dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• palopegteriparatide
Fanapt (iloperidone)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

iloperidone + palopegteriparatide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• paroxetine
Fanapt (iloperidone)

+

paroxetine

1 interaction

Monitor/Modify Tx

iloperidone + paroxetine

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, other adverse effects (hepatic metabolism inhibited, additive effects)

• pentazocine
Fanapt (iloperidone)

+

pentazocine

1 interaction

Monitor/Modify Tx

iloperidone + pentazocine

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• pentobarbital
Fanapt (iloperidone)

+

pentobarbital

1 interaction

Monitor/Modify Tx

iloperidone + pentobarbital

monitor respiratory rate, BP: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• perindopril
Fanapt (iloperidone)

+

perindopril

1 interaction

Monitor/Modify Tx

iloperidone + perindopril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• perphenazine
Fanapt (iloperidone)

+

perphenazine

1 interaction

Monitor/Modify Tx

iloperidone + perphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, severe hypotension, including orthostasis, syncope (additive effects)

• phenobarbital
Fanapt (iloperidone)

+

phenobarbital

1 interaction

Monitor/Modify Tx

iloperidone + phenobarbital

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• pindolol
Fanapt (iloperidone)

+

pindolol

1 interaction

Monitor/Modify Tx

iloperidone + pindolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• pioglitazone
Fanapt (iloperidone)

+

pioglitazone

1 interaction

Monitor/Modify Tx

iloperidone + pioglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• posaconazole
Fanapt (iloperidone)

+

posaconazole

1 interaction

Monitor/Modify Tx

iloperidone + posaconazole

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• pramipexole
Fanapt (iloperidone)

+

pramipexole

1 interaction

Monitor/Modify Tx

iloperidone + pramipexole

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• pramlintide
Fanapt (iloperidone)

+

pramlintide

1 interaction

Monitor/Modify Tx

iloperidone + pramlintide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• pregabalin
Fanapt (iloperidone)

+

pregabalin

1 interaction

Monitor/Modify Tx

iloperidone + pregabalin

monitor respiratory rate: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• primidone
Fanapt (iloperidone)

+

primidone

1 interaction

Monitor/Modify Tx

iloperidone + primidone

monitor respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, iloperidone may decr. seizure threshold)

• procarbazine
Fanapt (iloperidone)

+

procarbazine

1 interaction

Monitor/Modify Tx

iloperidone + procarbazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• prochlorperazine
Fanapt (iloperidone)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

iloperidone + prochlorperazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• propofol
Fanapt (iloperidone)

+

propofol

1 interaction

Monitor/Modify Tx

iloperidone + propofol

monitor BP, respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• propranolol
Fanapt (iloperidone)

+

propranolol

1 interaction

Monitor/Modify Tx

iloperidone + propranolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• protriptyline
Fanapt (iloperidone)

+

protriptyline

1 interaction

Monitor/Modify Tx

iloperidone + protriptyline

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• quazepam
Fanapt (iloperidone)

+

quazepam

1 interaction

Monitor/Modify Tx

iloperidone + quazepam

monitor BP, respiratory rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• quinapril
Fanapt (iloperidone)

+

quinapril

1 interaction

Monitor/Modify Tx

iloperidone + quinapril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• ramipril
Fanapt (iloperidone)

+

ramipril

1 interaction

Monitor/Modify Tx

iloperidone + ramipril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• remifentanil
Fanapt (iloperidone)

+

remifentanil

1 interaction

Monitor/Modify Tx

iloperidone + remifentanil

monitor respiratory rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• remimazolam
Fanapt (iloperidone)

+

remimazolam

1 interaction

Monitor/Modify Tx

iloperidone + remimazolam

monitor BP, respiratory rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of hypotension (including orthostasis, syncope), profound CNS and respiratory depression, psychomotor impairment (additive effects)

• repaglinide
Fanapt (iloperidone)

+

repaglinide

1 interaction

Monitor/Modify Tx

iloperidone + repaglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rilzabrutinib
Fanapt (iloperidone)

+

rilzabrutinib

1 interaction

Monitor/Modify Tx

iloperidone + rilzabrutinib

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• riociguat
Fanapt (iloperidone)

+

riociguat

1 interaction

Monitor/Modify Tx

iloperidone + riociguat

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• ritonavir
Fanapt (iloperidone)

+

ritonavir

1 interaction

Monitor/Modify Tx

iloperidone + ritonavir

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• rolapitant
Fanapt (iloperidone)

+

rolapitant

1 interaction

Monitor/Modify Tx

iloperidone + rolapitant

monitor ECG: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• ropinirole
Fanapt (iloperidone)

+

ropinirole

1 interaction

Monitor/Modify Tx

iloperidone + ropinirole

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• ropivacaine
Fanapt (iloperidone)

+

ropivacaine

1 interaction

Monitor/Modify Tx

iloperidone + ropivacaine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• rosiglitazone
Fanapt (iloperidone)

+

rosiglitazone

1 interaction

Monitor/Modify Tx

iloperidone + rosiglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rotigotine transdermal
Fanapt (iloperidone)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

iloperidone + rotigotine transdermal

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, including orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• sacubitril
Fanapt (iloperidone)

+

sacubitril

1 interaction

Monitor/Modify Tx

iloperidone + sacubitril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• saxagliptin
Fanapt (iloperidone)

+

saxagliptin

1 interaction

Monitor/Modify Tx

iloperidone + saxagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• semaglutide
Fanapt (iloperidone)

+

semaglutide

1 interaction

Monitor/Modify Tx

iloperidone + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sildenafil
Fanapt (iloperidone)

+

sildenafil

1 interaction

Monitor/Modify Tx

iloperidone + sildenafil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sitagliptin
Fanapt (iloperidone)

+

sitagliptin

1 interaction

Monitor/Modify Tx

iloperidone + sitagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sodium ferric gluconate complex
Fanapt (iloperidone)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

iloperidone + sodium ferric gluconate complex

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sotagliflozin
Fanapt (iloperidone)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

iloperidone + sotagliflozin

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sparsentan
Fanapt (iloperidone)

+

sparsentan

1 interaction

Monitor/Modify Tx

iloperidone + sparsentan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• spironolactone
Fanapt (iloperidone)

+

spironolactone

1 interaction

Monitor/Modify Tx

iloperidone + spironolactone

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• sufentanil
Fanapt (iloperidone)

+

sufentanil

1 interaction

Monitor/Modify Tx

iloperidone + sufentanil

monitor respiratory rate, BP; decr. sufentanil start dose, consider decr. iloperidone dose, use lowest effective doses: combo may incr. risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• suvorexant
Fanapt (iloperidone)

+

suvorexant

1 interaction

Monitor/Modify Tx

iloperidone + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tadalafil
Fanapt (iloperidone)

+

tadalafil

1 interaction

Monitor/Modify Tx

iloperidone + tadalafil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• tagraxofusp
Fanapt (iloperidone)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

iloperidone + tagraxofusp

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• taletrectinib
Fanapt (iloperidone)

+

taletrectinib

1 interaction

Monitor/Modify Tx

iloperidone + taletrectinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tapentadol
Fanapt (iloperidone)

+

tapentadol

1 interaction

Monitor/Modify Tx

iloperidone + tapentadol

monitor respiratory rate, BP; decrease dose of one or both drugs, use lowest effective doses and shortest duration of concomitant treatment: combo may increase risk of profound CNS and respiratory depression, psychomotor impairment, severe hypotension, including orthostasis, syncope (additive effects)

• taurine
Fanapt (iloperidone)

+

taurine

1 interaction

Monitor/Modify Tx

iloperidone + taurine

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• telmisartan
Fanapt (iloperidone)

+

telmisartan

1 interaction

Monitor/Modify Tx

iloperidone + telmisartan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• temazepam
Fanapt (iloperidone)

+

temazepam

1 interaction

Monitor/Modify Tx

iloperidone + temazepam

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• terbinafine
Fanapt (iloperidone)

+

terbinafine

1 interaction

Monitor/Modify Tx

iloperidone + terbinafine

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• thiothixene
Fanapt (iloperidone)

+

thiothixene

1 interaction

Monitor/Modify Tx

iloperidone + thiothixene

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (including orthostasis, syncope), extrapyramidal symptoms, hyperthermia (additive effects)

• timolol
Fanapt (iloperidone)

+

timolol

1 interaction

Monitor/Modify Tx

iloperidone + timolol

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• timolol ophthalmic
Fanapt (iloperidone)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

iloperidone + timolol ophthalmic

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• tipranavir
Fanapt (iloperidone)

+

tipranavir

1 interaction

Monitor/Modify Tx

iloperidone + tipranavir

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• tirzepatide
Fanapt (iloperidone)

+

tirzepatide

1 interaction

Monitor/Modify Tx

iloperidone + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• tizanidine
Fanapt (iloperidone)

+

tizanidine

1 interaction

Monitor/Modify Tx

iloperidone + tizanidine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• tolcapone
Fanapt (iloperidone)

+

tolcapone

1 interaction

Monitor/Modify Tx

iloperidone + tolcapone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• torsemide
Fanapt (iloperidone)

+

torsemide

1 interaction

Monitor/Modify Tx

iloperidone + torsemide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• trandolapril
Fanapt (iloperidone)

+

trandolapril

1 interaction

Monitor/Modify Tx

iloperidone + trandolapril

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• trazodone
Fanapt (iloperidone)

+

trazodone

1 interaction

Monitor/Modify Tx

iloperidone + trazodone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• treprostinil
Fanapt (iloperidone)

+

treprostinil

1 interaction

Monitor/Modify Tx

iloperidone + treprostinil

monitor BP: combo may incr. risk of severe hypotension, including orthostasis, syncope (additive effects)

• triamterene
Fanapt (iloperidone)

+

triamterene

1 interaction

Monitor/Modify Tx

iloperidone + triamterene

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• triazolam
Fanapt (iloperidone)

+

triazolam

1 interaction

Monitor/Modify Tx

iloperidone + triazolam

monitor BP, respiratory rate: combo may incr. risk of CNS and respiratory depression, psychomotor impairment, hypotension, including orthostasis, syncope (additive effects)

• trifluoperazine
Fanapt (iloperidone)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

iloperidone + trifluoperazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal symptoms, hyperthermia, severe hypotension, including orthostasis, syncope (additive effects)

• trimipramine
Fanapt (iloperidone)

+

trimipramine

1 interaction

Monitor/Modify Tx

iloperidone + trimipramine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, including orthostasis, syncope (additive effects)

• tucatinib
Fanapt (iloperidone)

+

tucatinib

1 interaction

Monitor/Modify Tx

iloperidone + tucatinib

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• valsartan
Fanapt (iloperidone)

+

valsartan

1 interaction

Monitor/Modify Tx

iloperidone + valsartan

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• vardenafil
Fanapt (iloperidone)

+

vardenafil

1 interaction

Monitor/Modify Tx

iloperidone + vardenafil

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• verapamil
Fanapt (iloperidone)

+

verapamil

1 interaction

Monitor/Modify Tx

iloperidone + verapamil

monitor ECG, BP: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, hypotension (including orthostasis, syncope), other adverse effects (hepatic metabolism inhibited, additive effects)

• voriconazole
Fanapt (iloperidone)

+

voriconazole

1 interaction

Monitor/Modify Tx

iloperidone + voriconazole

monitor ECG; decr. iloperidone dose 50%: combo may incr. iloperidone levels, risk of QT prolongation, cardiac arrhythmias, other adverse effects (hepatic metabolism inhibited)

• vosoritide
Fanapt (iloperidone)

+

vosoritide

1 interaction

Monitor/Modify Tx

iloperidone + vosoritide

monitor BP: combo may incr. risk of hypotension, including orthostasis, syncope (additive effects)

• zaleplon
Fanapt (iloperidone)

+

zaleplon

1 interaction

Monitor/Modify Tx

iloperidone + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Fanapt (iloperidone)

+

ziconotide

1 interaction

Monitor/Modify Tx

iloperidone + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Fanapt (iloperidone)

+

zolpidem

1 interaction

Monitor/Modify Tx

iloperidone + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)