Invega Trinza

Overview

paliperidone

atypical antipsychotic

• CYP3A4 substrate
• P-gp substrate
• CNS depression
• decreases central histamine effects
• dopamine antagonist
• extrapyramidal effects
• hyperglycemic effects
• hyperprolactinemic effects
• hyperthermia
• hypotensive effects
• lowers seizure threshold
• prolongs QT interval (known)

Contraindicated

• cisapride
Invega Trinza (paliperidone palmitate)

+

cisapride

1 interaction

Contraindicated

paliperidone + cisapride

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• domperidone
Invega Trinza (paliperidone palmitate)

+

domperidone

1 interaction

Contraindicated

paliperidone + domperidone

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• dronedarone
Invega Trinza (paliperidone palmitate)

+

dronedarone

1 interaction

Contraindicated

paliperidone + dronedarone

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levoketoconazole
Invega Trinza (paliperidone palmitate)

+

levoketoconazole

1 interaction

Contraindicated

paliperidone + levoketoconazole

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pimozide
Invega Trinza (paliperidone palmitate)

+

pimozide

1 interaction

Contraindicated

paliperidone + pimozide

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia (additive effects)

• thioridazine
Invega Trinza (paliperidone palmitate)

+

thioridazine

1 interaction

Contraindicated

paliperidone + thioridazine

contraindicated: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

Avoid/Use Alternative

• adagrasib
Invega Trinza (paliperidone palmitate)

+

adagrasib

1 interaction

Avoid/Use Alternative

paliperidone + adagrasib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• aldesleukin
Invega Trinza (paliperidone palmitate)

+

aldesleukin

1 interaction

Avoid/Use Alternative

paliperidone + aldesleukin

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, severe or life-threatening hypotension (incl. orthostasis, syncope), seizures (additive effects)

• amifampridine
Invega Trinza (paliperidone palmitate)

+

amifampridine

1 interaction

Avoid/Use Alternative

paliperidone + amifampridine

consider alternative: combo may incr. risk of seizures (additive effects)

• amiodarone
Invega Trinza (paliperidone palmitate)

+

amiodarone

1 interaction

Avoid/Use Alternative

paliperidone + amiodarone

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• anagrelide
Invega Trinza (paliperidone palmitate)

+

anagrelide

1 interaction

Avoid/Use Alternative

paliperidone + anagrelide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• apalutamide
Invega Trinza (paliperidone palmitate)

+

apalutamide

1 interaction

Avoid/Use Alternative

paliperidone + apalutamide

use alternative or monitor ECG, consider oral paliperidone dose adjustment: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. paliperidone levels, efficacy (additive effects; hepatic metab. induced, P-gp-mediated transport induced)

• apomorphine
Invega Trinza (paliperidone palmitate)

+

apomorphine

1 interaction

Avoid/Use Alternative

paliperidone + apomorphine

use alternative or monitor ECG, BP: combo may decr. efficacy of both drugs; may incr. risk of QT prolongation, cardiac arrhythmias, severe hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment (antagonistic effects; additive effects)

• aripiprazole bimonthly injection
Invega Trinza (paliperidone palmitate)

+

aripiprazole bimonthly injection

1 interaction

Avoid/Use Alternative

paliperidone + aripiprazole bimonthly injection

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension (incl. orthostasis, syncope), other adverse effects (additive effects, duplicate tx)

• aripiprazole lauroxil
Invega Trinza (paliperidone palmitate)

+

aripiprazole lauroxil

1 interaction

Avoid/Use Alternative

paliperidone + aripiprazole lauroxil

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension (incl. orthostasis, syncope), other adverse effects (additive effects, duplicate tx)

• aripiprazole monthly injection
Invega Trinza (paliperidone palmitate)

+

aripiprazole monthly injection

1 interaction

Avoid/Use Alternative

paliperidone + aripiprazole monthly injection

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension (incl. orthostasis, syncope), other adverse effects (additive effects, duplicate tx)

• aripiprazole oral
Invega Trinza (paliperidone palmitate)

+

aripiprazole oral

1 interaction

Avoid/Use Alternative

paliperidone + aripiprazole oral

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension (incl. orthostasis, syncope), other adverse effects (additive effects, duplicate tx)

• arsenic trioxide
Invega Trinza (paliperidone palmitate)

+

arsenic trioxide

1 interaction

Avoid/Use Alternative

paliperidone + arsenic trioxide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• artemether/lumefantrine
Invega Trinza (paliperidone palmitate)

+

artemether/ lumefantrine

1 interaction

Avoid/Use Alternative

paliperidone + artemether/ lumefantrine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• asenapine
Invega Trinza (paliperidone palmitate)

+

asenapine

1 interaction

Avoid/Use Alternative

paliperidone + asenapine

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• azithromycin
Invega Trinza (paliperidone palmitate)

+

azithromycin

1 interaction

Avoid/Use Alternative

paliperidone + azithromycin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• bedaquiline
Invega Trinza (paliperidone palmitate)

+

bedaquiline

1 interaction

Avoid/Use Alternative

paliperidone + bedaquiline

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• benztropine
Invega Trinza (paliperidone palmitate)

+

benztropine

1 interaction

Avoid/Use Alternative

paliperidone + benztropine

consider alternative: combo may incr. risk of hyperthermia, incl. life-threatening (additive effects)

• bromocriptine
Invega Trinza (paliperidone palmitate)

+

bromocriptine

1 interaction

Avoid/Use Alternative

paliperidone + bromocriptine

use alternative or monitor BP, glucose (type 2 diabetes mellitus pts): combo may decr. efficacy of both drugs; may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (antagonistic effects; additive effects)

• butalbital
Invega Trinza (paliperidone palmitate)

+

butalbital

1 interaction

Avoid/Use Alternative

paliperidone + butalbital

IM PALIPERIDONE: use alternative or monitor resp. rate; ORAL PALIPERIDONE: monitor resp. rate, consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment (hepatic metab. induced; additive effects)

• cabergoline
Invega Trinza (paliperidone palmitate)

+

cabergoline

1 interaction

Avoid/Use Alternative

paliperidone + cabergoline

use alternative or monitor BP: combo may decr. efficacy of both drugs; may incr. risk of hypotension, incl. orthostasis, syncope (antagonistic effects; additive effects)

• cabozantinib
Invega Trinza (paliperidone palmitate)

+

cabozantinib

1 interaction

Avoid/Use Alternative

paliperidone + cabozantinib

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• carbamazepine
Invega Trinza (paliperidone palmitate)

+

carbamazepine

1 interaction

Avoid/Use Alternative

paliperidone + carbamazepine

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: monitor BP; consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. syncope; may alter seizure control (hepatic metab. induced; P-gp-mediated transport induced; additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• ceritinib
Invega Trinza (paliperidone palmitate)

+

ceritinib

1 interaction

Avoid/Use Alternative

paliperidone + ceritinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• chloroquine
Invega Trinza (paliperidone palmitate)

+

chloroquine

1 interaction

Avoid/Use Alternative

paliperidone + chloroquine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, extrapyramidal sx (additive effects)

• ciprofloxacin
Invega Trinza (paliperidone palmitate)

+

ciprofloxacin

1 interaction

Avoid/Use Alternative

paliperidone + ciprofloxacin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• citalopram
Invega Trinza (paliperidone palmitate)

+

citalopram

1 interaction

Avoid/Use Alternative

paliperidone + citalopram

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• clarithromycin
Invega Trinza (paliperidone palmitate)

+

clarithromycin

1 interaction

Avoid/Use Alternative

paliperidone + clarithromycin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clofazimine
Invega Trinza (paliperidone palmitate)

+

clofazimine

1 interaction

Avoid/Use Alternative

paliperidone + clofazimine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• clonidine
Invega Trinza (paliperidone palmitate)

+

clonidine

1 interaction

Avoid/Use Alternative

paliperidone + clonidine

if ADHD use, avoid combo; otherwise, monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• codeine
Invega Trinza (paliperidone palmitate)

+

codeine

1 interaction

Avoid/Use Alternative

paliperidone + codeine

avoid combo if antitussive use; otherwise monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• crizotinib
Invega Trinza (paliperidone palmitate)

+

crizotinib

1 interaction

Avoid/Use Alternative

paliperidone + crizotinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• danshen
Invega Trinza (paliperidone palmitate)

+

danshen

1 interaction

Avoid/Use Alternative

paliperidone + danshen

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (P-gp-mediated transport induced)

• degarelix
Invega Trinza (paliperidone palmitate)

+

degarelix

1 interaction

Avoid/Use Alternative

paliperidone + degarelix

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• desflurane
Invega Trinza (paliperidone palmitate)

+

desflurane

1 interaction

Avoid/Use Alternative

paliperidone + desflurane

use alternative or monitor ECG, resp. rate, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS and resp. depression, psychomotor impairment (additive effects)

• desipramine
Invega Trinza (paliperidone palmitate)

+

desipramine

1 interaction

Avoid/Use Alternative

paliperidone + desipramine

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, hyperthermia (additive effects)

• dexmedetomidine
Invega Trinza (paliperidone palmitate)

+

dexmedetomidine

1 interaction

Avoid/Use Alternative

paliperidone + dexmedetomidine

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope (additive effects)

• dexmedetomidine injection
Invega Trinza (paliperidone palmitate)

+

dexmedetomidine injection

1 interaction

Avoid/Use Alternative

paliperidone + dexmedetomidine injection

use alternative or monitor ECG, BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment, severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• diazepam
Invega Trinza (paliperidone palmitate)

+

diazepam

1 interaction

Avoid/Use Alternative

paliperidone + diazepam

use alternative or monitor BP, resp. rate, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• dicloxacillin
Invega Trinza (paliperidone palmitate)

+

dicloxacillin

1 interaction

Avoid/Use Alternative

paliperidone + dicloxacillin

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (P-gp-mediated transport induced)

• disopyramide
Invega Trinza (paliperidone palmitate)

+

disopyramide

1 interaction

Avoid/Use Alternative

paliperidone + disopyramide

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, hyperthermia (additive effects)

• dofetilide
Invega Trinza (paliperidone palmitate)

+

dofetilide

1 interaction

Avoid/Use Alternative

paliperidone + dofetilide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• donepezil
Invega Trinza (paliperidone palmitate)

+

donepezil

1 interaction

Avoid/Use Alternative

paliperidone + donepezil

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• doxylamine
Invega Trinza (paliperidone palmitate)

+

doxylamine

1 interaction

Avoid/Use Alternative

paliperidone + doxylamine

avoid combo if doxylamine use for pregnancy-related nausea/vomiting, otherwise caution advised: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia (additive effects)

• droperidol
Invega Trinza (paliperidone palmitate)

+

droperidol

1 interaction

Avoid/Use Alternative

paliperidone + droperidol

use alternative or monitor ECG; decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx (additive effects)

• efavirenz
Invega Trinza (paliperidone palmitate)

+

efavirenz

1 interaction

Avoid/Use Alternative

paliperidone + efavirenz

IM PALIPERIDONE: use alternative or monitor ECG; ORAL PALIPERIDONE: monitor ECG, consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (P-gp-mediated transport induced; additive effects)

• encorafenib
Invega Trinza (paliperidone palmitate)

+

encorafenib

1 interaction

Avoid/Use Alternative

paliperidone + encorafenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. paliperidone levels, efficacy (additive effects; hepatic metab. induced)

• entrectinib
Invega Trinza (paliperidone palmitate)

+

entrectinib

1 interaction

Avoid/Use Alternative

paliperidone + entrectinib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment (additive effects)

• enzalutamide
Invega Trinza (paliperidone palmitate)

+

enzalutamide

1 interaction

Avoid/Use Alternative

paliperidone + enzalutamide

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider oral paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (hepatic metab. induced)

• ephedra
Invega Trinza (paliperidone palmitate)

+

ephedra

1 interaction

Avoid/Use Alternative

paliperidone + ephedra

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• epirubicin
Invega Trinza (paliperidone palmitate)

+

epirubicin

1 interaction

Avoid/Use Alternative

paliperidone + epirubicin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• eribulin
Invega Trinza (paliperidone palmitate)

+

eribulin

1 interaction

Avoid/Use Alternative

paliperidone + eribulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• erythromycin
Invega Trinza (paliperidone palmitate)

+

erythromycin

1 interaction

Avoid/Use Alternative

paliperidone + erythromycin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ethanol
Invega Trinza (paliperidone palmitate)

+

ethanol

1 interaction

Avoid/Use Alternative

paliperidone + ethanol

avoid combo: combo may incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• etrasimod
Invega Trinza (paliperidone palmitate)

+

etrasimod

1 interaction

Avoid/Use Alternative

paliperidone + etrasimod

consider alternative or monitor HR, ECG: combo may incr. risk of bradycardia, AV block, QT prolongation, cardiac arrhythmias (additive effects)

• fexinidazole
Invega Trinza (paliperidone palmitate)

+

fexinidazole

1 interaction

Avoid/Use Alternative

paliperidone + fexinidazole

if possible, do not initiate fexinidazole until 5 half-lives after paliperidone D/C; use alternative or monitor ECG during and x7 days after fexinidazole tx: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• flecainide
Invega Trinza (paliperidone palmitate)

+

flecainide

1 interaction

Avoid/Use Alternative

paliperidone + flecainide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fluorouracil
Invega Trinza (paliperidone palmitate)

+

fluorouracil

1 interaction

Avoid/Use Alternative

paliperidone + fluorouracil

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fluoxetine
Invega Trinza (paliperidone palmitate)

+

fluoxetine

1 interaction

Avoid/Use Alternative

paliperidone + fluoxetine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• foscarnet
Invega Trinza (paliperidone palmitate)

+

foscarnet

1 interaction

Avoid/Use Alternative

paliperidone + foscarnet

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fosphenytoin
Invega Trinza (paliperidone palmitate)

+

fosphenytoin

1 interaction

Avoid/Use Alternative

paliperidone + fosphenytoin

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; P-gp-mediated transport induced; additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• gilteritinib
Invega Trinza (paliperidone palmitate)

+

gilteritinib

1 interaction

Avoid/Use Alternative

paliperidone + gilteritinib

use alternative or monitor ECG, electrolytes, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope (additive effects)

• givinostat
Invega Trinza (paliperidone palmitate)

+

givinostat

1 interaction

Avoid/Use Alternative

paliperidone + givinostat

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• glasdegib
Invega Trinza (paliperidone palmitate)

+

glasdegib

1 interaction

Avoid/Use Alternative

paliperidone + glasdegib

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• goserelin
Invega Trinza (paliperidone palmitate)

+

goserelin

1 interaction

Avoid/Use Alternative

paliperidone + goserelin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. goserelin efficacy (additive effects, androgen deprivation may prolong QT; paliperidone may cause hyperprolactinemia, decr. GnRH receptors)

• grapefruit
Invega Trinza (paliperidone palmitate)

+

grapefruit

1 interaction

Avoid/Use Alternative

paliperidone + grapefruit

use alternative or monitor ECG w/ large amounts of grapefruit (>1L juice): combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• haloperidol
Invega Trinza (paliperidone palmitate)

+

haloperidol

1 interaction

Avoid/Use Alternative

paliperidone + haloperidol

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal sx (additive effects)

• histrelin
Invega Trinza (paliperidone palmitate)

+

histrelin

1 interaction

Avoid/Use Alternative

paliperidone + histrelin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. histrelin efficacy (additive effects, androgen deprivation may prolong QT; paliperidone may cause hyperprolactinemia, decr. GnRH receptors)

• hydrocodone
Invega Trinza (paliperidone palmitate)

+

hydrocodone

1 interaction

Avoid/Use Alternative

paliperidone + hydrocodone

avoid combo if antitussive use; otherwise monitor resp. rate, BP, ECG, electrolytes, especially if hydrocodone ER doses >160 mg/day; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, incl. orthostasis, syncope (additive effects)

• hydroxychloroquine
Invega Trinza (paliperidone palmitate)

+

hydroxychloroquine

1 interaction

Avoid/Use Alternative

paliperidone + hydroxychloroquine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, seizures (additive effects)

• hydroxyzine
Invega Trinza (paliperidone palmitate)

+

hydroxyzine

1 interaction

Avoid/Use Alternative

paliperidone + hydroxyzine

use alternative or monitor ECG; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia (additive effects)

• ibutilide
Invega Trinza (paliperidone palmitate)

+

ibutilide

1 interaction

Avoid/Use Alternative

paliperidone + ibutilide

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• iloperidone
Invega Trinza (paliperidone palmitate)

+

iloperidone

1 interaction

Avoid/Use Alternative

paliperidone + iloperidone

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• inotuzumab ozogamicin
Invega Trinza (paliperidone palmitate)

+

inotuzumab ozogamicin

1 interaction

Avoid/Use Alternative

paliperidone + inotuzumab ozogamicin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• isocarboxazid
Invega Trinza (paliperidone palmitate)

+

isocarboxazid

1 interaction

Avoid/Use Alternative

paliperidone + isocarboxazid

use alternative or monitor BP during and x10 days after isocarboxazid use: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• isoflurane
Invega Trinza (paliperidone palmitate)

+

isoflurane

1 interaction

Avoid/Use Alternative

paliperidone + isoflurane

use alternative or monitor ECG, BP, resp. rate: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS and resp. depression, psychomotor impairment (additive effects)

• ivabradine
Invega Trinza (paliperidone palmitate)

+

ivabradine

1 interaction

Avoid/Use Alternative

paliperidone + ivabradine

consider alternative or monitor HR, ECG: combo may incr. risk of bradycardia, AV block, QT prolongation, cardiac arrhythmias (additive effects)

• ivosidenib
Invega Trinza (paliperidone palmitate)

+

ivosidenib

1 interaction

Avoid/Use Alternative

paliperidone + ivosidenib

avoid combo: combo may decr. paliperidone levels, efficacy; may incr. risk of QT prolongation, cardiac arrhythmias (hepatic metab. induced; additive effects)

• kava
Invega Trinza (paliperidone palmitate)

+

kava

1 interaction

Avoid/Use Alternative

paliperidone + kava

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx (additive effects)

• kratom
Invega Trinza (paliperidone palmitate)

+

kratom

1 interaction

Avoid/Use Alternative

paliperidone + kratom

use alternative or monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment (additive effects)

• lefamulin
Invega Trinza (paliperidone palmitate)

+

lefamulin

1 interaction

Avoid/Use Alternative

paliperidone + lefamulin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• leuprolide
Invega Trinza (paliperidone palmitate)

+

leuprolide

1 interaction

Avoid/Use Alternative

paliperidone + leuprolide

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. leuprolide efficacy (additive effects, androgen deprivation may prolong QT; paliperidone may cause hyperprolactinemia, decr. GnRH receptors)

• levofloxacin
Invega Trinza (paliperidone palmitate)

+

levofloxacin

1 interaction

Avoid/Use Alternative

paliperidone + levofloxacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lofexidine
Invega Trinza (paliperidone palmitate)

+

lofexidine

1 interaction

Avoid/Use Alternative

paliperidone + lofexidine

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• lonafarnib
Invega Trinza (paliperidone palmitate)

+

lonafarnib

1 interaction

Avoid/Use Alternative

paliperidone + lonafarnib

use alternative or monitor HR, ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• loperamide
Invega Trinza (paliperidone palmitate)

+

loperamide

1 interaction

Avoid/Use Alternative

paliperidone + loperamide

use alternative or monitor ECG, esp. if loperamide dose >16mg/day: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lopinavir/ritonavir
Invega Trinza (paliperidone palmitate)

+

lopinavir/ ritonavir

1 interaction

Avoid/Use Alternative

paliperidone + lopinavir/ ritonavir

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lorlatinib
Invega Trinza (paliperidone palmitate)

+

lorlatinib

1 interaction

Avoid/Use Alternative

paliperidone + lorlatinib

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (P-gp-mediated transport induced)

• lumacaftor/ivacaftor
Invega Trinza (paliperidone palmitate)

+

lumacaftor/ ivacaftor

1 interaction

Avoid/Use Alternative

paliperidone + lumacaftor/ ivacaftor

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (hepatic metab. induced; P-gp-mediated transport possibly induced)

• macimorelin
Invega Trinza (paliperidone palmitate)

+

macimorelin

1 interaction

Avoid/Use Alternative

paliperidone + macimorelin

avoid combo, allowing sufficient washout time before diagnostic test: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• metaxalone
Invega Trinza (paliperidone palmitate)

+

metaxalone

1 interaction

Avoid/Use Alternative

paliperidone + metaxalone

use alternative or monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• methadone
Invega Trinza (paliperidone palmitate)

+

methadone

1 interaction

Avoid/Use Alternative

paliperidone + methadone

use alternative or monitor ECG, BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, incl. orthostasis, syncope (additive effects)

• metoclopramide
Invega Trinza (paliperidone palmitate)

+

metoclopramide

1 interaction

Avoid/Use Alternative

paliperidone + metoclopramide

avoid combo: combo may incr. risk of CNS depression, psychomotor impairment, neuroleptic malignant syndrome, extrapyramidal sx (additive effects)

• midazolam
Invega Trinza (paliperidone palmitate)

+

midazolam

1 interaction

Avoid/Use Alternative

paliperidone + midazolam

use alternative or monitor resp. rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• mifepristone
Invega Trinza (paliperidone palmitate)

+

mifepristone

1 interaction

Avoid/Use Alternative

paliperidone + mifepristone

use alternative or monitor ECG if daily mifepristone use: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mitotane
Invega Trinza (paliperidone palmitate)

+

mitotane

1 interaction

Avoid/Use Alternative

paliperidone + mitotane

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; combo may incr. risk of CNS depression, psychomotor impairment (hepatic metab. induced; additive effects)

• mobocertinib
Invega Trinza (paliperidone palmitate)

+

mobocertinib

1 interaction

Avoid/Use Alternative

paliperidone + mobocertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• moxifloxacin
Invega Trinza (paliperidone palmitate)

+

moxifloxacin

1 interaction

Avoid/Use Alternative

paliperidone + moxifloxacin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• nilotinib
Invega Trinza (paliperidone palmitate)

+

nilotinib

1 interaction

Avoid/Use Alternative

paliperidone + nilotinib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oliceridine
Invega Trinza (paliperidone palmitate)

+

oliceridine

1 interaction

Avoid/Use Alternative

paliperidone + oliceridine

use alternative or monitor ECG, resp. rate, BP: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, incl. orthostasis, syncope (additive effects)

• ondansetron
Invega Trinza (paliperidone palmitate)

+

ondansetron

1 interaction

Avoid/Use Alternative

paliperidone + ondansetron

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• osimertinib
Invega Trinza (paliperidone palmitate)

+

osimertinib

1 interaction

Avoid/Use Alternative

paliperidone + osimertinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxaliplatin
Invega Trinza (paliperidone palmitate)

+

oxaliplatin

1 interaction

Avoid/Use Alternative

paliperidone + oxaliplatin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• oxybate
Invega Trinza (paliperidone palmitate)

+

oxybate

1 interaction

Avoid/Use Alternative

paliperidone + oxybate

use alternative or monitor resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, syncope (additive effects)

• ozanimod
Invega Trinza (paliperidone palmitate)

+

ozanimod

1 interaction

Avoid/Use Alternative

paliperidone + ozanimod

consider alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pacritinib
Invega Trinza (paliperidone palmitate)

+

pacritinib

1 interaction

Avoid/Use Alternative

paliperidone + pacritinib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• palonosetron
Invega Trinza (paliperidone palmitate)

+

palonosetron

1 interaction

Avoid/Use Alternative

paliperidone + palonosetron

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• panobinostat
Invega Trinza (paliperidone palmitate)

+

panobinostat

1 interaction

Avoid/Use Alternative

paliperidone + panobinostat

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pasireotide
Invega Trinza (paliperidone palmitate)

+

pasireotide

1 interaction

Avoid/Use Alternative

paliperidone + pasireotide

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pazopanib
Invega Trinza (paliperidone palmitate)

+

pazopanib

1 interaction

Avoid/Use Alternative

paliperidone + pazopanib

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pentamidine
Invega Trinza (paliperidone palmitate)

+

pentamidine

1 interaction

Avoid/Use Alternative

paliperidone + pentamidine

use alternative or monitor ECG, BP; risk may be lower w/ nebulized pentamidine: combo may incr. risk of QT prolongation, cardiac arrhythmias, severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• pentobarbital
Invega Trinza (paliperidone palmitate)

+

pentobarbital

1 interaction

Avoid/Use Alternative

paliperidone + pentobarbital

IM PALIPERIDONE: use alternative or monitor resp. rate, BP; ORAL PALIPERIDONE: monitor resp. rate, BP, consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (hepatic metab. induced; additive effects)

• phenelzine
Invega Trinza (paliperidone palmitate)

+

phenelzine

1 interaction

Avoid/Use Alternative

paliperidone + phenelzine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• phenobarbital
Invega Trinza (paliperidone palmitate)

+

phenobarbital

1 interaction

Avoid/Use Alternative

paliperidone + phenobarbital

IM PALIPERIDONE: use alternative or monitor resp. rate, BP, ECG; ORAL PALIPERIDONE: monitor resp. rate, BP, ECG, consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope; may alter seizure control (hepatic metab. induced; P-gp-mediated transport possibly induced; additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• phenytoin
Invega Trinza (paliperidone palmitate)

+

phenytoin

1 interaction

Avoid/Use Alternative

paliperidone + phenytoin

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS depression, psychomotor impairment; may alter seizure control (hepatic metab. induced; P-gp-mediated transport induced; additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• pimavanserin
Invega Trinza (paliperidone palmitate)

+

pimavanserin

1 interaction

Avoid/Use Alternative

paliperidone + pimavanserin

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pitolisant
Invega Trinza (paliperidone palmitate)

+

pitolisant

1 interaction

Avoid/Use Alternative

paliperidone + pitolisant

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. pitolisant efficacy (additive effects; antagonistic effects)

• ponesimod
Invega Trinza (paliperidone palmitate)

+

ponesimod

1 interaction

Avoid/Use Alternative

paliperidone + ponesimod

use alternative or monitor HR, ECG: combo may incr. risk of bradycardia, AV block, QT prolongation, cardiac arrhythmias (additive effects)

• primidone
Invega Trinza (paliperidone palmitate)

+

primidone

1 interaction

Avoid/Use Alternative

paliperidone + primidone

IM PALIPERIDONE: use alternative or monitor resp. rate; ORAL PALIPERIDONE: monitor resp. rate, consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy; may incr. risk of CNS and resp. depression, psychomotor impairment; may alter seizure control (hepatic metab. induced, P-gp-mediated transport possibly induced; additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• procainamide
Invega Trinza (paliperidone palmitate)

+

procainamide

1 interaction

Avoid/Use Alternative

paliperidone + procainamide

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• promethazine
Invega Trinza (paliperidone palmitate)

+

promethazine

1 interaction

Avoid/Use Alternative

paliperidone + promethazine

use alternative or monitor ECG, BP, resp. rate; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment, seizures, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• propafenone
Invega Trinza (paliperidone palmitate)

+

propafenone

1 interaction

Avoid/Use Alternative

paliperidone + propafenone

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope (additive effects)

• quetiapine
Invega Trinza (paliperidone palmitate)

+

quetiapine

1 interaction

Avoid/Use Alternative

paliperidone + quetiapine

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• quinidine (antiarrhythmic)
Invega Trinza (paliperidone palmitate)

+

quinidine (antiarrhythmic)

1 interaction

Avoid/Use Alternative

paliperidone + quinidine (antiarrhythmic)

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• quinidine (CYP2D6 inhibitor)
Invega Trinza (paliperidone palmitate)

+

quinidine (CYP2D6 inhibitor)

1 interaction

Avoid/Use Alternative

paliperidone + quinidine (CYP2D6 inhibitor)

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• quinine
Invega Trinza (paliperidone palmitate)

+

quinine

1 interaction

Avoid/Use Alternative

paliperidone + quinine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• quizartinib
Invega Trinza (paliperidone palmitate)

+

quizartinib

1 interaction

Avoid/Use Alternative

paliperidone + quizartinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rasagiline
Invega Trinza (paliperidone palmitate)

+

rasagiline

1 interaction

Avoid/Use Alternative

paliperidone + rasagiline

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• revumenib
Invega Trinza (paliperidone palmitate)

+

revumenib

1 interaction

Avoid/Use Alternative

paliperidone + revumenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ribociclib
Invega Trinza (paliperidone palmitate)

+

ribociclib

1 interaction

Avoid/Use Alternative

paliperidone + ribociclib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• rifabutin
Invega Trinza (paliperidone palmitate)

+

rifabutin

1 interaction

Avoid/Use Alternative

paliperidone + rifabutin

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (hepatic metab. induced; P-gp-mediated transport possibly induced)

• rifampin
Invega Trinza (paliperidone palmitate)

+

rifampin

1 interaction

Avoid/Use Alternative

paliperidone + rifampin

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (hepatic metab. induced; P-gp-mediated transport possibly induced)

• rifapentine
Invega Trinza (paliperidone palmitate)

+

rifapentine

1 interaction

Avoid/Use Alternative

paliperidone + rifapentine

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (P-gp-mediated transport possibly induced)

• rilpivirine
Invega Trinza (paliperidone palmitate)

+

rilpivirine

1 interaction

Avoid/Use Alternative

paliperidone + rilpivirine

consider alternative or monitor ECG; risk may be lower w/ IM rilpivirine: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• romidepsin
Invega Trinza (paliperidone palmitate)

+

romidepsin

1 interaction

Avoid/Use Alternative

paliperidone + romidepsin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ropeginterferon alfa-2b
Invega Trinza (paliperidone palmitate)

+

ropeginterferon alfa-2b

1 interaction

Avoid/Use Alternative

paliperidone + ropeginterferon alfa-2b

use alternative: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• rucaparib
Invega Trinza (paliperidone palmitate)

+

rucaparib

1 interaction

Avoid/Use Alternative

paliperidone + rucaparib

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• safinamide
Invega Trinza (paliperidone palmitate)

+

safinamide

1 interaction

Avoid/Use Alternative

paliperidone + safinamide

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selegiline
Invega Trinza (paliperidone palmitate)

+

selegiline

1 interaction

Avoid/Use Alternative

paliperidone + selegiline

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selegiline transdermal
Invega Trinza (paliperidone palmitate)

+

selegiline transdermal

1 interaction

Avoid/Use Alternative

paliperidone + selegiline transdermal

use alternative: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• selpercatinib
Invega Trinza (paliperidone palmitate)

+

selpercatinib

1 interaction

Avoid/Use Alternative

paliperidone + selpercatinib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sertraline
Invega Trinza (paliperidone palmitate)

+

sertraline

1 interaction

Avoid/Use Alternative

paliperidone + sertraline

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• sevoflurane
Invega Trinza (paliperidone palmitate)

+

sevoflurane

1 interaction

Avoid/Use Alternative

paliperidone + sevoflurane

use alternative or monitor ECG, BP, resp. rate: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• siponimod
Invega Trinza (paliperidone palmitate)

+

siponimod

1 interaction

Avoid/Use Alternative

paliperidone + siponimod

consider alternative or monitor HR, ECG: combo may incr. risk of bradycardia, AV block, QT prolongation, cardiac arrhythmias (additive effects)

• solifenacin
Invega Trinza (paliperidone palmitate)

+

solifenacin

1 interaction

Avoid/Use Alternative

paliperidone + solifenacin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia (additive effects)

• sorafenib
Invega Trinza (paliperidone palmitate)

+

sorafenib

1 interaction

Avoid/Use Alternative

paliperidone + sorafenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sotalol
Invega Trinza (paliperidone palmitate)

+

sotalol

1 interaction

Avoid/Use Alternative

paliperidone + sotalol

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope (additive effects)

• St. John's wort
Invega Trinza (paliperidone palmitate)

+

St. John's wort

1 interaction

Avoid/Use Alternative

paliperidone + St. John's wort

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (hepatic metab. induced; P-gp-mediated transport induced)

• telavancin
Invega Trinza (paliperidone palmitate)

+

telavancin

1 interaction

Avoid/Use Alternative

paliperidone + telavancin

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tetrabenazine
Invega Trinza (paliperidone palmitate)

+

tetrabenazine

1 interaction

Avoid/Use Alternative

paliperidone + tetrabenazine

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, neuroleptic malignant syndrome, extrapyramidal sx, CNS depression, psychomotor impairment (additive effects)

• thalidomide
Invega Trinza (paliperidone palmitate)

+

thalidomide

1 interaction

Avoid/Use Alternative

paliperidone + thalidomide

use alternative or monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tipranavir
Invega Trinza (paliperidone palmitate)

+

tipranavir

1 interaction

Avoid/Use Alternative

paliperidone + tipranavir

IM PALIPERIDONE: use alternative; ORAL PALIPERIDONE: consider paliperidone dose adjustment: combo may decr. paliperidone levels, efficacy (P-gp-mediated transport induced)

• toremifene
Invega Trinza (paliperidone palmitate)

+

toremifene

1 interaction

Avoid/Use Alternative

paliperidone + toremifene

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tramadol
Invega Trinza (paliperidone palmitate)

+

tramadol

1 interaction

Avoid/Use Alternative

paliperidone + tramadol

use alternative or monitor resp. rate, ECG, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, seizures, QT prolongation, cardiac arrhythmias, severe hypotension, incl. orthostasis, syncope (additive effects)

• tranylcypromine
Invega Trinza (paliperidone palmitate)

+

tranylcypromine

1 interaction

Avoid/Use Alternative

paliperidone + tranylcypromine

use alternative or monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• trazodone
Invega Trinza (paliperidone palmitate)

+

trazodone

1 interaction

Avoid/Use Alternative

paliperidone + trazodone

use alternative or monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• triclabendazole
Invega Trinza (paliperidone palmitate)

+

triclabendazole

1 interaction

Avoid/Use Alternative

paliperidone + triclabendazole

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trifluridine
Invega Trinza (paliperidone palmitate)

+

trifluridine

1 interaction

Avoid/Use Alternative

paliperidone + trifluridine

use alternative or monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• trimethobenzamide
Invega Trinza (paliperidone palmitate)

+

trimethobenzamide

1 interaction

Avoid/Use Alternative

paliperidone + trimethobenzamide

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx (additive effects)

• triptorelin
Invega Trinza (paliperidone palmitate)

+

triptorelin

1 interaction

Avoid/Use Alternative

paliperidone + triptorelin

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias; may decr. triptorelin efficacy (additive effects, androgen deprivation may prolong QT; paliperidone may cause hyperprolactinemia, decr. GnRH receptors)

• turmeric
Invega Trinza (paliperidone palmitate)

+

turmeric

1 interaction

Avoid/Use Alternative

paliperidone + turmeric

IM PALIPERIDONE: use alternative w/ oral turmeric; ORAL PALIPERIDONE: consider paliperidone dose adjustment w/ oral turmeric: combo may decr. paliperidone levels, efficacy (P-gp-mediated transport induced)

• vandetanib
Invega Trinza (paliperidone palmitate)

+

vandetanib

1 interaction

Avoid/Use Alternative

paliperidone + vandetanib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• vemurafenib
Invega Trinza (paliperidone palmitate)

+

vemurafenib

1 interaction

Avoid/Use Alternative

paliperidone + vemurafenib

use alternative or monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• ziprasidone
Invega Trinza (paliperidone palmitate)

+

ziprasidone

1 interaction

Avoid/Use Alternative

paliperidone + ziprasidone

avoid combo: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, other adverse effects (additive effects, duplicate tx)

• zuranolone
Invega Trinza (paliperidone palmitate)

+

zuranolone

1 interaction

Avoid/Use Alternative

paliperidone + zuranolone

use alternative or consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

Monitor/Modify Tx

• acarbose
Invega Trinza (paliperidone palmitate)

+

acarbose

1 interaction

Monitor/Modify Tx

paliperidone + acarbose

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• acebutolol
Invega Trinza (paliperidone palmitate)

+

acebutolol

1 interaction

Monitor/Modify Tx

paliperidone + acebutolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• albuterol
Invega Trinza (paliperidone palmitate)

+

albuterol

1 interaction

Monitor/Modify Tx

paliperidone + albuterol

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• albuterol inhaled
Invega Trinza (paliperidone palmitate)

+

albuterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + albuterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• alfentanil
Invega Trinza (paliperidone palmitate)

+

alfentanil

1 interaction

Monitor/Modify Tx

paliperidone + alfentanil

monitor BP, resp. rate; decr. dose of one or both drugs: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• alfuzosin
Invega Trinza (paliperidone palmitate)

+

alfuzosin

1 interaction

Monitor/Modify Tx

paliperidone + alfuzosin

monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope (additive effects)

• aliskiren
Invega Trinza (paliperidone palmitate)

+

aliskiren

1 interaction

Monitor/Modify Tx

paliperidone + aliskiren

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• alogliptin
Invega Trinza (paliperidone palmitate)

+

alogliptin

1 interaction

Monitor/Modify Tx

paliperidone + alogliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• alprazolam
Invega Trinza (paliperidone palmitate)

+

alprazolam

1 interaction

Monitor/Modify Tx

paliperidone + alprazolam

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• amantadine
Invega Trinza (paliperidone palmitate)

+

amantadine

1 interaction

Monitor/Modify Tx

paliperidone + amantadine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• amifostine
Invega Trinza (paliperidone palmitate)

+

amifostine

1 interaction

Monitor/Modify Tx

paliperidone + amifostine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• amiloride
Invega Trinza (paliperidone palmitate)

+

amiloride

1 interaction

Monitor/Modify Tx

paliperidone + amiloride

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• amisulpride
Invega Trinza (paliperidone palmitate)

+

amisulpride

1 interaction

Monitor/Modify Tx

paliperidone + amisulpride

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• amitriptyline
Invega Trinza (paliperidone palmitate)

+

amitriptyline

1 interaction

Monitor/Modify Tx

paliperidone + amitriptyline

monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, hyperthermia (additive effects)

• amlodipine
Invega Trinza (paliperidone palmitate)

+

amlodipine

1 interaction

Monitor/Modify Tx

paliperidone + amlodipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• amoxapine
Invega Trinza (paliperidone palmitate)

+

amoxapine

1 interaction

Monitor/Modify Tx

paliperidone + amoxapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• apraclonidine ophthalmic
Invega Trinza (paliperidone palmitate)

+

apraclonidine ophthalmic

1 interaction

Monitor/Modify Tx

paliperidone + apraclonidine ophthalmic

monitor BP if apraclonidine IOP adjunct use; postop use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• aprocitentan
Invega Trinza (paliperidone palmitate)

+

aprocitentan

1 interaction

Monitor/Modify Tx

paliperidone + aprocitentan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• arformoterol inhaled
Invega Trinza (paliperidone palmitate)

+

arformoterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + arformoterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• articaine
Invega Trinza (paliperidone palmitate)

+

articaine

1 interaction

Monitor/Modify Tx

paliperidone + articaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• asciminib
Invega Trinza (paliperidone palmitate)

+

asciminib

1 interaction

Monitor/Modify Tx

paliperidone + asciminib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• atenolol
Invega Trinza (paliperidone palmitate)

+

atenolol

1 interaction

Monitor/Modify Tx

paliperidone + atenolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• avanafil
Invega Trinza (paliperidone palmitate)

+

avanafil

1 interaction

Monitor/Modify Tx

paliperidone + avanafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• azilsartan medoxomil
Invega Trinza (paliperidone palmitate)

+

azilsartan medoxomil

1 interaction

Monitor/Modify Tx

paliperidone + azilsartan medoxomil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• baclofen intrathecal
Invega Trinza (paliperidone palmitate)

+

baclofen intrathecal

1 interaction

Monitor/Modify Tx

paliperidone + baclofen intrathecal

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• benazepril
Invega Trinza (paliperidone palmitate)

+

benazepril

1 interaction

Monitor/Modify Tx

paliperidone + benazepril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• berberine
Invega Trinza (paliperidone palmitate)

+

berberine

1 interaction

Monitor/Modify Tx

paliperidone + berberine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• berotralstat
Invega Trinza (paliperidone palmitate)

+

berotralstat

1 interaction

Monitor/Modify Tx

paliperidone + berotralstat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• betaxolol
Invega Trinza (paliperidone palmitate)

+

betaxolol

1 interaction

Monitor/Modify Tx

paliperidone + betaxolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• betaxolol ophthalmic
Invega Trinza (paliperidone palmitate)

+

betaxolol ophthalmic

1 interaction

Monitor/Modify Tx

paliperidone + betaxolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• bethanechol
Invega Trinza (paliperidone palmitate)

+

bethanechol

1 interaction

Monitor/Modify Tx

paliperidone + bethanechol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• bexagliflozin
Invega Trinza (paliperidone palmitate)

+

bexagliflozin

1 interaction

Monitor/Modify Tx

paliperidone + bexagliflozin

monitor glucose, BP: combo may incr. risk of hypotension, incl. orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• bisoprolol
Invega Trinza (paliperidone palmitate)

+

bisoprolol

1 interaction

Monitor/Modify Tx

paliperidone + bisoprolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• bortezomib
Invega Trinza (paliperidone palmitate)

+

bortezomib

1 interaction

Monitor/Modify Tx

paliperidone + bortezomib

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• brexpiprazole
Invega Trinza (paliperidone palmitate)

+

brexpiprazole

1 interaction

Monitor/Modify Tx

paliperidone + brexpiprazole

monitor BP: combo may incr. risk of hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia (additive effects)

• brimonidine ophthalmic
Invega Trinza (paliperidone palmitate)

+

brimonidine ophthalmic

1 interaction

Monitor/Modify Tx

paliperidone + brimonidine ophthalmic

monitor BP if elevated IOP use; OTC ocular redness use OK: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• brimonidine topical
Invega Trinza (paliperidone palmitate)

+

brimonidine topical

1 interaction

Monitor/Modify Tx

paliperidone + brimonidine topical

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• bumetanide
Invega Trinza (paliperidone palmitate)

+

bumetanide

1 interaction

Monitor/Modify Tx

paliperidone + bumetanide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• bupivacaine
Invega Trinza (paliperidone palmitate)

+

bupivacaine

1 interaction

Monitor/Modify Tx

paliperidone + bupivacaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• bupivacaine liposomal
Invega Trinza (paliperidone palmitate)

+

bupivacaine liposomal

1 interaction

Monitor/Modify Tx

paliperidone + bupivacaine liposomal

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• buprenorphine
Invega Trinza (paliperidone palmitate)

+

buprenorphine

1 interaction

Monitor/Modify Tx

paliperidone + buprenorphine

monitor resp. rate, ECG, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, incl. orthostasis, syncope (additive effects)

• bupropion
Invega Trinza (paliperidone palmitate)

+

bupropion

1 interaction

Monitor/Modify Tx

paliperidone + bupropion

consider lower bupropion doses: combo may incr. risk of seizures (additive effects)

• butorphanol
Invega Trinza (paliperidone palmitate)

+

butorphanol

1 interaction

Monitor/Modify Tx

paliperidone + butorphanol

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• canagliflozin
Invega Trinza (paliperidone palmitate)

+

canagliflozin

1 interaction

Monitor/Modify Tx

paliperidone + canagliflozin

monitor BP, glucose: combo may incr. risk of hypotension, incl. orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• candesartan cilexetil
Invega Trinza (paliperidone palmitate)

+

candesartan cilexetil

1 interaction

Monitor/Modify Tx

paliperidone + candesartan cilexetil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• cannabis
Invega Trinza (paliperidone palmitate)

+

cannabis

1 interaction

Monitor/Modify Tx

paliperidone + cannabis

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• captopril
Invega Trinza (paliperidone palmitate)

+

captopril

1 interaction

Monitor/Modify Tx

paliperidone + captopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• cariprazine
Invega Trinza (paliperidone palmitate)

+

cariprazine

1 interaction

Monitor/Modify Tx

paliperidone + cariprazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects, duplicate tx)

• carteolol ophthalmic
Invega Trinza (paliperidone palmitate)

+

carteolol ophthalmic

1 interaction

Monitor/Modify Tx

paliperidone + carteolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• carvedilol
Invega Trinza (paliperidone palmitate)

+

carvedilol

1 interaction

Monitor/Modify Tx

paliperidone + carvedilol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• chlordiazepoxide
Invega Trinza (paliperidone palmitate)

+

chlordiazepoxide

1 interaction

Monitor/Modify Tx

paliperidone + chlordiazepoxide

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• chloroprocaine
Invega Trinza (paliperidone palmitate)

+

chloroprocaine

1 interaction

Monitor/Modify Tx

paliperidone + chloroprocaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• chlorothiazide
Invega Trinza (paliperidone palmitate)

+

chlorothiazide

1 interaction

Monitor/Modify Tx

paliperidone + chlorothiazide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• chlorpromazine
Invega Trinza (paliperidone palmitate)

+

chlorpromazine

1 interaction

Monitor/Modify Tx

paliperidone + chlorpromazine

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• chlorthalidone
Invega Trinza (paliperidone palmitate)

+

chlorthalidone

1 interaction

Monitor/Modify Tx

paliperidone + chlorthalidone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• cilostazol
Invega Trinza (paliperidone palmitate)

+

cilostazol

1 interaction

Monitor/Modify Tx

paliperidone + cilostazol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• clevidipine
Invega Trinza (paliperidone palmitate)

+

clevidipine

1 interaction

Monitor/Modify Tx

paliperidone + clevidipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• clobazam
Invega Trinza (paliperidone palmitate)

+

clobazam

1 interaction

Monitor/Modify Tx

paliperidone + clobazam

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• clofarabine
Invega Trinza (paliperidone palmitate)

+

clofarabine

1 interaction

Monitor/Modify Tx

paliperidone + clofarabine

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• clomipramine
Invega Trinza (paliperidone palmitate)

+

clomipramine

1 interaction

Monitor/Modify Tx

paliperidone + clomipramine

monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, seizures, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• clonazepam
Invega Trinza (paliperidone palmitate)

+

clonazepam

1 interaction

Monitor/Modify Tx

paliperidone + clonazepam

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• clorazepate
Invega Trinza (paliperidone palmitate)

+

clorazepate

1 interaction

Monitor/Modify Tx

paliperidone + clorazepate

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• clozapine
Invega Trinza (paliperidone palmitate)

+

clozapine

1 interaction

Monitor/Modify Tx

paliperidone + clozapine

monitor ECG, BP, HR, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, seizures, hyperthermia, extrapyramidal effects (additive effects)

• coenzyme Q-10
Invega Trinza (paliperidone palmitate)

+

coenzyme Q-10

1 interaction

Monitor/Modify Tx

paliperidone + coenzyme Q-10

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• colesevelam
Invega Trinza (paliperidone palmitate)

+

colesevelam

1 interaction

Monitor/Modify Tx

paliperidone + colesevelam

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• dapagliflozin
Invega Trinza (paliperidone palmitate)

+

dapagliflozin

1 interaction

Monitor/Modify Tx

paliperidone + dapagliflozin

monitor glucose, BP: combo may decr. antidiabetic agent efficacy; may incr. risk of hypotension, incl. orthostasis, syncope (antagonistic effects; additive effects)

• daridorexant
Invega Trinza (paliperidone palmitate)

+

daridorexant

1 interaction

Monitor/Modify Tx

paliperidone + daridorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• dasatinib
Invega Trinza (paliperidone palmitate)

+

dasatinib

1 interaction

Monitor/Modify Tx

paliperidone + dasatinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• denileukin diftitox
Invega Trinza (paliperidone palmitate)

+

denileukin diftitox

1 interaction

Monitor/Modify Tx

paliperidone + denileukin diftitox

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• deutetrabenazine
Invega Trinza (paliperidone palmitate)

+

deutetrabenazine

1 interaction

Monitor/Modify Tx

paliperidone + deutetrabenazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, neuroleptic malignant syndrome, extrapyramidal sx, CNS depression, psychomotor impairment (additive effects)

• dihydrocodeine
Invega Trinza (paliperidone palmitate)

+

dihydrocodeine

1 interaction

Monitor/Modify Tx

paliperidone + dihydrocodeine

monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• diltiazem
Invega Trinza (paliperidone palmitate)

+

diltiazem

1 interaction

Monitor/Modify Tx

paliperidone + diltiazem

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• dinutuximab
Invega Trinza (paliperidone palmitate)

+

dinutuximab

1 interaction

Monitor/Modify Tx

paliperidone + dinutuximab

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• dipyridamole
Invega Trinza (paliperidone palmitate)

+

dipyridamole

1 interaction

Monitor/Modify Tx

paliperidone + dipyridamole

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• doxazosin
Invega Trinza (paliperidone palmitate)

+

doxazosin

1 interaction

Monitor/Modify Tx

paliperidone + doxazosin

monitor BP, especially during doxazosin initiation/titration: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• doxepin
Invega Trinza (paliperidone palmitate)

+

doxepin

1 interaction

Monitor/Modify Tx

paliperidone + doxepin

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• dronabinol
Invega Trinza (paliperidone palmitate)

+

dronabinol

1 interaction

Monitor/Modify Tx

paliperidone + dronabinol

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• dulaglutide
Invega Trinza (paliperidone palmitate)

+

dulaglutide

1 interaction

Monitor/Modify Tx

paliperidone + dulaglutide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• duloxetine
Invega Trinza (paliperidone palmitate)

+

duloxetine

1 interaction

Monitor/Modify Tx

paliperidone + duloxetine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• eliglustat
Invega Trinza (paliperidone palmitate)

+

eliglustat

1 interaction

Monitor/Modify Tx

paliperidone + eliglustat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• empagliflozin
Invega Trinza (paliperidone palmitate)

+

empagliflozin

1 interaction

Monitor/Modify Tx

paliperidone + empagliflozin

monitor BP, glucose: combo may incr. risk of hypotension, incl. orthostasis, syncope; may decr. antidiabetic agent efficacy (additive effects; antagonistic effects)

• enalapril
Invega Trinza (paliperidone palmitate)

+

enalapril

1 interaction

Monitor/Modify Tx

paliperidone + enalapril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• enalaprilat
Invega Trinza (paliperidone palmitate)

+

enalaprilat

1 interaction

Monitor/Modify Tx

paliperidone + enalaprilat

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• entacapone
Invega Trinza (paliperidone palmitate)

+

entacapone

1 interaction

Monitor/Modify Tx

paliperidone + entacapone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• eplerenone
Invega Trinza (paliperidone palmitate)

+

eplerenone

1 interaction

Monitor/Modify Tx

paliperidone + eplerenone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• epoprostenol
Invega Trinza (paliperidone palmitate)

+

epoprostenol

1 interaction

Monitor/Modify Tx

paliperidone + epoprostenol

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• ertugliflozin
Invega Trinza (paliperidone palmitate)

+

ertugliflozin

1 interaction

Monitor/Modify Tx

paliperidone + ertugliflozin

monitor glucose, BP: combo may decr. antidiabetic agent efficacy; may incr. risk of hypotension, incl. orthostasis, syncope (antagonistic effects; additive effects)

• escitalopram
Invega Trinza (paliperidone palmitate)

+

escitalopram

1 interaction

Monitor/Modify Tx

paliperidone + escitalopram

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• esketamine
Invega Trinza (paliperidone palmitate)

+

esketamine

1 interaction

Monitor/Modify Tx

paliperidone + esketamine

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• esmolol
Invega Trinza (paliperidone palmitate)

+

esmolol

1 interaction

Monitor/Modify Tx

paliperidone + esmolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• estazolam
Invega Trinza (paliperidone palmitate)

+

estazolam

1 interaction

Monitor/Modify Tx

paliperidone + estazolam

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• eszopiclone
Invega Trinza (paliperidone palmitate)

+

eszopiclone

1 interaction

Monitor/Modify Tx

paliperidone + eszopiclone

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ethacrynic acid
Invega Trinza (paliperidone palmitate)

+

ethacrynic acid

1 interaction

Monitor/Modify Tx

paliperidone + ethacrynic acid

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• ethanol (in some formulations)
Invega Trinza (paliperidone palmitate)

+

ethanol (in some formulations)

1 interaction

Monitor/Modify Tx

paliperidone + ethanol (in some formulations)

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• etomidate
Invega Trinza (paliperidone palmitate)

+

etomidate

1 interaction

Monitor/Modify Tx

paliperidone + etomidate

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• exenatide
Invega Trinza (paliperidone palmitate)

+

exenatide

1 interaction

Monitor/Modify Tx

paliperidone + exenatide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• felodipine
Invega Trinza (paliperidone palmitate)

+

felodipine

1 interaction

Monitor/Modify Tx

paliperidone + felodipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• fenoldopam
Invega Trinza (paliperidone palmitate)

+

fenoldopam

1 interaction

Monitor/Modify Tx

paliperidone + fenoldopam

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• fentanyl
Invega Trinza (paliperidone palmitate)

+

fentanyl

1 interaction

Monitor/Modify Tx

paliperidone + fentanyl

monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ferumoxytol
Invega Trinza (paliperidone palmitate)

+

ferumoxytol

1 interaction

Monitor/Modify Tx

paliperidone + ferumoxytol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• fingolimod
Invega Trinza (paliperidone palmitate)

+

fingolimod

1 interaction

Monitor/Modify Tx

paliperidone + fingolimod

monitor ECG overnight during fingolimod initiation/titration: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• flaxseed
Invega Trinza (paliperidone palmitate)

+

flaxseed

1 interaction

Monitor/Modify Tx

paliperidone + flaxseed

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• flibanserin
Invega Trinza (paliperidone palmitate)

+

flibanserin

1 interaction

Monitor/Modify Tx

paliperidone + flibanserin

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• fluconazole
Invega Trinza (paliperidone palmitate)

+

fluconazole

1 interaction

Monitor/Modify Tx

paliperidone + fluconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fluphenazine
Invega Trinza (paliperidone palmitate)

+

fluphenazine

1 interaction

Monitor/Modify Tx

paliperidone + fluphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• flurazepam
Invega Trinza (paliperidone palmitate)

+

flurazepam

1 interaction

Monitor/Modify Tx

paliperidone + flurazepam

monitor BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• formoterol inhaled
Invega Trinza (paliperidone palmitate)

+

formoterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + formoterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• fosinopril
Invega Trinza (paliperidone palmitate)

+

fosinopril

1 interaction

Monitor/Modify Tx

paliperidone + fosinopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• foslevodopa
Invega Trinza (paliperidone palmitate)

+

foslevodopa

1 interaction

Monitor/Modify Tx

paliperidone + foslevodopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• fostemsavir
Invega Trinza (paliperidone palmitate)

+

fostemsavir

1 interaction

Monitor/Modify Tx

paliperidone + fostemsavir

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• furosemide
Invega Trinza (paliperidone palmitate)

+

furosemide

1 interaction

Monitor/Modify Tx

paliperidone + furosemide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• gabapentin
Invega Trinza (paliperidone palmitate)

+

gabapentin

1 interaction

Monitor/Modify Tx

paliperidone + gabapentin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• gabapentin enacarbil
Invega Trinza (paliperidone palmitate)

+

gabapentin enacarbil

1 interaction

Monitor/Modify Tx

paliperidone + gabapentin enacarbil

monitor resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment (additive effects)

• garlic
Invega Trinza (paliperidone palmitate)

+

garlic

1 interaction

Monitor/Modify Tx

paliperidone + garlic

monitor BP w/ supplemental garlic; dietary intake OK: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• gemtuzumab ozogamicin
Invega Trinza (paliperidone palmitate)

+

gemtuzumab ozogamicin

1 interaction

Monitor/Modify Tx

paliperidone + gemtuzumab ozogamicin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• gepirone
Invega Trinza (paliperidone palmitate)

+

gepirone

1 interaction

Monitor/Modify Tx

paliperidone + gepirone

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• glimepiride
Invega Trinza (paliperidone palmitate)

+

glimepiride

1 interaction

Monitor/Modify Tx

paliperidone + glimepiride

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glipizide
Invega Trinza (paliperidone palmitate)

+

glipizide

1 interaction

Monitor/Modify Tx

paliperidone + glipizide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• glyburide
Invega Trinza (paliperidone palmitate)

+

glyburide

1 interaction

Monitor/Modify Tx

paliperidone + glyburide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• granisetron
Invega Trinza (paliperidone palmitate)

+

granisetron

1 interaction

Monitor/Modify Tx

paliperidone + granisetron

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• guanfacine
Invega Trinza (paliperidone palmitate)

+

guanfacine

1 interaction

Monitor/Modify Tx

paliperidone + guanfacine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• hydralazine
Invega Trinza (paliperidone palmitate)

+

hydralazine

1 interaction

Monitor/Modify Tx

paliperidone + hydralazine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• hydrochlorothiazide
Invega Trinza (paliperidone palmitate)

+

hydrochlorothiazide

1 interaction

Monitor/Modify Tx

paliperidone + hydrochlorothiazide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• hydromorphone
Invega Trinza (paliperidone palmitate)

+

hydromorphone

1 interaction

Monitor/Modify Tx

paliperidone + hydromorphone

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• ifosfamide
Invega Trinza (paliperidone palmitate)

+

ifosfamide

1 interaction

Monitor/Modify Tx

paliperidone + ifosfamide

D/C one or both drugs if encephalopathy occurs; otherwise, caution advised: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• iloprost
Invega Trinza (paliperidone palmitate)

+

iloprost

1 interaction

Monitor/Modify Tx

paliperidone + iloprost

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• iloprost inhaled
Invega Trinza (paliperidone palmitate)

+

iloprost inhaled

1 interaction

Monitor/Modify Tx

paliperidone + iloprost inhaled

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• imipramine
Invega Trinza (paliperidone palmitate)

+

imipramine

1 interaction

Monitor/Modify Tx

paliperidone + imipramine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), hyperthermia (additive effects)

• indapamide
Invega Trinza (paliperidone palmitate)

+

indapamide

1 interaction

Monitor/Modify Tx

paliperidone + indapamide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• insulin
Invega Trinza (paliperidone palmitate)

+

insulin

1 interaction

Monitor/Modify Tx

paliperidone + insulin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• iohexol
Invega Trinza (paliperidone palmitate)

+

iohexol

1 interaction

Monitor/Modify Tx

paliperidone + iohexol

if intrathecal iohexol use, D/C paliperidone at least 48h before myelography, may resume at least 24h after procedure: combo may incr. risk of seizures (additive effects)

• iopamidol
Invega Trinza (paliperidone palmitate)

+

iopamidol

1 interaction

Monitor/Modify Tx

paliperidone + iopamidol

caution advised if intrathecal iopamidol use; consider holding paliperidone at least 48h before and at least 24h after intrathecal iopamidol: combo may incr. risk of seizures (additive effects)

• irbesartan
Invega Trinza (paliperidone palmitate)

+

irbesartan

1 interaction

Monitor/Modify Tx

paliperidone + irbesartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• iron sucrose
Invega Trinza (paliperidone palmitate)

+

iron sucrose

1 interaction

Monitor/Modify Tx

paliperidone + iron sucrose

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• isosorbide dinitrate
Invega Trinza (paliperidone palmitate)

+

isosorbide dinitrate

1 interaction

Monitor/Modify Tx

paliperidone + isosorbide dinitrate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isosorbide mononitrate
Invega Trinza (paliperidone palmitate)

+

isosorbide mononitrate

1 interaction

Monitor/Modify Tx

paliperidone + isosorbide mononitrate

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• isradipine
Invega Trinza (paliperidone palmitate)

+

isradipine

1 interaction

Monitor/Modify Tx

paliperidone + isradipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• ketamine
Invega Trinza (paliperidone palmitate)

+

ketamine

1 interaction

Monitor/Modify Tx

paliperidone + ketamine

monitor resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression (incl. life-threatening), psychomotor impairment (additive effects)

• labetalol
Invega Trinza (paliperidone palmitate)

+

labetalol

1 interaction

Monitor/Modify Tx

paliperidone + labetalol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• landiolol
Invega Trinza (paliperidone palmitate)

+

landiolol

1 interaction

Monitor/Modify Tx

paliperidone + landiolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lapatinib
Invega Trinza (paliperidone palmitate)

+

lapatinib

1 interaction

Monitor/Modify Tx

paliperidone + lapatinib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• lemborexant
Invega Trinza (paliperidone palmitate)

+

lemborexant

1 interaction

Monitor/Modify Tx

paliperidone + lemborexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• lenvatinib
Invega Trinza (paliperidone palmitate)

+

lenvatinib

1 interaction

Monitor/Modify Tx

paliperidone + lenvatinib

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levalbuterol inhaled
Invega Trinza (paliperidone palmitate)

+

levalbuterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + levalbuterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• levobunolol ophthalmic
Invega Trinza (paliperidone palmitate)

+

levobunolol ophthalmic

1 interaction

Monitor/Modify Tx

paliperidone + levobunolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• levodopa
Invega Trinza (paliperidone palmitate)

+

levodopa

1 interaction

Monitor/Modify Tx

paliperidone + levodopa

monitor BP: combo may decr. efficacy of both drugs; may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (antagonistic effects; additive effects)

• levorphanol
Invega Trinza (paliperidone palmitate)

+

levorphanol

1 interaction

Monitor/Modify Tx

paliperidone + levorphanol

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• lidocaine
Invega Trinza (paliperidone palmitate)

+

lidocaine

1 interaction

Monitor/Modify Tx

paliperidone + lidocaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• linagliptin
Invega Trinza (paliperidone palmitate)

+

linagliptin

1 interaction

Monitor/Modify Tx

paliperidone + linagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• liraglutide
Invega Trinza (paliperidone palmitate)

+

liraglutide

1 interaction

Monitor/Modify Tx

paliperidone + liraglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• lisinopril
Invega Trinza (paliperidone palmitate)

+

lisinopril

1 interaction

Monitor/Modify Tx

paliperidone + lisinopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lithium
Invega Trinza (paliperidone palmitate)

+

lithium

1 interaction

Monitor/Modify Tx

paliperidone + lithium

D/C one or both drugs if encephalopathy occurs: combo may incr. risk of encephalopathic syndrome, extrapyramidal sx (additive effects)

• lorazepam
Invega Trinza (paliperidone palmitate)

+

lorazepam

1 interaction

Monitor/Modify Tx

paliperidone + lorazepam

monitor resp. rate, BP; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• losartan
Invega Trinza (paliperidone palmitate)

+

losartan

1 interaction

Monitor/Modify Tx

paliperidone + losartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• loxapine
Invega Trinza (paliperidone palmitate)

+

loxapine

1 interaction

Monitor/Modify Tx

paliperidone + loxapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), extrapyramidal sx, hyperthermia (additive effects)

• lubiprostone
Invega Trinza (paliperidone palmitate)

+

lubiprostone

1 interaction

Monitor/Modify Tx

paliperidone + lubiprostone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• lumateperone
Invega Trinza (paliperidone palmitate)

+

lumateperone

1 interaction

Monitor/Modify Tx

paliperidone + lumateperone

monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects, duplicate tx)

• lurasidone
Invega Trinza (paliperidone palmitate)

+

lurasidone

1 interaction

Monitor/Modify Tx

paliperidone + lurasidone

monitor ECG, BP; consider lowest lurasidone start dose, titrate slowly: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia (additive effects)

• magnesium sulfate
Invega Trinza (paliperidone palmitate)

+

magnesium sulfate

1 interaction

Monitor/Modify Tx

paliperidone + magnesium sulfate

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• maraviroc
Invega Trinza (paliperidone palmitate)

+

maraviroc

1 interaction

Monitor/Modify Tx

paliperidone + maraviroc

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• mavorixafor
Invega Trinza (paliperidone palmitate)

+

mavorixafor

1 interaction

Monitor/Modify Tx

paliperidone + mavorixafor

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• mefloquine
Invega Trinza (paliperidone palmitate)

+

mefloquine

1 interaction

Monitor/Modify Tx

paliperidone + mefloquine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• meperidine
Invega Trinza (paliperidone palmitate)

+

meperidine

1 interaction

Monitor/Modify Tx

paliperidone + meperidine

monitor resp. rate, ECG, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, QT prolongation, cardiac arrhythmias, severe hypotension, incl. orthostasis, syncope (additive effects)

• mepivacaine
Invega Trinza (paliperidone palmitate)

+

mepivacaine

1 interaction

Monitor/Modify Tx

paliperidone + mepivacaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• metformin
Invega Trinza (paliperidone palmitate)

+

metformin

1 interaction

Monitor/Modify Tx

paliperidone + metformin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• methohexital
Invega Trinza (paliperidone palmitate)

+

methohexital

1 interaction

Monitor/Modify Tx

paliperidone + methohexital

monitor BP, resp. rate: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• methyldopa
Invega Trinza (paliperidone palmitate)

+

methyldopa

1 interaction

Monitor/Modify Tx

paliperidone + methyldopa

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• methylene blue injection
Invega Trinza (paliperidone palmitate)

+

methylene blue injection

1 interaction

Monitor/Modify Tx

paliperidone + methylene blue injection

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• metolazone
Invega Trinza (paliperidone palmitate)

+

metolazone

1 interaction

Monitor/Modify Tx

paliperidone + metolazone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• metoprolol
Invega Trinza (paliperidone palmitate)

+

metoprolol

1 interaction

Monitor/Modify Tx

paliperidone + metoprolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• metronidazole
Invega Trinza (paliperidone palmitate)

+

metronidazole

1 interaction

Monitor/Modify Tx

paliperidone + metronidazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• midostaurin
Invega Trinza (paliperidone palmitate)

+

midostaurin

1 interaction

Monitor/Modify Tx

paliperidone + midostaurin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• miglitol
Invega Trinza (paliperidone palmitate)

+

miglitol

1 interaction

Monitor/Modify Tx

paliperidone + miglitol

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• milrinone
Invega Trinza (paliperidone palmitate)

+

milrinone

1 interaction

Monitor/Modify Tx

paliperidone + milrinone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• minoxidil
Invega Trinza (paliperidone palmitate)

+

minoxidil

1 interaction

Monitor/Modify Tx

paliperidone + minoxidil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• mirtazapine
Invega Trinza (paliperidone palmitate)

+

mirtazapine

1 interaction

Monitor/Modify Tx

paliperidone + mirtazapine

monitor ECG, BP; consider decr. dose of one or both drugs: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension (incl. orthostasis, syncope), CNS depression, psychomotor impairment, hyperthermia (additive effects)

• moexipril
Invega Trinza (paliperidone palmitate)

+

moexipril

1 interaction

Monitor/Modify Tx

paliperidone + moexipril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• molindone
Invega Trinza (paliperidone palmitate)

+

molindone

1 interaction

Monitor/Modify Tx

paliperidone + molindone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• morphine
Invega Trinza (paliperidone palmitate)

+

morphine

1 interaction

Monitor/Modify Tx

paliperidone + morphine

monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• nadolol
Invega Trinza (paliperidone palmitate)

+

nadolol

1 interaction

Monitor/Modify Tx

paliperidone + nadolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nalbuphine
Invega Trinza (paliperidone palmitate)

+

nalbuphine

1 interaction

Monitor/Modify Tx

paliperidone + nalbuphine

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• nateglinide
Invega Trinza (paliperidone palmitate)

+

nateglinide

1 interaction

Monitor/Modify Tx

paliperidone + nateglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• nattokinase
Invega Trinza (paliperidone palmitate)

+

nattokinase

1 interaction

Monitor/Modify Tx

paliperidone + nattokinase

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• naxitamab
Invega Trinza (paliperidone palmitate)

+

naxitamab

1 interaction

Monitor/Modify Tx

paliperidone + naxitamab

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nebivolol
Invega Trinza (paliperidone palmitate)

+

nebivolol

1 interaction

Monitor/Modify Tx

paliperidone + nebivolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nelarabine
Invega Trinza (paliperidone palmitate)

+

nelarabine

1 interaction

Monitor/Modify Tx

paliperidone + nelarabine

withhold nelarabine if Grade 2 or greater somnolence occurs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• niacin (vitamin B3)
Invega Trinza (paliperidone palmitate)

+

niacin (vitamin B3)

1 interaction

Monitor/Modify Tx

paliperidone + niacin (vitamin B3)

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nicardipine
Invega Trinza (paliperidone palmitate)

+

nicardipine

1 interaction

Monitor/Modify Tx

paliperidone + nicardipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nifedipine
Invega Trinza (paliperidone palmitate)

+

nifedipine

1 interaction

Monitor/Modify Tx

paliperidone + nifedipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nimodipine
Invega Trinza (paliperidone palmitate)

+

nimodipine

1 interaction

Monitor/Modify Tx

paliperidone + nimodipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nisoldipine
Invega Trinza (paliperidone palmitate)

+

nisoldipine

1 interaction

Monitor/Modify Tx

paliperidone + nisoldipine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nitric oxide
Invega Trinza (paliperidone palmitate)

+

nitric oxide

1 interaction

Monitor/Modify Tx

paliperidone + nitric oxide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• nitrite
Invega Trinza (paliperidone palmitate)

+

nitrite

1 interaction

Monitor/Modify Tx

paliperidone + nitrite

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• nitroglycerin
Invega Trinza (paliperidone palmitate)

+

nitroglycerin

1 interaction

Monitor/Modify Tx

paliperidone + nitroglycerin

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• nitroprusside
Invega Trinza (paliperidone palmitate)

+

nitroprusside

1 interaction

Monitor/Modify Tx

paliperidone + nitroprusside

monitor BP: combo may incr. risk of severe or life-threatening hypotension, incl. orthostasis, syncope (additive effects)

• nortriptyline
Invega Trinza (paliperidone palmitate)

+

nortriptyline

1 interaction

Monitor/Modify Tx

paliperidone + nortriptyline

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• ofloxacin
Invega Trinza (paliperidone palmitate)

+

ofloxacin

1 interaction

Monitor/Modify Tx

paliperidone + ofloxacin

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• olanzapine
Invega Trinza (paliperidone palmitate)

+

olanzapine

1 interaction

Monitor/Modify Tx

paliperidone + olanzapine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), hyperthermia, extrapyramidal sx (additive effects, duplicate tx)

• olmesartan medoxomil
Invega Trinza (paliperidone palmitate)

+

olmesartan medoxomil

1 interaction

Monitor/Modify Tx

paliperidone + olmesartan medoxomil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• olodaterol inhaled
Invega Trinza (paliperidone palmitate)

+

olodaterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + olodaterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• opicapone
Invega Trinza (paliperidone palmitate)

+

opicapone

1 interaction

Monitor/Modify Tx

paliperidone + opicapone

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• opium
Invega Trinza (paliperidone palmitate)

+

opium

1 interaction

Monitor/Modify Tx

paliperidone + opium

monitor resp. rate, BP; decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• osilodrostat
Invega Trinza (paliperidone palmitate)

+

osilodrostat

1 interaction

Monitor/Modify Tx

paliperidone + osilodrostat

monitor ECG: combo may incr. risk of QT interval prolongation, cardiac arrhythmias (additive effects)

• oxazepam
Invega Trinza (paliperidone palmitate)

+

oxazepam

1 interaction

Monitor/Modify Tx

paliperidone + oxazepam

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• oxybutynin
Invega Trinza (paliperidone palmitate)

+

oxybutynin

1 interaction

Monitor/Modify Tx

paliperidone + oxybutynin

decr. dose of one or both drugs or consider oxybutynin transdermal patch: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia; somnolence less likely w/ oxybutynin transdermal patch (additive effects)

• oxycodone
Invega Trinza (paliperidone palmitate)

+

oxycodone

1 interaction

Monitor/Modify Tx

paliperidone + oxycodone

monitor resp. rate, BP; decr. oxycodone start dose by at least 50%, consider decr. paliperidone dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• oxymorphone
Invega Trinza (paliperidone palmitate)

+

oxymorphone

1 interaction

Monitor/Modify Tx

paliperidone + oxymorphone

monitor resp. rate, BP; decr. oxymorphone start dose by at least 50%, consider decr. paliperidone dose, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• palopegteriparatide
Invega Trinza (paliperidone palmitate)

+

palopegteriparatide

1 interaction

Monitor/Modify Tx

paliperidone + palopegteriparatide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• pentazocine
Invega Trinza (paliperidone palmitate)

+

pentazocine

1 interaction

Monitor/Modify Tx

paliperidone + pentazocine

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• perindopril
Invega Trinza (paliperidone palmitate)

+

perindopril

1 interaction

Monitor/Modify Tx

paliperidone + perindopril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• perphenazine
Invega Trinza (paliperidone palmitate)

+

perphenazine

1 interaction

Monitor/Modify Tx

paliperidone + perphenazine

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, severe hypotension, incl. orthostasis, syncope (additive effects)

• phenoxybenzamine
Invega Trinza (paliperidone palmitate)

+

phenoxybenzamine

1 interaction

Monitor/Modify Tx

paliperidone + phenoxybenzamine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• phentolamine
Invega Trinza (paliperidone palmitate)

+

phentolamine

1 interaction

Monitor/Modify Tx

paliperidone + phentolamine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• pindolol
Invega Trinza (paliperidone palmitate)

+

pindolol

1 interaction

Monitor/Modify Tx

paliperidone + pindolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• pioglitazone
Invega Trinza (paliperidone palmitate)

+

pioglitazone

1 interaction

Monitor/Modify Tx

paliperidone + pioglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• posaconazole
Invega Trinza (paliperidone palmitate)

+

posaconazole

1 interaction

Monitor/Modify Tx

paliperidone + posaconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pralsetinib
Invega Trinza (paliperidone palmitate)

+

pralsetinib

1 interaction

Monitor/Modify Tx

paliperidone + pralsetinib

monitor ECG; consider monitoring electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• pramipexole
Invega Trinza (paliperidone palmitate)

+

pramipexole

1 interaction

Monitor/Modify Tx

paliperidone + pramipexole

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• pramlintide
Invega Trinza (paliperidone palmitate)

+

pramlintide

1 interaction

Monitor/Modify Tx

paliperidone + pramlintide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• prazosin
Invega Trinza (paliperidone palmitate)

+

prazosin

1 interaction

Monitor/Modify Tx

paliperidone + prazosin

monitor BP, especially during prazosin initiation/titration: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• pregabalin
Invega Trinza (paliperidone palmitate)

+

pregabalin

1 interaction

Monitor/Modify Tx

paliperidone + pregabalin

monitor resp. rate: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment; may alter seizure control (additive effects; antagonistic effects, paliperidone may decr. seizure threshold)

• primaquine
Invega Trinza (paliperidone palmitate)

+

primaquine

1 interaction

Monitor/Modify Tx

paliperidone + primaquine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• procarbazine
Invega Trinza (paliperidone palmitate)

+

procarbazine

1 interaction

Monitor/Modify Tx

paliperidone + procarbazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• prochlorperazine
Invega Trinza (paliperidone palmitate)

+

prochlorperazine

1 interaction

Monitor/Modify Tx

paliperidone + prochlorperazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), extrapyramidal sx, hyperthermia (additive effects)

• propofol
Invega Trinza (paliperidone palmitate)

+

propofol

1 interaction

Monitor/Modify Tx

paliperidone + propofol

monitor BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• propranolol
Invega Trinza (paliperidone palmitate)

+

propranolol

1 interaction

Monitor/Modify Tx

paliperidone + propranolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• protriptyline
Invega Trinza (paliperidone palmitate)

+

protriptyline

1 interaction

Monitor/Modify Tx

paliperidone + protriptyline

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• quazepam
Invega Trinza (paliperidone palmitate)

+

quazepam

1 interaction

Monitor/Modify Tx

paliperidone + quazepam

monitor BP, resp. rate; consider decr. dose of one or both drugs: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• quinapril
Invega Trinza (paliperidone palmitate)

+

quinapril

1 interaction

Monitor/Modify Tx

paliperidone + quinapril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• ramipril
Invega Trinza (paliperidone palmitate)

+

ramipril

1 interaction

Monitor/Modify Tx

paliperidone + ramipril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• ranolazine
Invega Trinza (paliperidone palmitate)

+

ranolazine

1 interaction

Monitor/Modify Tx

paliperidone + ranolazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• relugolix
Invega Trinza (paliperidone palmitate)

+

relugolix

1 interaction

Monitor/Modify Tx

paliperidone + relugolix

if prostate cancer use, monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects, androgen deprivation may prolong QT)

• remifentanil
Invega Trinza (paliperidone palmitate)

+

remifentanil

1 interaction

Monitor/Modify Tx

paliperidone + remifentanil

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• remimazolam
Invega Trinza (paliperidone palmitate)

+

remimazolam

1 interaction

Monitor/Modify Tx

paliperidone + remimazolam

monitor BP, resp. rate; use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of hypotension (incl. orthostasis, syncope), profound CNS and resp. depression, psychomotor impairment (additive effects)

• repaglinide
Invega Trinza (paliperidone palmitate)

+

repaglinide

1 interaction

Monitor/Modify Tx

paliperidone + repaglinide

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• riociguat
Invega Trinza (paliperidone palmitate)

+

riociguat

1 interaction

Monitor/Modify Tx

paliperidone + riociguat

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• risperidone
Invega Trinza (paliperidone palmitate)

+

risperidone

1 interaction

Monitor/Modify Tx

paliperidone + risperidone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• ropinirole
Invega Trinza (paliperidone palmitate)

+

ropinirole

1 interaction

Monitor/Modify Tx

paliperidone + ropinirole

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• ropivacaine
Invega Trinza (paliperidone palmitate)

+

ropivacaine

1 interaction

Monitor/Modify Tx

paliperidone + ropivacaine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• rosiglitazone
Invega Trinza (paliperidone palmitate)

+

rosiglitazone

1 interaction

Monitor/Modify Tx

paliperidone + rosiglitazone

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• rotigotine transdermal
Invega Trinza (paliperidone palmitate)

+

rotigotine transdermal

1 interaction

Monitor/Modify Tx

paliperidone + rotigotine transdermal

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope; may decr. efficacy of both drugs (additive effects; antagonistic effects)

• sacituzumab govitecan
Invega Trinza (paliperidone palmitate)

+

sacituzumab govitecan

1 interaction

Monitor/Modify Tx

paliperidone + sacituzumab govitecan

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• sacubitril
Invega Trinza (paliperidone palmitate)

+

sacubitril

1 interaction

Monitor/Modify Tx

paliperidone + sacubitril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• salmeterol inhaled
Invega Trinza (paliperidone palmitate)

+

salmeterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + salmeterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• saxagliptin
Invega Trinza (paliperidone palmitate)

+

saxagliptin

1 interaction

Monitor/Modify Tx

paliperidone + saxagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• semaglutide
Invega Trinza (paliperidone palmitate)

+

semaglutide

1 interaction

Monitor/Modify Tx

paliperidone + semaglutide

monitor glucose in type 2 diabetes mellitus pts: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sildenafil
Invega Trinza (paliperidone palmitate)

+

sildenafil

1 interaction

Monitor/Modify Tx

paliperidone + sildenafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• silodosin
Invega Trinza (paliperidone palmitate)

+

silodosin

1 interaction

Monitor/Modify Tx

paliperidone + silodosin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• sitagliptin
Invega Trinza (paliperidone palmitate)

+

sitagliptin

1 interaction

Monitor/Modify Tx

paliperidone + sitagliptin

monitor glucose: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• sodium ferric gluconate complex
Invega Trinza (paliperidone palmitate)

+

sodium ferric gluconate complex

1 interaction

Monitor/Modify Tx

paliperidone + sodium ferric gluconate complex

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• sotagliflozin
Invega Trinza (paliperidone palmitate)

+

sotagliflozin

1 interaction

Monitor/Modify Tx

paliperidone + sotagliflozin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• sparsentan
Invega Trinza (paliperidone palmitate)

+

sparsentan

1 interaction

Monitor/Modify Tx

paliperidone + sparsentan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• spironolactone
Invega Trinza (paliperidone palmitate)

+

spironolactone

1 interaction

Monitor/Modify Tx

paliperidone + spironolactone

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• sufentanil
Invega Trinza (paliperidone palmitate)

+

sufentanil

1 interaction

Monitor/Modify Tx

paliperidone + sufentanil

monitor resp. rate, BP, decr. sufentanil start dose, consider decr. paliperidone dose, use lowest effective doses: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• sunitinib
Invega Trinza (paliperidone palmitate)

+

sunitinib

1 interaction

Monitor/Modify Tx

paliperidone + sunitinib

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• suvorexant
Invega Trinza (paliperidone palmitate)

+

suvorexant

1 interaction

Monitor/Modify Tx

paliperidone + suvorexant

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• tacrolimus
Invega Trinza (paliperidone palmitate)

+

tacrolimus

1 interaction

Monitor/Modify Tx

paliperidone + tacrolimus

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• tadalafil
Invega Trinza (paliperidone palmitate)

+

tadalafil

1 interaction

Monitor/Modify Tx

paliperidone + tadalafil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tagraxofusp
Invega Trinza (paliperidone palmitate)

+

tagraxofusp

1 interaction

Monitor/Modify Tx

paliperidone + tagraxofusp

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tamsulosin
Invega Trinza (paliperidone palmitate)

+

tamsulosin

1 interaction

Monitor/Modify Tx

paliperidone + tamsulosin

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tapentadol
Invega Trinza (paliperidone palmitate)

+

tapentadol

1 interaction

Monitor/Modify Tx

paliperidone + tapentadol

monitor resp. rate, BP, decr. dose of one or both drugs, use lowest effective doses and shortest duration of concomitant tx: combo may incr. risk of profound CNS and resp. depression, psychomotor impairment, severe hypotension, incl. orthostasis, syncope (additive effects)

• taurine
Invega Trinza (paliperidone palmitate)

+

taurine

1 interaction

Monitor/Modify Tx

paliperidone + taurine

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tazemetostat
Invega Trinza (paliperidone palmitate)

+

tazemetostat

1 interaction

Monitor/Modify Tx

paliperidone + tazemetostat

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• telmisartan
Invega Trinza (paliperidone palmitate)

+

telmisartan

1 interaction

Monitor/Modify Tx

paliperidone + telmisartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• temazepam
Invega Trinza (paliperidone palmitate)

+

temazepam

1 interaction

Monitor/Modify Tx

paliperidone + temazepam

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• terazosin
Invega Trinza (paliperidone palmitate)

+

terazosin

1 interaction

Monitor/Modify Tx

paliperidone + terazosin

monitor BP, especially during terazosin initiation/titration: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• terbutaline
Invega Trinza (paliperidone palmitate)

+

terbutaline

1 interaction

Monitor/Modify Tx

paliperidone + terbutaline

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• thiothixene
Invega Trinza (paliperidone palmitate)

+

thiothixene

1 interaction

Monitor/Modify Tx

paliperidone + thiothixene

monitor BP; consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment, hypotension (incl. orthostasis, syncope), extrapyramidal sx, hyperthermia (additive effects)

• timolol
Invega Trinza (paliperidone palmitate)

+

timolol

1 interaction

Monitor/Modify Tx

paliperidone + timolol

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• timolol ophthalmic
Invega Trinza (paliperidone palmitate)

+

timolol ophthalmic

1 interaction

Monitor/Modify Tx

paliperidone + timolol ophthalmic

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• tirzepatide
Invega Trinza (paliperidone palmitate)

+

tirzepatide

1 interaction

Monitor/Modify Tx

paliperidone + tirzepatide

monitor glucose if type 2 diabetes mellitus use: combo may decr. antidiabetic agent efficacy (antagonistic effects)

• tizanidine
Invega Trinza (paliperidone palmitate)

+

tizanidine

1 interaction

Monitor/Modify Tx

paliperidone + tizanidine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tolcapone
Invega Trinza (paliperidone palmitate)

+

tolcapone

1 interaction

Monitor/Modify Tx

paliperidone + tolcapone

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• tolterodine
Invega Trinza (paliperidone palmitate)

+

tolterodine

1 interaction

Monitor/Modify Tx

paliperidone + tolterodine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment, hyperthermia (additive effects)

• torsemide
Invega Trinza (paliperidone palmitate)

+

torsemide

1 interaction

Monitor/Modify Tx

paliperidone + torsemide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• trandolapril
Invega Trinza (paliperidone palmitate)

+

trandolapril

1 interaction

Monitor/Modify Tx

paliperidone + trandolapril

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• treprostinil
Invega Trinza (paliperidone palmitate)

+

treprostinil

1 interaction

Monitor/Modify Tx

paliperidone + treprostinil

monitor BP: combo may incr. risk of severe hypotension, incl. orthostasis, syncope (additive effects)

• triamterene
Invega Trinza (paliperidone palmitate)

+

triamterene

1 interaction

Monitor/Modify Tx

paliperidone + triamterene

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• triazolam
Invega Trinza (paliperidone palmitate)

+

triazolam

1 interaction

Monitor/Modify Tx

paliperidone + triazolam

monitor resp. rate, BP: combo may incr. risk of CNS and resp. depression, psychomotor impairment, hypotension, incl. orthostasis, syncope (additive effects)

• trifluoperazine
Invega Trinza (paliperidone palmitate)

+

trifluoperazine

1 interaction

Monitor/Modify Tx

paliperidone + trifluoperazine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, extrapyramidal sx, hyperthermia, severe hypotension, incl. orthostasis, syncope (additive effects)

• trimipramine
Invega Trinza (paliperidone palmitate)

+

trimipramine

1 interaction

Monitor/Modify Tx

paliperidone + trimipramine

monitor BP: combo may incr. risk of CNS depression, psychomotor impairment, hyperthermia, hypotension, incl. orthostasis, syncope (additive effects)

• valbenazine
Invega Trinza (paliperidone palmitate)

+

valbenazine

1 interaction

Monitor/Modify Tx

paliperidone + valbenazine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• valsartan
Invega Trinza (paliperidone palmitate)

+

valsartan

1 interaction

Monitor/Modify Tx

paliperidone + valsartan

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• vardenafil
Invega Trinza (paliperidone palmitate)

+

vardenafil

1 interaction

Monitor/Modify Tx

paliperidone + vardenafil

monitor ECG, BP: combo may incr. risk of QT prolongation, cardiac arrhythmias, hypotension, incl. orthostasis, syncope (additive effects)

• venlafaxine
Invega Trinza (paliperidone palmitate)

+

venlafaxine

1 interaction

Monitor/Modify Tx

paliperidone + venlafaxine

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias, CNS depression, psychomotor impairment (additive effects)

• verapamil
Invega Trinza (paliperidone palmitate)

+

verapamil

1 interaction

Monitor/Modify Tx

paliperidone + verapamil

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• vilanterol inhaled
Invega Trinza (paliperidone palmitate)

+

vilanterol inhaled

1 interaction

Monitor/Modify Tx

paliperidone + vilanterol inhaled

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• voclosporin
Invega Trinza (paliperidone palmitate)

+

voclosporin

1 interaction

Monitor/Modify Tx

paliperidone + voclosporin

monitor ECG, electrolytes: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• voriconazole
Invega Trinza (paliperidone palmitate)

+

voriconazole

1 interaction

Monitor/Modify Tx

paliperidone + voriconazole

monitor ECG: combo may incr. risk of QT prolongation, cardiac arrhythmias (additive effects)

• vosoritide
Invega Trinza (paliperidone palmitate)

+

vosoritide

1 interaction

Monitor/Modify Tx

paliperidone + vosoritide

monitor BP: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• yohimbe
Invega Trinza (paliperidone palmitate)

+

yohimbe

1 interaction

Monitor/Modify Tx

paliperidone + yohimbe

monitor BP, especially w/ high yohimbe doses: combo may incr. risk of hypotension, incl. orthostasis, syncope (additive effects)

• zaleplon
Invega Trinza (paliperidone palmitate)

+

zaleplon

1 interaction

Monitor/Modify Tx

paliperidone + zaleplon

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• ziconotide
Invega Trinza (paliperidone palmitate)

+

ziconotide

1 interaction

Monitor/Modify Tx

paliperidone + ziconotide

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)

• zolpidem
Invega Trinza (paliperidone palmitate)

+

zolpidem

1 interaction

Monitor/Modify Tx

paliperidone + zolpidem

consider decr. dose of one or both drugs: combo may incr. risk of CNS depression, psychomotor impairment (additive effects)