Select a medication above to begin.
Verzenio
abemaciclib
Adult Dosing .
Dosage forms: TAB: 50 mg, 100 mg, 150 mg, 200 mg
Special Note
- [uses, dosing may vary]
- Info: refer to institution protocols and pkg insert prior to prescribing for uses and dosing incl. toxicity-related dose adjustments
hormone receptor-positive HER2-negative breast CA, early
- [adjuvant tx, combo w/ tamoxifen or aromatase inhibitor]
- Dose: 150 mg PO bid x2y; Info: for patients w/ node-positive early dz at high risk of recurrence; use w/ LHRH agonist per standard practice in pre/perimenopausal patients if used in combo w/ aromatase inhibitor; do not cut/crush/chew tab
hormone receptor-positive HER2-negative breast CA, advanced or metastatic
- [first-line tx, combo w/ aromatase inhibitor]
- Dose: 150 mg PO bid; Info: use w/ LHRH agonist per standard practice in pre/perimenopausal patients; do not cut/crush/chew tab
- [progressive dz, combo w/ fulvestrant]
- Dose: 150 mg PO bid; Info: use w/ LHRH agonist per standard practice in pre/perimenopausal patients; do not cut/crush/chew tab
- [progressive dz, monotherapy]
- Dose: 200 mg PO bid; Info: do not cut/crush/chew tab
renal dosing
- [see below]
- CrCl >30: no adjustment; CrCl <30: not defined
- HD/PD: not defined
hepatic dosing
- [adjust dose frequency]
- Child-Pugh Class C: give usual dose qd
Peds Dosing .
Peds dosing is currently unavailable or not applicable for this drug.
Contraindications / Cautions .
- hypersensitivity to drug or ingredient
- avoid: breastfeeding during tx and for at least 3wk after D/C
- caution: patients of childbearing potential
- caution: hepatic impairment, Child-Pugh Class C
- caution: thromboembolism history
Drug Interactions .
Overview
abemaciclib
kinase inhibitor
- CYP3A4 substrate
- MATE1 inhibitor
- MATE2-K inhibitor
- OCT2 inhibitor
- immunosuppressive oncologic agent
- myelosuppressive oncologic agent
- thrombogenic effects
Contraindicated
- adenovirus vaccine, live
- BCG live intravesical
- chikungunya vaccine, live
- cholera vaccine, live
- dengue vaccine, live
- dofetilide
- influenza nasal vaccine, live
- measles/mumps/rubella vaccine, live
- rotavirus vaccine, live
- smallpox vaccine, live
- talimogene laherparepvec
- typhoid vaccine, live
- varicella vaccine, live
- yellow fever vaccine, live
Avoid/Use Alternative
- apalutamide
- bosentan
- butalbital
- carbamazepine
- cenobamate
- ceritinib
- chloramphenicol
- cladribine oral
- dabrafenib
- deferiprone
- dexrazoxane
- efavirenz
- encorafenib
- enzalutamide
- etrasimod
- etravirine
- fexinidazole
- fosphenytoin
- ganciclovir
- grapefruit
- ivosidenib
- ketoconazole
- levoketoconazole
- lopinavir/ritonavir
- lorlatinib
- lumacaftor/ivacaftor
- mavacamten
- mitapivat
- mitotane
- modafinil
- nafcillin
- pacritinib
- palifermin
- penicillamine
- pentobarbital
- pexidartinib
- phenobarbital
- phenytoin
- pimecrolimus topical
- primaquine
- primidone
- rabies vaccine
- radium Ra 223 dichloride
- repotrectinib
- rifabutin
- rifampin
- rifapentine
- ritonavir
- ropeginterferon alfa-2b
- sotorasib
- St. John's wort
- tranexamic acid
- vaccinia immune globulin
- valganciclovir
Monitor/Modify Tx
- abrocitinib
- adagrasib
- aflibercept
- albendazole
- alemtuzumab
- allopurinol
- alprazolam
- aminocaproic acid
- amiodarone
- amlodipine
- angiotensin II
- anthrax immune globulin
- anthrax vaccine
- anti-inhibitor coagulant complex
- anti-thymocyte globulin
- antihemophilic factor (factor VIII)/von Willebrand factor complex
- aprepitant
- asciminib
- asenapine
- asparaginase
- atazanavir
- atidarsagene autotemcel
- atorvastatin
- auranofin
- avacopan
- avatrombopag
- axitinib
- azathioprine
- balsalazide
- baricitinib
- bazedoxifene
- belumosudil
- benznidazole
- berberine
- berotralstat
- betibeglogene autotemcel
- bevacizumab
- bicalutamide
- binimetinib
- botulism immune globulin
- brolucizumab
- C1 esterase inhibitor
- cabozantinib
- calaspargase
- capivasertib
- carfilzomib
- celecoxib
- chikungunya vaccine
- chlorzoxazone
- chorionic gonadotropin
- cidofovir
- cilostazol
- cimetidine
- ciprofloxacin
- clarithromycin
- clofazimine
- clotrimazole oropharyngeal
- clozapine
- coagulation factor IX
- coagulation factor VIIa
- cobicistat
- colchicine
- concizumab
- conivaptan
- COVID-19 vaccine
- cranberry
- crizotinib
- cyclophosphamide
- cyclosporine
- cytomegalovirus immune globulin
- danazol
- dapsone
- darbepoetin alfa
- daridorexant
- darunavir
- deferasirox
- deflazacort
- desogestrel (contraceptive)
- deuruxolitinib
- dexamethasone
- diclofenac
- diclofenac topical
- dienogest (contraceptive)
- diflunisal
- diltiazem
- diosmin
- diphtheria/tetanus vaccine
- diphtheria/tetanus/pertussis vaccine
- dronedarone
- drospirenone (contraceptive)
- drospirenone (hormone replacement)
- duvelisib
- ebola vaccine, live
- efbemalenograstim alfa
- eflapegrastim (G-CSF)
- elivaldogene autotemcel
- eltrombopag
- entrectinib
- epirubicin
- epoetin alfa
- erythromycin
- estetrol (contraceptive)
- estradiol (contraceptive)
- estradiol (hormone replacement)
- estrogens, conjugated (hormone replacement)
- estrogens, esterified (hormone replacement)
- ethinyl estradiol (contraceptive)
- ethinyl estradiol (hormone replacement)
- ethynodiol (contraceptive)
- etodolac
- etonogestrel (contraceptive)
- everolimus
- exagamglogene autotemcel
- factor XIII concentrate
- faricimab
- fedratinib
- fenofibrate
- fenofibric acid
- fenoprofen
- filgrastim (G-CSF)
- finerenone
- fitusiran
- flibanserin
- fluconazole
- flucytosine
- fluphenazine
- flurbiprofen
- fluvoxamine
- follitropin
- fosamprenavir
- fosaprepitant
- foscarnet
- fostamatinib
- fruquintinib
- gepotidacin
- ginkgo
- givinostat
- givosiran
- glecaprevir
- goldenseal
- grazoprevir
- Haemophilus b vaccine
- hepatitis A vaccine
- hepatitis B immune globulin
- hepatitis B vaccine
- human papillomavirus vaccine
- hydroxychloroquine
- hydroxyurea
- ibuprofen
- idelalisib
- imatinib
- immune globulin
- indomethacin
- influenza H5N1 vaccine
- influenza vaccine
- interferon beta 1a
- interferon beta 1b
- interferon gamma 1b
- iohexol
- iomeprol
- iopamidol
- isavuconazonium
- isoniazid
- istradefylline
- itraconazole
- ivacaftor
- Japanese encephalitis vaccine
- ketoprofen
- ketorolac
- kratom
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- leflunomide
- lenacapavir
- lenalidomide
- lenvatinib
- letermovir
- levonorgestrel (contraceptive)
- levonorgestrel (hormone replacement)
- linezolid
- lomitapide
- lonafarnib
- lovastatin
- lovotibeglogene autotemcel
- lumateperone
- lurasidone
- luspatercept
- lusutrombopag
- lymphocyte immune globulin, anti-thymocyte globulin
- maribavir
- mavorixafor
- meclofenamate
- medroxyprogesterone (contraceptive)
- medroxyprogesterone (hormone replacement)
- megestrol
- meloxicam
- meningococcal vaccine
- menotropins
- mercaptopurine
- mesalamine
- mesalamine rectal
- metformin
- methotrexate
- methoxy polyethylene glycol-epoetin beta
- methyltestosterone
- mifepristone
- momelotinib
- mycophenolate mofetil
- mycophenolic acid
- nabumetone
- naproxen
- necitumumab
- nefazodone
- nelfinavir
- netupitant
- nicardipine
- nilotinib
- nintedanib
- nirogacestat
- norelgestromin (contraceptive)
- norethindrone (contraceptive)
- norethindrone (hormone replacement)
- norgestimate (contraceptive)
- norgestrel (contraceptive)
- olaparib
- olsalazine
- osilodrostat
- ospemifene
- oxaprozin
- palbociclib
- pazopanib
- pegaspargase
- pegfilgrastim (G-CSF)
- peginterferon alfa 2a
- peginterferon beta 1a
- pentamidine
- peppermint
- pibrentasvir
- pindolol
- piroxicam
- pirtobrutinib
- pneumococcal vaccine
- poliovirus vaccine
- pomalidomide
- ponatinib
- porfimer
- posaconazole
- procainamide
- progesterone (hormone replacement)
- progesterone vaginal (hormone replacement)
- proguanil
- prothrombin complex concentrate (human)
- pyrimethamine
- quercetin
- ramucirumab
- ranibizumab
- ranolazine
- remdesivir
- respiratory syncytial virus vaccine
- resveratrol
- Rho(D) immune globulin
- ribavirin
- ribociclib
- rilzabrutinib
- ritlecitinib
- rituximab
- romiplostim
- rucaparib
- ruxolitinib topical
- sargramostim (GM-CSF)
- sarilumab
- satralizumab
- segesterone (contraceptive)
- selpercatinib
- sipuleucel-T
- sirolimus
- smallpox/mpox vaccine, live
- sodium tetradecyl sulfate
- sotatercept
- spironolactone
- stiripentol
- succimer
- sulfasalazine
- sulindac
- teplizumab
- teriflunomide
- testosterone
- thalidomide
- ticagrelor
- tick-borne encephalitis vaccine
- tipranavir
- tivozanib
- tocilizumab
- tofacitinib
- tolvaptan
- toremifene
- treosulfan
- tretinoin
- trimethoprim
- trofinetide
- tucatinib
- typhoid vaccine
- upadacitinib
- vadadustat
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vancomycin
- varicella zoster immune globulin
- verapamil
- viloxazine
- von Willebrand factor
- vonoprazan
- voriconazole
- vorinostat
- voxelotor
- xanomeline
- zidovudine
- zileuton
- ziv-aflibercept
- zopapogene imadenovec
Caution Advised
- abatacept
- adalimumab
- anakinra
- anifrolumab
- armodafinil
- artemether/lumefantrine
- basiliximab
- beclomethasone inhaled
- beclomethasone nasal
- belatacept
- belimumab
- belzutifan
- betamethasone
- bexarotene
- bimekizumab
- brigatinib
- brodalumab
- budesonide
- budesonide inhaled
- budesonide nasal
- budesonide rectal
- canakinumab
- certolizumab pegol
- clobazam
- clobetasol ophthalmic
- corticotropin
- cortisone
- crovalimab
- dalfampridine
- danicopan
- danshen
- darolutamide
- delgocitinib topical
- deucravacitinib
- dexamethasone ophthalmic
- dicloxacillin
- difluprednate ophthalmic
- dimethyl fumarate
- diroximel fumarate
- dupilumab
- echinacea
- eculizumab
- efgartigimod alfa
- elafibranor
- elagolix
- emapalumab
- enasidenib
- eslicarbazepine acetate
- etanercept
- felbamate
- fingolimod
- fludrocortisone
- flunisolide nasal
- fluocinolone intravitreal
- fluorometholone ophthalmic
- fluticasone furoate
- fluticasone propionate
- garlic
- ginseng, Asian
- glycerol phenylbutyrate
- golimumab
- griseofulvin
- guselkumab
- hydrocortisone
- hydrocortisone ophthalmic
- inebilizumab
- infliximab
- iptacopan
- ixekizumab
- lamivudine
- lebrikizumab
- loteprednol ophthalmic
- memantine
- meropenem
- methylprednisolone
- mirikizumab
- mitoxantrone
- mobocertinib
- mometasone implant
- mometasone inhaled
- mometasone nasal
- monomethyl fumarate
- nadofaragene firadenovec intravesical
- natalizumab
- nevirapine
- nipocalimab
- ocrelizumab
- odevixibat
- ofatumumab
- olutasidenib
- omaveloxolone
- oxcarbazepine
- ozanimod
- pegcetacoplan
- perampanel
- pioglitazone
- ponesimod
- pozelimab
- pramipexole
- prednisolone
- prednisolone ophthalmic
- prednisone
- raloxifene
- ravulizumab
- rilonacept
- risankizumab
- rozanolixizumab
- rufinamide
- secukinumab
- siltuximab
- siponimod
- spesolimab
- sunvozertinib
- sutimlimab
- suzetrigine
- tacrolimus
- tamoxifen
- tazemetostat
- tecovirimat
- telotristat ethyl
- tezepelumab
- tildrakizumab
- topiramate
- tovorafenib
- tralokinumab
- triamcinolone
- tuberculin purified protein derivative
- ublituximab
- ustekinumab
- vaborbactam
- vedolizumab
- vemurafenib
- vilobelimab
- vinblastine
- voclosporin
- vorasidenib
- zanubrutinib
- zilucoplan
Adverse Reactions .
Serious Reactions
- diarrhea, severe
- neutropenia
- febrile neutropenia
- sepsis
- interstitial lung dz
- pneumonitis, non-infectious
- hepatotoxicity
- acute kidney injury
- venous thromboembolism
- cerebral infarction
- MI
- cardiac arrest
- cardiac failure
- ventricular fibrillation
- cerebral hemorrhage
Common Reactions
- diarrhea
- infection
- neutropenia
- fatigue
- nausea
- vomiting
- headache
- appetite decr.
- alopecia
- stomatitis
- dizziness
- rash
- peripheral edema
- fever
- pruritus
- abdominal pain
- dysgeusia
- dyspepsia
- hepatotoxicity
- nail disorder
- lacrimation incr.
- cough
- pneumonitis
- interstitial lung dz
- weight decr.
- venous thromboembolism
- constipation
- Cr incr.
- anemia
- lymphocytes decr.
- platelets decr.
- ALT or AST incr.
- hypokalemia
Safety/Monitoring .
Monitoring Parameters
pregnancy test at baseline; CBC w/ diff, LFTs at baseline, then q2wk x2mo, then qmo x2mo and as clinically indicated; signs/symptoms of interstitial lung dz, thromboembolism
Pregnancy/Lactation .
Pregnancy
Clinical Summary
weigh risk/benefit during pregnancy; no human data available; risk of teratogenicity and decr. fetal wt based on animal data at 1x or greater systemic exposure and drug's mechanism of action
Individuals of Reproductive Potential
obtain pregnancy test before tx start; avoid pregnancy by using effective contraception during tx and x3wk after D/C in patients of childbearing potential
Lactation
Clinical Summary
avoid breastfeeding during tx and for at least 3wk after D/C; no human data available to assess risk of infant harm or effects on milk production
Pharmacology .
Metabolism: liver primarily; CYP450: 3A4 substrate; Info: active metabolites
Excretion: feces 81%, urine 3%; Half-life: 18.3h
Subclass: Kinase Inhibitors, CDK Inhibitors
Mechanism of Action
inhibits cyclin-dependent kinase (CDK) 4 and 6, leading to decr. malignant cellular proliferation
Formulary .
No Formulary Selected
Join Now to View Patient Handouts!
Create a FREE epocrates Online account to access patient medication instructions. Your patients and caregivers will appreciate you printing these friendly handouts, available in English and Spanish. Each handout addresses common concerns such as how to take the medication, and possible side effects.
Current Members: Sign In.
Pill Pictures
Join Now to View Pill Pictures!
Create a FREE epocrates Online account to access full-color images of medications within the drug monograph.
Current Members: Sign In.