Highlights & Basics
- Shock is commonly diagnosed when signs of hypoperfusion are associated with low or declining blood pressure.
- Shock may result from a number of disease processes, including pump failure (cardiogenic), loss of intravascular volume (hypovolemic), failure of vasoregulation (distributive), or obstruction to blood flow (obstructive).
- Initial treatment aims to optimize oxygen delivery and reverse hypoperfusion through volume resuscitation, vasoactive agents for refractory hypotension due to vasodilation, management of cardiac dysfunction, and treatment of the underlying cause.
- Management of shock is best undertaken in a critical care environment.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
Cecconi M, De Backer D, Antonelli M, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014 Dec;40(12):1795-815.[Abstract][Full Text]
Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-247.[Abstract][Full Text]
McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726.[Abstract][Full Text]
Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022 May 3;79(17):e263-421.[Abstract][Full Text]
van Diepen S, Katz JN, Albert NM, et al. Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2017 Oct 17;136(16):e232-68.[Abstract][Full Text]
1. Cecconi M, De Backer D, Antonelli M, et al. Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med. 2014 Dec;40(12):1795-815.[Abstract][Full Text]
2. Evans L, Rhodes A, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Intensive Care Med. 2021 Nov;47(11):1181-247.[Abstract][Full Text]
3. McDonagh TA, Metra M, Adamo M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726.[Abstract][Full Text]
4. Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA guideline for the management of heart failure: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2022 May 3;79(17):e263-421.[Abstract][Full Text]
5. De Backer D, Biston P, Devriendt J, et al; SOAP II Investigators. Comparison of dopamine and norepinephrine in the treatment of shock. N Engl J Med. 2010 Mar 4;362(9):779-89.[Abstract]
6. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med. 2001 Jul;29(7):1303-10.[Abstract]
7. Brun-Buisson C, Meshaka P, Pinton P, et al. EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med. 2004 Apr;30(4):580-8.[Abstract]
8. Engel C, Brunkhorst FM, Bone HG, et al. Epidemiology of sepsis in Germany: results from a national prospective multicenter study. Intensive Care Med. 2007 Apr;33(4):606-18.[Abstract]
9. Esteban A, Frutos-Vivar F, Ferguson ND, et al. Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward. Crit Care Med. 2007 May;35(5):1284-9.[Abstract]
10. Goldberg RJ, Samad NA, Yarzebski J, et al. Temporal trends in cardiogenic shock complicating acute myocardial infarction. N Engl J Med. 1999 Apr 15;340(15):1162-8.[Abstract][Full Text]
11. Babaev A, Frederick PD, Pasta DJ, et al. Trends in management and outcomes of patients with acute myocardial infarction complicated by cardiogenic shock. JAMA. 2005 Jul 27;294(4):448-54.[Abstract][Full Text]
12. Steg PG, Goldberg RJ, Gore JM, et al. Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE). Am J Cardiol. 2002 Aug 15;90(4):358-63.[Abstract]
13. Koek HL, Kardaun JW, Gevers E, et al. Acute myocardial infarction incidence and hospital mortality: routinely collected national data versus linkage of national registers. Eur J Epidemiol. 2007;22(11):755-62.[Abstract][Full Text]
14. Roger VL, Jacobsen SJ, Weston SA, et al. Trends in the incidence and survival of patients with hospitalized myocardial infarction, Olmsted County, Minnesota, 1979 to 1994. Ann Intern Med. 2002 Mar 5;136(5):341-8.[Abstract]
15. Chioncel O, Parissis J, Mebazaa A, et al. Epidemiology, pathophysiology and contemporary management of cardiogenic shock - a position statement from the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail. 2020 Aug;22(8):1315-41.[Abstract][Full Text]
16. Thiele H, Ohman EM, Desch S, et al. Management of cardiogenic shock. Eur Heart J. 2015 May 21;36(20):1223-30.[Abstract][Full Text]
17. Thomas NJ, Carcillo JA. Hypovolemic shock in pediatric patients. New Horiz. 1998 May;6(2):120-9.[Abstract]
18. Centers for Disease Control and Prevention, National Center for Injury Prevention and Control. Web-based injury statistics query and reporting system (WISQARS). Dec 2021 [internet publication].[Full Text]
19. Rossaint R, Bouillon B, Cerny V, et al. The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition. Crit Care. 2016 Apr 12;20:100.[Abstract][Full Text]
20. Cannon JW. Hemorrhagic shock. N Engl J Med. 2018 Jan 25;378(4):370-9.[Abstract]
21. Geppert A, Steiner A, Zorn G, et al. Multiple organ failure in patients with cardiogenic shock is associated with high plasma levels of interleukin-6. Crit Care Med. 2002 Sep;30(9):1987-94.[Abstract]
22. Edgren G, Almqvist R, Hartman M, et al. Splenectomy and the risk of sepsis: a population-based cohort study. Ann Surg. 2014 Dec;260(6):1081-7.[Abstract]
23. Brodie BR, Hansen C, Stuckey TD, et al. Door-to-balloon time with primary percutaneous coronary intervention for acute myocardial infarction impacts late cardiac mortality in high-risk patients and patients presenting early after the onset of symptoms. J Am Coll Cardiol. 2006 Jan 17;47(2):289-95.[Abstract][Full Text]
24. Royal College of Physicians. National early warning score (NEWS) 2. December 2017 [internet publication].[Full Text]
25. Carney N, Totten AM, O'Reilly C, et al. Guidelines for the management of severe traumatic brain injury, Fourth Edition. Neurosurgery. 2017 Jan 1;80(1):6-15.[Abstract][Full Text]
26. Rususcitation Council UK. Resuscitation guidelines: the ABCDE approach. 2021 [internet publication].[Full Text]
27. Berger T, Green J, Horeczko T, et al. Shock index and early recognition of sepsis in the emergency department: pilot study. West J Emerg Med. 2013 Mar;14(2):168-74.[Abstract][Full Text]
28. National Patient Safety Agency. Alert: Blood control safety cannula and needle thoracostomy for tension pneumothorax. April 2020 [internet publication].[Full Text]
29. Leigh-Smith S, Harris T. Tension pneumothorax - time for a re-think? Emerg Med J. 2005 Jan;22(1):8-16. [Abstract][Full Text]
30. Jones R, Hollingsworth J. Tension pneumothoraces not responding to needle thoracocentesis. Emerg Med J. 2002 Mar;19(2):176-7.[Abstract][Full Text]
31. Ibanez B, James S, Agewall S, et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2018 Jan 7;39(2):119-77.[Abstract][Full Text]
32. Lee JW. Fluid and electrolyte disturbances in critically ill patients. Electrolyte Blood Press. 2010 Dec;8(2):72-81.[Abstract][Full Text]
33. Bonanno FG. Clinical pathology of the shock syndromes. J Emerg Trauma Shock. 2011 Apr;4(2):233-43.[Abstract][Full Text]
34. O'Driscoll BR, Howard LS, Earis J, et al. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017 Jun;72(suppl 1):ii1-90.[Abstract]
35. Marik PE, Bellomo R. Stress hyperglycemia: an essential survival response!. Crit Care. 2013 Mar 6;17(2):305.[Abstract][Full Text]
36. Nassar BS, Schmidt GA. Capnography during critical illness. Chest. 2016 Feb;149(2):576-85.[Abstract]
37. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001 Nov 8;345(19):1368-77.[Abstract][Full Text]
38. Gilbert RE, Mok Q, Dwan K, et al. Impregnated central venous catheters for prevention of bloodstream infection in children (the CATCH trial): a randomised controlled trial. Lancet. 2016 Apr 23;387(10029):1732-42.[Abstract]
39. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38.[Abstract]
40. Levin A, Warnock DG, Mehta RL, et al. Improving outcomes from acute kidney injury: report of an initiative. Am J Kidney Dis. 2007 Jul;50(1):1-4.[Abstract]
41. Revelly JP, Tappy L, Martinez A, et al. Lactate and glucose metabolism in severe sepsis and cardiogenic shock. Crit Care Med. 2005 Oct;33(10):2235-40.[Abstract]
42. Carvounis CP, Nisar S, Guro-Razuman S. Significance of the fractional excretion of urea in the differential diagnosis of acute renal failure. Kidney Int. 2002 Dec;62(6):2223-9.[Abstract][Full Text]
43. Joint British Diabetes Societies Inpatient Care Group. The management of diabetic ketoacidosis in adults. June 2021 [internet publication].[Full Text]
44. Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol. 2008 Jan;3(1):208-25.[Abstract][Full Text]
45. Kitabchi AE, Umpierrez GE, Murphy MB, et al. Management of hyperglycemic crises in patients with diabetes. Diabetes Care. 2001 Jan;24(1):131-53.[Abstract]
46. Kitabchi AE, Umpierrez GE, Miles JM, et al. Hyperglycemic crises in adult patients with diabetes. Diabetes Care. 2009 Jul;32(7):1335-43.[Abstract][Full Text]
47. Chalupa P, Beran O, Herwald H, et al. Evaluation of potential biomarkers for the discrimination of bacterial and viral infections. Infection. 2011 Oct;39(5):411-7.[Abstract]
48. McCann FJ, Chapman SJ, Yu WC, et al. Ability of procalcitonin to discriminate infection from non-infective inflammation using two pleural disease settings. PLoS One. 2012;7(12):e49894.[Abstract][Full Text]
49. Becker KL, Snider R, Nylen ES. Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations. Crit Care Med. 2008 Mar;36(3):941-52.[Abstract]
50. Phua J, Koay ES, Lee KH. Lactate, procalcitonin, and amino-terminal pro-B-type natriuretic peptide versus cytokine measurements and clinical severity scores for prognostication in septic shock. Shock. 2008 Mar;29(3):328-33.[Abstract][Full Text]
51. Subramaniam B, Talmor D. Echocardiography for management of hypotension in the intensive care unit. Crit Care Med. 2007 Aug;35(8 suppl):S401-7.[Abstract]
52. Beaulieu Y. Bedside echocardiography in the assessment of the critically ill. Crit Care Med. 2007 May;35(5 suppl):S235-49.[Abstract]
53. Joseph MX, Disney PJ, Da Costa R, et al. Transthoracic echocardiography to identify or exclude cardiac cause of shock. Chest. 2004 Nov;126(5):1592-7.[Abstract]
54. van Diepen S, Katz JN, Albert NM, et al. Contemporary management of cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2017 Oct 17;136(16):e232-68.[Abstract][Full Text]
55. Lubner M, Demertzis J, Lee JY, et al. CT evaluation of shock viscera: a pictorial review. Emerg Radiol. 2008 Jan;15(1):1-11.[Abstract]
56. Tarrant AM, Ryan MF, Hamilton PA, et al. A pictorial review of hypovolaemic shock in adults. Br J Radiol. 2008 Mar;81(963):252-7.[Abstract]
57. Konstantinides SV, Meyer G, Becattini C, et al. 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS). Eur Heart J. 2020 Jan 21;41(4):543-603.[Abstract][Full Text]
58. National Institute for Health and Care Excellence. Nice guideline NG158: venous thromboembolic diseases: diagnosis, management and thrombophilia testing. March 2020 [internet publication].[Full Text]
59. Kristensen AK, Holler JG, Hallas J, et al. Is shock index a valid predictor of mortality in emergency department patients with hypertension, diabetes, high age, or receipt of beta- or calcium channel blockers? Ann Emerg Med. 2016 Jan;67(1):106-13.[Abstract]
60. Subbe CP, Kruger M, Rutherford P, et al. Validation of a modified Early Warning Score in medical admissions. QJM. 2001 Oct;94(10):521-6.[Abstract][Full Text]
61. National Institute for Health and Care Excellence. Suspected sepsis: recognition, diagnosis and early management. Mar 2024 [internet publication]. [Full Text]
62. Golden DBK, Wang J, Waserman S, et al. Anaphylaxis: a 2023 practice parameter update. Ann Allergy Asthma Immunol. 2024 Feb;132(2):124-76.[Abstract][Full Text]
63. Panchal AR, Bartos JA, Cabañas JG, et al. Part 3: Adult Basic and Advanced Life Support: 2020 American Heart Association guidelines for cardiopulmonary resuscitation and emergency cardiovascular care. Circulation. 2020 Oct 20;142(16_suppl_2):S366-S468.[Abstract][Full Text]
64. Lott C, Truhlář A, Alfonzo A, et al. European Resuscitation Council Guidelines 2021: Cardiac arrest in special circumstances. Resuscitation. 2021 Apr;161:152-219.[Abstract][Full Text]
65. Nieminen MS, Böhm M, Cowie MR, et al. Executive summary of the guidelines on the diagnosis and treatment of acute heart failure. Eur Heart J. 2005 Feb;26(4):384-416.[Abstract][Full Text]
66. Davis AL, Carcillo JA, Aneja RK, et al. American College of Critical Care Medicine clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock. Crit Care Med. 2017 Jun;45(6):1061-93.[Abstract]
67. McNulty PH, King N, Scott S, et al. Effects of supplemental oxygen administration on coronary blood flow in patients undergoing cardiac catheterization. Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1057-62.[Abstract][Full Text]
68. Rawles JM, Kenmure AC. Controlled trial of oxygen in uncomplicated myocardial infarction. Br Med J. 1976 May 8;1(6018):1121-3.[Abstract][Full Text]
69. Ferreyro BL, Angriman F, Munshi L, et al. Association of noninvasive oxygenation strategies with all-cause mortality in adults with acute hypoxemic respiratory failure: a systematic feview and meta-analysis. JAMA. 2020 Jul 7;324(1):57-67.[Abstract][Full Text]
70. Finfer S, Bellomo R, Boyce N, et al; the SAFE study investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004 May 27;350(22):2247-56.[Abstract][Full Text]
71. Roberts I, Blackhall K, Alderson P, et al. Human albumin solution for resuscitation and volume expansion in critically ill patients. Cochrane Database Syst Rev. 2011 Nov 9;(11):CD001208.[Abstract][Full Text]
72. Lewis SR, Pritchard MW, Evans DJ, et al. Colloids versus crystalloids for fluid resuscitation in critically ill people. Cochrane Database Syst Rev. 2018 Aug 3;(8):CD000567.[Abstract][Full Text]
73. US Food and Drug Administration. Labeling changes on mortality, kidney injury, and excess bleeding with hydroxyethyl starch products. Jul 2021 [internet publication].[Full Text]
74. European Medicines Agency. PRAC recommends suspending hydroxyethyl-starch solutions for infusion from the market. Feb 2022 [internet publication].[Full Text]
75. Semler MW, Self WH, Wanderer JP, et al. Balanced crystalloids versus saline in critically ill adults. N Engl J Med. 2018 Mar 1;378(9):829-39.[Abstract][Full Text]
76. Inohara T, Kohsaka S, Fukuda K, et al. The challenges in the management of right ventricular infarction. Eur Heart J Acute Cardiovasc Care. 2013 Sep;2(3):226-34.[Abstract][Full Text]
77. Association of Anaesthetists. AAGBI guidelines: the use of blood components and their alternatives 2016. April 2016 [internet publication].[Full Text]
78. Antonelli M, Levy M, Andrews PJ, et al. Hemodynamic monitoring in shock and implications for management: international consensus conference, Paris, France, 27-28 April 2006. Intensive Care Med. 2007 Apr;33(4):575-90.[Abstract]
79. Kivikko M, Pollesello P, Tarvasmäki T, et al. Effect of baseline characteristics on mortality in the SURVIVE trial on the effect of levosimendan vs dobutamine in acute heart failure: Sub-analysis of the Finnish patients. Int J Cardiol. 2016 Jul 15;215:26-31.[Abstract][Full Text]
80. Abraham WT, Adams KF, Fonarow GC, et al. In-hospital mortality in patients with acute decompensated heart failure requiring intravenous vasoactive medications: an analysis from the Acute Decompensated Heart Failure National Registry (ADHERE). J Am Coll Cardiol. 2005 Jul 5;46(1):57-64.[Abstract][Full Text]
81. Asfar P, Meziani F, Hamel JF, et al. High versus low blood-pressure target in patients with septic shock. N Engl J Med. 2014 Apr 24;370(17):1583-93.[Abstract]
82. Geller BJ, Sinha SS, Kapur NK, et al. Escalating and de-escalating temporary mechanical circulatory support in cardiogenic shock: a scientific statement from the American Heart Association. Circulation. 2022 Aug 9;146(6):e50-68.[Abstract][Full Text]
83. Hochman JS, Sleeper LA, Webb JG, et al; SHOCK Investigators. Early revascularization and long-term survival in cardiogenic shock complicating acute myocardial infarction. JAMA. 2006 Jun 7;295(21):2511-5.[Abstract][Full Text]
84. Ahmad Y, Sen S, Shun-Shin MJ, et al. Intra-aortic balloon pump therapy for acute myocardial infarction: a meta-analysis. JAMA Intern Med. 2015 Jun;175(6):931-9.[Abstract]
85. Unverzagt S, Buerke M, de Waha A, et al. Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock. Cochrane Database Syst Rev. 2015 Mar 27;(3):CD007398.[Abstract][Full Text]
86. Zheng XY, Wang Y, Chen Y, et al. The effectiveness of intra-aortic balloon pump for myocardial infarction in patients with or without cardiogenic shock: a meta-analysis and systematic review. BMC Cardiovasc Disord. 2016 Jul 8;16(1):148.[Abstract][Full Text]
87. Adler Y, Charron P. The 2015 ESC Guidelines on the diagnosis and management of pericardial diseases. Eur Heart J. 2015 Nov 7;36(42):2873-4.[Abstract][Full Text]
88. Rhodes A, Phillips G, Beale R, et al. The Surviving Sepsis Campaign bundles and outcome: results from the International Multicentre Prevalence Study on Sepsis (the IMPreSS study). Intensive Care Med. 2015 Sep;41(9):1620-8.[Abstract]
89. Levy MM, Rhodes A, Phillips GS, et al. Surviving Sepsis Campaign: association between performance metrics and outcomes in a 7.5-year study. Intensive Care Med. 2014 Nov;40(11):1623-33. [Abstract][Full Text]
90. Seymour CW, Gesten F, Prescott HC, et al. Time to treatment and mortality during mandated emergency care for sepsis. N Engl J Med. 2017 Jun 8;376(23):2235-44.[Abstract][Full Text]
91. Ker K, Roberts I, Shakur H, et al. Antifibrinolytic drugs for acute traumatic injury. Cochrane Database Syst Rev. 2015 May 9;(5):CD004896.[Abstract][Full Text]
92. Werdan K, Buerke M, Geppert A, et al. Infarction-related cardiogenic shock- diagnosis, monitoring and therapy-a German-Austrian S3 guideline. Dtsch Arztebl Int. 2021 Feb 12;118(6):88-95.[Abstract][Full Text]
93. National Patient Safety Agency. Alert: Blood control safety cannula and needle thoracostomy for tension pneumothorax. April 2020 [internet publication].[Full Text]
94. Leigh-Smith S, Harris T. Tension pneumothorax - time for a re-think? Emerg Med J. 2005 Jan;22(1):8-16. [Abstract][Full Text]
95. Jones R, Hollingsworth J. Tension pneumothoraces not responding to needle thoracocentesis. Emerg Med J. 2002 Mar;19(2):176-7.[Abstract][Full Text]
96. Kusminsky RE. Complications of central venous catheterization. J Am Coll Surg. 2007 Apr;204(4):681-96.[Abstract]
97. McGee DC, Gould MK. Preventing complications of central venous catheterization. N Engl J Med. 2003 Mar 20;348(12):1123-33.[Abstract][Full Text]
98. Smith RN, Nolan JP. Central venous catheters. BMJ. 2013 Nov 11;347:f6570.[Abstract][Full Text]
99. Reich DL. Monitoring in anesthesia and perioperative care. Cambridge: Cambridge University Press; 2011.
100. Abbott Northwestern Hospital Internal Medicine Residency. Internal jugular central venous line. 2022 [internet publication].[Full Text]
101. Bishop L, Dougherty L, Bodenham A, et al. Guidelines on the insertion and management of central venous access devices in adults. Int J Lab Hematol. 2007 Aug;29(4):261-78.[Abstract]
102. Practice guidelines for central venous access 2020: an updated report by the American Society of Anesthesiologists Task Force on Central Venous Access. Anesthesiology. 2020 Jan;132(1):8-43.[Abstract][Full Text]
103. Fletcher SJ, Bodenham AR. Safe placement of central venous catheters: where should the tip of the catheter lie? Br J Anaesth. 2000 Aug;85(2):188-91.[Abstract]
104. Gibson F, Bodenham A. Misplaced central venous catheters: applied anatomy and practical management. Br J Anaesth. 2013 Mar;110(3):333-46.[Abstract][Full Text]
105. Schuster M, Nave H, Piepenbrock S, et al. The carina as a landmark in central venous catheter placement. Br J Anaesth. 2000 Aug;85(2):192-4.[Abstract]
106. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.[Abstract][Full Text]
107. Royal College of Nursing. Catheter care: RCN guidance for health care professionals. Jul 2021 [internet publication].[Full Text]
108. Royal College of Nursing. Catheter care: guidance for health care professionals. Jul 2021 [internet publication].[Full Text]
109. Calder I, Pearce A, eds. Core topics in airway management. 2nd ed. Cambridge: Cambridge University Press; 2011.
110. Soar J, Böttiger BW, Carli P, et al. European Resuscitation Council Guidelines 2021: Adult advanced life support. Resuscitation. 2021 Apr;161:115-51.[Abstract]
111. Konstantinides SV, Barco S, Lankeit M, et al. Management of pulmonary embolism: an update. J Am Coll Cardiol. 2016 Mar 1;67(8):976-90.[Abstract][Full Text]
112. Kearon C, Akl EA, Ornelas J, et al. Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report. Chest. 2016 Feb;149(2):315-52.[Abstract][Full Text]
113. Schierhout G, Roberts I. Fluid resuscitation with colloid or crystalloid solutions in critically ill patients: a systematic review of randomised trials. BMJ. 1998 Mar 28;316(7136):961-4.[Abstract][Full Text]
114. Choi PT, Yip G, Quinonez LG, Cook DJ. Crystalloids vs. colloids in fluid resuscitation: a systematic review. Crit Care Med. 1999 Jan;27(1):200-10.[Abstract]
115. Akech S, Ledermann H, Maitland K. Choice of fluids for resuscitation in children with severe infection and shock: systematic review. BMJ. 2010 Sep 2;341:c4416.[Abstract][Full Text]
116. Caironi P, Tognoni G, Masson S, et al. Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med. 2014 Apr 10;370(15):1412-21.[Abstract][Full Text]
117. Zampieri FG, Machado FR, Biondi RS, et al. Effect of Intravenous Fluid Treatment With a Balanced Solution vs 0.9% Saline Solution on Mortality in Critically Ill Patients: The BaSICS Randomized Clinical Trial. JAMA. 2021 Aug 10 [Epub ahead of print].[Abstract][Full Text]
118. Zarychanski R, Abou-Setta AM, Turgeon AF, et al. Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis. JAMA. 2013 Feb 20;309(7):678-88.[Abstract][Full Text]
119. Gayet-Ageron A, Prieto-Merino D, Ker K, et al. Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients. Lancet. 2018 Jan 13;391(10116):125-32.[Abstract][Full Text]
120. Schmidt M, Burrell A, Roberts L, et al. Predicting survival after ECMO for refractory cardiogenic shock: the survival after veno-arterial-ECMO (SAVE)-score. Eur Heart J. 2015 Sep 1;36(33):2246-56.[Abstract][Full Text]
121. Ouweneel DM, Schotborgh JV, Limpens J, et al. Extracorporeal life support during cardiac arrest and cardiogenic shock: a systematic review and meta-analysis. Intensive Care Med. 2016 Dec;42(12):1922-34.[Abstract][Full Text]
122. Chakaramakkil MJ, Sivathasan C. ECMO and Short-term support for cardiogenic shock in heart failure. Curr Cardiol Rep. 2018 Aug 16;20(10):87.[Abstract]
123. Chang T, Tu YK, Lee CT, et al. Effects of polymyxin B hemoperfusion on mortality in patients with severe sepsis and septic shock: a systemic review, meta-analysis update, and disease severity subgroup meta-analysis. Crit Care Med. 2017 Aug;45(8):e858-64.[Abstract][Full Text]
124. Dellinger RP, Bagshaw SM, Antonelli M, et al. Effect of targeted polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level: the EUPHRATES randomized clinical trial. JAMA. 2018 Oct 9;320(14):1455-63.[Abstract]
125. Plurad DS, Chiu W, Raja AS, et al. Monitoring modalities and assessment of fluid status: a practice management guideline from the Eastern Association for the Surgery of Trauma. J Trauma Acute Care Surg. 2018 Jan;84(1):37-49.[Abstract][Full Text]
126. Resuscitation Council UK. Emergency treatment of anaphylaxis: Guidelines for healthcare providers. May 2021 [internet publication].[Full Text]
127. Paul M, Dickstein Y, Raz-Pasteur A. Antibiotic de-escalation for bloodstream infections and pneumonia: systematic review and meta-analysis. Clin Microbiol Infect. 2016 Dec;22(12):960-7.[Abstract]
Key Articles
Referenced Articles
Sign in to access our clinical decision support tools