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Diseases

Atrial myxoma

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Atrial myxoma is the most common of the rare benign primary cardiac tumors.

  • Usually found in the left atrium and typically attached to the septum.

  • Most common presentation is with symptoms of mitral valve obstruction, followed by embolic manifestations. Constitutional symptoms include fever, fatigue, and weight loss.

  • The only definitive treatment is surgical.

Two-dimensional echocardiogram showing a right atrial mass suggestive of a myxoma
Two-dimensional echocardiogram showing a right atrial mass suggestive of a myxoma
From the collection of Dr Syed Wamique Yusuf, Department of Cardiology, University of Texas MD Anderson Cancer Center; used with permission

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Large left atrial myxoma

            Large left atrial myxoma

          • Macroscopic view of a left atrial myxoma

            Macroscopic view of a left atrial myxoma

          • Two-dimensional echocardiogram showing a right atrial mass suggestive of a myxoma

            Two-dimensional echocardiogram showing a right atrial mass suggestive of a myxoma

          • Atrial myxoma identified on echocardiography (A) and following surgical resection (B)

            Atrial myxoma identified on echocardiography (A) and following surgical resection (B)

          • Chest CT demonstrating a mass in the right atrium (RA) subsequently confirmed to be an atrial myxoma

            Chest CT demonstrating a mass in the right atrium (RA) subsequently confirmed to be an atrial myxoma. RV = right ventricle, LV = left ventricle

          • Two-dimensional echocardiogram of a right atrial thrombus (note not attached to septum)

            Two-dimensional echocardiogram of a right atrial thrombus (note not attached to septum)

          • Transesophageal echocardiogram showing a catheter in the superior vena cava and a right atrial throm

            Transesophageal echocardiogram showing a catheter in the superior vena cava and a right atrial thrombus (note not attached to septum)

          Citations

            Key Articles

            • Pinede L, Duhaut P, Loire R. Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases. Medicine (Baltimore). 2001 May;80(3):159-72.[Abstract]

            • Edwards A, Bermudez C, Piwonka G, et al. Carney's syndrome: complex myxomas. Report of four cases and review of the literature. Cardiovasc Surg. 2002 Jun;10(3):264-75.[Abstract]

            • Grossniklaus HE. McLean IW, Gillespie JJ. Bilateral eyelid myxomas in Carney's complex. Br J Ophthalmol. 1991 Apr;75(4):251-2.[Abstract][Full Text]

            • Ohara N, Komiya I, Yamauchi K, et al. Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations. Intern Med. 1993 Jan;32(1):60-2.[Abstract][Full Text]

            Other Online Resources

            • Texas Heart Institute: heart sounds auscultation

            Referenced Articles

            • 1. Zhang R, Tang Z, Qiao Q, et al. Anesthesia management of atrial myxoma resection with multiple cerebral aneurysms: a case report and review of the literature. BMC Anesthesiol. 2020 Jul 4;20(1):164.[Abstract][Full Text]

            • 2. Reynen K. Frequency of primary tumors of the heart. Am J Cardiol. 1996 Jan 1;77(1):107.[Abstract]

            • 3. Bussani R, Castrichini M, Restivo L, et al. Cardiac tumors: diagnosis, prognosis, and treatment. Curr Cardiol Rep. 2020 Oct 10;22(12):169.[Abstract][Full Text]

            • 4. Pinede L, Duhaut P, Loire R. Clinical presentation of left atrial cardiac myxoma. A series of 112 consecutive cases. Medicine (Baltimore). 2001 May;80(3):159-72.[Abstract]

            • 5. Edwards A, Bermudez C, Piwonka G, et al. Carney's syndrome: complex myxomas. Report of four cases and review of the literature. Cardiovasc Surg. 2002 Jun;10(3):264-75.[Abstract]

            • 6. Grossniklaus HE. McLean IW, Gillespie JJ. Bilateral eyelid myxomas in Carney's complex. Br J Ophthalmol. 1991 Apr;75(4):251-2.[Abstract][Full Text]

            • 7. Ohara N, Komiya I, Yamauchi K, et al. Carney's complex with primary pigmented nodular adrenocortical disease and spotty pigmentations. Intern Med. 1993 Jan;32(1):60-2.[Abstract][Full Text]

            • 8. Acebo E, Val-Bernal JF, Gomez-Roman JJ, et al. Clinicopathologic study and DNA analysis of 37 cardiac myxomas: a 28-year experience. Chest. 2003 May;123(5):1379-85.[Abstract]

            • 9. Cotran RS, Kumar V, Robbins SL. Robbins pathologic basis of disease. 5th ed. Philadelphia, PA: Saunders; 1994.

            • 10. Griborio-Guzman AG, Aseyev OI, Shah H, et al. Cardiac myxomas: clinical presentation, diagnosis and management. Heart. 2022 May 12;108(11):827-33.[Abstract]

            • 11. Boyacıoğlu K, Kalender M, Dönmez AA, et al. Outcomes following embolization in patients with cardiac myxoma. J Card Surg. 2017 Oct;32(10):621-6.[Abstract]

            • 12. Shavit L, Appelbaum L, Grenader T. Atrial myxoma presenting with total occlusion of the abdominal aorta and multiple peripheral embolism. Eur J Intern Med. 2007 Jan;18(1):74-5.[Abstract]

            • 13. Panos A, Kalangos A, Sztajzel J. Left atrial myxoma presenting with myocardial infarction. Case report and review of the literature. Int J Cardiol. 1997 Oct 31;62(1):73-5.[Abstract]

            • 14. Rongjing D, Kun X. Myocardial infarction in a woman with no apparent risk factors. Lancet. 2007 Jul 28;370(9584):360.[Abstract]

            • 15. Reardon MJ, Malaisrie SC, Walkes JC, et al. Cardiac autotransplantation for primary cardiac tumors. Ann Thorac Surg. 2006 Aug;82(2):645-50.[Abstract]

            • 16. Karabinis A, Samanidis G, Khoury M, et al. Clinical presentation and treatment of cardiac myxoma in 153 patients. Medicine (Baltimore). 2018 Sep;97(37):e12397.[Abstract][Full Text]

            • 17. Jiang CX, Wang JG, Qi RD, et al. Long-term outcome of patients with atrial myxoma after surgical intervention: analysis of 403 cases. J Geriatr Cardiol. 2019 Apr;16(4):338-43.[Abstract][Full Text]

            • 18. Bjessmo S, Ivert T. Cardiac myxoma: 40 years' experience in 63 patients. Ann Thorac Surg. 1997 Mar;63(3):697-700.[Abstract]

            • 19. McAllister SM, Bornstein AM, Callen JP. Painful acral purpura. Arch Dermatol. 1998 Jul;134(7):789-91.[Abstract]

            • 20. Kajihara N, Tanoue Y, Eto M, et al. Surgical experience of cardiac tumors: early and late results. Surg Today. 2006;36(7):602-7.[Abstract]

            • 21. Sugimoto T, Ogawa K, Asada T, et al. The problems of surgical treatment for cardiac myxoma and associated lesions. Surg Today. 1994;24(8):673-80.[Abstract]

            • 22. Keeling IM, Oberwalder P, Anelli-Monti M, et al. Cardiac myxomas: 24 years of experience in 49 patients. Eur J Cardiothorac Surg. 2002 Dec;22(6):971-7.[Abstract]

            • 23. McCarthy PM, Piehler JM, Schaff HV, et al. The significance of multiple, recurrent, and "complex" cardiac myxomas. J Thorac Cardiovasc Surg. 1986 Mar;91(3):389-96.[Abstract]

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