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Diseases

Mastitis and breast abscess

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Breast infections (including infectious mastitis and breast abscess) more commonly affect women aged 15-45 years, especially those who are lactating. However, mastitis and breast abscess can occur at any age.

  • Staphylococcus aureus is the most frequent pathogen isolated.

  • Prompt and appropriate management of mastitis usually leads to a timely resolution and prevents complications, such as a breast abscess.

  • Breast abscess requires both the removal of pus and antibiotic therapy. Interventions can include aspiration and incision and drainage procedures.

  • It is imperative to identify and treat any underlying coexistent causes of infection to facilitate resolution and prevent recurrence. It is also necessary to exclude breast carcinoma.

Lactational mastitis: microscopy image showing hypersecretory glands associated with inflammation
Lactational mastitis: microscopy image showing hypersecretory glands associated with inflammation
From the collection of Liron Pantanowitz, MD, Tufts University School of Medicine, MA

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Nonlactating breast abscess due to periductal mastitis

            Nonlactating breast abscess due to periductal mastitis

          • Lactational mastitis: microscopy image showing hypersecretory glands associated with inflammation

            Lactational mastitis: microscopy image showing hypersecretory glands associated with inflammation

          • Duct ectasia with a central calcified keratin plug and associated giant cell inflammatory response

            Duct ectasia with a central calcified keratin plug and associated giant cell inflammatory response

          • Tubercular mastitis: mammogram showing a mass lesion in the upper outer quadrant

            Tubercular mastitis: mammogram showing a mass lesion in the upper outer quadrant

          • Microscopy image of non-necrotizing granulomatous inflammation in the breast

            Microscopy image of non-necrotizing granulomatous inflammation in the breast

          • Ultrasound image showing a well-circumscribed hypoechoic breast abscess

            Ultrasound image showing a well-circumscribed hypoechoic breast abscess

          • Needle aspiration of a breast abscess under ultrasound guidance: note the needle piercing the absces

            Needle aspiration of a breast abscess under ultrasound guidance: note the needle piercing the abscess to the right of the image

          • Aspirated material: a group of benign apocrine cells associated with acute and chronic inflammation

            Aspirated material: a group of benign apocrine cells associated with acute and chronic inflammation in keeping with a breast abscess (ThinPrep stain)

          • A breast abscess that developed during breast-feeding

            A breast abscess that developed during breast-feeding

          • Leukocyte counts and bacteria quantification in breast milk

            Leukocyte counts and bacteria quantification in breast milk

          Citations

            Key Articles

            • World Health Organization. Mastitis: causes and management. 2000 [internet publication].[Full Text]

            • Wilson E, Woodd SL, Benova L. Incidence of and risk factors for lactational mastitis: a systematic review. J Hum Lact. 2020 Nov;36(4):673-86.[Abstract][Full Text]

            • Trop I, Dugas A, David J, et al. Breast abscesses: evidence-based algorithms for diagnosis, management, and follow-up. Radiographics. 2011 Oct;31(6):1683-99.[Abstract][Full Text]

            Referenced Articles

            • 1. World Health Organization. Mastitis: causes and management. 2000 [internet publication].[Full Text]

            • 2. Wilson E, Woodd SL, Benova L. Incidence of and risk factors for lactational mastitis: a systematic review. J Hum Lact. 2020 Nov;36(4):673-86.[Abstract][Full Text]

            • 3. Amir LH, Forster D, McLachlan H, et al. Incidence of breast abscess in lactating women: report from an Australian cohort. BJOG. 2004 Dec;111(12):1378-81.[Abstract]

            • 4. Dener C, Inan A. Breast abscesses in lactating women. World J Surg. 2003 Feb;27(2):130-3.[Abstract]

            • 5. Ammann AM, Pratt CG, Lewis JD, et al. Breast infections: a review of current literature. Am J Surg. 2024 Feb;228:78-82.[Abstract][Full Text]

            • 6. Marinopoulos S, Lourantou D, Gatzionis T, et al. Breast tuberculosis: diagnosis, management and treatment. Int J Surg Case Rep. 2012 Jul 20;3(11):548-50.[Abstract][Full Text]

            • 7. Khanna R, Prasanna GV, Gupta P, et al. Mammary tuberculosis: report on 52 cases. Postgrad Med J. 2002 Jul;78(921):422-4.[Abstract][Full Text]

            • 8. Sagara Y, Hatakeyama S, Kumabe A, et al. Breast tuberculosis presenting with intractable mastitis: a case report. J Med Case Rep. 2021 Mar 4;15(1):101.[Abstract][Full Text]

            • 9. Al-Khaffaf B, Knox F, Bundred NJ. Idiopathic granulomatous mastitis: a 25-year experience. J Am Coll Surg. 2008 Feb;206(2):269-73.[Abstract]

            • 10. Stafford I, Hernandez J, Laibl V, et al. Community-acquired methicillin-resistant Staphylococcus aureus among patients with puerperal mastitis requiring hospitalization. Obstet Gynecol. 2008 Sep;112(3):533-7.[Abstract]

            • 11. Russell SP, Neary C, Abd Elwahab S, et al. Breast infections - microbiology and treatment in an era of antibiotic resistance. Surgeon. 2020 Feb;18(1):1-7.[Abstract][Full Text]

            • 12. Moazzez A, Kelso RL, Towfigh S, et al. Breast abscess bacteriologic features in the era of community-acquired methicillin-resistant Staphylococcus aureus epidemics. Arch Surg. 2007 Sep;142(9):881-4.[Abstract][Full Text]

            • 13. Olsen CG, Gordon RE Jr. Breast disorders in nursing mothers. Am Fam Physician. 1990 May;41(5):1509-16.[Abstract]

            • 14. Edmiston CE Jr, Walker AP, Krepel CJ, et al. The nonpuerperal breast infection: aerobic and anaerobic microbial recovery from acute and chronic disease. J Infect Dis. 1990 Sep;162(3):695-9.[Abstract]

            • 15. Gollapalli V, Liao J, Dudakovic A, et al. Risk factors for development and recurrence of primary breast abscesses. J Am Coll Surg. 2010 Jul;211(1):41-8.[Abstract]

            • 16. Pantanowitz L, Connolly JL. Pathology of the breast associated with HIV/AIDS. Breast J. 2002 Jul-Aug;8(4):234-43.[Abstract]

            • 17. Gewurz BE, Dezube BJ, Pantanowitz L. HIV and the breast. AIDS Read. 2005 Aug;15(8):392-6, 399-402.[Abstract]

            • 18. Johnson PE, Hanson KD. Acute puerperal mastitis in the augmented breast. Plast Reconstr Surg. 1996 Sep;98(4):723-5.[Abstract]

            • 19. Jacobs VR, Golombeck K, Jonat W, et al. Mastitis nonpuerperalis after nipple piercing: time to act. Int J Fertil Womens Med. 2003 Sep-Oct;48(5):226-31.[Abstract]

            • 20. Kataria K, Srivastava A, Dhar A. Management of lactational mastitis and breast abscesses: review of current knowledge and practice. Indian J Surg. 2013 Dec;75(6):430-5.[Abstract][Full Text]

            • 21. Kvist LJ, Rydhstroem H. Factors related to breast abscess after delivery: a population-based study. BJOG. 2005 Aug;112(8):1070-4.[Abstract]

            • 22. David M, Handa P, Castaldi M. Predictors of outcomes in managing breast abscesses a large retrospective single-center analysis. Breast J. 2018 May 20;24(5):755-63.[Abstract]

            • 23. Echo A, Otake LR, Mehrara BJ, et al. Surgical management of silicone mastitis: case series and review of the literature. Aesthetic Plast Surg. 2013 Aug;37(4):738-45.[Abstract][Full Text]

            • 24. Rizzo M, Peng L, Frisch A, et al. Breast abscesses in nonlactating women with diabetes: clinical features and outcome. Am J Med Sci. 2009 Aug;338(2):123-6.[Abstract]

            • 25. Foxman B, D'Arcy H, Gillespie B, et al. Lactation mastitis: occurrence and medical management among 946 breastfeeding women in the United States. Am J Epidemiol. 2002 Jan 15;155(2):103-14.[Abstract][Full Text]

            • 26. Versluijs-Ossewaarde FN, Roumen RM, Goris RJ. Subareolar breast abscesses: characteristics and results of surgical treatment. Breast J. 2005 May-Jun;11(3):179-82.[Abstract]

            • 27. Bharat A, Gao F, Aft RL, et al. Predictors of primary breast abscesses and recurrence. World J Surg. 2009 Dec;33(12):2582-6.[Abstract]

            • 28. Leach RD, Eykyn SJ, Phillips I, et al. Anaerobic subareolar breast abscess. Lancet. 1979 Jan 6;1(8106):35-7.[Abstract]

            • 29. Zadrozny S, Westreich D, Hudgens MG, et al. Effect of postnatal HIV treatment on clinical mastitis and breast inflammation in HIV-infected breast-feeding women. Paediatr Perinat Epidemiol. 2017 Feb 16;31(2):134-43.[Abstract][Full Text]

            • 30. Trop I, Dugas A, David J, et al. Breast abscesses: evidence-based algorithms for diagnosis, management, and follow-up. Radiographics. 2011 Oct;31(6):1683-99.[Abstract][Full Text]

            • 31. Das DK, Sodhani P, Kashyap V, et al. Inflammatory lesions of the breast: diagnosis by fine needle aspiration. Cytopathology. 1992;3(5):281-9.[Abstract]

            • 32. Thomsen AC, Espersen T, Maigaard S. Course and treatment of milk stasis, noninfectious inflammation of the breast, and infectious mastitis in nursing women. Am J Obstet Gynecol. 1984 Jul 1;149(5):492-5.[Abstract]

            • 33. Kvist LJ, Larsson BW, Hall-Lord ML, et al. The role of bacteria in lactational mastitis and some considerations of the use of antibiotic treatment. Int Breastfeed J. 2008 Apr 7;3:6.[Abstract][Full Text]

            • 34. Reddin A, McCrea ES, Keramati B. Inflammatory breast disease: mammographic spectrum. South Med J. 1988 Aug;81(8):981-4, 988.[Abstract]

            • 35. Muttarak M. Abscess in the non-lactating breast: radiodiagnostic aspects. Australas Radiol. 1996 Aug;40(3):223-5.[Abstract]

            • 36. Kamal RM, Hamed ST, Salem DS. Classification of inflammatory breast disorders and step by step diagnosis. Breast J. 2009 Jul-Aug;15(4):367-80.[Abstract]

            • 37. Hamit HF, Ragsdale TH. Mammary tuberculosis. J R Soc Med. 1982 Oct;75(10):764-5.[Abstract][Full Text]

            • 38. Rajagopala S, Agarwal R. Tubercular mastitis in men: case report and systematic review. Am J Med. 2008 Jun;121(6):539-44.[Abstract]

            • 39. Georgian-Smith D, Lawton TJ, Moe RE, et al. Lupus mastitis: radiologic and pathologic features. AJR Am J Roentgenol. 2002 May;178(5):1233-5.[Abstract][Full Text]

            • 40. Kellams A; Academy of Breastfeeding Medicine Protocol Committee. ABM clinical protocol #36: the mastitis spectrum. Breastfeed Med. 2022 Sep;17(9):776.[Abstract][Full Text]

            • 41. American College of Obstetricians and Gynecologists. Diagnosis and management of benign breast disorders. Jun 2016 [internet publication].​[Full Text]

            • 42. Jahanfar S, Ng CJ, Teng CL. Antibiotics for mastitis in breastfeeding women. Cochrane Database Syst Rev. 2013 Feb 28;(2):CD005458.[Abstract][Full Text]

            • 43. Spencer JP. Management of mastitis in breastfeeding women. Am Fam Physician. 2008 Sep 15;78(6):727-31.[Abstract]

            • 44. Arroyo R, Martín V, Maldonado A, et al. Treatment of infectious mastitis during lactation: antibiotics versus oral administration of Lactobacilli isolated from breast milk. Clin Infect Dis. 2010 Jun 15;50(12):1551-8.[Abstract]

            • 45. Spencer JP, Gonzalez LS 3rd, Barnhart DJ. Medications in the breast-feeding mother. Am Fam Physician. 2001 Jul 1;64(1):119-26.[Abstract]

            • 46. Coia JE, Duckworth GJ, Edwards DI, et al. Guidelines for the control and prevention of meticillin-resistant Staphylococcus aureus (MRSA) in healthcare facilities. J Hosp Infect. 2006 Apr 3;63(suppl 1):S1-44.[Abstract][Full Text]

            • 47. Branch-Elliman W, Golen TH, Gold HS, et al. Risk factors for Staphylococcus aureus postpartum breast abscess. Clin Infect Dis. 2012 Jan 1;54(1):71-7.[Abstract]

            • 48. Reddy P, Qi C, Zembower T, et al. Postpartum mastitis and community-acquired methicillin-resistant Staphylococcus aureus. Emerg Infect Dis. 2007 Feb;13(2):298-301.[Abstract][Full Text]

            • 49. Moellering RC Jr. Current treatment options for community-acquired methicillin-resistant Staphylococcus aureus infection. Clin Infect Dis. 2008 Apr 1;46(7):1032-7.[Abstract][Full Text]

            • 50. Johnson MD, Decker CF. Antimicrobial agents in treatment of MRSA infections. Dis Mon. 2008 Dec;54(12):793-800.[Abstract]

            • 51. Todd SR, Dahlgren FS, Traeger MS, et al. No visible dental staining in children treated with doxycycline for suspected Rocky Mountain Spotted Fever. J Pediatr. 2015 May;166(5):1246-51.[Abstract][Full Text]

            • 52. ​National Library of Medicine. Drugs and Lactation Database (LactMed®): Doxycycline. Jan 2021 [internet publication].[Full Text]

            • 53. Lei X, Chen K, Zhu L, et al. Treatments for idiopathic granulomatous mastitis: systematic review and meta-analysis. Breastfeed Med. 2017 Jul 21;12(7):415-21.[Abstract]

            • 54. Hanavadi S, Pereira G, Mansel RE. How mammillary fistulas should be managed. Breast J. 2005 Jul-Aug;11(4):254-6.[Abstract]

            • 55. Lam E, Chan T, Wiseman SM. Breast abscess: evidence based management recommendations. Expert Rev Anti Infect Ther. 2014 May 3;12(7):753-62.[Abstract]

            • 56. Lannin DR. Twenty-two year experience with recurring subareolar abscess andlactiferous duct fistula treated by a single breast surgeon. Am J Surg. 2004 Oct;188(4):407-10.[Abstract][Full Text]

            • 57. Wei J, Zhang J, Fu D. Negative suction drain through a mini periareolar incision for the treatment of lactational breast abscess shortens hospital stay and increases breastfeeding rates. Breastfeed Med. 2016 Jun 1;11:259-60.[Abstract]

            • 58. Berens P, Swaim L, Peterson B. Incidence of methicillin-resistant Staphylococcus aureus in postpartum breast abscesses. Breastfeed Med. 2010 Jun;5(3):113-5.[Abstract]

            • 59. Committee on Pediatric Aids. Infant feeding and transmission of human immunodeficiency virus in the United States. Pediatrics. 2013 Jan 28;131(2):391-6.[Abstract][Full Text]

            • 60. World Health Organization. Updates on HIV and infant feeding: guideline. 2016 [internet publication].[Full Text]

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