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Diseases

Acquired torticollis

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Cervical dystonia (spasmodic torticollis) is a rare, typically idiopathic, brain disorder causing involuntary neck movements.

  • Often associated with pain.

  • Patients may be able to relieve their symptoms by touching their neck, head, or face in a certain way (sensory trick or alleviating maneuver).

  • Targeted intramuscular injection of botulinum toxin is the therapy with the best proven efficacy. Oral drugs and physical therapy may also have a role in the treatment of the condition.

  • Treatment options for refractory cervical dystonia include deep brain stimulation, radiofrequency ablation, selective surgical denervation, and intrathecal baclofen.

Patient with moderate left torticollis or neck rotation, mild right laterocollis or lateral neck fle
Patient with moderate left torticollis or neck rotation, mild right laterocollis or lateral neck flexion, and mild retrocollis or neck extension
From the collection of Dr David Sommer

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Patient with moderate left torticollis or neck rotation, mild right laterocollis or lateral neck fle

            Patient with moderate left torticollis or neck rotation, mild right laterocollis or lateral neck flexion, and mild retrocollis or neck extension

          • Patient with severe left torticollis (note hypertrophy of right sternocleidomastoid muscle)

            Patient with severe left torticollis (note hypertrophy of right sternocleidomastoid muscle)

          • Patient using sensory trick with reduction in dystonia severity

            Patient using sensory trick with reduction in dystonia severity

          Citations

            Key Articles

            • Albanese A, Bhatia KP, Cardoso F, et al. Isolated cervical dystonia: diagnosis and classification. Mov Disord. 2023 Aug;38(8):1367-78.[Abstract][Full Text]

            • Albanese A, Asmus F, Bhatia KP, et al. EFNS guidelines on diagnosis and treatment of primary dystonias. Eur J Neurol. 2011 Jan;18(1):5-18.[Abstract][Full Text]

            • Rodrigues FB, Duarte GS, Marques RE, et al. Botulinum toxin type A therapy for cervical dystonia. Cochrane Database Syst Rev. 2020 Nov 12;11:CD003633.[Abstract][Full Text]

            Other Online Resources

            • MDS: Revised Toronto Western Spasmodic Torticollis Rating Scale and Psychiatric Screening Tool (TWSTRS-2 & TWSTRS-PSYCH)
            • Dystonia Medical Research Foundation
            • Dystonia UK

            Referenced Articles

            • 1. Albanese A, Bhatia KP, Cardoso F, et al. Isolated cervical dystonia: diagnosis and classification. Mov Disord. 2023 Aug;38(8):1367-78.[Abstract][Full Text]

            • 2. Stacy M. Epidemiology, clinical presentation, and diagnosis of cervical dystonia. Neurol Clin. 2008 May;26(suppl 1):23-42.[Abstract]

            • 3. Medina A, Nilles C, Martino D, et al. The prevalence of idiopathic or inherited isolated dystonia: a systematic review and meta-analysis. Mov Disord Clin Pract. 2022 Oct;9(7):860-8.[Abstract][Full Text]

            • 4. Ortiz R, Scheperjans F, Mertsalmi T, et al. The prevalence of adult-onset isolated dystonia in Finland 2007-2016. PLoS One. 2018 Nov 20;13(11):e0207729.[Abstract][Full Text]

            • 5. Dressler D, Altenmüller E, Giess R, et al. The epidemiology of dystonia: the Hannover epidemiology study. J Neurol. 2022 Dec;269(12):6483-93.[Abstract][Full Text]

            • 6. Marras C, Van den Eeden SK, Fross RD, et al. Minimum incidence of primary cervical dystonia in a multiethnic health care population. Neurology. 2007 Aug 14;69(7):676-80.[Abstract]

            • 7. LaHue SC, Albers K, Goldman S, et al. Cervical dystonia incidence and diagnostic delay in a multiethnic population. Mov Disord. 2020 Mar;35(3):450-6.[Abstract][Full Text]

            • 8. LeDoux MS, Vemula SR, Xiao J, et al. Clinical and genetic features of cervical dystonia in a large multicenter cohort. Neurol Genet. 2016 Jun;2(3):e69.[Abstract][Full Text]

            • 9. Defazio G, Aniello MS, Masi G, et al. Frequency of familial aggregation in primary adult-onset cranial cervical dystonia. Neurol Sci. 2003 Oct;24(3):168-9.[Abstract]

            • 10. Xiao J, Uitti RJ, Zhao Y, et al. Mutations in CIZ1 cause adult onset primary cervical dystonia. Ann Neurol. 2012 Apr;71(4):458-69.[Abstract][Full Text]

            • 11. Sun YV, Li C, Hui Q, et al. A multi-center genome-wide association study of cervical dystonia. Mov Disord. 2021 Dec;36(12):2795-801.[Abstract][Full Text]

            • 12. van Harten PN, Kahn RS. Tardive dystonia. Schizophr Bull. 1999;25(4):741-8.[Abstract]

            • 13. Molloy A, Kimmich O, Williams L, et al. An evaluation of the role of environmental factors in the disease penetrance of cervical dystonia. J Neurol Neurosurg Psychiatry. 2015 Mar;86(3):331-5.[Abstract]

            • 14. Macerollo A, Edwards MJ, Huang HC, et al. Peripheral trauma and risk of dystonia: what are the evidences and potential co-risk factors from a population insurance database? PLoS One. 2019 May 10;14(5):e0216772.[Abstract][Full Text]

            • 15. Shaikh AG, Zee DS, Crawford JD, et al. Cervical dystonia: a neural integrator disorder. Brain. 2016 Oct;139(pt 10):2590-9.[Abstract][Full Text]

            • 16. Huang X, Zhang M, Li B, et al. Structural and functional brain abnormalities in idiopathic cervical dystonia: a multimodal meta-analysis. Parkinsonism Relat Disord. 2022 Oct;103:153-65.[Abstract]

            • 17. Delnooz CC, Pasman JW, Beckmann CF, et al. Altered striatal and pallidal connectivity in cervical dystonia. Brain Struct Funct. 2015 Jan;220(1):513-23.[Abstract]

            • 18. Werle RW, Takeda SY, Zonta MB, et al. The physical, social and emotional aspects are the most affected in the quality of life of the patients with cervical dystonia. Arq Neuropsiquiatr. 2014 Jun;72(6):405-10.[Abstract]

            • 19. Muller J, Wissel J, Masuhr F, et al. Clinical characteristics of the geste antagoniste in cervical dystonia. J Neurol. 2001 Jun;248(6):478-82.[Abstract]

            • 20. Jahanshahi M. Factors that ameliorate or aggravate spasmodic torticollis. J Neurol Neurosurg Psychiatry. 2000 Feb;68(2):227-9.[Abstract][Full Text]

            • 21. Albanese A, Asmus F, Bhatia KP, et al. EFNS guidelines on diagnosis and treatment of primary dystonias. Eur J Neurol. 2011 Jan;18(1):5-18.[Abstract][Full Text]

            • 22. Albanese A, Barnes MP, Bhatia KP, et al. A systematic review on the diagnosis and treatment of primary (idiopathic) dystonia and dystonia plus syndromes: report of an EFNS/MDS-ES Task Force. Eur J Neurol. 2006 May;13(5):433-44.[Abstract][Full Text]

            • 23. Loudovici-Krug D, Derlien S, Best N, et al. Physiotherapy for cervical dystonia: a systematic review of randomised controlled trials. Toxins (Basel). 2022 Nov 11;14(11):784.[Abstract][Full Text]

            • 24. Hu W, Rundle-Gonzalez V, Kulkarni SJ, et al. A randomized study of botulinum toxin versus botulinum toxin plus physical therapy for treatment of cervical dystonia. Parkinsonism Relat Disord. 2019 Jun;63:195-8.[Abstract][Full Text]

            • 25. Duarte GS, Castelão M, Rodrigues FB, et al. Botulinum toxin type A versus botulinum toxin type B for cervical dystonia. Cochrane Database Syst Rev. 2016 Oct 26;(10):CD004314.[Abstract][Full Text]

            • 26. Comella CL, Jankovic J, Shannon KM, et al. Comparison of botulinum toxin serotypes A and B for the treatment of cervical dystonia. Neurology. 2005 Nov 8;65(9):1423-9.[Abstract]

            • 27. Camargo CH, Teive HA, Becker N, et al. Botulinum toxin type A and cervical dystonia: a seven-year follow-up. Arq Neuropsiquiatr. 2011 Oct;69(5):745-50.[Abstract][Full Text]

            • 28. Aradi S, Hauser RA. Current use of neurotoxins for alleviating symptoms of cervical dystonia. Expert Rev Neurother. 2024 Aug;24(8):787-97.[Abstract]

            • 29. Brans JW, Lindeboom R, Snoek JW, et al. Botulinum toxin versus trihexyphenidyl in cervical dystonia: a prospective, randomized, double-blind controlled trial. Neurology. 1996 Apr;46(4):1066-72.[Abstract]

            • 30. Brashear A. Botulinum toxin type A in the treatment of patients with cervical dystonia. Biologics. 2009;3:1-7.[Abstract][Full Text]

            • 31. Truong D, Duane DD, Jankovic J, et al. Efficacy and safety of botulinum type A toxin (Dysport) in cervical dystonia: results of the first US randomized, double-blind, placebo-controlled study. Mov Disord. 2005 Jul;20(7):783-91.[Abstract]

            • 32. Comella CL, Jankovic J, Truong DD, et al. Efficacy and safety of incobotulinumtoxinA (NT 201, XEOMIN(®), botulinum neurotoxin type A, without accessory proteins) in patients with cervical dystonia. J Neurol Sci. 2011 Sep 15;308(1-2):103-9.[Abstract]

            • 33. Marques RE, Duarte GS, Rodrigues FB, et al. Botulinum toxin type B for cervical dystonia. Cochrane Database Syst Rev. 2016 May 13;(5):CD004315.[Abstract][Full Text]

            • 34. Comella CL, Jankovic J, Hauser RA, et al. Efficacy and safety of daxibotulinumtoxinA for injection in cervical dystonia: ASPEN-1 phase 3 randomized controlled trial. Neurology. 2024 Feb 27;102(4):e208091.[Abstract][Full Text]

            • 35. Pappert EJ, Germanson T; Myobloc/Neurobloc European Cervical Dystonia Study Group. Botulinum toxin type B vs. type A in toxin-naive patients with cervical dystonia: randomized, double-blind, noninferiority trial. Mov Disord. 2008 Mar 15;23(4):510-7.[Abstract]

            • 36. Rodrigues FB, Duarte GS, Marques RE, et al. Botulinum toxin type A therapy for cervical dystonia. Cochrane Database Syst Rev. 2020 Nov 12;11:CD003633.[Abstract][Full Text]

            • 37. Yi YG, Kim K, Yi Y, et al. Botulinum toxin type A injection for cervical dystonia in adults with dyskinetic cerebral palsy. Toxins (Basel). 2018 May 16;10(5):E203.[Abstract][Full Text]

            • 38. Marsh WA, Monroe DM, Brin MF, et al. Systematic review and meta-analysis of the duration of clinical effect of onabotulinumtoxinA in cervical dystonia. BMC Neurol. 2014 Apr 27;14:91.[Abstract][Full Text]

            • 39. Nijmeijer SW, Koelman JH, Kamphuis DJ, et al. Muscle selection for treatment of cervical dystonia with botulinum toxin-a systematic review. Parkinsonism Relat Disord. 2012 Jul;18(6):731-6.[Abstract]

            • 40. Castagna A, Albanese A. Management of cervical dystonia with botulinum neurotoxins and EMG/ultrasound guidance. Neurol Clin Pract. 2019 Feb;9(1):64-73.[Abstract][Full Text]

            • 41. Hong JS, Sathe GG, Niyonkuru C, et al. Elimination of dysphagia using ultrasound guidance for botulinum toxin injections in cervical dystonia. Muscle Nerve. 2012 Oct;46(4):535-9.[Abstract]

            • 42. Swope D, Barbano R. Treatment recommendations and practical applications of botulinum toxin treatment of cervical dystonia. Neurol Clin. 2008 May;26(suppl 1):54-65.[Abstract]

            • 43. Coleman C, Hubble J, Schwab J, et al. Immunoresistance in cervical dystonia patients after treatment with abobotulinumtoxinA. Int J Neurosci. 2012 Jul;122(7):358-62.[Abstract]

            • 44. Tassorelli C, Mancini F, Balloni L, et al. Botulinum toxin and neuromotor rehabilitation: an integrated approach to idiopathic cervical dystonia. Mov Disord. 2006 Dec;21(12):2240-3.[Abstract]

            • 45. Apkon SD, Cassidy D. Safety considerations in the use of botulinum toxins in children with cerebral palsy. PM R. 2010 Apr;2(4):282-4.[Abstract]

            • 46. Kiss ZH, Doig-Beyaert K, Eliasziw M, et al. The Canadian multicentre study of deep brain stimulation for cervical dystonia. Brain. 2007 Nov;130(Pt 11):2879-86.[Abstract]

            • 47. Rodrigues FB, Duarte GS, Prescott D, et al. Deep brain stimulation for dystonia. Cochrane Database Syst Rev. 2019 Jan 10;(1):CD012405.[Abstract][Full Text]

            • 48. Volkmann J, Mueller J, Deuschl G, et al. Pallidal neurostimulation in patients with medication-refractory cervical dystonia: a randomised, sham-controlled trial. Lancet Neurol. 2014 Sep;13(9):875-84.[Abstract]

            • 49. Cacciola F, Farah JO, Eldridge PR, et al. Bilateral deep brain stimulation for cervical dystonia: long-term outcome in a series of 10 patients. Neurosurgery. 2010 Oct;67(4):957-63.[Abstract]

            • 50. Skogseid IM, Ramm-Pettersen J, Volkmann J, et al. Good long-term efficacy of pallidal stimulation in cervical dystonia: a prospective, observer-blinded study. Eur J Neurol. 2012 Apr;19(4):610-5.[Abstract]

            • 51. Ostrem JL, Racine CA, Glass GA, et al. Subthalamic nucleus deep brain stimulation in primary cervical dystonia. Neurology. 2011 Mar 8;76(10):870-8.[Abstract]

            • 52. Cohen-Gadol AA, Ahlskog JE, Matsumoto JY, et al. Selective peripheral denervation for the treatment of intractable spasmodic torticollis: experience with 168 patients at the Mayo Clinic. J Neurosurg. 2003 Jun;98(6):1247-54.[Abstract]

            • 53. Wang J, Li J, Han L, et al. Selective peripheral denervation for the treatment of spasmodic torticollis: long-term follow-up results from 648 patients. Acta Neurochir (Wien). 2015 Mar;157(3):427-33; discussion 433.[Abstract]

            • 54. Ravindran K, Ganesh Kumar N, Englot DJ, et al. Deep brain stimulation versus peripheral denervation for cervical dystonia: a systematic review and meta-analysis. World Neurosurg. 2019 Feb;122:e940-6.[Abstract][Full Text]

            • 55. Chung M, Han I, Chung SS, et al. Effectiveness of selective peripheral denervation in combination with pallidal deep brain stimulation for the treatment of cervical dystonia. Acta Neurochir (Wien). 2015 Mar;157(3):435-42.[Abstract]

            • 56. Dykstra DD, Mendez A, Chappuis D, et al. Treatment of cervical dystonia and focal hand dystonia by high cervical continuously infused intrathecal baclofen: a report of 2 cases. Arch Phys Med Rehabil. 2005 Apr;86(4):830-3.[Abstract]

            • 57. Lew MF, Brashear A, Factor S. The safety and efficacy of botulinum toxin type B in the treatment of patients with cervical dystonia: summary of three controlled clinical trials. Neurology. 2000;55(12 suppl 5):S29-35.[Abstract]

            • 58. Teng F, Malam Djibo I, Chen S, et al. Efficacy of single-photon emission computed tomography aided botulinum toxin injection in cervical dystonia: a double-blind, randomized study. Parkinsonism Relat Disord. 2021 Oct;91:77-82.[Abstract][Full Text]

            • 59. Jahanshahi M, Marion MH, Marsden CD. Natural history of adult-onset idiopathic torticollis. Arch Neurol. 1990 May;47(5):548-52.[Abstract]

            • 60. Berman BD, Groth CL, Sillau SH, et al. Risk of spread in adult-onset isolated focal dystonia: a prospective international cohort study. J Neurol Neurosurg Psychiatry. 2020 Mar;91(3):314-20.[Abstract][Full Text]

            • 61. Camfield L, Ben-Shlomo Y, Warner TT. Impact of cervical dystonia on quality of life. Mov Disord. 2002 Jul;17(4):838-41.[Abstract]

            • 62. Slawek J, Friedman A, Potulska A, et al. Factors affecting the health-related quality of life of patients with cervical dystonia and the impact of botulinum toxin type A injections. Funct Neurol. 2007 Apr-Jun;22(2):95-100.[Abstract]

            • 63. Rinnerthaler M, Mueller J, Weichbold V, et al. Social stigmatization in patients with cranial and cervical dystonia. Mov Disord. 2006 Oct;21(10):1636-40.[Abstract]

            • 64. Ortiz RM, Scheperjans F, Mertsalmi T, et al. Comorbidity and retirement in cervical dystonia. J Neurol. 2019 Sep;266(9):2216-23.[Abstract][Full Text]

            • 65. Rondot P, Marchand MP, Dellatolas G. Spasmodic torticollis--review of 220 patients. Can J Neurol Sci. 1991 May;18(2):143-51.[Abstract]

            • 66. Jankovic J, Leder S, Warner D, et al. Cervical dystonia: clinical findings and associated movement disorders. Neurology. 1991 Jul;41(7):1088-91.[Abstract]

            • 67. Molho ES, Agarwal N, Regan K, et al. Effect of cervical dystonia on employment: a retrospective analysis of the ability of treatment to restore premorbid employment status. Mov Disord. 2009 Jul 15;24(9):1384-7.[Abstract]

            • 68. Boyce MJ, McCambridge AB, Bradnam LV, et al. The barriers and facilitators to satisfaction with botulinum neurotoxin treatment in people with cervical dystonia: a systematic review. Neurol Sci. 2022 Aug;43(8):4663-70.[Abstract][Full Text]

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