Highlights & Basics
- Breathing disorder that is frequently mistaken for asthma.
- Accurate diagnosis is made by a multidisciplinary team, which can include a speech language pathologist, a primary care physician, an asthma/allergy specialist, a pulmonologist, a psychologist, a psychiatrist, a sports medicine specialist, an athletic trainer, and a gastroenterologist.
- Diagnosis is established through the case history, laryngeal visualization, and pulmonary function studies.
- Behavioral therapy by a speech language pathologist is the standard treatment.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Normal larynx: normal color of vocal folds and surrounding structures, smooth vocal fold edges
Irritable larynx: bilateral erythema of the arytenoid complex bilaterally with tissue changes suggestive of early granuloma
Laryngopharyngeal reflux: bilateral edema and erythema of the vocal folds with epithelial layer thickness, interarytenoid thickness
Reproduction of breathing attack: adduction of arytenoid complex during inhalation
Abduction breathing exercise: abduction of the arytenoid complex bilaterally with nasal inhalation
Citations
Mathers-Schmidt BA. Paradoxical vocal fold motion: a tutorial on a complex disorder and the speech-language pathologist's role. Am J Speech Lang Pathol. 2001;10:111-125.
Morrison M, Rammage L, Emami AJ. The irritable larynx syndrome. J Voice. 1999;13:447-455.[Abstract]
Mathers-Schmidt BA, Brilla LR. Inspiratory muscle training in exercise-induced paradoxical vocal fold motion. J Voice. 2005;19:635-644.[Abstract]
1. Andrianopoulos MV, Gallivan GJ, Gallivan KH. PVCM, PVCD, EPL, and irritable larynx syndrome: what are we talking about and how do we treat it? J Voice. 2000;14:607-618.[Abstract]
2. Maschka DA, Bauman NM, McCray PB Jr, et al. A classification scheme for paradoxical vocal cord motion. Laryngoscope. 1997;107:1429-1435.[Abstract]
3. Mathers-Schmidt BA. Paradoxical vocal fold motion: a tutorial on a complex disorder and the speech-language pathologist's role. Am J Speech Lang Pathol. 2001;10:111-125.
4. Al-Alwan A, Kaminsky D. Vocal cord dysfunction in athletes: clinical presentation and review of the literature. Phys Sportsmed. 2012;40:22-27.[Abstract]
5. Patel RR, Venediktov R, Schooling T, et al. Evidence-based systematic review: effects of speech-language pathology treatment for individuals with paradoxical vocal fold motion. Am J Speech Lang Pathol. 2015;24:566-584.[Abstract]
6. Sachdeva R, Hussain E, Moss MM, et al. Vocal cord dysfunction and feeding difficulties after pediatric cardiovascular surgery. J Pediatr. 2007;151:312-315.[Abstract]
7. Silvers WS, Levine JS, Poole JA, et al. Inlet patch of gastric mucosa in upper esophagus causing chronic cough and vocal cord dysfunction. Ann Allergy Asthma Immunol. 2006;96:112-115.[Abstract]
8. Neema PK, Sinha PK, Varma PK, et al. Vocal cord dysfunction in two patients after mitral valve replacement: consequences and mechanism. J Cardiothorac Vasc Anesth. 2005;19:83-85.[Abstract]
9. Kinghorn K, Dhamee S. Paradoxical vocal cord motion: a postoperative dilemma - a case report. Middle East J Anesthesiol. 2006;18:1203-1207.[Abstract]
10. Arndt GA, Voth BR. Paradoxical vocal cord motion in the recovery room: a masquerader of pulmonary dysfunction. Can J Anaesth. 1996;43:1249-1251.[Abstract]
11. Hammer G, Schwinn D, Wollman H. Postoperative complications due to paradoxical vocal cord motion. Anesthesiology. 1987;66:686-687.[Abstract]
12. Harbison J, Dodd J, McNicholas WT. Paradoxical vocal cord motion causing stridor after thyroidectomy. Thorax. 2000;55:533-534.[Abstract][Full Text]
13. Michelsen LG, Vanderspek AF. An unexpected functional cause of upper airway obstruction. Anaesthesia. 1988;43:1028-1030.[Abstract]
14. Roberts KW, Crnkovic A, Steiniger JR. Post-anesthesia paradoxical vocal cord motion successfully treated with midazolam. Anesthesiology. 1998;89:517-519.[Abstract]
15. Sukhani R, Barclay J, Chow J. Paradoxical vocal cord motion: an unusual cause of stridor in the recovery room. Anesthesiology. 1993;79:177-180.[Abstract]
16. Bastian RW, Richardson BE. Postintubation phonatory insufficiency: an elusive diagnosis. Otolaryngol Head Neck Surg. 2001;124:625-633.[Abstract]
17. Powell SA, Nguyen CT, Gaziano J, et al. Mass psychogenic illness presenting as acute stridor in an adolescent female cohort. Ann Otol Rhinol Laryngol. 2007;116:525-531.[Abstract]
18. Kenn K, Willer G, Bizer C, et al. Prevalence of vocal cord dysfunction in patients with dyspnea: first prospective clinical study. Am J Respir Crit Care Med. 1997;155:A965.
19. Morris MJ, Allan PF, Perkins PJ. Vocal cord dysfunction: etiologies and treatment. Clin Pulm Med. 2006;13:73-86.
20. Brugman S. The many faces of vocal cord dysfunction: what 36 years of literature tells us. Am J Respir Crit Care Med. 2003;167:A588.
21. Newman KB, Dubester SN. Vocal cord dysfunction: masquerader of asthma. Semin Respir Crit Care Med. 1994;15:161.
22. Gavin LA, Wamboldt M, Brugman S, et al. Psychological and family characteristics of adolescents with vocal cord dysfunction. J Asthma. 1998;35:409-417.[Abstract]
23. Newman KB, Mason UG 3rd, Schmaling KB. Clinical features of vocal cord dysfunction. Am J Respir Crit Care Med. 1995;152:1382-1386.[Abstract]
24. Hicks M, Brugman SM, Katial R. Vocal cord dysfunction/paradoxical vocal fold motion. Prim Care. 2008;35:81-103.[Abstract]
25. Kenn K. Vocal cord dysfunction: what do we really know? A review [in German]. Pneumologie. 2007;61:431-439.[Abstract]
26. Parker JM, Guerrero ML. Airway function in women: bronchial hyperresponsiveness, cough, and vocal cord dysfunction. Clin Chest Med. 2004;25:321-330.[Abstract]
27. Altman KW, Mirza N, Ruiz C, et al. Paradoxical vocal fold motion: presentation and treatment options. J Voice. 2000;14:99-103.[Abstract]
28. Morris MJ, Deal LE, Bean DR, et al. Vocal cord dysfunction in patients with exertional dyspnea. Chest. 1999;116:1676-1682.[Abstract][Full Text]
29. Campisi ES, Schneiderman JE, Owen B, et al. Exercise-induced laryngeal obstruction: Quality initiative to improve assessment and management. Int J Pediatr Otorhinolaryngol. 2019 Dec;127:109677.[Abstract][Full Text]
30. Morrison M, Rammage L, Emami AJ. The irritable larynx syndrome. J Voice. 1999;13:447-455.[Abstract]
31. Olivier CE, Argentão DG, Lima RP, et al. The nasal provocation test combined with spirometry establishes paradoxical vocal fold motion in allergic subjects. Allergy Asthma Proc. 2013;34:453-458.[Abstract]
32. Halvorsen T, Walsted ES, Bucca C, et al. Inducible laryngeal obstruction: an official joint European Respiratory Society and European Laryngological Society statement. Eur Respir J. 2017 Sep;50(3):.[Abstract][Full Text]
33. Cukier-Blaj S, Bewley A, Aviv JE, et al. Paradoxical vocal fold motion: a sensory-motor laryngeal disorder. Laryngoscope. 2008;118:367-370.[Abstract]
34. Perkner JJ, Fennelly KP, Balkissoon R, et al. Irritant-associated vocal cord dysfunction. J Occup Environ Med. 1998;40:136-143.[Abstract]
35. de la Hoz RE, Shohet MR, Bienenfeld LA, et al. Vocal cord dysfunction in former World Trade Center (WTC) rescue and recovery workers and volunteers. Am J Ind Med. 2008;51:161-165.[Abstract]
36. Allan PF, Abouchahine S, Harvis L, et al. Progressive vocal cord dysfunction subsequent to a chlorine gas exposure. J Voice. 2006;20:291-296.[Abstract]
37. Huggins JT, Kaplan A, Martin-Harris B, et al. Eucalyptus as a specific irritant causing vocal cord dysfunction. Ann Allergy Asthma Immunol. 2004;93:299-303.[Abstract]
38. Munoz X, Roger A, De la Rosa D, et al. Occupational vocal cord dysfunction due to exposure to wood dust and xerographic toner. Scand J Work Environ Health. 2007;33:153-158.[Abstract]
39. Smith B, Milstein C, Rolfes B, et al. Paradoxical vocal fold motion (PVFM) in pediatric otolaryngology. Am J Otolaryngol. 2017 Mar - Apr;38(2):230-232.[Abstract]
40. Duflo S, Thibeault SL. Anatomy of the larynx and physiology of phonation. In: Merati AL, Bielamowicz S, eds. Textbook of laryngology. San Diego, CA: Plural Publishing; 2007:31.
41. Sasaki CT, Weaver EM. Physiology of the larynx. Am J Med. 1997;103:9S-18S.[Abstract]
42. Henriquez VM, Schulz GM, Bielamowicz S, et al. Laryngeal reflex responses are not modulated during human voice and respiratory tasks. J Physiol. 2007;585:779-789.[Abstract][Full Text]
43. Ludlow C. Physiology of airway regulation. In: Merati AL, Bielamowicz S, eds. Textbook of laryngology. San Diego, CA: Plural Publishing; 2007:51.
44. Reix P, St-Hilaire M, Praud JP. Laryngeal sensitivity in the neonatal period: from bench to bedside. Pediatr Pulmonol. 2007;42:674-682.[Abstract]
45. Phua SY, McGarvey LP, Ngu MC, et al. Patients with gastro-oesophageal reflux disease and cough have impaired laryngopharyngeal mechanosensitivity. Thorax. 2005;60:488-491.[Abstract][Full Text]
46. Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice. 2002;16:274-277.[Abstract]
47. Kahrilas PJ, Altman KW, Chang AB, et al. Chronic Cough Due to Gastroesophageal Reflux in Adults: CHEST Guideline and Expert Panel Report. Chest. 2016 Dec;150(6):1341-1360.[Abstract][Full Text]
48. Altman KW, Simpson CB, Amin MR, et al. Cough and paradoxical vocal fold motion. Otolaryngol Head Neck Surg. 2002;127:501-511.[Abstract]
49. Jain S, Bandi V, Officer T, et al. Role of vocal cord function and dysfunction in patients presenting with symptoms of acute asthma exacerbation. J Asthma. 2006;43:207-212.[Abstract]
50. Christopher KL, Wood RP 2nd, Eckert RC, et al. Vocal-cord dysfunction presenting as asthma. N Engl J Med. 1983;308:1566-1570.[Abstract]
51. McFadden ER Jr, Zawadski DK. Vocal cord dysfunction masquerading as exercise-induced asthma. a physiologic cause for "choking" during athletic activities. Am J Respir Crit Care Med. 1996;153:942-947.[Abstract]
52. Powell DM, Karanfilov BI, Beechler KB, et al. Paradoxical vocal cord dysfunction in juveniles. Arch Otolaryngol Head Neck Surg. 2000;126:29-34.[Abstract][Full Text]
53. Husein OF, Husein TN, Gardner R, et al. Formal psychological testing in patients with paradoxical vocal fold dysfunction. Laryngoscope. 2008;118:740-747.[Abstract]
54. Wenning GK, Tison F, Ben Shlomo Y, et al. Multiple system atrophy: a review of 203 pathologically proven cases. Mov Disord. 1997;12:133-147.[Abstract]
55. Bannister R, Gibson W, Michaels L, et al. Laryngeal abductor paralysis in multiple system atrophy: a report on three necropsied cases, with observations on the laryngeal muscles and the nuclei ambigui. Brain. 1981;104:351-368.[Abstract]
56. Vetrugno R, Liguori R, Cortelli P, et al. Sleep-related stridor due to dystonic vocal cord motion and neurogenic tachypnea/tachycardia in multiple system atrophy. Mov Disord. 2007;22:673-678.[Abstract]
57. Shiba K, Isono S, Nakazawa K. Paradoxical vocal cord motion: a review focused on multiple system atrophy. Auris Nasus Larynx. 2007;34:443-452.[Abstract]
58. Shiba K, Isono S. Tracheostomy abolishes paradoxical activation of the vocal cord adductor in multiple system atrophy. Auris Nasus Larynx. 2006;33:295-298.[Abstract]
59. Iranzo A. Sleep and breathing in multiple system atrophy. Curr Treat Options Neurol. 2007;9:347-353.[Abstract]
60. Dromey C, Nissen SL, Roy N, et al. Articulatory changes following treatment of muscle tension dysphonia: preliminary acoustic evidence. J Speech Lang Hear Res. 2008;51:196-208.[Abstract]
61. Grillone GA, Blitzer A, Brin MF, et al. Treatment of adductor laryngeal breathing dystonia with botulinum toxin type A. Laryngoscope. 1994;104:30-32.[Abstract]
62. Larsen B, Caruso LJ, Villariet DB. Paradoxical vocal cord motion: an often misdiagnosed cause of postoperative stridor. J Clin Anesth. 2004;16:230-234.[Abstract]
63. Franca MC. Differential diagnosis in paradoxical vocal fold movement (PVFM): an interdisciplinary task. Int J Pediatr Otorhinolaryngol. 2014;78:2169-2173.[Abstract]
64. Gimenez LM, Zafra H. Vocal cord dysfunction: an update. Ann Allergy Asthma Immunol. 2011;106:267-274.[Abstract]
65. Sandage MJ, Zelazny SK. Paradoxical vocal fold motion in children and adolescents. Lang Speech Hear Serv Sch. 2004;35:353-362.[Abstract]
66. Hartley NA, Petty BE, Johnson B, et al. Comparative analysis of clinical profile: chronic cough vs paradoxical vocal fold motion. Respir Med. 2015;109:1516-1520.[Abstract]
67. Vertigan AE, Gibson PG, Theodoros DG, et al. A review of voice and upper airway function in chronic cough and paradoxical vocal cord movement. Curr Opin Allergy Clin Immunol. 2007;7:37-42.[Abstract]
68. Roy N, Ford CN, Bless DM. Muscle tension dysphonia and spasmodic dysphonia: the role of manual laryngeal tension reduction in diagnosis and management. Ann Otol Rhinol Laryngol. 1996;105:851-856.[Abstract]
69. Mikita J, Parker J. High levels of medical utilization by ambulatory patients with vocal cord dysfunction as compared to age- and gender-matched asthmatics. Chest. 2006;129:905-908.[Abstract][Full Text]
70. Gartner-Schmidt JL, Shembel AC, Zullo TG, et al. Development and validation of the Dyspnea Index (DI): a severity index for upper airway-related dyspnea. J Voice. 2014;28:775-782.[Abstract]
71. De Guzman V, Ballif CL, Maurer R, et al. Validation of the dyspnea index in adolescents with exercise-induced paradoxical vocal fold motion. JAMA Otolaryngol Head Neck Surg. 2014;140:823-828.[Abstract]
72. Ibrahim WH, Gheriani HA, Almohamed AA, et al. Paradoxical vocal cord motion disorder: past, present and future. Postgrad Med J. 2007;83:164-172.[Abstract]
73. Wilson JJ, Wilson EM. Practical management: vocal cord dysfunction in athletes. Clin J Sport Med. 2006;16:357-360.[Abstract]
74. Olin JT, Clary MS, Connors D, et al. Glottic configuration in patients with exercise-induced stridor: a new paradigm. Laryngoscope. 2014;124:2568-2573.[Abstract]
75. Murry T, Cukier-Blaj S, Kelleher A, et al. Laryngeal and respiratory patterns in patients with paradoxical vocal fold motion. Respir Med. 2011;105:1891-1895.[Abstract][Full Text]
76. Peters EJ, Hatley TK, Crater SE, et al. Sinus computed tomography scan and markers of inflammation in vocal cord dysfunction and asthma. Ann Allergy Asthma Immunol. 2003;90:316-322.[Abstract][Full Text]
77. Aviv JE. Clinical assessment of pharyngolaryngeal sensitivity. Am J Med. 2000;108(suppl 4a):68S-72S.[Abstract]
78. Nolan PK, Chrysler M, Phillips G, et al. Pulse oximetry coupled with spirometry in the emergency department helps differentiate an asthma exacerbation from possible vocal cord dysfunction. Pediatr Pulmonol. 2007;42:605-609.[Abstract]
79. Richter GT, Rutter MJ, deAlarcon A, et al. Late-onset laryngomalacia: a variant of disease. Arch Otolaryngol Head Neck Surg. 2008;134:75-80.[Abstract][Full Text]
80. National Institute on Deafness and Other Communication Disorders. Vocal fold paralysis. October 2011. http://www.nidcd.nih.gov/ (last accessed 28 October 2016).[Full Text]
81. The Voice Foundation. Overview of diagnosis, treatment and prevention. http://www.voicefoundation.org/ (last accessed 28 October 2016).[Full Text]
82. Landwehr LP, Wood RP 2nd, Blager FB, et al. Vocal cord dysfunction mimicking exercise-induced bronchospasm in adolescents. Pediatrics. 1996;98:971-974.[Abstract]
83. Wolfe JM, Meth BM. Vocal cord dysfunction mimicking a severe asthma attack. J Emerg Med. 1999;17:39-41.[Abstract]
84. Baldwin MK, Benumof JL. Paradoxical vocal cord movement: a unique case of occurrence and treatment. Anesthesiology. 2007;107:359.[Abstract]
85. Weir M. Vocal cord dysfunction mimics asthma and may respond to heliox. Clin Pediatr (Phila). 2002;41:37-41.[Abstract]
86. Gose JE. Acute workup of vocal cord dysfunction. Ann Allergy Asthma Immunol. 2003;91:318.[Abstract]
87. Murry T, Sapienza C. The role of voice therapy in the management of paradoxical vocal fold motion, chronic cough, and laryngospasm. Otolaryngol Clin North Am. 2010;43:73-83, viii-ix.[Abstract]
88. Reitz JR, Gorman S, Kegyes J. Behavioral management of paradoxical vocal fold motion. Perspect Voice Voice Disord; 2014;24:64-70.[Full Text]
89. Matrka L. Paradoxic vocal fold movement disorder. Otolaryngol Clin North Am. 2014;47:135-146.[Abstract]
90. Sullivan MD, Heywood BM, Beukelman DR. A treatment for vocal cord dysfunction in female athletes: an outcome study. Laryngoscope. 2001;111:1751-1755.[Abstract]
91. Gillespie A, Gartner-Schmidt J. Odor induced laryngeal hypersensitivity. Perspect Voice Voice Disord. 2006;16:10-15.
92. Koufman JA, Block C. Differential diagnosis of paradoxical vocal fold movement. Am J Speech Lang Pathol. 2008;17:327-334.[Abstract]
93. Guglani L, Atkinson S, Hosanagar A, et al. A systematic review of psychological interventions for adult and pediatric patients with vocal cord dysfunction. Front Pediatr. 2014;2:82.[Abstract][Full Text]
94. Ruddy BH, Davenport P, Baylor J, et al. Inspiratory muscle strength training with behavioral therapy in a case of a rower with presumed exercise-induced paradoxical vocal-fold dysfunction. Int J Pediatr Otorhinolaryngol. 2004;68:1327-1332.[Abstract]
95. Mathers-Schmidt BA, Brilla LR. Inspiratory muscle training in exercise-induced paradoxical vocal fold motion. J Voice. 2005;19:635-644.[Abstract]
96. Hatzelis V, Murry T. Paradoxical vocal fold motion: respiratory retraining to manage long-term symptoms. J Soc Bras Fonoaudiol. 2012;24:80-85.[Abstract]
97. Anbar RD, Hehir DA. Hypnosis as a diagnostic modality for vocal cord dysfunction. Pediatrics. 2000;106:E81.[Abstract][Full Text]
98. Warnes E, Allen KD. Biofeedback treatment of paradoxical vocal fold motion and respiratory distress in an adolescent girl. J Appl Behav Anal. 2005;38:529-532.[Abstract][Full Text]
99. Gallena SK, Johnson AT, Vossoughi J. Short-Term Intensive Therapy and Outcomes for Athletes With Paradoxical Vocal Fold Motion Disorder. Am J Speech Lang Pathol. 2019 Feb 21;28(1):83-95.[Abstract][Full Text]
100. Katz DH, Sella O, Golan H, et al. Buteyko Breathing Technique for Exertion-Induced Paradoxical Vocal Fold Motion (EI-PVFM). J Voice. 2019 Aug 12;:.[Abstract][Full Text]
101. Park DP, Ayres JG, McLeod DT, et al. Vocal cord dysfunction treated with long-term tracheostomy: 2 case studies. Ann Allergy Asthma Immunol. 2007;98:591-594.[Abstract]
102. Maillard I, Schweizer V, Broccard A, et al. Use of botulinum toxin type A to avoid tracheal intubation or tracheostomy in severe paradoxical vocal cord movement. Chest. 2000;118:874-877.[Abstract][Full Text]
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