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Diseases

Evaluation of vaginal bleeding

OVERVIEW

  • Summary
  • Urgent Considerations
  • Etiology

DIAGNOSIS

  • Differential Diagnosis
  • Diagnostic Approach

IMAGES

  • Library

REFERENCES

  • Citations
  • Credits

Summary

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Classification

Abnormal vaginal bleeding is classified by age and gravidity:
  • Before menarche

  • During reproductive years: non-pregnant

  • During reproductive years: pregnant

  • Postmenopausal

Disorders of menstrual bleeding, including intermenstrual bleeding, are discussed in the topic, Evaluation of abnormal uterine bleeding .

Epidemiology

Vaginal bleeding before menarche is uncommon and is most often caused by trauma.[1]
Prevalence estimates for postcoital bleeding vary from 0.7% to 9% among women of reproductive age.[2] [3] [4] Incidence is highest among patients ages 26-30 years.[5]
Bleeding during early pregnancy is common, affecting 25% of women during the first trimester.[6] [7]
Up to 11% of women report postmenopausal bleeding, with highest rates in the first year after the menopause.[8]
content by BMJ Group
Last updated

Library

  • Cervical erosion

    Cervical erosion

  • Cervical polyp

    Cervical polyp

Citations

    Key Articles

    • Workowski KA, Bachmann LH, Chan PA, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.[Abstract][Full Text]

    • National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. Jun 2026 [internet publication].[Full Text]

    • American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 193: tubal ectopic pregnancy. Mar 2018 [internet publication].

    • ​American College of Radiology. ACR appropriateness criteria: first trimester vaginal bleeding. 2025 [internet publication].[Full Text]

    Referenced Articles

    • 1. Söderström HF, Carlsson A, Börjesson A, et al. Vaginal bleeding in prepubertal girls: etiology and clinical management. J Pediatr Adolesc Gynecol. 2016 Jun;29(3):280-5.[Abstract]

    • 2. Lindner LE, Geerling S, Nettum JA, et al. Clinical characteristics of women with chlamydial cervicitis. J Reprod Med. 1988 Aug;33(8):684-90.[Abstract]

    • 3. Shapley M, Jordan K, Croft PR. An epidemiological survey of symptoms of menstrual loss in the community. Br J Gen Pract. 2004 May;54(502):359-63.[Abstract][Full Text]

    • 4. Viikki M, Pukkala E, Hakama M. Bleeding symptoms and subsequent risk of gynecological and other cancers. Acta Obstet Gynecol Scand. 1998 May;77(5):564-9.[Abstract]

    • 5. Cohen O, Schejter E, Agizim R, et al. Postcoital bleeding is a predictor for cervical dysplasia. PLoS One. 2019 May 23;14(5):e0217396.[Abstract][Full Text]

    • 6. Everett C. Incidence and outcome of bleeding before the 20th week of pregnancy: prospective study from general practice. BMJ. 1997 Jul 5;315(7099):32-4.[Abstract][Full Text]

    • 7. Hasan R, Baird DD, Herring AH, et al. Association between first-trimester vaginal bleeding and miscarriage. Obstet Gynecol. 2009 Oct;114(4):860-7.[Abstract][Full Text]

    • 8. Astrup K, Olivarius Nde F. Frequency of spontaneously occurring postmenopausal bleeding in the general population. Acta Obstet Gynecol Scand. 2004 Feb;83(2):203-7.[Abstract][Full Text]

    • 9. Puttemans P, Benagiano G, Gargett C, et al. Neonatal uterine bleeding as a biomarker for reproductive disorders during adolescence: a worldwide call for systematic registration by nurse midwife. J Matern Fetal Neonatal Med. 2017 Jun;30(12):1434-6.[Abstract][Full Text]

    • 10. Brosens I, Benagiano G. Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells? Fertil Steril. 2013 Sep;100(3):622-3.[Full Text]

    • 11. Stricker T, Navratil F, Sennhauser FH. Vaginal foreign bodies. J Paediatr Child Health. 2004 Apr;40(4):205-7.[Abstract]

    • 12. Dwiggins M, Gomez-Lobo V. Current review of prepubertal vaginal bleeding. Curr Opin Obstet Gynecol. 2017 Oct;29(5):322-7.[Abstract]

    • 13. Striegel AM, Myers JB, Sorensen MD, et al. Vaginal discharge and bleeding in girls younger than 6 years. J Urol. 2006 Dec;176(6 Pt 1):2632-5.[Abstract]

    • 14. Tarney CM, Han J. Postcoital bleeding: a review on etiology, diagnosis, and management. Obstet Gynecol Int. 2014;2014:192087.[Abstract][Full Text]

    • 15. Workowski KA, Bachmann LH, Chan PA, et al. Sexually Transmitted Infections Treatment Guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.[Abstract][Full Text]

    • 16. Wilson JF. In the clinic. Vaginitis and cervicitis. Ann Intern Med. 2009 Sep 1;151(5):ITC3-1-15; quiz ITC3-16.

    • 17. Taylor SN. Cervicitis of unknown etiology. Curr Infect Dis Rep. 2014 Jul;16(7):409.[Abstract]

    • 18. World Health Organization. Cervical cancer. Mar 2024 [internet publication].​[Full Text]

    • 19. International Collaboration of Epidemiological Studies of Cervical Cancer. Cervical carcinoma and sexual behavior: collaborative reanalysis of individual data on 15,461 women with cervical carcinoma and 29,164 women without cervical carcinoma from 21 epidemiological studies. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1060-9.[Abstract][Full Text]

    • 20. Hessol NA, Whittemore H, Vittinghoff E, et al. Incidence of first and second primary cancers diagnosed among people with HIV, 1985-2013: a population-based, registry linkage study. Lancet HIV. 2018 Nov;5(11):e647-55.[Abstract]

    • 21. International Collaboration of Epidemiological Studies of Cervical Cancer, Appleby P, Beral V, et al. Cervical cancer and hormonal contraceptives: collaborative reanalysis of individual data for 16,573 women with cervical cancer and 35,509 women without cervical cancer from 24 epidemiological studies. Lancet. 2007 Nov 10;370(9599):1609-21.[Abstract]

    • 22. Shapley M, Jordan J, Croft PR. A systematic review of postcoital bleeding and risk of cervical cancer. Br J Gen Pract. 2006 Jun;56(527):453-60.[Abstract][Full Text]

    • 23. National Comprehensive Cancer Network. ​NCCN clinical practice guidelines in oncology: vaginal cancer [internet publication].[Full Text]

    • 24. Wiley DJ, Douglas J, Beutner K, et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis. 2002 Oct 15;35(Suppl 2):S210-24.[Abstract][Full Text]

    • 25. National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. Jun 2026 [internet publication].[Full Text]

    • 26. Panelli DM, Phillips CH, Brady PC. Incidence, diagnosis and management of tubal and nontubal ectopic pregnancies: a review. Fertil Res Pract. 2015 Oct 15;1:15.[Abstract][Full Text]

    • 27. Furlong LA. Ectopic pregnancy risk when contraception fails. A review. J Reprod Med. 2002 Nov;47(11):881-5.[Abstract]

    • 28. Wilcox AJ, Weinberg CR, O'Connor JF, et al. Incidence of early loss of pregnancy. N Engl J Med. 1988 Jul 28;319(4):189-94.[Abstract]

    • 29. Expert Panel on GYN and OB Imaging; Shipp TD, Poder L, et al. ACR appropriateness criteria® second and third trimester vaginal bleeding. J Am Coll Radiol. 2020 Nov;17(11S):S497-504.[Abstract][Full Text]

    • 30. Ananth CV, Keyes KM, Hamilton A, et al. An international contrast of rates of placental abruption: an age-period-cohort analysis. PLoS One. 2015 May 27;10(5):e0125246.[Abstract][Full Text]

    • 31. El-Kady D, Gilbert WM, Anderson J, et al. Trauma during pregnancy: an analysis of maternal and fetal outcomes in a large population. Am J Obstet Gynecol. 2004 Jun;190(6):1661-8.[Abstract]

    • 32. Ananth CV, Smulian JC, Vintzileos AM. Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies. Obstet Gynecol. 1999 Apr;93(4):622-8.[Abstract]

    • 33. Addis A, Moretti ME, Ahmed Syed F, et al. Fetal effects of cocaine: an updated meta-analysis. Reprod Toxicol. 2001 Jul-Aug;15(4):341-69.[Abstract]

    • 34. Rasmussen S, Irgens LM, Dalaker K. Outcome of pregnancies subsequent to placental abruption: a risk assessment. Acta Obstet Gynecol Scand. 2000 Jun;79(6):496-501.[Abstract]

    • 35. Silver RM, Branch DW. Placenta accreta spectrum. N Engl J Med. 2018 Apr 19;378(16):1529-36.

    • 36. Conde-Agudelo A, Rosas-Bermudez A, Kafury-Goeta AC. Effects of birth spacing on maternal health: a systematic review. Am J Obstet Gynecol. 2007;196:297-308.[Abstract]

    • 37. American College of Obstetricians and Gynecologists' Committee on Practice Bulletins-Gynecology. ACOG Committee Opinion No. 743: low-dose aspirin use during pregnancy. Obstet Gynecol. 2018 Jul;132(1):e44-52.[Abstract][Full Text]

    • 38. Roberge S, Bujold E, Nicolaides KH. Meta-analysis on the effect of aspirin use for prevention of preeclampsia on placental abruption and antepartum hemorrhage. Am J Obstet Gynecol. 2018 May;218(5):483-9.[Abstract][Full Text]

    • 39. Souter V, Painter I, Sitcov K, et al. Propensity score analysis of low-dose aspirin and bleeding complications in pregnancy. Ultrasound Obstet Gynecol. 2024 Jan;63(1):81-7.[Abstract][Full Text]

    • 40. Hastie R, Tong S, Wikström AK, et al. Aspirin use during pregnancy and the risk of bleeding complications: a Swedish population-based cohort study. Am J Obstet Gynecol. 2021 Jan;224(1):95.e1-95.[Abstract]

    • 41. Yip KC, Luo Z, Huang X, et al. The role of aspirin dose and initiation time in the prevention of preeclampsia and corresponding complications: a meta-analysis of RCTs. Arch Gynecol Obstet. 2022 Jun;305(6):1465-79.[Abstract]

    • 42. Henderson JT, Vesco KK, Senger CA, et al. Aspirin use to prevent preeclampsia and related morbidity and mortality: updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2021 Sep 28;326(12):1192-206.[Abstract][Full Text]

    • 43. Clarke MA, Long BJ, Del Mar Morillo A, et al. Association of endometrial cancer risk with postmenopausal bleeding in women: a systematic review and meta-analysis. JAMA Intern Med. 2018 Sep 1;178(9):1210-22.[Abstract][Full Text]

    • 44. Bankhead CR, Collins C, Stokes-Lampard H, et al. Identifying symptoms of ovarian cancer: a qualitative and quantitative study. BJOG. 2008 Jul;115(8):1008-14.[Abstract][Full Text]

    • 45. Practice Committee of American Society for Reproductive Medicine. Medical treatment of ectopic pregnancy: a committee opinion. Fertil Steril. 2013 Sep;100(3):638-44.[Abstract][Full Text]

    • 46. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 193: tubal ectopic pregnancy. Mar 2018 [internet publication].

    • 47. Elson CJ, Salim R, Potdar N, et al; Royal College of Obstetricians and Gynaecologists. Diagnosis and management of ectopic pregnancy: green-top guideline no. 21. BJOG. 2016 Dec;123(13):e15-e55.[Full Text]

    • 48. Casanovas M, Kramer T, Clarke V, et al. Somatic symptoms following sexual assault in adolescents: a prospective longitudinal study. Psychol Health Med. 2022 Mar;27(3):546-58.[Abstract][Full Text]

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    • 51. Palusci VJ, Cox EO, Shatz EM, et al. Urgent medical assessment after child sexual abuse. Child Abuse Negl. 2006 Apr;30(4):367-80.[Abstract]

    • 52. Orbach Y, Hershkowitz I, Lamb ME, et al. Assessing the value of structured protocols for forensic interviews of alleged child abuse victims. Child Abuse Negl. 2000 Jun;24(6):733-52.[Abstract]

    • 53. American College of Obstetricians and Gynecologists. Updated guidance regarding the role of transvaginal ultrasonography in evaluating the endometrium of individuals with postmenopausal bleeding. Obstet Gynecol. 2026 Jul 1;148(1):e87-91.[Abstract][Full Text]

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    • 55. Spitzer RF, Kives S, Caccia N, et al. Retrospective review of unintentional female genital trauma at a pediatric referral center. Pediatr Emerg Care. 2008 Dec;24(12):831-5.[Abstract]

    • 56. Brander EPA, McQuillan SK. Prepubertal vulvovaginitis. CMAJ. 2018 Jul 3;190(26):E800.[Full Text]

    • 57. Brook G, Church H, Evans C, et al. 2019 UK National guideline for consultations requiring sexual history taking: Clinical Effectiveness Group British Association for Sexual Health and HIV. Int J STD AIDS. 2020 Sep;31(10):920-38.[Abstract]

    • 58. Evans D, Goldstein S, Loewy A, et al. No. 385-Indications for pelvic examination. J Obstet Gynaecol Can. 2019 Aug;41(8):1221-34.[Abstract]

    • 59. Crochet JR, Bastian LA, Chireau MV. Does this woman have an ectopic pregnancy?: the rational clinical examination systematic review. JAMA. 2013 Apr 24;309(16):1722-9.[Abstract]

    • 60. Cohen PA, Jhingran A, Oaknin A, et al. Cervical cancer. Lancet. 2019 Jan 12;393(10167):169-82.[Abstract]

    • 61. Royal College of Obstetricians and Gynaecologists. Antepartum haemorrhage (Green-top guideline No. 63). 5 Dec 2011 [internet publication].[Full Text]

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    • 63. Castelo-Branco C, Cancelo MJ, Villero J, et al. Management of post-menopausal vaginal atrophy and atrophic vaginitis. Maturitas. 2005 Nov 15;52 (1 Suppl):S46-52.[Abstract]

    • 64. Oyelese Y, Ananth CV. Placental abruption. Obstet Gynecol. 2006 Oct;108(4):1005-16.[Abstract]

    • 65. ​American College of Radiology. ACR appropriateness criteria: first trimester vaginal bleeding. 2025 [internet publication].[Full Text]

    • 66. Expert Panel on GYN and OB Imaging; Patel-Lippmann KK, Wasnik AP, et al. ACR appropriateness criteria® clinically suspected adnexal mass, no acute symptoms: 2023 update. J Am Coll Radiol. 2024 Jun;21(6S):S79-99.[Abstract][Full Text]

    • 67. Yudin MH, Hillier SL, Wiesenfeld HC, et al. Vaginal polymorphonuclear leukocytes and bacterial vaginosis as markers for histologic endometritis among women without symptoms of pelvic inflammatory disease. Am J Obstet Gynecol. 2003 Feb;188(2):318-23.[Abstract]

    • 68. American Cancer Society. Key statistics for endometrial cancer​. Jan 2026 [internet publication].[Full Text]

    • 69. Updated guidance regarding the role of transvaginal ultrasonography in evaluating the endometrium of individuals with postmenopausal bleeding. Obstet Gynecol. 2026 Jul 1;148(1):e87-91.[Abstract][Full Text]

    • 70. Morrison J, Balega J, Buckley L, et al. British Gynaecological Cancer Society (BGCS) uterine cancer guidelines: recommendations for practice. Eur J Obstet Gynecol Reprod Biol. 2022 Mar;270:50-89.[Full Text]

    • 71. Coeman D, Van Belle Y, Vanderick G, et al. Hysteroscopic findings in patients with a cervical polyp. Am J Obstet Gynecol. 1993 Dec;169(6):1563-5.[Abstract]

    • 72. Doll KM, Romano SS, Marsh EE, et al. Estimated performance of transvaginal ultrasonography for evaluation of postmenopausal bleeding in a simulated cohort of black and white women in the US. JAMA Oncol. 2021 Aug 1;7(8):1158-65.[Abstract][Full Text]

    • 73. Doll KM, Pike M, Alson J, et al. Endometrial thickness as diagnostic triage for endometrial cancer among black individuals. JAMA Oncol. 2024 Aug 1;10(8):1068-76.[Abstract][Full Text]

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    • 81. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation. J Clin Microbiol. 1991 Feb;29(2):297-301.[Abstract][Full Text]

    • 82. British Society for Paediatric and Adolescent Gynaecology. Genital trauma in girls. Jun 2017 [internet publication].[Full Text]

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