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Diseases

Evaluation of ptosis

OVERVIEW

  • Summary
  • Urgent Considerations
  • Etiology

DIAGNOSIS

  • Differential Diagnosis
  • Diagnostic Approach

IMAGES

  • Library

REFERENCES

  • Citations
  • Credits

Summary

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Ptosis, or blepharoptosis, refers to the drooping or downward displacement of the upper eyelid. The levator muscle, its aponeurosis, and the superior tarsal muscle are responsible for upper eyelid resting position and elevation. When these structures are compromised, the resultant depressed eyelid position can reduce the amount of light entering the eye, thereby degrading visual acuity. In pseudoptosis, aberrant structural relationships of the intact globe, bony, and soft-tissue attachments may cause secondary eyelid abnormalities.
Congenital myogenic, acquired aponeurotic, and involutional forms of ptosis represent the most common causes of ptosis among children and adults.[1] [2] Adults may be affected by associated involutional changes to the facial soft tissues that exacerbate or mask signs of ptosis. The vast majority of patients with ptosis do not present to the ophthalmologist or oculoplastic surgeon for evaluation and treatment. Of those who do, symptoms include headache, brow ache, and decreased visual acuity and visual field. Visual acuity improves with manual elevation of the eyelid and facial soft tissues. Superior visual field loss is most common; however, central vision can also be adversely affected. Any acute onset of ptosis, especially with other ocular or orbital symptoms, justifies further investigation with ophthalmologic consultation.[3]Images
content by BMJ Group
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Library

  • Sagittal view of eyelid anatomy

    Sagittal view of eyelid anatomy

  • ​Bilateral, asymmetric, congenital myogenic ptosis

    ​Bilateral, asymmetric, congenital myogenic ptosis

  • ​Ptosis in a 6-year-old boy. Ptosis is normally due to weakness of the levator muscle of the upper e

    ​Ptosis in a 6-year-old boy. Ptosis is normally due to weakness of the levator muscle of the upper eyelid, here of the left eye (at right). This patient has had this condition since birth, and has had three operations aimed at correcting the condition

  • ​Drooping eyelid (ptosis) in 69 year old female patient due to myasthenia gravis (MG). MG is a rare

    ​Drooping eyelid (ptosis) in 69 year old female patient due to myasthenia gravis (MG). MG is a rare autoimmune neuromuscular disorder that weakens and fatigues the body's voluntary muscles, which include the muscles that control movement of the eyes and eyelids

  • Measurement of vertical interpalpebral fissure

    Measurement of vertical interpalpebral fissure

  • Position of upper eyelid in downgaze

    Position of upper eyelid in downgaze

  • Position of upper eyelid in upgaze

    Position of upper eyelid in upgaze

  • Measurement of margin-reflex distance

    Measurement of margin-reflex distance

  • ​Ptosis in an 89 year old male patient following a botox injection to correct double vision (diplopi

    ​Ptosis in an 89 year old male patient following a botox injection to correct double vision (diplopia)

  • ​Oculomotor nerve palsy. Face of a 36-year-old woman with third nerve palsy after surgery to treat a

    ​Oculomotor nerve palsy. Face of a 36-year-old woman with third nerve palsy after surgery to treat a subarachnoid haemorrhage. A berry aneurysm, a common localised dilation of an intercranial artery, caused the subarachnoid hemorrhage. Third nerve palsy is a dysfunction of the third cranial nerve, the oculomotor nerve, which controls the movement of the eyes. It leads to an inability to move the eye, double vision, a fixed and non-reactive pupil and eyelid drooping (ptosis, seen here, right eye)

  • ​Oculomotor nerve palsy. Face of a 36-year-old woman with third nerve palsy after surgery to treat a

    ​Oculomotor nerve palsy. Face of a 36-year-old woman with third nerve palsy after surgery to treat a subarachnoid haemorrhage. A berry aneurysm, a common localised dilation of an intercranial artery, caused the subarachnoid hemorrhage. Third nerve palsy is a dysfunction of the third cranial nerve, the oculomotor nerve, which controls the movement of the eyes. It leads to an inability to move the eye, double vision, a fixed and non-reactive pupil and eyelid drooping (ptosis, seen here, right eye)

  • ​Male patient suffering from post-traumatic acquired ptosis, likely caused by an injury to the eyeli

    ​Male patient suffering from post-traumatic acquired ptosis, likely caused by an injury to the eyelid

Citations

    Key Articles

    • Finsterer J. Ptosis: causes, presentation, and management. Aesthetic Plast Surg. 2003;27:193-204.[Abstract]

    • Yanovitch T, Buckley E. Diagnosis and management of third nerve palsy. Curr Opin Ophthalmol. 2007 Sep;18(5):373-8.[Abstract]

    • American College of Radiology. ACR Appropriateness Criteria. Orbits, vision and visual loss. 2017 [internet publication].[Full Text]

    Other Online Resources

    • Benign Essential Blepharospasm Research Foundation

    Referenced Articles

    • 1. Thakker MM, Rubin PA. Mechanisms of acquired blepharoptosis. Ophthalmol Clin North Am. 2002;12:101-111.[Abstract]

    • 2. Bodker FS, Olson JJ, Putterman AM. Acquired blepharoptosis secondary to essential blepharospasm. Ophthalmic Surg. 1993;24:546-550.[Abstract]

    • 3. Anderson RL, Nowinski TS. The five-flap technique for blepharophimosis. Arch Ophthalmol. 1989;107:448-452.[Abstract]

    • 4. Finsterer J. Ptosis: causes, presentation, and management. Aesthetic Plast Surg. 2003;27:193-204.[Abstract]

    • 5. Frueh BR. The mechanistic classification of ptosis. Ophthalmology. 1980;87:1019-1021.[Abstract]

    • 6. Small RG, Sabates NR, Burrows D. The measurement and definition of ptosis. Ophthal Plast Reconstr Surg. 1989;5:171-175.[Abstract]

    • 7. Harthan JS, Opitz DL, Fromstein SR, et al. Diagnosis and treatment of anterior uveitis: optometric management. Clin Optom (Auckl). 2016;8:23-35.[Abstract][Full Text]

    • 8. Koursh DM, Modjtahedi SP, Selva D, et al. The blepharochalasis syndrome. Surv Ophthalmol. 2009;54:235-244.[Abstract]

    • 9. Weinberg DA, Lesser RL, Vollmer TL. Ocular myasthenia: a protean disorder. Surv Ophthalmol. 1994;39:169-210.[Abstract]

    • 10. Scott IU, Siatkowski MR. Thyroid eye disease. Semin Ophthalmol. 1999;14:52-61.[Abstract]

    • 11. Biousse V, Newman NJ. Neuro-ophthalmology of mitochondrial diseases. Curr Opin Neurol. 2003;16:35-43.[Abstract]

    • 12. Yanovitch T, Buckley E. Diagnosis and management of third nerve palsy. Curr Opin Ophthalmol. 2007 Sep;18(5):373-8.[Abstract]

    • 13. Walton KA, Buono LM. Horner syndrome. Curr Opin Ophthalmol. 2003;14:357-363.[Abstract]

    • 14. Clark BJ, Kemp EG, Behan WM, et al. Abnormal extracellular material in the levator palpebrae superioris complex in congenital ptosis. Arch Ophthalmol. 1995;113:1414-1419.[Abstract]

    • 15. Shuey NH. Ocular myasthenia gravis: a review and practical guide for clinicians. Clin Exp Optom. 2022 Mar;105(2):205-13.[Abstract]

    • 16. Parbhu KC, Galler KE, Li C, et al. Underestimation of soft tissue entrapment by computed tomography in orbital floor fractures in the pediatric population. Ophthalmology. 2008;115:1620-1625.[Abstract]

    • 17. American College of Radiology. ACR Appropriateness Criteria. Orbits, vision and visual loss. 2017 [internet publication].[Full Text]

    • 18. George A, Haydar AA, Adams WM. Imaging of Horner's syndrome. Clin Radiol. 2008;63:499-505.[Abstract]

    • 19. ​American College of Radiology. ACR appropriateness criteria: Horner syndrome. 2025 [internet publication].[Full Text]

    • 20. Bilyk JR. Periocular infection. Curr Opin Ophthalmol. 2007;18:414-423.[Abstract]

    • 21. Lessner A, Stern GA. Preseptal and orbital cellulitis. Infect Dis Clin North Am. 1992;6:933-952.[Abstract]

    • 22. Olson JJ, Putterman A. Loss of vertical palpebral fissure height on downgaze in acquired blepharoptosis. Arch Ophthalmol. 1995;113:1293-1297.[Abstract]

    • 23. Bernardino CR, Rubin PA. Ptosis after cataract surgery. Semin Ophthalmol. 2002;17:144-148.[Abstract]

    • 24. Bort-Martí AR, Rowe FJ, Ruiz Sifre L, et al. Botulinum toxin for the treatment of strabismus. Cochrane Database Syst Rev. 2023 Mar 14;3(3):CD006499.[Abstract]

    • 25. Duarte GS, Rodrigues FB, Marques RE, et al. Botulinum toxin type A therapy for blepharospasm. Cochrane Database Syst Rev. 2020 Nov 19;11(11):CD004900.[Abstract][Full Text]

    • 26. Camargo CP, Xia J, Costa CS, et al. Botulinum toxin type A for facial wrinkles. Cochrane Database Syst Rev. 2021 Jul 5;7(7):CD011301.[Abstract][Full Text]

    • 27. Weiss AH. The swollen and droopy eyelid: signs of systemic disease. Pediatr Clin North Am. 1993;40:789-804.[Abstract]

    • 28. American Society of Plastic Surgeons. Evidence-based clinical practice guideline: eyelid surgery for upper visual field improvement​. 2022 [internet publication].[Full Text]

    • 29. American Academy of Ophthalmology, EyeWiki. Blepharoptosis. May 2023 [internet publication].​[Full Text]

    • 30. ​American Academy of Ophthalmology, EyeWiki. Myasthenia gravis. May 2023 [internet publication].[Full Text]

    • 31. American Academy of Ophthalmology, EyeWiki. Thyroid eye disease. Jul 2023 [internet publication].​[Full Text]

    • 32. ​American Academy of Ophthalmology, EyeWiki. Horner syndrome. Jul 2023 [internet publication].[Full Text]

    • 33. Kubal WS. Imaging of orbital trauma. Radiographics. 2008;28:1729-1739.[Abstract]

    • 34. Hellmich B, Agueda A, Monti S, et al. 2018 Update of the EULAR recommendations for the management of large vessel vasculitis. Ann Rheum Dis. 2020 Jan;79(1):19-30.[Abstract][Full Text]

    • 35. Mackie SL, Dejaco C, Appenzeller S, et al. British Society for Rheumatology guideline on diagnosis and treatment of giant cell arteritis. Rheumatology (Oxford). 2020 Mar 1;59(3):e1-23.[Abstract][Full Text]

    • 36. Mollan SP, Paemeleire K, Versijpt J, et al. European Headache Federation recommendations for neurologists managing giant cell arteritis. J Headache Pain. 2020 Mar 17;21(1):28.[Abstract][Full Text]

    • 37. Dejaco C, Ramiro S, Bond M, et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice: 2023 update. Ann Rheum Dis. 2023 Aug 7:ard-2023-224543.[Abstract][Full Text]

    • 38. Maz M, Chung SA, Abril A, et al. 2021 American College of Rheumatology/Vasculitis Foundation guideline for the management of giant cell arteritis and takayasu arteritis. Arthritis Rheumatol. 2021 Aug;73(8):1349-65.[Abstract][Full Text]

    • 39. Ponte C, Grayson PC, Robson JC, et al. 2022 American College of Rheumatology/EULAR classification criteria for giant cell arteritis. Ann Rheum Dis. 2022 Dec;81(12):1647-53.[Abstract][Full Text]

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