Highlights & Basics
- Dermatophyte infections may be diagnosed clinically. However, speciation via fungal culture and proof of mycologic cure via serial fungal culture may aid patient care.
- Confirm diagnosis of onychomycosis (fungal nail disease) and tinea capitis (fungal scalp infection) prior to treatment if possible.
- Limited tinea corporis (body) infection can usually be managed with topical therapy alone. Systemic therapy is preferred for tinea capitis (scalp), tinea barbae (beard), tinea manuum (hands), and onychomycosis (nails).
- Most fungal infections of the skin are mild. However, in cases of immunocompromise, fungi can sometimes cause severe disease.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Tinea corporis of the axilla. Central clearing with an active border of inflammation noted. Satellite lesion is present
Annular lesion on the elbow, with a silvery scale. No central clearing. Microscopic exam with potassium hydroxide revealed no fungal elements. Despite the resemblance to tinea corporis, there was a similar lesion on the extensor surface of both knees and a family history that together confirmed the diagnosis of psoriasis
Tinea capitis
Tinea capitis in a child with Fitzpatrick type VI skin with the typical appearance of fine scale and brown hair, which may be visualised as black dots
A kerion (abscess due to dermatophyte infection) in a child with Fitzpatrick type 1 skin
Tinea barbae. Note the pustules in the follicles, redness, and scaling
Tinea manuum. On the extensor surface of the hand there is extensive inflammation, scaling, hyperkeratosis, and erythema
Tinea manuum
Tinea pedis. Intense inflammation produces hyperpigmentation and vesicle formation. Vesiculobullous form of tinea pedis
Vesiculobullous form of tinea pedis and onychomycosis
Distal lateral subungual onychomycosis
Majocchi granuloma
Infant presenting with rash formerly known as moniliasis, now called candidiasis, caused by Candida spp.
Citations
Ameen M, Lear JT, Madan V, et al. British Association of Dermatologists' guidelines for the management of onychomycosis 2014. Br J Dermatol. 2014 Nov;171(5):937-58.[Abstract][Full Text]
Fuller LC, Barton RC, Mohd Mustapa MF, et al. British Association of Dermatologists' guidelines for the management of tinea capitis 2014. Br J Dermatol. 2014 Sep;171(3):454-63.[Abstract][Full Text]
Fuller LC, Barton RC, Mohd Mustapa MF, et al. British Association of Dermatologists' guidelines for the management of tinea capitis 2014. Br J Dermatol. 2014 Sep;171(3):454-63.[Abstract][Full Text]
Foley K, Gupta AK, Versteeg S, et al. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database Syst Rev. 2020 Jan 16;(1):CD012093.[Abstract][Full Text]
1. Weitzman I, Summerbell RC. The dermatophytes. Clin Microbiol Rev. 1995 Apr;8(2):240-59.[Abstract][Full Text]
2. Coloe JR, Diab M, Moennich J, et al. Tinea capitis among children in the Columbus area, Ohio, USA. Mycoses. 2010 Mar 1;53(2):158-62.[Abstract]
3. Abdel-Rahman SM, Farrand N, Schuenemann E, et al. The prevalence of infections with Trichophyton tonsurans in schoolchildren: the CAPITIS study. Pediatrics. 2010 May;125(5):966-73.[Abstract]
4. Drake LA, Dinehart SM, Farmer ER, et al. Guidelines of care for superficial mycotic infections of the skin: tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. Guidelines/Outcomes Committee. American Academy of Dermatology. J Am Acad Dermatol. 1996 Feb;34(2 Pt 1):282-6.[Abstract]
5. Faergemann J, Baran R. Epidemiology, clinical presentation and diagnosis of onychomycosis. Br J Dermatol. 2003 Sep;149(suppl 65):1-4.[Abstract]
6. Gupta AK, Jain HC, Lynde CW, et al. Prevalence and epidemiology of unsuspected onychomycosis in patients visiting dermatologists' offices in Ontario, Canada - a multicenter survey of 2001 patients. Int J Dermatol. 1997 Oct;36(10):783-7.[Abstract]
7. Gupta AK, Versteeg SG, Shear NH. Onychomycosis in the 21st century: an update on diagnosis, epidemiology, and treatment. J Cutan Med Surg. 2017 Nov/Dec;21(6):525-39.[Abstract]
8. Gupta AK, Daigle D, Foley KA. The prevalence of culture-confirmed toenail onychomycosis in at-risk patient populations. J Eur Acad Dermatol Venereol. 2015 Jun;29(6):1039-44.[Abstract]
9. Daggett C, Brodell RT, Daniel CR, et al. Onychomycosis in athletes. Am J Clin Dermatol. 2019 Oct;20(5):691-8.[Abstract]
10. Shemer A, Gupta AK, Amichai B, et al. Increased risk of tinea pedis and onychomycosis among swimming pool employees in Netanya Area, Israel. Mycopathologia. 2016 Dec;181(11-12):851-6.[Abstract]
11. Macura AB. Dermatophyte infections. Int J Dermatol. 1993 May;32(5):313-23.[Abstract]
12. Daly RF, House J, Stanek D, et al; National Association of State Public Health Veterinarians Animal Contact Compendium Committee. Compendium of measures to prevent disease associated with animals in public settings, 2017. J Am Vet Med Assoc. 2017 Dec 1;251(11):1268-92.[Abstract][Full Text]
13. Ameen M, Lear JT, Madan V, et al. British Association of Dermatologists' guidelines for the management of onychomycosis 2014. Br J Dermatol. 2014 Nov;171(5):937-58.[Abstract][Full Text]
14. Bassiri-Jahromi S, Sadeghi G, Paskiaee FA. Evaluation of the association of superficial dermatophytosis and athletic activities with special reference to its prevention and control. Int J Dermatol. 2010 Oct;49(10):1159-64.[Abstract]
15. Bang CH, Yoon JW, Lee HJ, et al. Evaluation of relationships between onychomycosis and vascular diseases using sequential pattern mining. Sci Rep. 2018 Dec 14;8(1):17840.[Abstract]
16. Lipner SR, Scher RK. Onychomycosis: clinical overview and diagnosis. J Am Acad Dermatol. 2019 Apr;80(4):835-51.[Abstract]
17. Ankad BS, Mukherjee SS, Nikam BP, et al. Dermoscopic characterization of dermatophytosis: a preliminary observation. Indian Dermatol Online J. 2020 Mar-Apr;11(2):202-7.[Abstract][Full Text]
18. Leung AKC, Hon KL, Leong KF, et al. Tinea capitis: an updated review. Recent Pat Inflamm Allergy Drug Discov. 2020;14(1):58-68.[Abstract]
19. Mochizuki T, Tsuboi R, Iozumi K, et al. Guidelines for the management of dermatomycosis (2019). J Dermatol. 2020 Dec;47(12):1343-73.[Abstract]
20. Gupta AK, Drummond-Main C, Cooper EA, et al. Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment. J Am Acad Dermatol. 2012 Mar;66(3):494-502.[Abstract]
21. Rajagopalan M, Inamadar A, Mittal A, et al. Expert consensus on the management of dermatophytosis in India (ECTODERM India). BMC Dermatol. 2018 Jul 24;18(1):6.[Abstract][Full Text]
22. Elewski BE. Onychomycosis: pathogenesis, diagnosis, and management. Clin Microbiol Rev. 1998 Jul;11(3):415-29.[Abstract][Full Text]
23. Fuller LC, Barton RC, Mohd Mustapa MF, et al. British Association of Dermatologists' guidelines for the management of tinea capitis 2014. Br J Dermatol. 2014 Sep;171(3):454-63.[Abstract][Full Text]
24. Motamedi M, Mirhendi H, Zomorodian K, et al. Clinical evaluation of beta-tubulin real-time PCR for rapid diagnosis of dermatophytosis, a comparison with mycological methods. Mycoses. 2017 Oct;60(10):692-6.[Abstract]
25. Jeelani S, Ahmed QM, Lanker AM, et al. Histopathological examination of nail clippings using PAS staining (HPE-PAS): gold standard in diagnosis of onychomycosis. Mycoses. 2015 Jan;58(1):27-32.[Abstract]
26. Spiliopoulou A, Bartzavali C, Jelastopulu E, et al. Evaluation of a commercial PCR test for the diagnosis of dermatophyte nail infections. J Med Microbiol. 2015 Jan;64(Pt 1):25-31.[Abstract]
27. Miteva M, Tosti A. Hair and scalp dermatoscopy. J Am Acad Dermatol. 2012 Nov;67(5):1040-8.[Abstract]
28. Cinotti E, Perrot JL, Labeille B, et al. Reflectance confocal microscopy for cutaneous infections and infestations. J Eur Acad Dermatol Venereol. 2016 May;30(5):754-63.[Abstract]
29. Public Health England. Fungal skin and nail infections: diagnosis and laboratory investigation guide for primary care. June 2017 [internet publication].[Full Text]
30. Fuller LC, Barton RC, Mohd Mustapa MF, et al. British Association of Dermatologists' guidelines for the management of tinea capitis 2014. Br J Dermatol. 2014 Sep;171(3):454-63.[Abstract][Full Text]
31. Chang CH, Young-Xu Y, Kurth T, et al. The safety of oral antifungal treatments for superficial dermatophytosis and onychomycosis: a meta-analysis. Am J Med. 2007 Sep;120(9):791-8.[Abstract]
32. Gupta AK, Cooper EA, Bowen JE, et al. Meta-analysis: griseofulvin efficacy in the treatment of tinea capitis. J Drugs Dermatol. 2008 Apr;7(4):369-72.[Abstract]
33. Tey HL, Tan AS, Chan YC. Meta-analysis of randomized, controlled trials comparing griseofulvin and terbinafine in the treatment of tinea capitis. J Am Acad Dermatol. 2011 Apr;64(4):663-70.[Abstract]
34. Chen X, Jiang X, Yang M, et al. Systemic antifungal therapy for tinea capitis in children. Cochrane Database Syst Rev. 2016 May 12;(5):CD004685.[Abstract][Full Text]
35. Chen S, Sun KY, Feng XW, et al. Efficacy and safety of itraconazole use in infants. World J Pediatr. 2016 Nov;12(4):399-407. [Abstract]
36. US Food & Drug Administration. FDA drug safety communication: FDA warns that prescribing of Nizoral (ketoconazole) oral tablets for unapproved uses including skin and nail infections continues; linked to patient death. June 2016 [internet publication].[Full Text]
37. Crawford F, Hollis S. Topical treatments for fungal infections of the skin and nails of the foot. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD001434.[Abstract][Full Text]
38. Rotta I, Ziegelmann PK, Otuki MF, et al. Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments. JAMA Dermatol. 2013 Mar;149(3):341-9.[Abstract]
39. Parish LC, Parish JL, Routh HB, et al. A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. J Drugs Dermatol. 2011 Oct;10(10):1142-7.[Abstract]
40. Parish LC, Parish JL, Routh HB, et al. A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis. J Drugs Dermatol. 2011 Nov;10(11):1282-8.[Abstract]
41. El-Gohary M, van Zuuren EJ, Fedorowicz Z, et al. Topical antifungal treatments for tinea cruris and tinea corporis. Cochrane Database Syst Rev. 2014 Aug 4;(8):CD009992.[Abstract][Full Text]
42. Gold M, Dhawan S, Verma A, et al. Efficacy and safety of naftifine HCl cream 2% in the treatment of pediatric subjects with tinea corporis. J Drugs Dermatol. 2016 Jun 1;15(6):743-8.[Abstract]
43. Leung AK, Lam JM, Leong KF, et al. Tinea corporis: an updated review. Drugs Context. 2020;9:2020-5-6.[Abstract][Full Text]
44. de Sá DC, Lamas AP, Tosti A. Oral therapy for onychomycosis: an evidence-based review. Am J Clin Dermatol. 2014 Feb;15(1):17-36.[Abstract]
45. Yin Z, Xu J, Luo D. A meta-analysis comparing long-term recurrences of toenail onychomycosis after successful treatment with terbinafine versus itraconazole. J Dermatolog Treat. 2012 Dec;23(6):449-52.[Abstract]
46. Kreijkamp-Kaspers S, Hawke K, Guo L, et al. Oral antifungal medication for toenail onychomycosis. Cochrane Database Syst Rev. 2017 Jul 14;(7):CD010031.[Abstract][Full Text]
47. Gupta AK, Stec N, Bamimore MA, et al. The efficacy and safety of pulse vs. continuous therapy for dermatophyte toenail onychomycosis. J Eur Acad Dermatol Venereol. 2020 Mar;34(3):580-8.[Abstract]
48. Kreijkamp-Kaspers S, Hawke KL, van Driel ML. Oral medications to treat toenail fungal infection. JAMA. 2018 Jan 23;319(4):397-8.[Abstract]
49. Piraccini BM, Tosti A. White superficial onychomycosis: epidemiological, clinical, and pathological study of 79 patients. Arch Dermatol. 2004 Jun;140(6):696-701.[Abstract][Full Text]
50. Foley K, Gupta AK, Versteeg S, et al. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database Syst Rev. 2020 Jan 16;(1):CD012093.[Abstract][Full Text]
51. Elewski BE, Rich P, Pollak R, et al. Efinaconazole 10% solution in the treatment of toenail onychomycosis: two phase III multicenter, randomized, double-blind studies. J Am Acad Dermatol. 2013 Apr;68(4):600-8.[Abstract]
52. Elewski BE, Aly R, Baldwin SL, et al. Efficacy and safety of tavaborole topical solution, 5%, a novel boron-based antifungal agent, for the treatment of toenail onychomycosis: results from 2 randomized phase-III studies. J Am Acad Dermatol. 2015 Jul;73(1):62-9.[Abstract][Full Text]
53. Gupta AK, Hall S, Zane LT, et al. Evaluation of the efficacy and safety of tavaborole topical solution, 5%, in the treatment of onychomycosis of the toenail in adults: a pooled analysis of an 8-week, post-study follow-up from two randomized phase 3 studies. J Dermatolog Treat. 2018 Feb;29(1):44-8. [Abstract]
54. Baran R, Tosti A, Hartmane I, et al. An innovative water-soluble biopolymer improves efficacy of ciclopirox nail lacquer in the management of onychomycosis. J Eur Acad Dermatol Venereol. 2009 Jul;23(7):773-81.[Abstract]
55. Gupta AK, Fleckman P, Baran R. Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis. J Am Acad Dermatol. 2000 Oct;43(4 Suppl):S70-80.[Abstract]
56. Friedlander SF. The optimal therapy for tinea capitis. Pediatr Dermatol. 2000 Jul-Aug;17(4):325-6.[Abstract]
57. Elewski BE. Treatment of tinea capitis: beyond griseofulvin. J Am Acad Dermatol. 1999 Jun;40(6 Pt 2):S27-30.[Abstract]
58. Hart R, Bell-Syer SE, Crawford F, et al. Systematic review of topical treatments for fungal infections of the skin and nails of the feet. BMJ. 1999 Jul 10;319(7202):79-82.[Abstract]
59. Bell-Syer SE, Hart R, Crawford F, et al. A systematic review of oral treatments for fungal infections of the skin of the feet. J Dermatolog Treat. 2001 Jun;12(2):69-74.[Abstract]
60. Ma W, Si C, Kasyanju Carrero LM, et al. Laser treatment for onychomycosis: a systematic review and meta-analysis. Medicine (Baltimore). 2019 Nov;98(48):e17948.[Abstract][Full Text]
61. Foley K, Gupta AK, Versteeg S, et al. Topical and device-based treatments for fungal infections of the toenails. Cochrane Database Syst Rev. 2020 Jan 16;(1):CD012093.[Abstract][Full Text]
62. Elewski B, Pollak R, Ashton S, et al. A randomized, placebo- and active-controlled, parallel-group, multicentre, investigator-blinded study of four treatment regimens of posaconazole in adults with toenail onychomycosis. Br J Dermatol. 2012 Feb;166(2):389-98.[Abstract]
63. Sigurgeirsson B, van Rossem K, Malahias S, et al. A phase II, randomized, double-blind, placebo-controlled, parallel group, dose-ranging study to investigate the efficacy and safety of 4 dose regimens of oral albaconazole in patients with distal subungual onychomycosis. J Am Acad Dermatol. 2013 Sep;69(3):416-25.[Abstract]
64. Watanabe S, Tsubouchi I, Okubo A. Efficacy and safety of fosravuconazole L-lysine ethanolate, a novel oral triazole antifungal agent, for the treatment of onychomycosis: a multicenter, double-blind, randomized phase III study. J Dermatol. 2018 Oct;45(10):1151-9.[Abstract][Full Text]
65. Noguchi H, Matsumoto T, Kimura U, et al. Fosravuconazole to treat severe onychomycosis in the elderly. J Dermatol. 2021 Feb;48(2):228-31.[Abstract]
66. Canadian Paediatric Society. Antifungal agents for common outpatient paediatric infections. June 2019 [internet publication].[Full Text]
67. Ely JW, Rosenfeld S, Seabury Stone M. Diagnosis and management of tinea infections. Am Fam Physician. 2014 Nov 15;90(10):702-10.[Abstract][Full Text]
68. Kakourou T, Uksal U; European Society for Pediatric Dermatology. Guidelines for the management of tinea capitis in children. Pediatr Dermatol. 2010 May-Jun;27(3):226-8.[Abstract][Full Text]
69. Scher RK, Baran R. Onychomycosis in clinical practice: factors contributing to recurrence. Br J Dermatol. 2003 Sep;149(suppl 65):5-9.[Abstract]
Key Articles
Referenced Articles
Sign in to access our clinical decision support tools