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Highlights & Basics
- Infectious mononucleosis is characterized by the classic triad of fever, pharyngitis, and lymphadenopathy, along with atypical lymphocytosis. It is often subclinical in young children.
- Caused by infection with Epstein-Barr virus (EBV) in 80% to 90% of cases. Positive serologic test for antibodies against EBV is usually diagnostic.
- Rare but potentially life-threatening complications include severe upper airway obstruction, splenic rupture, fulminant hepatitis, encephalitis, severe thrombocytopenia, and hemolytic anemia.
- Treatment is usually symptomatic.
Quick Reference
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Definition
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Citations
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