Highlights & Basics
- Hepatitis C virus transmission is through percutaneous exposure to infected blood, most commonly through injection of illicit drugs or transfusion of unscreened blood and blood products in developed countries, or via unsafe injection practices in resource-poor countries.
- Following acute exposure to hepatitis C virus, many patients develop chronic hepatitis C. Most infections are asymptomatic; however, hepatic inflammation is often present and can lead to progressive hepatic fibrosis.
- The goal of treatment is to eradicate the virus, achieve a sustained virologic response, and prevent disease progression. Oral direct-acting antiviral therapies are standard treatment.
- Long-term complications of chronic infection include cirrhosis or hepatocellular carcinoma.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
American Association for the Study of Liver Diseases; Infectious Diseases Society of America. HCV guidance: recommendations for testing, managing, and treating hepatitis C. Dec 2023 [internet publication].[Full Text]
- CDC: hepatitis C, acute 2020 case definition
- CDC: hepatitis C, chronic 2020 case definition
- BMJ Best Practice podcast: hepatitis C - what have been our successes so far?
- AASLD/IDSA: HCV guidance - recommendations for testing, managing, and treating hepatitis C
- AASLD/IDSA: HCV resistance primer
- AASLD/IDSA: simplified HCV treatment for treatment-naive patients without cirrhosis
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