epocrates logo
epocrates logo
epocrates logo
  • 0

Diseases

Amphetamine/methamphetamine use disorder

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

AAFont SizeShareMore Information
Key Highlights
  • Amphetamine and methamphetamine use disorders involve compulsive substance use despite negative consequences.

  • Polysubstance use, for example with opioids, is an increasing problem, and increases mortality.

  • Psychosocial interventions such as contingency management, cognitive behavioral therapy (CBT), motivational interviewing, Matrix model, and community reinforcement approach are the mainstays of treatment; no medication has yet proven effective.

  • Effective management strategies incorporate a degree of long-term continuing care in addition to acute management of exacerbations.

  • Evaluation and management of co-occurring psychiatric conditions is essential.

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Citations

            Key Articles

            • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition, text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.​

            • National Institute on Drug Abuse. Methamphetamine research report: what is methamphetamine? Oct 2019 [internet publication].​[Full Text]

            • Paulus MP, Stewart JL. Neurobiology, clinical presentation, and treatment of methamphetamine use disorder: a review. JAMA Psychiatry. 2020 Sep 1;77(9):959-66.[Abstract][Full Text]

            • Substance Abuse and Mental Health Services Administration (SAMHSA). Treatment for stimulant use disorders: updated 2021. Treatment Improvement Protocol (TIP) series, no. 33. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 1999 (updated 2021).[Abstract][Full Text]

            • World Health Organization. Guidelines for identification and management of substance use and substance use disorders in pregnancy. Nov 2014 [internet publication].​[Full Text]

            • Siefried KJ, Acheson LS, Lintzeris N, et al. Pharmacological treatment of methamphetamine/amphetamine dependence: a systematic review. CNS Drugs. 2020 Apr;34(4):337-65.[Abstract][Full Text]

            • Soares E, Pereira FC. Pharmacotherapeutic strategies for methamphetamine use disorder: mind the subgroups. Expert Opin Pharmacother. 2019 Dec;20(18):2273-93.[Abstract]

            Other Online Resources

            • ​National Institute on Drug Abuse (NIDA): TAPS - Tobacco, Alcohol, Prescription medication, and other Substance use tool​
            • ​Narcotics Anonymous

            Referenced Articles

            • 1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition, text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.​

            • 2. Kish SJ. Pharmacologic mechanisms of crystal meth. CMAJ. 2008 Jun 17;178(13):1679-82.[Abstract][Full Text]

            • 3. Panenka WJ, Procyshyn RM, Lecomte T, et al. Methamphetamine use: a comprehensive review of molecular, preclinical and clinical findings. Drug Alcohol Depend. 2013 May 1;129(3):167-79.[Abstract]

            • 4. Moszczynska A. Neurobiology and clinical manifestations of methamphetamine neurotoxicity. Psychiatr Times. 2016 Sep;33(9):16-8.[Abstract][Full Text]

            • 5. National Institute on Drug Abuse. Methamphetamine research report: what is methamphetamine? Oct 2019 [internet publication].​[Full Text]

            • 6. Paulus MP, Stewart JL. Neurobiology, clinical presentation, and treatment of methamphetamine use disorder: a review. JAMA Psychiatry. 2020 Sep 1;77(9):959-66.[Abstract][Full Text]

            • 7. United Nations Office on Drugs and Crime. World drug report 2022. Jun 2022 [internet publication].​[Full Text]

            • 8. Stoneberg DM, Shukla RK, Magness MB. Global methamphetamine trends: an evolving problem. Int Crim Just Rev. 2017;28(2):136-61.​​[Full Text]

            • 9. European Monitoring Centre for Drugs and Drug Addiction. EU drug market: methamphetamine. 2022 [internet publication].​[Full Text]

            • 10. Substance Abuse and Mental Health Services Administration (SAMHSA). 2021 National Survey of Drug Use and Health (NSDUH) releases. 2021 [internet publication].[Full Text]

            • 11. Chen T, Spiller HA, Badeti J, et al. Methamphetamine exposures reported to United States poison control centers, 2000-2019. Clin Toxicol (Phila). 2021 Aug;59(8):705-14.[Abstract]

            • 12. Monitoring the Future. Methamphetamine: trends in last 12 months prevalence of use in 8th, 10th, and 12th grade​. 2023 [internet publication].[Full Text]

            • 13. ​American Society of Addiction Medicine/American Academy of Addiction Psychiatry. The ASAM/AAAP clinical practice guideline on the management of stimulant use disorder. J Addict Med. 2024 May-Jun;18(1S):1-56.​[Full Text]

            • 14. Centers for Disease Control and Prevention. CDC WONDERSearch: ​about underlying cause of death, 1999-2020. 2023 [internet publication].[Full Text]

            • 15. Hedegaard H, Bastian BA, Trinidad JP, et al. Drugs most frequently involved in drug overdose deaths: United States, 2011-2016. Natl Vital Stat Rep. 2018 Dec;67(9):1-14.[Abstract][Full Text]

            • 16. Winkelman TNA, Admon LK, Jennings L, et al. Evaluation of amphetamine-related hospitalizations and associated clinical outcomes and costs in the United States. JAMA Netw Open. 2018 Oct 5;1(6):e183758.[Abstract][Full Text]

            • 17. Hedegaard H, Bastian BA, Trinidad JP, et al. Regional differences in the drugs most frequently involved in drug overdose deaths: United States, 2017. Natl Vital Stat Rep. 2019 Oct;68(12):1-16.[Abstract][Full Text]

            • 18. Kariisa M, Scholl L, Wilson N, et al. Drug overdose deaths involving cocaine and psychostimulants with abuse potential - United States, 2003-2017. MMWR Morb Mortal Wkly Rep. 2019 May 3;68(17):388-95.[Abstract][Full Text]

            • 19. Luethi D, Liechti ME. Designer drugs: mechanism of action and adverse effects. Arch Toxicol. 2020 Apr;94(4):1085-133.[Abstract][Full Text]

            • 20. Daniulaityte R, Silverstein SM, Crawford TN, et al. Methamphetamine use and its correlates among individuals with opioid use disorder in a Midwestern U.S. city. Subst Use Misuse. 2020;55(11):1781-9.[Abstract][Full Text]

            • 21. Glick SN, Klein KS, Tinsley J, et al. Increasing heroin-methamphetamine (goofball) use and related morbidity among Seattle area people who inject drugs. Am J Addict. 2021 Mar;30(2):183-91.[Abstract][Full Text]

            • 22. Glick SN, Burt R, Kummer K, et al. Increasing methamphetamine injection among non-MSM who inject drugs in King County, Washington. Drug Alcohol Depend. 2018 Jan 1;182:86-92.[Abstract][Full Text]

            • 23. Substance Abuse and Mental Health Services Administration (SAMHSA). Treatment for stimulant use disorders: updated 2021. Treatment Improvement Protocol (TIP) series, no. 33. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 1999 (updated 2021).[Abstract][Full Text]

            • 24. Centers for Disease Control and Prevention. Annual surveillance report of drug-related risks and outcomes: United States, 2019. ​Nov 2019 [internet publication].[Full Text]

            • 25. Pro G, Hayes C, Montgomery BEE, et al. Demographic and geographic shifts in the preferred route of methamphetamine administration among treatment cases in the US, 2010-2019. Drug Alcohol Depend. 2022 Aug 1;237:109535.[Abstract]

            • 26. European Monitoring Centre for Drugs and Drug Addiction. European drug report 2017. 2017 [internet publication].[Full Text]

            • 27. Salo R, Flower K, Kielstein A, et al. Psychiatric comorbidity in methamphetamine dependence. Psychiatry Res. 2011 Apr 30;186(2-3):356-61.[Abstract][Full Text]

            • 28. Akindipe T, Wilson D, Stein DJ. Psychiatric disorders in individuals with methamphetamine dependence: prevalence and risk factors. Metab Brain Dis. 2014 Jun;29(2):351-7.[Abstract]

            • 29. Zhou Y, Hu Y, Wang Q, et al. Association between white matter microstructure and cognitive function in patients with methamphetamine use disorder. Hum Brain Mapp. 2023 Feb 1;44(2):304-14.[Abstract][Full Text]

            • 30. Hart CL, Marvin CB, Silver R, et al. Is cognitive functioning impaired in methamphetamine users? A critical review. Neuropsychopharmacology. 2012 Feb;37(3):586-608.[Abstract][Full Text]

            • 31. Basterfield C, Hester R, Bowden SC. A meta-analysis of the relationship between abstinence and neuropsychological functioning in methamphetamine use disorder. Neuropsychology. 2019 Jul;33(5):739-53.[Abstract]

            • 32. Sung YH, Cho SC, Hwang J, et al. Relationship between N-acetyl-aspartate in gray and white matter of abstinent methamphetamine abusers and their history of drug abuse: a proton magnetic resonance spectroscopy study. Drug Alcohol Depend. 2007 Apr 17;88(1):28-35.[Abstract]

            • 33. Hall MG, Alhassoon OM, Stern MJ, et al. Gray matter abnormalities in cocaine versus methamphetamine-dependent patients: a neuroimaging meta-analysis. Am J Drug Alcohol Abuse. 2015;41(4):290-9.[Abstract]

            • 34. Lyoo IK, Yoon S, Kim TS, et al. Predisposition to and effects of methamphetamine use on the adolescent brain. Mol Psychiatry. 2015 Dec;20(12):1516-24.[Abstract][Full Text]

            • 35. Davidson C, Gow AJ, Lee TH, et al. Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment. Brain Res Brain Res Rev. 2001 Aug;36(1):1-22.[Abstract]

            • 36. Whitesell M, Bachand A, Peel J, et al. Familial, social, and individual factors contributing to risk for adolescent substance use. J Addict. 2013 Mar 20;2013:579310.[Abstract][Full Text]

            • 37. Kilpatrick DG, Acierno R, Saunders B, et al. Risk factors for adolescent substance abuse and dependence: data from a national sample. J Consult Clin Psychol. 2000 Feb;68(1):19-30.[Abstract]

            • 38. Hawkins JD, Catalano RF, Miller JY. Risk and protective factors for alcohol and other drug problems in adolescence and early adulthood: implications for substance abuse prevention. Psychol Bull. 1992 Jul;112(1):64-105.[Abstract]

            • 39. Chen Y, Zhang J, Sun Y. The relationship between childhood abuse and depression in a sample of Chinese people who use methamphetamine. Int J Clin Health Psychol. 2019 Sep;19(3):181-18.[Abstract][Full Text]

            • 40. Simpson JL, Grant KM, Daly PM, et al. Psychological burden and gender differences in methamphetamine-dependent individuals in treatment. J Psychoactive Drugs. 2016 Sep-Oct;48(4):261-9.[Abstract]

            • 41. Svingen L, Dykstra RE, Simpson JL, et al. Associations between family history of substance use, childhood trauma, and age of first drug use in persons with methamphetamine dependence. J Addict Med. 2016 Jul-Aug;10(4):269-73.[Abstract]

            • 42. Hendrickson RG, Horowitz BZ, Norton RL. "Parachuting" meth: a novel delivery method for methamphetamine and delayed-onset toxicity from "body stuffing". Clin Toxicol (Phila). 2006;44(4):379-82.[Abstract]

            • 43. Regier DA, Farmer ME, Rae DS, et al. Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. JAMA. 1990 Nov 21;264(19):2511-8.[Abstract]

            • 44. O'Neil KA, Conner BT, Kendall PC. Internalizing disorders and substance use disorders in youth: comorbidity, risk, temporal order, and implications for intervention. Clin Psychol Rev. 2011 Feb;31(1):104-12.[Abstract]

            • 45. Shadur JM, Lejuez CW. Adolescent substance use and comorbid psychopathology: emotion regulation deficits as a transdiagnostic risk factor. Curr Addict Rep. 2015 Dec 1;2(4):354-63.[Abstract][Full Text]

            • 46. McKetin R, Kothe A, Baker AL, et al. Predicting abstinence from methamphetamine use after residential rehabilitation: findings from the Methamphetamine Treatment Evaluation Study. Drug Alcohol Rev. 2018 Jan;37(1):70-8.[Abstract]

            • 47. Glasner-Edwards S, Marinelli-Casey P, Hillhouse M, et al; Methamphetamine Treatment Project Corporate Authors. Depression among methamphetamine users: association with outcomes from the Methamphetamine Treatment Project at 3-year follow-up. J Nerv Ment Dis. 2009 Apr;197(4):225-31.[Abstract][Full Text]

            • 48. US Preventive Services Task Force, Krist AH, Davidson KW, et al. Primary care-based interventions to prevent illicit drug use in children, adolescents, and young adults: US Preventive Services Task Force recommendation statement. JAMA. 2020 May 26;323(20):2060-6.[Abstract][Full Text]

            • 49. Perrin EC, Sheldrick RC, McMenamy JM, et al. Improving parenting skills for families of young children in pediatric settings: a randomized clinical trial. JAMA Pediatr. 2014 Jan;168(1):16-24.[Abstract]

            • 50. Sanders MR, Kirby JN, Tellegen CL, et al. The triple P-positive parenting program: a systematic review and meta-analysis of a multi-level system of parenting support. Clin Psychol Rev. 2014 Jun;34(4):337-57.[Abstract]

            • 51. Chadi N, Walker-Harding L, Committee On Substance Use And Prevention. Nonmedical use of controlled medications by adolescents and young adults: clinical report. Pediatrics. 2024 Dec 1;154(6):e2024069298.[Abstract][Full Text]

            • 52. ​Mullen JM, Richards JR, Crawford AT. Amphetamine related psychiatric disorders. StatPearls. Treasure Island (FL): StatPearls Publishing; 2022.[Abstract][Full Text]

            • 53. Brecht ML, Herbeck D. Time to relapse following treatment for methamphetamine use: a long-term perspective on patterns and predictors. Drug Alcohol Depend. 2014 Jun 1;139:18-25.[Abstract][Full Text]

            • 54. Yimsaard P, Maes MM, Verachai V, et al. Pattern of methamphetamine use and the time lag to methamphetamine dependence. J Addict Med. 2018 Mar/Apr;12(2):92-8.[Abstract][Full Text]

            • 55. Chen LY, Strain EC, Alexandre PK, et al. Correlates of nonmedical use of stimulants and methamphetamine use in a national sample. Addict Behav. 2014 May;39(5):829-36.[Abstract][Full Text]

            • 56. Ellis MS, Kasper ZA, Cicero TJ. Twin epidemics: the surging rise of methamphetamine use in chronic opioid users. Drug Alcohol Depend. 2018 Dec 1;193:14-20.[Abstract]

            • 57. Lineberry TW, Bostwick JM. Methamphetamine abuse: a perfect storm of complications. Mayo Clin Proc. 2006 Jan;81(1):77-84.[Abstract]

            • 58. Romanelli F, Smith KM. Clinical effects and management of methamphetamine abuse. Pharmacotherapy. 2006 Aug;26(8):1148-56.[Abstract]

            • 59. Schep LJ, Slaughter RJ, Beasley DM. The clinical toxicology of metamfetamine. Clin Toxicol (Phila). 2010 Aug;48(7):675-94.[Abstract]

            • 60. Department of Health and Social Care (UK). Drug misuse and dependence: UK guidelines on clinical management. Dec 2017 [internet publication].​[Full Text]

            • 61. Glasner-Edwards S, Mooney LJ. Methamphetamine psychosis: epidemiology and management. CNS Drugs. 2014 Dec;28(12):1115-26.[Abstract][Full Text]

            • 62. Yeo KK, Wijetunga M, Ito H, et al. The association of methamphetamine use and cardiomyopathy in young patients. Am J Med. 2007 Feb;120(2):165-71.[Abstract]

            • 63. Chin KM, Channick RN, Rubin LJ. Is methamphetamine use associated with idiopathic pulmonary arterial hypertension? Chest. 2006 Dec;130(6):1657-63.[Abstract]

            • 64. Goodchild JH, Donaldson M. Methamphetamine abuse and dentistry: a review of the literature and presentation of a clinical case. Quintessence Int. 2007 Jul-Aug;38(7):583-90.[Abstract]

            • 65. Hargraves D, White C, Frederick R, et al. Implementing SBIRT (Screening, Brief Intervention and Referral to Treatment) in primary care: lessons learned from a multi-practice evaluation portfolio. Public Health Rev. 2017;38:31.[Abstract][Full Text]

            • 66. American College of Surgeons. Best practices guidelines: screening and intervention for mental health disorders and substance use and misuse in the acute trauma patient​. Dec 2022 [internet publication].[Full Text]

            • 67. US Preventive Services Task Force. Final recommendation statement. Unhealthy drug use: screening. Jun 2020 [internet publication].[Full Text]

            • 68. Levy SJ, Williams JF; Committee on Substance Use and Prevention. Substance use screening, brief intervention, and referral to treatment. Pediatrics. 2016 Jul;138(1):e20161211.[Abstract][Full Text]

            • 69. National Institute for Health and Care Excellence. Postnatal care. Apr 2021 [internet publication].​[Full Text]

            • 70. McKay JR. Impact of continuing care on recovery from substance use disorder. Alcohol Res. 2021 Jan 21;41(1):01.[Abstract][Full Text]

            • 71. Iturralde E, Weisner CM, Adams SR, et al. Patterns of health care use 5 years after an intervention linking patients in addiction treatment with a primary care practitioner. JAMA Netw Open. 2022 Nov 1;5(11):e2241338.[Abstract][Full Text]

            • 72. Minozzi S, Saulle R, Amato L, et al. Psychosocial interventions for stimulant use disorder. Cochrane Database Syst Rev. 2024 Feb 15;2(2):CD011866.[Abstract][Full Text]

            • 73. US Department of Veterans Affairs. VA/DoD clinical practice guidelines​: management of substance use disorder (SUD). Aug 2021 [internet publication].​[Full Text]

            • 74. United Nations Office on Drugs and Crime. UNODC treatment of stimulant use disorders: current practices and promising perspectives​. May 2019 [internet publication].​[Full Text]

            • 75. American Society of Addiction Medicine. Engagement and retention of nonabstinent patients in substance use treatment: clinical consideration for addiction treatment providers. Oct 2024 [internet publication].[Full Text]

            • 76. McGovern R, Newham JJ, Addison MT, et al. Effectiveness of psychosocial interventions for reducing parental substance misuse. Cochrane Database Syst Rev. 2021 Mar 16;3(3):CD012823.[Abstract][Full Text]

            • 77. Stuart AM, Baker AL, Denham AMJ, et al. Psychological treatment for methamphetamine use and associated psychiatric symptom outcomes: a systematic review. J Subst Abuse Treat. 2020 Feb;109:61-79.[Abstract][Full Text]

            • 78. De Crescenzo F, Ciabattini M, D'Alò GL, et al. Comparative efficacy and acceptability of psychosocial interventions for individuals with cocaine and amphetamine addiction: a systematic review and network meta-analysis. PLoS Med. 2018 Dec;15(12):e1002715.[Abstract][Full Text]

            • 79. Rawson RA, McCann MJ, Flammino F, et al. A comparison of contingency management and cognitive-behavioral approaches for stimulant-dependent individuals. Addiction. 2006 Feb;101(2):267-74.[Abstract]

            • 80. Brown HD, DeFulio A. Contingency management for the treatment of methamphetamine use disorder: a systematic review. Drug Alcohol Depend. 2020 Nov 1;216:108307.[Abstract]

            • 81. Ronsley C, Nolan S, Knight R, et al. Treatment of stimulant use disorder: a systematic review of reviews. PLoS One. 2020;15(6):e0234809.[Abstract][Full Text]

            • 82. Rawson R, Gonzales R, Brethen P. Treatment of methamphetamine use disorders: an update. J Subst Abuse Treat. 2002 Sep;23(2):145-50.[Abstract]

            • 83. Roll JM, Petry NM, Stitzer ML, et al. Contingency for the treatment of methamphetamine use disorder. Am J Psychiatry. 2006 Nov;163(11):1993-9.[Abstract]

            • 84. Bentzley BS, Han SS, Neuner S, et al. Comparison of treatments for cocaine use disorder among adults: a systematic review and meta-analysis. JAMA Netw Open. 2021 May 3;4(5):e218049.[Abstract][Full Text]

            • 85. Higgins ST, Budney AJ, Bickel WK, et al. Incentives improve outcome in outpatient behavioral treatment of cocaine dependence. Arch Gen Psychiatry. 1994 Jul;51(7):568-76.[Abstract]

            • 86. Rawson RA, Huber A, McCann M, et al. A comparison of contingency management and cognitive-behavioral approaches during methadone maintenance treatment for cocaine dependence. Arch Gen Psychiatry. 2002 Sep;59(9):817-24.[Abstract][Full Text]

            • 87. Prendergast M, Podus D, Finney J, et al. Contingency management for treatment of substance use disorders: a meta-analysis. Addiction. 2006 Nov;101(11):1546-60.[Abstract]

            • 88. Colfax G, Santos GM, Chu P, et al. Amphetamine-group substances and HIV. Lancet. 2010 Aug 7;376(9739):458-74.[Abstract]

            • 89. McPherson SM, Burduli E, Smith CL, et al. A review of contingency management for the treatment of substance-use disorders: adaptation for underserved populations, use of experimental technologies, and personalized optimization strategies. Subst Abuse Rehabil. 2018;9:43-57.[Abstract][Full Text]

            • 90. Kurti AN, Davis DR, Redner R, et al. A review of the literature on remote monitoring technology in incentive-based interventions for health-related behavior change. Transl Issues Psychol Sci. 2016 Jun;2(2):128-52.[Abstract][Full Text]

            • 91. Harada T, Tsutomi H, Mori R, et al. Cognitive-behavioural treatment for amphetamine-type stimulants (ATS)-use disorders. Cochrane Database Syst Rev. 2018 Dec 22;(12):CD011315.[Abstract][Full Text]

            • 92. Dutra L, Stathopoulou G, Basden SL, et al. A meta-analytic review of psychosocial interventions for substance use disorders. Am J Psychiatry. 2008 Feb;165(2):179-87.[Abstract][Full Text]

            • 93. Maude-Griffin PM, Hohenstein JM, Humfleet GL, et al. Superior efficacy of cognitive-behavioral therapy for urban crack cocaine abusers: main and matching effects. J Consult Clin Psychol. 1998 Oct;66(5):832-7.[Abstract]

            • 94. Rohsenow DJ, Monti PM, Martin RA, et al. Brief coping skills treatment for cocaine abuse: 12-month substance use outcomes. J Consult Clin Psychol. 2000 Jun;68(3):515-20.[Abstract]

            • 95. Carroll KM, Rounsaville BJ, Gordon LT, et al. Psychotherapy and pharmacotherapy for ambulatory cocaine abusers. Arch Gen Psychiatry. 1994 Mar;51(3):177-87.[Abstract]

            • 96. Schwenker R, Dietrich CE, Hirpa S, et al. Motivational interviewing for substance use reduction. Cochrane Database Syst Rev. 2023 Dec 12;12(12):CD008063.[Abstract]

            • 97. Shoptaw S, Reback CJ, Peck JA, et al. Behavioral treatment approaches for methamphetamine dependence and HIV-related sexual risk behaviors among urban gay and bisexual men. Drug Alcohol Depend. 2005 May 9;78(2):125-34.[Abstract]

            • 98. AshaRani PV, Hombali A, Seow E, et al. Non-pharmacological interventions for methamphetamine use disorder: a systematic review. Drug Alcohol Depend. 2020 Jul 1;212:108060.[Abstract][Full Text]

            • 99. Amiri Z, Mirzaee B, Sabet M. Evaluating the efficacy of regulated 12-session Matrix Model in reducing susceptibility in methamphetamine-dependent individuals. Int J Med Res Health Sci. 2016;5(2):77-85.​[Full Text]

            • 100. De Giorgi R, Cassar C, Loreto D'alò G, et al. Psychosocial interventions in stimulant use disorders: a systematic review and qualitative synthesis of randomized controlled trials. Riv Psichiatr. 2018 Sep-Oct;53(5):233-55.[Abstract][Full Text]

            • 101. ​​McLellan AT, Hagan TA, Meyers K, et al. "Intensive" outpatient substance abuse treatment: comparisons with "traditional" outpatient treatment. J Addict Dis. 1997;16(2):57-84.[Abstract]

            • 102. Vocci FJ, Montoya ID. Psychological treatments for stimulant misuse, comparing and contrasting those for amphetamine dependence and those for cocaine dependence. Curr Opin Psychiatry. 2009 May;22(3):263-8.[Abstract][Full Text]

            • 103. Wouldes T, LaGasse L, Sheridan J, et al. Maternal methamphetamine use during pregnancy and child outcome: what do we know? N Z Med J. 2004 Nov 26;117(1206):U1180.[Abstract]

            • 104. Eze N, Smith LM, LaGasse LL, et al. School-aged outcomes following prenatal methamphetamine exposure: 7.5-year follow-up from the Infant Development, Environment, and Lifestyle Study. J Pediatr. 2016 Mar;170:34-8.e1.[Abstract][Full Text]

            • 105. World Health Organization. Guidelines for identification and management of substance use and substance use disorders in pregnancy. Nov 2014 [internet publication].​[Full Text]

            • 106. Washio Y, Atreyapurapu S, Hayashi Y, et al. Systematic review on use of health incentives in U.S. to change maternal health behavior. Prev Med. 2021 Apr;145:106442.[Abstract]

            • 107. Siefried KJ, Acheson LS, Lintzeris N, et al. Pharmacological treatment of methamphetamine/amphetamine dependence: a systematic review. CNS Drugs. 2020 Apr;34(4):337-65.[Abstract][Full Text]

            • 108. Soares E, Pereira FC. Pharmacotherapeutic strategies for methamphetamine use disorder: mind the subgroups. Expert Opin Pharmacother. 2019 Dec;20(18):2273-93.[Abstract]

            • 109. Lee NK, Jenner L, Harney A, et al. Pharmacotherapy for amphetamine dependence: a systematic review. Drug Alcohol Depend. 2018 Oct 1;191:309-37.[Abstract]

            • 110. Chan B, Freeman M, Kondo K, et al. Pharmacotherapy for methamphetamine/amphetamine use disorder - a systematic review and meta-analysis. Addiction. 2019 Dec;114(12):2122-36.[Abstract]

            • 111. Shearer J, Darke S, Rodgers C, et al. A double-blind, placebo-controlled trial of modafinil (200 mg/day) for methamphetamine dependence. Addiction. 2009 Feb;104(2):224-33.[Abstract]

            • 112. Longo M, Wickes W, Smout M, et al. Randomized controlled trial of dexamphetamine maintenance for the treatment of methamphetamine dependence. Addiction. 2010 Jan;105(1):146-54.[Abstract]

            • 113. Ling W, Chang L, Hillhouse M, et al. Sustained-release methylphenidate in a randomized trial of treatment of methamphetamine use disorder. Addiction. 2014 Sep;109(9):1489-500.[Abstract][Full Text]

            • 114. Miles SW, Sheridan J, Russell B, et al. Extended-release methylphenidate for treatment of amphetamine/methamphetamine dependence: a randomized, double-blind, placebo-controlled trial. Addiction. 2013 Jul;108(7):1279-86.[Abstract]

            • 115. Solhi H, Jamilian HR, Kazemifar AM, et al. Methylphenidate vs. resperidone in treatment of methamphetamine dependence: a clinical trial. Saudi Pharm J. 2014 Jul;22(3):191-4.[Abstract][Full Text]

            • 116. Ray LA, Bujarski S, Courtney KE, et al. The effects of naltrexone on subjective response to methamphetamine in a clinical sample: a double-blind, placebo-controlled laboratory study. Neuropsychopharmacology. 2015 Sep;40(10):2347-56.[Abstract][Full Text]

            • 117. Comer SD, Mogali S, Saccone PA, et al. Effects of acute oral naltrexone on the subjective and physiological effects of oral D-amphetamine and smoked cocaine in cocaine abusers. Neuropsychopharmacology. 2013 Nov;38(12):2427-38.[Abstract][Full Text]

            • 118. Stoops WW, Rush CR. Combination pharmacotherapies for stimulant use disorder: a review of clinical findings and recommendations for future research. Expert Rev Clin Pharmacol. 2014 May;7(3):363-74.[Abstract][Full Text]

            • 119. Trivedi MH, Walker R, Ling W, et al. Bupropion and naltrexone in methamphetamine use disorder. N Engl J Med. 2021 Jan 14;384(2):140-53.[Abstract][Full Text]

            • 120. De La Garza R 2nd, Newton TF, Haile CN, et al. Rivastigmine reduces "Likely to use methamphetamine" in methamphetamine-dependent volunteers. Prog Neuropsychopharmacol Biol Psychiatry. 2012 Apr 27;37(1):141-6.[Abstract]

            • 121. Chang CH, Liou MF, Liu CY, et al. Efficacy of repetitive transcranial magnetic stimulation in patients with methamphetamine use disorder: a systematic review and meta-analysis of double-blind randomized controlled trials. Front Psychiatry. 2022 May 27;13:904252.[Abstract][Full Text]

            • 122. Makani R, Pradhan B, Shah U, et al. Role of repetitive transcranial magnetic stimulation (rTMS) in treatment of addiction and related disorders: a systematic review. Curr Drug Abuse Rev. 2017;10(1):31-43.[Abstract]

            • 123. Kosten T, Owens SM. Immunotherapy for the treatment of drug abuse. Pharmacol Ther. 2005 Oct;108(1):76-85.[Abstract]

            • 124. Collins KC, Schlosburg JE, Bremer PT, et al. Methamphetamine vaccines: improvement through hapten design. J Med Chem. 2016 Apr 28;59(8):3878-85.[Abstract][Full Text]

            • 125. Farahzadi MH, Moazen-Zadeh E, Razaghi E, et al. Riluzole for treatment of men with methamphetamine dependence: a randomized, double-blind, placebo-controlled clinical trial. J Psychopharmacol. 2019 Mar;33(3):305-15.[Abstract]

            • 126. Goldberg SB, Pace B, Griskaitis M, et al. Mindfulness-based interventions for substance use disorders. Cochrane Database Syst Rev. 2021 Oct 20;(10):CD011723.[Abstract][Full Text]

            • 127. Maneesang W, Hengpraprom S, Kalayasiri R. Effectiveness of mindfulness-based therapy and counseling programs (MBTC) on relapses to methamphetamine dependence at a substance dependency treatment center. Psychiatry Res. 2022 Nov;317:114886.[Abstract]

            • 128. Rostami R, Dehghani-Arani F. Neurofeedback training as a new method in treatment of crystal methamphetamine dependent patients: a preliminary study. Appl Psychophysiol Biofeedback. 2015 Sep;40(3):151-61.[Abstract]

            • 129. Crowley R, Kirschner N, Dunn AS, et al. Health and public policy to facilitate effective prevention and treatment of substance use disorders involving illicit and prescription drugs: an American College of Physicians position paper. Ann Intern Med. 2017 May 16;166(10):733-6.[Abstract][Full Text]

            • 130. Calabria BD, Degenhardt L, Briegleb C, et al. Systematic review of prospective studies investigating "remission" from amphetamine, cannabis, cocaine or opioid dependence. Addict Behav. 2010 Aug;35(8):741-9.[Abstract]

            • 131. Turnipseed SD, Richards JR, Kirk D, et al. Frequency of acute coronary syndrome in patients presenting to the emergency department with chest pain after methamphetamine use. J Emerg Med. 2003 May;24(4):369-73.[Abstract]

            • 132. Mortelmans LJM, Bogaerts PJM, Hellemans S, et al. Spontaneous pneumomediastinum and myocarditis following ecstasy use: a case report. Eur J Emerg Med. 2005 Feb;12(1):36-8.[Abstract]

            • 133. Dickson SD, Thomas IC, Bhatia HS, et al. Methamphetamine-associated heart failure hospitalizations across the United States: geographic and social disparities. J Am Heart Assoc. 2021 Aug 17;10(16):e018370.[Abstract][Full Text]

            • 134. Swalwell CI, Davis GG. Methamphetamine as a risk factor for acute aortic dissection. J Forensic Sci. 1999 Jan;44(1):23-6.[Abstract]

            • 135. Rejali D, Glen P, Odom N. Pneumomediastinum following ecstasy (methylenedioxymethamphetamine, MDMA) ingestion in two people at the same "rave". J Laryngol Otol. 2002 Jan;116(1):75-6.[Abstract]

            • 136. National Toxicology Program. NTP-CERHR monograph on the potential human reproductive and developmental effects of amphetamines. NTP CERHR MON. 2005 Jul;(16):i-III-1.[Abstract][Full Text]

            • 137. Tucker P. Substance misuse and early psychosis. Australas Psychiatry. 2009 Aug;17(4):291-4.[Abstract]

            • 138. Shoptaw S, Reback CJ. Associations between methamphetamine use and HIV among men who have sex with men: a model for guiding public policy. J Urban Health. 2006 Nov;83(6):1151-7.[Abstract][Full Text]

            • 139. Silber BY, Croft RJ, Papafotiou K, et al. The effects of d-amphetamine and methamphetamine on attention and psychomotor performance. Psychopharmacology (Berl). 2006 Aug;187(2):154-69.[Abstract]

            • 140. Sheridan J, Bennett S, Coggan C, et al. Injury with methamphetamine use: a review of the literature. Harm Reduct J. 2006 Mar 29;3:14.[Abstract][Full Text]

            • 141. Fischer B, Haydon E, Rehm J, et al. Injection drug use and the hepatitis C virus: considerations for a targeted treatment approach - the case study of Canada. J Urban Health. 2004 Sep;81(3):428-47.[Abstract][Full Text]

            • 142. Centers for Disease Control and Prevention. Vaccines and immunizations: adult immunization schedule by age​: recommendations for ages 19 years or older, United States, 2025. Nov 2024 [internet publication].​[Full Text]

            • 143. US Public Health Service. Preexposure prophylaxis for the prevention ​of HIV infection in the United States - 2021 update. 2021 [internet publication].​[Full Text]

          Have feedback?
          Tell us about your experience
          Scroll to Top
          epocrates logo

          Sign in to access our clinical decision support tools

          Sign inCreate Account
          Download Epocrates from the App StoreDownload Epocrates from the Play Store
          About UsFeaturesBusiness SolutionsHelp & Feedback
          © 2026 epocrates, Inc.   Terms of UsePrivacy PolicyEditorial PolicyDo Not Sell or Share My Information