Amphetamine use disorder - Symptoms, Causes, Images, and Treatment Options

Diseases

Highlights & Basics

Key Highlights

Amphetamine and methamphetamine use disorders involve compulsive substance use despite negative consequences.
Polysubstance use, for example with opioids, is an increasing problem, and increases mortality.
Psychosocial interventions such as contingency management, cognitive behavioral therapy (CBT), motivational interviewing, Matrix model, and community reinforcement approach are the mainstays of treatment; no medication has yet proven effective.
Effective management strategies incorporate a degree of long-term continuing care in addition to acute management of exacerbations.
Evaluation and management of co-occurring psychiatric conditions is essential.

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History & Exam
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Definition

Epidemiology

Etiology

Pathophysiology

Citations

Key Articles

American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th edition, text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.
National Institute on Drug Abuse. Methamphetamine research report: what is methamphetamine? Oct 2019 [internet publication].[Full Text]
Paulus MP, Stewart JL. Neurobiology, clinical presentation, and treatment of methamphetamine use disorder: a review. JAMA Psychiatry. 2020 Sep 1;77(9):959-66.[Abstract][Full Text]
Substance Abuse and Mental Health Services Administration (SAMHSA). Treatment for stimulant use disorders: updated 2021. Treatment Improvement Protocol (TIP) series, no. 33. Rockville (MD): Substance Abuse and Mental Health Services Administration (US); 1999 (updated 2021).[Abstract][Full Text]
World Health Organization. Guidelines for identification and management of substance use and substance use disorders in pregnancy. Nov 2014 [internet publication].[Full Text]
Siefried KJ, Acheson LS, Lintzeris N, et al. Pharmacological treatment of methamphetamine/amphetamine dependence: a systematic review. CNS Drugs. 2020 Apr;34(4):337-65.[Abstract][Full Text]
Soares E, Pereira FC. Pharmacotherapeutic strategies for methamphetamine use disorder: mind the subgroups. Expert Opin Pharmacother. 2019 Dec;20(18):2273-93.[Abstract]

Other Online Resources

National Institute on Drug Abuse (NIDA): TAPS - Tobacco, Alcohol, Prescription medication, and other Substance use tool
Narcotics Anonymous

Referenced Articles

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