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Diseases

Pericarditis

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Pericarditis symptoms include sharp, severe retrosternal chest pain worse with inspiration and a supine position. 

  • The classic physical finding is a pericardial friction rub. A low-grade fever may be present.

  • Diagnostic signs include widespread electrocardiographic ST elevation or PR depression and a new or worsening pericardial effusion on echocardiography; blood tests generally suggest systemic inflammation.

  • Treatment is directed at any underlying systemic disorder. Idiopathic or viral pericarditis responds to nonsteroidal anti-inflammatory drugs and colchicine.

  • Complications include chronic recurrent pericarditis, cardiac tamponade, and constrictive pericarditis.

ECG in a patient with acute pericarditis, showing diffuse ST-segment elevation in the precordial lea
ECG in a patient with acute pericarditis, showing diffuse ST-segment elevation in the precordial leads. There is also PR-segment depression in leads V2-V6 (arrows)
Rathore S, Dodds PA. BMJ Case Reports 2009; doi:10.1136/bcr.2006.097071

Quick Reference

  • History & Exam

    • Key Factors

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      • Diagnostics Tests

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          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Constrictive pericarditis identified at autopsy; the right section is scar tissue cut from the very

            Constrictive pericarditis identified at autopsy; the right section is scar tissue cut from the very front of the heart

          • ECG in a patient with acute pericarditis, showing diffuse ST-segment elevation in the precordial lea

            ECG in a patient with acute pericarditis, showing diffuse ST-segment elevation in the precordial leads. There is also PR-segment depression in leads V2-V6 (arrows)

          • Chest CT showing a double layer of pericardial calcification in a 56-year-old male patient with idio

            Chest CT showing a double layer of pericardial calcification in a 56-year-old male patient with idiopathic calcific constrictive pericarditis

          • Chest CT in a baby with purulent pericarditis showing a pericardial collection with compression of t

            Chest CT in a baby with purulent pericarditis showing a pericardial collection with compression of the left (LV) and right (RV) ventricles

          • Echocardiogram in a baby with purulent pericarditis, showing a pericardial collection. LV = left ven

            Echocardiogram in a baby with purulent pericarditis, showing a pericardial collection. LV = left ventricle, RV = right ventricle

          • Open surgery in a baby with purulent pericarditis; the abscess is indicated by the arrow

            Open surgery in a baby with purulent pericarditis; the abscess is indicated by the arrow

          • Pericardectomy in a 56-year-old male patient with idiopathic calcific constrictive pericarditis. The

            Pericardectomy in a 56-year-old male patient with idiopathic calcific constrictive pericarditis. The pericardium is thickened and calcified

          Citations

            Key Articles

            • Adler Y, Charron P, Imazio M, et al; ESC Scientific Document Group. 2015 ESC guidelines for the diagnosis and management of pericardial diseases. Eur Heart J. 2015 Nov 7;36(42):2921-64.[Abstract][Full Text]

            • Chiabrando JG, Bonaventura A, Vecchié A, et al. Management of acute and recurrent pericarditis: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Jan 7;75(1):76-92.[Abstract][Full Text]

            • Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2021 Nov 30;144(22):e368-454.[Abstract][Full Text]

            Referenced Articles

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            • 2. Imazio M, Brucato A, Mayosi BM, et al. Medical therapy of pericardial diseases: part II: noninfectious pericarditis, pericardial effusion and constrictive pericarditis. J Cardiovasc Med (Hagerstown). 2010 Nov;11(11):785-94.[Abstract]

            • 3. Imazio M, Brucato A, Mayosi BM, et al. Medical therapy of pericardial diseases: part I: idiopathic and infectious pericarditis. J Cardiovasc Med (Hagerstown). 2010 Oct;11(10):712-22.[Abstract]

            • 4. Jensen TB, Kheyr MAE, Mohey R. Constrictive pericarditis caused by Cutibacterium (Propionibacterium) acnes: a case report and review of literature. IDCases. 2017 Sep 28;10:79-82.[Abstract][Full Text]

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            • 13. Troughton RW, Asher CR, Klein AL. Pericarditis. Lancet. 2004 Feb 28;363(9410):717-27.[Abstract]

            • 14. Little WC, Freeman GL. Pericardial disease. Circulation. 2006 Mar 28;113(12):1622-32.[Abstract][Full Text]

            • 15. Ariyarajah V, Spodick DH. Acute pericarditis: diagnostic cues and common electrocardiographic manifestations. Cardiol Rev. 2007 Jan-Feb;15(1):24-30.[Abstract]

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            • 17. Kytö V, Sipilä J, Rautava P. Clinical profile and influences on outcomes in patients hospitalized for acute pericarditis. Circulation. 2014 Oct 28;130(18):1601-6.[Abstract][Full Text]

            • 18. Chiabrando JG, Bonaventura A, Vecchié A, et al. Management of acute and recurrent pericarditis: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 Jan 7;75(1):76-92.[Abstract][Full Text]

            • 19. Buba F. Cardiovascular opportunistic infections in HIV disease. Biomed Res. 2011;22(3):279-84.[Full Text]

            • 20. Imazio M, Gaita F, LeWinter M. Evaluation and treatment of pericarditis: a systematic review. JAMA. 2015 Oct 13;314(14):1498-506.[Abstract][Full Text]

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            • 22. Agrawal A, Bayat A, Bhagat U, et al. Incidence, predictors, and outcomes of acute pericarditis in patients with inflammatory bowel disease: a 10-year nationwide analysis. CJC Open. 2024 Nov;6(11):1379-85.[Abstract][Full Text]

            • 23. ​Qazi T, Christian KE, Farraye FA, et al. Pericardial manifestations in inflammatory bowel disease: a report of two cases. Cro Col. 2019 Oct;1(3):otz028.[Full Text]

            • 24. Parmar K, Subramanyam S, Del Rio-Pertuz G, et al. Cardiac adverse events after vaccination - a systematic review. Vaccines (Basel). 2022 Apr 29;10(5):700.[Abstract][Full Text]

            • 25. Mei R, Raschi E, Poluzzi E, et al. Recurrence of pericarditis after influenza vaccination: a case report and review of the literature. BMC Pharmacol Toxicol. 2018 May 5;19(1):20.[Abstract][Full Text]

            • 26. Centers for Disease Control and Prevention. Clinical considerations: myocarditis and pericarditis after receipt of COVID-19 vaccines among adolescents and young adults​. Oct 2023 [internet publication].[Full Text]

            • 27. Malik J, Zaidi SMJ, Rana AS, et al. Post-cardiac injury syndrome: an evidence-based approach to diagnosis and treatment. Am Heart J Plus. 2021 Dec;12:100068.[Abstract][Full Text]

            • 28. LeWinter MM, Kabbani S. Pericardial diseases. In: Zipes DP, Libby P, Bonow RO, et al, eds. Braunwald's heart disease. 7th ed. Philadelphia, PA: Elsevier Saunders; 2005:1757-80.

            • 29. Maisch B. Recurrent pericarditis: mysterious or not so mysterious? Eur Heart J. 2005 Apr;26(7):631-3.[Abstract][Full Text]

            • 30. Sagristà-Sauleda J, Permanyer-Miralda G, Soler-Soler J. Tuberculous pericarditis: ten year experience with a prospective protocol for diagnosis and treatment. J Am Coll Cardiol. 1988 Apr;11(4):724-8.[Abstract][Full Text]

            • 31. Lancellotti P, Nkomo VT, Badano LP, et al. Expert consensus for multi-modality imaging evaluation of cardiovascular complications of radiotherapy in adults: a report from the European Association of Cardiovascular Imaging and the American Society of Echocardiography. J Am Soc Echocardiogr. 2013 Sep;26(9):1013-32.[Abstract][Full Text]

            • 32. Imazio M, Brucato A, Forno D, et al. Efficacy and safety of colchicine for pericarditis prevention. Systematic review and meta-analysis. Heart. 2012 Jul;98(14):1078-82.[Abstract][Full Text]

            • 33. Imazio M, Brucato A, Rovere ME, et al. Colchicine prevents early postoperative pericardial and pleural effusions. Am Heart J. 2011 Sep;162(3):527-32.[Abstract]

            • 34. Lutschinger LL, Rigopoulos AG, Schlattmann P, et al. Meta-analysis for the value of colchicine for the therapy of pericarditis and of postpericardiotomy syndrome. BMC Cardiovasc Disord. 2019 Sep 2;19(1):207.[Abstract][Full Text]

            • 35. Malektojari A, Tahmasebipour R, Fadaeihosein M, et al. Pharmacological preventions and treatments for pericardial complications after open heart surgeries. Heart. 2025 Mar 26;111(8):353-61.[Abstract][Full Text]

            • 36. Imazio M, Spodick DH, Brucato A, et al. Diagnostic issues in the clinical management of pericarditis. Int J Clin Pract. 2010 Sep;64(10):1384-92.[Abstract]

            • 37. Imazio M, Spodick DH, Brucato A, et al. Controversial issues in the management of pericardial diseases. Circulation. 2010 Feb 23;121(7):916-28.[Abstract]

            • 38. Imazio M, Brucato A, Trinchero R, et al. Diagnosis and management of pericardial diseases. Nat Rev Cardiol. 2009 Dec;6(12):743-51.[Abstract]

            • 39. Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain: a report of the American College of Cardiology/American Heart Association Joint Committee on clinical practice guidelines. Circulation. 2021 Nov 30;144(22):e368-454.[Abstract][Full Text]

            • 40. Ezekowitz JA, O'Meara E, McDonald MA, et al. 2017 comprehensive update of the Canadian Cardiovascular Society guidelines for the management of heart failure. Can J Cardiol. 2017 Sep 6;33(11):1342-433.[Abstract][Full Text]

            • 41. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38.[Abstract]

            • 42. Kumar S, Khubber S, Reyaldeen R, et al. Advances in imaging and targeted therapies for recurrent pericarditis: a review. JAMA Cardiol. 2022 Sep 1;7(9):975-85.[Abstract]

            • 43. Seo HT, Kim YS, Ock HS, et al. Diagnostic performance of interferon-gamma release assay for diagnosis of tuberculous pericarditis: a meta-analysis. Int J Clin Pract. 2020 May;74(5):e13479.[Abstract]

            • 44. Yu G, Zhong F, Shen Y, et al. Diagnostic accuracy of the Xpert MTB/RIF assay for tuberculous pericarditis: a systematic review and meta-analysis. PLoS One. 2021 Sep 10;16(9):e0257220.[Abstract][Full Text]

            • 45. Imazio M, Brucato A, Derosa FG, et al. Aetiological diagnosis in acute and recurrent pericarditis: when and how. J Cardiovasc Med (Hagerstown). 2009 Mar;10(3):217-30.[Abstract]

            • 46. Tuon FF, Litvoc MN, Lopes MI. Adenosine deaminase and tuberculous pericarditis: a systematic review with meta-analysis. Acta Trop. 2006 Aug;99(1):67-74.[Abstract]

            • 47. Klein AL, Abbara S, Agler DA, et al. American Society of Echocardiography clinical recommendations for multimodality cardiovascular imaging of patients with pericardial disease. J Am Soc Echocardiogr. 2013 Sep;26(9):965-1012.[Abstract][Full Text]

            • 48. Braunwald E. Pericardial disease. In: Kasper DL, Braunwald E, Fauci AS, et al, eds. Harrison's internal medicine. 16th ed. New York: McGraw-Hill; 2005.

            • 49. Belic L, Stafford G, Allen JW, et al. Cardiac tamponade during anticoagulation. Management with a pericardial drain and continued anticoagulation. JAMA. 1978 Aug 18;240(7):672.[Abstract]

            • 50. Ala CK, Banerjee K, Chahine J, et al. D-dimer as a novel marker of inflammation in pericarditis. Paper presented at: The American College of Cardiology 68th Annual Scientific Sessions. 16-18 Mar 2019. New Orleans, LA. J Am Coll Cardiol. 2019 Mar;73(9 Suppl 1):984.​[Full Text]

            • 51. Bajaj N, Bozarth AL, Guillot J, et al. Clinical features in patients with pulmonary embolism at a community hospital: analysis of 4 years of data. J Thromb Thrombolysis. 2014 Apr;37(3):287-92.[Abstract]

            • 52. Brown G, Hogg K. Best evidence topic report. Diagnostic utility of electrocardiogram for diagnosing pulmonary embolism. Emerg Med J. 2005 Oct;22(10):729-30.[Abstract][Full Text]

            • 53. Sukhija R, Aronow WS, Ahn C, et al. Electrocardiographic abnormalities in patients with right ventricular dilation due to acute pulmonary embolism. Cardiology. 2006;105(1):57-60.[Abstract]

            • 54. McEwan T, Robinson PC. A systematic review of the infectious complications of colchicine and the use of colchicine to treat infections. Semin Arthritis Rheum. 2021 Feb;51(1):101-12.[Abstract][Full Text]

            • 55. Kim JH, Baggish AL, Levine BD, et al. Clinical considerations for competitive sports participation for athletes with cardiovascular abnormalities: a scientific statement from the American Heart Association and American College of Cardiology. Circulation. 2025 Mar 18;151(11):e716-61.[Abstract][Full Text]

            • 56. Pelliccia A, Solberg EE, Papadakis M, et al. Recommendations for participation in competitive and leisure time sport in athletes with cardiomyopathies, myocarditis, and pericarditis: position statement of the Sport Cardiology Section of the European Association of Preventive Cardiology (EAPC). Eur Heart J. 2019 Jan 1;40(1):19-33.[Abstract]

            • 57. Galluzzo A, Imazio M. Advances in medical therapy for pericardial diseases. Expert Rev Cardiovasc Ther. 2018 Sep;16(9):635-43.[Abstract]

            • 58. Rao SV, O'Donoghue ML, Ruel M, et al. 2025 ACC/AHA/ACEP/NAEMSP/SCAI guideline for the management of patients with acute coronary syndromes: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2025 Apr;151(13):e771-862.[Abstract][Full Text]

            • 59. Andreis A, Imazio M, Casula M, et al. Colchicine efficacy and safety for the treatment of cardiovascular diseases. Intern Emerg Med. 2021 Sep;16(6):1691-700.[Abstract][Full Text]

            • 60. Bayes-Genis A, Adler Y, de Luna AB, et al. Colchicine in pericarditis. Eur Heart J. 2017 Jun 7;38(22):1706-9.[Abstract]

            • 61. Lotrionte M, Biondi-Zoccai G, Imazio M, et al. International collaborative systematic review of controlled clinical trials on pharmacologic treatments for acute pericarditis and its recurrences. Am Heart J. 2010 Oct;160(4):662-70.[Abstract]

            • 62. Mayosi BM, Ntsekhe M, Bosch J, et al; IMPI Trial Investigators. Prednisolone and Mycobacterium indicus pranii in tuberculous pericarditis. N Engl J Med. 2014 Sep 18;371(12):1121-30.[Abstract][Full Text]

            • 63. George IA, Thomas B, Sadhu JS. Systematic review and meta-analysis of adjunctive corticosteroids in the treatment of tuberculous pericarditis. Int J Tuberc Lung Dis. 2018 May 1;22(5):551-6.[Abstract]

            • 64. Isiguzo G, Du Bruyn E, Howlett P, et al. Diagnosis and management of tuberculous pericarditis: what is new? Curr Cardiol Rep. 2020 Jan 15;22(1):2.[Abstract][Full Text]

            • 65. Liebenberg JJ, Dold CJ, Olivier LR. A prospective investigation into the effect of colchicine on tuberculous pericarditis. Cardiovasc J Afr. 2016 Nov/Dec;27(6):350-5.[Abstract][Full Text]

            • 66. Wiysonge CS, Ntsekhe M, Thabane L, et al. Interventions for treating tuberculous pericarditis. Cochrane Database Syst Rev. 2017 Sep 13;(9):CD000526.[Abstract][Full Text]

            • 67. Imazio M, Lazaros G, Gattorno M, et al. Anti-interleukin-1 agents for pericarditis: a primer for cardiologists. Eur Heart J. 2022 Aug 14;43(31):2946-57.[Abstract][Full Text]

            • 68. Vianello F, Cinetto F, Cavraro M, et al. Azathioprine in isolated recurrent pericarditis: a single centre experience. Int J Cardiol. 2011 Mar 17;147(3):477-8.[Abstract]

            • 69. Imazio M, Lazaros G, Picardi E, et al. Intravenous human immunoglobulins for refractory recurrent pericarditis: a systematic review of all published cases. J Cardiovasc Med (Hagerstown). 2016 Apr;17(4):263-9.[Abstract]

            • 70. Emmi G, Urban ML, Imazio M, et al. Use of interleukin-1 blockers in pericardial and cardiovascular diseases. Curr Cardiol Rep. 2018 Jun 14;20(8):61.[Abstract]

            • 71. Brucato A, Imazio M, Gattorno M, et al. Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence: The AIRTRIP randomized clinical trial. JAMA. 2016 Nov 8;316(18):1906-12.[Abstract][Full Text]

            • 72. Tzani A, Doulamis IP, Tzoumas A, et al. Meta-analysis of population characteristics and outcomes of patients undergoing pericardiectomy for constrictive pericarditis. Am J Cardiol. 2021 May 1;146:120-7.[Abstract]

            • 73. Pankuweit S, Ristić AD, Seferović PM, et al. Bacterial pericarditis: diagnosis and management. Am J Cardiovasc Drugs. 2005;5(2):103-12.[Abstract]

            • 74. Klein A, Cremer P, Kontzias A, et al. Clinical burden and unmet need in recurrent pericarditis: a systematic literature review. Cardiol Rev. 2022 Mar-Apr 01;30(2):59-69.[Abstract][Full Text]

            • 75. Imazio M, Brucato A, Maestroni S, et al. Risk of constrictive pericarditis after acute pericarditis. Circulation. 2011 Sep 13;124(11):1270-5.[Abstract][Full Text]

            • 76. Ling LH, Oh JK, Schaff HV, et al. Constrictive pericarditis in the modern era: evolving clinical spectrum and impact on outcome after pericardiectomy. Circulation. 1999 Sep 28;100(13):1380-6.[Abstract][Full Text]

            • 77. Alabed S, Cabello JB, Irving GJ, et al. Colchicine for pericarditis. Cochrane Database Syst Rev. 2014 Aug 28;(8):CD010652.[Abstract][Full Text]

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