Highlights & Basics
- Common cold is usually self-limited and resolves within a few days. Most people experience at least one common cold per year.
- Diagnosis is generally clinical, based on history and exam. Investigations may be required when symptoms worsen or do not resolve in the usual timeframe.
- Treatment includes reassurance that this is a self-limiting condition, rest, adequate fluid intake, and symptom relief. Antibiotics are not recommended.
- Complications include bacterial infections such as otitis media, sinusitis, or pneumonia.
Quick Reference
History & Exam
Key Factors
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Definition
Epidemiology
Etiology
Pathophysiology
Citations
Harris AM, Hicks LA, Qaseem A, et al. Appropriate antibiotic use for acute respiratory tract infection in adults: advice for high-value care from the American College of Physicians and the Centers for Disease Control and Prevention. Ann Intern Med. 2016 Mar 15;164(6):425-34.[Abstract][Full Text]
Jefferson T, Del Mar CB, Dooley L, et al. Physical interventions to interrupt or reduce the spread of respiratory viruses. Cochrane Database Syst Rev. 2020 Nov 20;11:CD006207.[Abstract][Full Text]
van Driel ML, Scheire S, Deckx L, et al. What treatments are effective for common cold in adults and children? BMJ. 2018 Oct 10;363:k3786.
De Sutter AI, Eriksson L, van Driel ML. Oral antihistamine-decongestant-analgesic combinations for the common cold. Cochrane Database Syst Rev. 2022 Jan 21;1:CD004976.[Abstract][Full Text]
Isbister GK, Prior F, Kilham HA. Restricting cough and cold medicines in children. J Paediatr Child Health. 2012 Feb;48(2):91-8.[Abstract]
Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014 Nov 24;(11):CD001831.[Abstract][Full Text]
Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013 Jun 4;(6):CD000247.[Abstract][Full Text]
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37. Coxeter P, Del Mar CB, McGregor L, et al. Interventions to facilitate shared decision making to address antibiotic use for acute respiratory infections in primary care. Cochrane Database Syst Rev. 2015 Nov 12;(11):CD010907.[Abstract][Full Text]
38. Guppy MP, Mickan SM, Del Mar CB, et al. Advising patients to increase fluid intake for treating acute respiratory infections. Cochrane Database Syst Rev. 2011 Feb 16;(2):CD004419.[Abstract][Full Text]
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40. Li S, Yue J, Dong BR, et al. Acetaminophen (paracetamol) for the common cold in adults. Cochrane Database Syst Rev. 2013 Jul 1;(7):CD008800.[Abstract][Full Text]
41. Eccles R. Efficacy and safety of over-the-counter analgesics in the treatment of common cold and flu. J Clin Pharm Ther. 2006 Aug;31(4):309-19.[Abstract]
42. Kim SY, Chang YJ, Cho HM, et al. Non-steroidal anti-inflammatory drugs for the common cold. Cochrane Database Syst Rev. 2015 Sep 21;(9):CD006362.[Abstract][Full Text]
43. McCarthy DM. Efficacy and gastrointestinal risk of aspirin used for the treatment of pain and cold. Best Pract Res Clin Gastroenterol. 2012 Apr;26(2):101-12.[Abstract]
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46. Centers for Disease Control and Prevention. Antibiotic prescribing and use in doctor's offices: common cold. Jun 2023 [internet publication].[Full Text]
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48. Deckx L, De Sutter AI, Guo L, et al. Nasal decongestants in monotherapy for the common cold. Cochrane Database Syst Rev. 2016 Oct 17;(10):CD009612.[Abstract][Full Text]
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54. AlBalawi ZH, Othman SS, AlFaleh K. Intranasal ipratropium bromide for the common cold. Cochrane Database Syst Rev. 2013 Jun 19;(6):CD008231.[Abstract][Full Text]
55. US Food and Drug Administration. Use caution when giving cough and cold products to kids. Feb 2018 [internet publication].[Full Text]
56. Green JL, Wang GS, Reynolds KM, et al. Safety profile of cough and cold medication use in pediatrics. Pediatrics. 2017 Jun;139(6). [Abstract][Full Text]
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58. Smith SM, Schroeder K, Fahey T. Over-the-counter (OTC) medications for acute cough in children and adults in community settings. Cochrane Database Syst Rev. 2014 Nov 24;(11):CD001831.[Abstract][Full Text]
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61. European Medicines Agency. EMA recommends withdrawal of pholcodine medicines from EU market. Dec 2022 [internet publication].[Full Text]
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67. Oduwole O, Udoh EE, Oyo-Ita A, et al. Honey for acute cough in children. Cochrane Database Syst Rev. 2018 Apr 10;(4):CD007094.[Abstract][Full Text]
68. El-Gohary M, Hay AD, Coventry P, et al. Corticosteroids for acute and subacute cough following respiratory tract infection: a systematic review. Fam Pract. 2013 Oct;30(5):492-500.[Abstract]
69. Kenealy T, Arroll B. Antibiotics for the common cold and acute purulent rhinitis. Cochrane Database Syst Rev. 2013 Jun 4;(6):CD000247.[Abstract][Full Text]
70. Spurling GK, Del Mar CB, Dooley L, et al. Delayed antibiotic prescriptions for respiratory infections. Cochrane Database Syst Rev. 2017 Sep 7;(9):CD004417.[Abstract][Full Text]
71. O'Sullivan JW, Harvey RT, Glasziou PP, et al. Written information for patients (or parents of child patients) to reduce the use of antibiotics for acute upper respiratory tract infections in primary care. Cochrane Database Syst Rev. 2016 Nov 25;(11):CD011360.[Abstract][Full Text]
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92. Hawke K, van Driel ML, Buffington BJ, et al. Homeopathic medicinal products for preventing and treating acute respiratory tract infections in children. Cochrane Database Syst Rev. 2018 Apr 9;4:CD005974.[Abstract][Full Text]
93. Mousnier A, Bell AS, Swieboda DP, et al. Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus. Nat Chem. 2018 Jun;10(6):599-606.[Abstract]
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