Highlights & Basics
- Epithelial ovarian cancer is the most common histologic subtype of ovarian cancer, and is the primary focus of this topic.
- Patients often present with vague, nonspecific symptoms such as abdominal bloating, early satiety, and dyspepsia (suggestive of upper abdominal disease). Other symptoms are more suggestive of pelvic disease, such as pelvic pain, abdominal or pelvic pressure, low back pain, and urinary urgency.
- Women with a suspicious pelvic mass should be referred to a gynecologic oncologist for further evaluation.
- If an ovarian mass is detected, biopsy and fine-needle aspiration are not routinely recommended as they can disseminate tumor cells into the peritoneal cavity. These procedures are also prone to sampling error and potential bleeding complications.
- Surgery is typically required for definitive diagnosis, staging, and tumor debulking.
Quick Reference
History & Exam
Key Factors
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Treatment Options
Definition
Epidemiology
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National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: ovarian cancer/fallopian tube cancer/primary peritoneal cancer [internet publication].[Full Text]
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Wright AA, Bohlke K, Armstrong DK, et al. Neoadjuvant chemotherapy for newly diagnosed, advanced ovarian cancer: Society of Gynecologic Oncology and American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2016 Oct 1;34(28):3460-73.[Abstract][Full Text]
Berek JS, Renz M, Kehoe S, et al. Cancer of the ovary, fallopian tube, and peritoneum: 2021 update. Int J Gynaecol Obstet. 2021 Oct;155 Suppl 1(suppl 1):61-85.[Abstract][Full Text]
Tew WP, Lacchetti C, Kohn EC, et al. Poly(ADP-Ribose) polymerase inhibitors in the management of ovarian cancer: ASCO guideline rapid recommendation update. J Clin Oncol. 2022 Nov 20;40(33):3878-81[Abstract][Full Text]
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