Highlights & Basics
- Pancreatic cancer is the third most common cause of cancer-related death in the US.
- Most common presentation is at 65-75 years of age with painless obstructive jaundice and weight loss. Generally presents late with advanced disease.
- Surgical resection offers the only hope for cure. Chemotherapy and radiation therapy, as primary treatment modalities, produce a small but statistically significant benefit. Adjuvant chemotherapy prolongs survival.
- Only a minority (5% to 10%) of patients can undergo potentially curative surgery: these patients have a 5-year survival of up to 22%, which decreases to <2% in the presence of distant metastasis.
- Patients with metastatic disease (50% to 55%) have a limited survival of only 3-6 months.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Trousseau sign in a patient with pancreatic adenocarcinoma
Contrast enhanced abdominal computed tomography scan showing (A) a large mass in the head of pancreas with encasement of the superior mesenteric artery (white arrow) and (B) dilated intrahepatic ducts (black arrowheads) and encasement of the superior mesenteric vein (white arrow)
Citations
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Sohal DPS, Kennedy EB, Cinar P, et al. Metastatic pancreatic cancer: ASCO guideline update. J Clin Oncol. 2020 Aug 5:JCO2001364.[Abstract][Full Text]
Von Hoff DD, Ervin T, Arena FP, et al. Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med. 2013 Oct 31;369(18):1691-703.[Abstract][Full Text]
Conroy T, Desseigne F, Ychou M, et al. FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. N Engl J Med. 2011 May 12;364(19):1817-25.[Abstract][Full Text]
Balaban EP, Mangu PB, Khorana AA, et al. Locally advanced, unresectable pancreatic cancer: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2016 Aug 1;34(22):2654-68.[Abstract][Full Text]
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