Highlights & Basics
- Respiratory transmission is the dominant mode of transmission, with proximity and ventilation being the key determinants of transmission risk. Transmission is more likely if contacts are exposed shortly before or after symptom onset in the index patient.
- Patients may be minimally symptomatic or asymptomatic, while others may present with severe pneumonia or other complications.
- People with comorbidities are at increased risk for severe disease, and the more comorbidities, the greater the risk. Hypertension, obesity, and diabetes are the most prevalent comorbidities.
- Diagnosis is confirmed with real-time reverse transcription polymerase chain reaction (RT-PCR); rapid antigen tests may be recommended in certain circumstances.
- Management depends on disease severity and focuses on infection prevention and control measures, symptom management, prevention of disease progression (e.g., antiviral treatment), optimized supportive care, and organ support in severe or critical illness.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Number of COVID-19 cases reported weekly by WHO Region, and global deaths, as of 28 April 2024
Illustration revealing ultrastructural morphology exhibited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) when viewed with electron microscopically
Multi-organ complications of COVID-19 and long COVID. The SARS-CoV-2 virus gains entry into the cells of multiple organs via the ACE2 receptor
Virus replication cycle
Transverse CT scans from a 32-year-old man, showing ground-glass opacity and consolidation of lower lobe of right lung near the pleura on day 1 after symptom onset (top panel), and bilateral ground-glass opacity and consolidation on day 7 after symptom onset
Citations
World Health Organization. Clinical management of COVID-19: living guideline, 18 August 2023. Aug 2023 [internet publication].[Full Text]
National Institute for Health and Care Excellence. COVID-19 rapid guideline: managing COVID-19. May 2024 [internet publication].[Full Text]
World Health Organization. Therapeutics and COVID-19: living guideline. Nov 2023 [internet publication].[Full Text]
Bhimraj A, Morgan RL, Hirsch Shumaker A, et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. Jun 2023 [internet publication].[Full Text]
- WHO: tracking SARS-CoV-2 variants
- UKHSA: SARS-CoV-2 - genome sequence prevalence and growth rate
- CDC: national and regional variant proportions
- WHO: COVID-19 dashboard
- CDC: COVID data tracker
- BMJ: visualising SARS-CoV-2 transmission routes and mitigations
- WHO: COVID-19 vaccines technical documents
- UK Health Security Agency: COVID-19 - the green book, chapter 14a
- CDC: interim clinical considerations for use of COVID-19 vaccines in the United States
- WHO: infection prevention and control in the context of COVID-19 - a guideline
- CDC: interim infection prevention and control recommendations for healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic
- WHO: advice for the public - coronavirus disease (COVID-19)
- BMJ Practice Pointer: remote management of covid-19 using home pulse oximetry and virtual ward support
- CDC: overview of testing for SARS-CoV-2
- BMJ practice pointer: testing for SARS-CoV-2 antibodies
- BMJ Practice Pointer: interpreting a covid-19 test result
- BSTI: radiology decision tool for suspected COVID-19
- BSTI: lung ultrasound (LUS) for COVID-19 patients in critical care areas
- British Association of Dermatologists: Covid-19 skin patterns
- BMJ: interpreting a lateral flow SARS-CoV-2 antigen test
- NHS England: pulse oximetry to detect early deterioration of patients with COVID-19 in primary and community care settings
- WHO: public health surveillance for COVID-19 - interim guidance
- CDC: coronavirus disease 2019 (COVID-19) 2020 interim case definition
- ECDC: case definition for COVID-19
- UKHSA: people with symptoms of a respiratory infection including COVID-19
- CDC: respiratory virus guidance
- WHO: home care for patients with suspected or confirmed COVID-19 and management of their contacts
- Clinical Frailty Scale
- IDSA: management of drug interactions with nirmatrelvir/ritonavir
- BMJ rapid recommendations: a living WHO guideline on drugs for COVID-19
- RECOVERY trial
- WHO: COVID-19 Solidarity therapeutics trial
- UK Health Security Agency: myocarditis and pericarditis after COVID-19 vaccination - clinical management guidance for healthcare professionals
- Examples of learned societies with treatment recommendations
- UKHSA: information for healthcare professionals on blood clotting following COVID-19 vaccination
- Health Education England: adult pulse oximetry monitoring video
- CDC: animals and COVID-19
- AAP: COVID-19 interim guidance - return to sports and physical activity
- WHO: coronavirus disease (COVID-19) pandemic
- CDC: COVID-19
- NHS England: COVID-19 advice and services
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