Highlights & Basics
- Non-Hodgkin lymphomas (NHLs) are a heterogeneous group of malignancies of the lymphoid system.
- Clinical history and presenting signs/symptoms depend on the type of lymphoma and stage at presentation.
- Diagnosis is confirmed by histopathology (e.g., biopsy of lymph node or extranodal organs) and immunophenotyping.
- Diffuse large B-cell lymphoma is the most common type of NHL.
- Treatment is based on the histologic subtype and stage of the lymphoma; symptom severity informs decisions about when to start therapy.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: B-cell lymphomas [internet publication].[Full Text]
National Comprehensive Cancer Network. NCCN clinical practice guidelines in oncology: T-cell lymphomas [internet publication].[Full Text]
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Vitolo U, Seymour JF, Martelli M, et al. Extranodal diffuse large B-cell lymphoma (DLBCL) and primary mediastinal B-cell lymphoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2016 Sep;27(suppl 5):v91-102.[Abstract][Full Text]
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