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Diseases

Evaluation of dysmenorrhea

OVERVIEW

  • Summary
  • Urgent Considerations
  • Etiology

DIAGNOSIS

  • Differential Diagnosis
  • Diagnostic Approach

IMAGES

  • Library

REFERENCES

  • Citations
  • Credits

Summary

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Dysmenorrhea is one of the most common gynecological symptoms affecting the quality of life of menstruating women.[1] [2] [3] [4]​ It is experienced as lower abdominal pain or uterine cramps that occur during the few days prior to and/or during menstruation, and usually subsides at the end of menstruation.
Dysmenorrhea is subcategorized into primary and secondary, although it is not always easy to distinguish between the two based on history and exam alone:
  • Primary dysmenorrhea occurs in the absence of pelvic pathology

  • Secondary dysmenorrhea occurs in the presence of pelvic pathology.

The prevalence is difficult to determine because different definitions and criteria are used, and dysmenorrhea is often underestimated and undertreated.[5] [6]​​​​​​​ The reported prevalence of dysmenorrhea varies substantially.[7]​ According to a systematic review by the World Health Organization in 2006, the prevalence of dysmenorrhea in menstruating women is between 16.8% and 81%.[8] A greater prevalence is generally observed in young women, with estimates ranging from 67% to 90% for those aged 17-24 years.[7] [9] [10]​​​​ An Australian study found that a higher proportion, 93%, of teenagers reported menstrual pain.[11] Studies in adult women are less consistent, with rates varying from 15% to 75%.[7] [9]​​ Dysmenorrhea can lead to absenteeism from work or school, with up to 50% reporting at least one episode of absence, and 5% to 14% reporting frequent absence.[12]
Factors that correlate positively with dysmenorrhea are smoking, early menarche, nulliparity, and family history.[13] [14] Dysmenorrhea is not associated with the duration of the menstrual cycle, but it usually coexists with heavy menstrual bleeding. Many women experience delays in diagnosis and management.[15] Validated questionnaires of patient reported outcomes may be useful in the initial assessment of dysmenorrhea and in assessing response to treatment.[16]

Primary dysmenorrhea

Primary dysmenorrhea often occurs in the 6-12 months following menarche, once ovulatory cycles have been established.[17] It is more common in adolescents and women under 30 years, although underlying pathology may still be present. Endometriosis is common in adolescents, with a mean prevalence of 64% in girls with dysmenorrhea at laparoscopy.[18]
Pain due to primary dysmenorrhea is usually lower abdominal and cramping in nature, and may radiate to the back and inner thigh. It usually occurs at the onset of menstruation, or precedes it by only a few hours, and typically lasts between 8 and 72 hours. The pain may be associated with other systemic symptoms such as vomiting, nausea, diarrhea, fatigue, and headache. There may also be increased sensitivity to pain.[4] The diagnosis can be made clinically. Investigations fail to reveal an underlying pelvic pathology.

Secondary dysmenorrhea

By contrast, secondary dysmenorrhea often occurs several years after the onset of menarche. It may arise as a new symptom when the woman is in her 30s or 40s in the setting of an identifiable pelvic disease. The pain is not consistently related to menstruation alone, and may occur throughout the luteal phase of the menstrual cycle. It may also worsen as menses progresses rather than being confined to the first 24-48 hours of menstruation. Accompanying symptoms, such as irregular or heavy bleeding, vaginal discharge and dyspareunia can be suggestive of an underlying pelvic pathology.[19]
Common causes of secondary dysmenorrhea are endometriosis, chronic pelvic inflammatory disease, adenomyosis, intrauterine polyps and fibroids. The presence of an intrauterine contraceptive device (IUCD) is a potential iatrogenic cause. Less common causes include congenital uterine abnormalities, cervical stenosis, and an ovarian pathology.
content by BMJ Group
Last updated

Library

  • Multiple polyps are identified on hysteroscopic examination of the uterine cavity in this patient wi

    Multiple polyps are identified on hysteroscopic examination of the uterine cavity in this patient with persistent vaginal spotting

  • Hysteroscopic image of a large pedunculated submucous uterine fibroid

    Hysteroscopic image of a large pedunculated submucous uterine fibroid

  • Laparoscopic image of endometriotic nodule

    Laparoscopic image of endometriotic nodule

  • Laparoscopic image of ovarian endometrioma

    Laparoscopic image of ovarian endometrioma

Citations

    Key Articles

    • Burnett M. Guideline no. 345: primary dysmenorrhea. J Obstet Gynaecol Can. 2025 May;47(5):102840.[Abstract]

    • ACOG Committee Opinion No. 760 Summary: Dysmenorrhea and Endometriosis in the Adolescent. Obstet Gynecol. 2018 Dec (Re-affirmed 2021);132(6):1517-8. [Abstract][Full Text]

    • Kho KA, Shields JK. Diagnosis and management of primary dysmenorrhea. JAMA. 2020 Jan 21;323(3):268-9.[Abstract]

    Referenced Articles

    • 1. Fernández-Martínez E, Onieva-Zafra MD, Parra-Fernández ML. The impact of dysmenorrhea on quality of life among Spanish female university students. Int J Environ Res Public Health. 2019 Feb 27;16(5):713.[Abstract][Full Text]

    • 2. Iacovides S, Avidon I, Bentley A, et al. Reduced quality of life when experiencing menstrual pain in women with primary dysmenorrhea. Acta Obstet Gynecol Scand. 2014 Feb;93(2):213-7.[Abstract][Full Text]

    • 3. Al-Jefout M, Seham AF, Jameel H, et al. Dysmenorrhea: prevalence and impact on quality of life among young adult Jordanian females. J Pediatr Adolesc Gynecol. 2015 Jun;28(3):173-85.[Abstract]

    • 4. Iacovides S, Avidon I, Baker FC. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update. 2015;21:762-78.[Abstract]

    • 5. Proctor M, Farquhar C. Diagnosis and management of dysmenorrhoea. BMJ. 2006;332:1134-1138.[Abstract]

    • 6. Burnett M. Guideline no. 345: primary dysmenorrhea. J Obstet Gynaecol Can. 2025 May;47(5):102840.[Abstract]

    • 7. Ju H, Jones M, Mishra G. The prevalence and risk factors of dysmenorrhea. Epidemiol Rev. 2014;36:104-13.[Abstract][Full Text]

    • 8. Latthe P, Latthe M, Say L, et al. WHO systematic review of prevalence of chronic pelvic pain: a neglected reproductive health morbidity. BMC Public Health. 2006 Jul 6;6:177.[Abstract][Full Text]

    • 9. Harlow SD, Ephross SA. Epidemiology of menstruation and its relevance to women's health. Epidemiol Rev. 1995;17(2):265-86.[Abstract]

    • 10. Kennedy S. Primary dysmenorrhoea. Lancet. 1997 Apr 19;349(9059):1116.[Abstract]

    • 11. Parker MA, Sneddon AE, Arbon P. The menstrual disorder of teenagers (MDOT) study: determining typical menstrual patterns and menstrual disturbance in a large population-based study of Australian teenagers. BJOG. 2010 Jan;117(2):185-92.[Abstract][Full Text]

    • 12. Burnett MA, Antao V, Black A, et al. Prevalence of primary dysmenorrhea in Canada. J Obstet Gynaecol Can. 2005;27:765-770.[Abstract]

    • 13. Harlow SD, Park M. A longitudinal study of risk factors for the occurrence, duration and severity of menstrual cramps in a cohort of college women. Br J Obstet Gynaecol. 1996;103:1134-42.[Abstract]

    • 14. Sundell G, Milsom I, Andersch B. Factors influencing the prevalence and severity of dysmenorrhoea in young women. Br J Obstet Gynaecol. 1990;97:588-594.[Abstract]

    • 15. Chen CX, Draucker CB, Carpenter JS. What women say about their dysmenorrhea: a qualitative thematic analysis. BMC Womens Health. 2018 Mar 2;18(1):47.[Abstract][Full Text]

    • 16. Gray TG, Moores KL, James E, et al. Development and initial validation of an electronic personal assessment questionnaire for menstrual, pelvic pain and gynaecological hormonal disorders (ePAQ-MPH). Eur J Obstet Gynecol Reprod Biol. 2019 Jul;238:148-156.[Abstract]

    • 17. ACOG Committee Opinion No. 760 Summary: Dysmenorrhea and Endometriosis in the Adolescent. Obstet Gynecol. 2018 Dec (Re-affirmed 2021);132(6):1517-8. [Abstract][Full Text]

    • 18. Hirsch M, Dhillon-Smith R, Cutner AS, et al. The prevalence of endometriosis in adolescents with pelvic pain: a systematic review. J Pediatr Adolesc Gynecol. 2020 Dec;33(6):623-30.[Abstract][Full Text]

    • 19. Dawood MY. Dysmenorrhea. Clin Obstet Gynecol. 1990;33:168-178.[Abstract]

    • 20. Lumsden MA, Baird DT. Intra-uterine pressure in dysmenorrhea. Acta Obstet Gynecol Scand. 1985;64:183-186.[Abstract]

    • 21. Altunyurt S, Göl M, Altunyurt S, et al. Primary dysmenorrhea and uterine blood flow: a color Doppler study. J Reprod Med. 2005;50:251-255.[Abstract]

    • 22. Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol. 2006;108:428-441.[Abstract]

    • 23. Lumsden MA, Kelly RW, Baird DT. Primary dysmenorrhoea: the importance of both prostaglandin E2 and F2 alpha. Br J Obstet Gynaecol. 1983;90:1135-1140.[Abstract]

    • 24. Chan WY, Dawood MY, Fuchs F. Relief of dysmenorrhea with the prostaglandin synthetase inhibitor ibuprofen: effect on prostaglandin levels in menstrual fluid. Am J Obstet Gynecol. 1979;135:102-108.[Abstract]

    • 25. Eden JA. Dysmenorrhea and premenstrual syndrome. In: Hacker NF, Moore JG, eds. Essentials of obstetrics and gynecology. 3rd edition. Philadelphia: WB Saunders; 1998.

    • 26. Hedenberg-Magnusson B, Ernberg M, Alstergren P, et al. Pain mediation by prostaglandin E2 and leukotriene B4 in the human masseter muscle. Acta Ondontol Scand. 2001;59:348-355.[Abstract]

    • 27. Akerlund M, Stromberg P, Forsling ML. Primary dysmenorrhoea and vasopressin. Br J Obstet Gynaecol. 1979;86:484-487.[Abstract]

    • 28. Liedman R, Hansson SR, Howe D, et al. Endometrial expression of vasopressin, oxytocin and their receptors in patients with primary dysmenorrhoea and healthy volunteers at ovulation. Eur J Obstet Gynecol Reprod Biol. 2008;137:189-192.[Abstract]

    • 29. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 110: noncontraceptive uses of hormonal contraceptives. Obstet Gynecol. 2010;115:206-218.[Abstract]

    • 30. Wong CL, Farquhar C, Roberts H, et al. Oral contraceptive pill for primary dysmenorrhoea. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD002120.[Abstract][Full Text]

    • 31. Marjoribanks J, Ayeleke RO, Farquhar C, et al. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev. 2015 Jul 30;(7):CD001751.[Abstract][Full Text]

    • 32. Low I, Wei SY, Lee PS, et al. Neuroimaging Studies of Primary Dysmenorrhea. Adv Exp Med Biol. 2018;1099:179-99.[Abstract]

    • 33. Wu MH, Shoji Y, Chuang PC, et al. Endometriosis: disease pathophysiology and the role of prostaglandins. Expert Rev Mol Med. 2007;9:1-20.[Abstract]

    • 34. Nelson AL, Massoudi N. New developments in intrauterine device use: focus on the US. Open Access J Contracept. 2016;7:127-141.[Abstract][Full Text]

    • 35. Imai A, Matsunami K, Takagi H, et al. Levonorgestrel-releasing intrauterine device used for dysmenorrhea: five-year literature review. Clin Exp Obstet Gynecol. 2014;41(5):495-8.[Abstract]

    • 36. National Institute for Health and Care Excellence. Ectopic pregnancy and miscarriage: diagnosis and initial management. Aug 2023 [internet publication].[Full Text]

    • 37. Andersen BR, Kallehave FL, Andersen HK. Antibiotics versus placebo for prevention of postoperative infection after appendicectomy. Cochrane Database Syst Rev. 2005 Jul 20;(3):CD001439.[Abstract][Full Text]

    • 38. Harel Z. Dysmenorrhea in adolescents and young adults: from pathophysiology to pharmacological treatments and management strategies. Expert Opin Pharmacother. 2008;9:2661-72.[Abstract]

    • 39. Fothergill DJ. Common menstrual problems in adolescence. Arch Dis Child Educ Pract Ed. 2010;95:199-203.[Abstract]

    • 40. Kho KA, Shields JK. Diagnosis and management of primary dysmenorrhea. JAMA. 2020 Jan 21;323(3):268-9.[Abstract]

    • 41. Saad Amer. Endometriosis. Obstetrics, Gynaecology and Reproductive Medicine. 2008;18:126-133.

    • 42. Bettendorf B, Shay S, Tu F. Dysmenorrhea: contemporary perspectives. Obstet Gynecol Surv. 2008;63:597-603.[Abstract]

    • 43. Latthe P, Mignini L, Gray R, et al. Factors predisposing women to chronic pelvic pain: systematic review. BMJ. 2006;332:749-755.[Abstract][Full Text]

    • 44. Chapron C, Dubuisson JB, Pansini V, et al. Routine clinical examination is not sufficient for diagnosing and locating deeply infiltrating endometriosis. J Am Assoc Gynecol Laparosc. 2002;9:115-119.[Abstract]

    • 45. Durain D. Primary dysmenorrhea: assessment and management update. J Midwifery Womens Health. 2004;49:520-528.[Abstract]

    • 46. British Association for Sexual Health and HIV (BASHH). United Kingdom National Guideline for the Management of Pelvic Inflammatory Disease. 2019 [internet publication].[Full Text]

    • 47. Howard FM. The role of laparoscopy as a diagnostic tool in chronic pelvic pain. Baillieres Best Pract Res Clin Obstet Gynaecol. 2000;14:467-94.[Abstract]

    • 48. Goller JL, De Livera AM, Fairley CK, et al. Population attributable fraction of pelvic inflammatory disease associated with chlamydia and gonorrhoea: a cross-sectional analysis of Australian sexual health clinic data. Sex Transm Infect. 2016 Nov;92(7):525-31.[Abstract][Full Text]

    • 49. Price MJ, Ades AE, Welton NJ, et al. Proportion of pelvic inflammatory disease cases caused by Chlamydia trachomatis: consistent picture from different methods. J Infect Dis. 2016 Aug 15;214(4):617-24.[Abstract][Full Text]

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