Highlights & Basics
- Epistaxis (nosebleed) is a common condition with a bimodal age distribution, occurring more frequently in the young and the old.
- 90% arise at Little's area of the anterior septum, the location of the Kiesselbach plexus.
- Precipitating factors include dry weather and other causes of nasal mucosal inflammation or hyperemia, such as allergy, viral rhinitis, bacterial rhinosinusitis, dust, or chemicals. Although rare, neoplasm may also cause nosebleed.
- Topical anesthesia and vasoconstriction are essential for initial treatment of active bleeding. If initial measures fail, almost all episodes may be controlled with anterior or anterior-posterior packing techniques.
- Bleeding may be refractory in the presence of coagulopathy.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Nasal vasculature demonstrating the vessels that form the Kiesselbach plexus
Nasal pledgets for application of decongestant and local anesthetic
Expanding nasal sponge tampons
Expanding nasal sponge pack in place
Deflated and inflated double-balloon nasal catheter
Double-balloon nasal catheter in place
Anterior-posterior traditional Foley catheter-gauze pack
Diagram of bleeding sites in nose to accompany written patient information
Citations
Tan L, Calhoun K. Epistaxis. Med Clin North Am. 1999 Jan;83(1):43-56.[Abstract]
Perretta L, Denslow B, Brown C. Emergency evaluation and management of epistaxis. Emerg Med Clin North Am. 1987 May;5(2):265-77.[Abstract]
Santos P, Lepore M. Epistaxis. In: Bailey B, Healy G, Johnson J, et al., eds. Head & neck surgery-otolaryngology. Philadelphia: Lippincott, Williams & Wilkins; 2001:415-28.
Massick D, Tobin E. Epistaxis. In: Cummings C, Flint P, Harker L, et al., eds. Otolaryngology-head and neck surgery. Philadelphia: Elsevier Mosby; 2005:942-61.
Santos P, Lepore M. Epistaxis. In: Bailey B, Healy G, Johnson J, et al., eds. Head & neck surgery-otolaryngology. Philadelphia: Lippincott, Williams & Wilkins; 2001:415-428.
Massick D, Tobin E. Epistaxis. In: Cummings C, Flint P, Harker L, et al., eds. Otolaryngology-head and neck surgery. Philadelphia: Elsevier Mosby; 2005:942-961.
Tunkel DE, Anne S, Payne SC, et al. Clinical practice guideline: nosebleed (epistaxis). Otolaryngol Head Neck Surg. 2020 Jan;162(1 suppl):S1-S38.[Abstract][Full Text]
Pond F, Sizeland A. Epistaxis: strategies for management. Aust Fam Physician. 2000 Oct;29(10):933-8.[Abstract]
Randall DA. Epistaxis packing. Practical pointers for nosebleed control. Postgrad Med. 2006 Jun-Jul;119(1):77-82.[Abstract]
Ruddy J, Proops DW, Pearman K, et al. Management of epistaxis in children. Int J Paediatr Otorhinolaryngol. 1991 Apr;21(2):139-42.[Abstract]
1. Tan L, Calhoun K. Epistaxis. Med Clin North Am. 1999 Jan;83(1):43-56.[Abstract]
2. Perretta L, Denslow B, Brown C. Emergency evaluation and management of epistaxis. Emerg Med Clin North Am. 1987 May;5(2):265-77.[Abstract]
3. Santos P, Lepore M. Epistaxis. In: Bailey B, Healy G, Johnson J, et al., eds. Head & neck surgery-otolaryngology. Philadelphia: Lippincott, Williams & Wilkins; 2001:415-28.
4. Massick D, Tobin E. Epistaxis. In: Cummings C, Flint P, Harker L, et al., eds. Otolaryngology-head and neck surgery. Philadelphia: Elsevier Mosby; 2005:942-61.
5. Santos P, Lepore M. Epistaxis. In: Bailey B, Healy G, Johnson J, et al., eds. Head & neck surgery-otolaryngology. Philadelphia: Lippincott, Williams & Wilkins; 2001:415-428.
6. Massick D, Tobin E. Epistaxis. In: Cummings C, Flint P, Harker L, et al., eds. Otolaryngology-head and neck surgery. Philadelphia: Elsevier Mosby; 2005:942-961.
7. Yau S. An update on epistaxis. Aust Fam Physician. 2015 Sep;44(9):653-6.[Abstract][Full Text]
8. Tunkel DE, Anne S, Payne SC, et al. Clinical practice guideline: nosebleed (epistaxis). Otolaryngol Head Neck Surg. 2020 Jan;162(1 suppl):S1-S38.[Abstract][Full Text]
9. Viehweg TL, Roberson JB, Hudson JW. Epistaxis: diagnosis and treatment. J Oral Maxillofac Surg. 2006 Mar;64(3):511-8.[Abstract]
10. Pond F, Sizeland A. Epistaxis: strategies for management. Aust Fam Physician. 2000 Oct;29(10):933-8.[Abstract]
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13. Viducich R, Blanda MP, Gerson LW. Posterior epistaxis: clinical features and acute complications. Ann Emerg Med. 1995 May;25(5):592-6.[Abstract]
14. Herkner H, Havel C, Müllner M, et al. Active epistaxis at ED presentation is associated with arterial hypertension. Am J Emerg Med. 2002 Mar;20(2):92-5.[Abstract]
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16. Byun H, Chung JH, Lee SH, et al. Association of hypertension with the risk and severity of epistaxis. JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;147(1):1-7.[Abstract]
17. Sanders YV, Fijnvandraat K, Boender J, et al. Bleeding spectrum in children with moderate or severe von Willebrand disease: relevance of pediatric-specific bleeding. Am J Hematol. 2015 Dec;90(12):1142-8.[Abstract][Full Text]
18. Soyka MB, Rufibach K, Huber A, et al. Is severe epistaxis associated with acetylsalicylic acid intake? Laryngoscope. 2010 Jan;120(1):200-7.[Abstract][Full Text]
19. Reibez EE, Bryan DJ, Ehrlichman RJ, et al. Surgical management of life threatening epistaxis in Osler-Weber-Rendu disease. Ann Plast Surg. 1995 Aug;35(2):208-13.[Abstract]
20. Lund VJ, Howard DJ. A treatment algorithm for the management of epistaxis in hereditary hemorrhagic telangiectasias. Am J Rhinol. 1999 Jul-Aug;13(4):319-22.[Abstract]
21. Javed F, Golagani A, Sharp H, et al. Potential effects of herbal medicines and nutritional supplements on coagulation in ENT practice. J Laryngol Otol. 2008 Feb;122(2):116-9.[Abstract]
22. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38.[Abstract]
23. Bequignon E, Vérillaud B, Robard L, et al. Guidelines of the French Society of Otorhinolaryngology (SFORL). First-line treatment of epistaxis in adults. Eur Ann Otorhinolaryngol Head Neck Dis. 2017 May;134(3):185-9.[Abstract][Full Text]
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26. Biggs TC, Nightingale K, Patel NN, et al. Should prophylactic antibiotics be used routinely in epistaxis patients with nasal packs? Ann R Coll Surg Engl. 2013 Jan;95(1):40-2.[Abstract][Full Text]
27. Randall DA. Epistaxis packing. Practical pointers for nosebleed control. Postgrad Med. 2006 Jun-Jul;119(1):77-82.[Abstract]
28. National ENT Trainee Research Network. The British Rhinological Society multidisciplinary consensus recommendations on the hospital management of epistaxis. J Laryngol Otol. 2017 Dec;131(12):1142-56.[Abstract]
29. Barr G. Silver nitrate cautery and epistaxis. Arch Emerg Med. 1989 Sep;6(3):233.[Abstract][Full Text]
30. Upile T, Jerjes W, Sipaul F, et al. A change in UK epistaxis management. Eur Arch Otorhinolaryngol. 2008 Nov;265(11):1349-54.[Abstract]
31. Morganstein S. Surgical management of epistaxis. Arch Otolaryngol Head Neck Surg. 1987 Dec;113(12):1338.[Abstract]
32. Moshaver A, Harris JR, Liu R, et al. Early operative intervention versus conventional treatment in epistaxis: randomized prospective trial. J Otolaryngol. 2004 Jun;33(3):185-8.[Abstract]
33. Durr DG. Endoscopic electrosurgical management of posterior epistaxis: shifting paradigm. J Otolaryngol. 2004 Aug;33(4):211-6.[Abstract]
34. Stankiewicz J. Nasal endoscopy and control of epistaxis. Curr Opin Otolaryngol Head Neck Surg. 2004 Feb;12(1):43-5.[Abstract]
35. Kumar S, Shetty A, Rockey J, et al. Contemporary surgical treatment of epistaxis: what is the evidence for sphenopalatine artery ligation? Clin Otolaryngol Allied Sci. 2003 Aug;28(4):360-3.[Abstract]
36. Strong E, Bell D, Johnson L, et al. Intractable epistaxis: transantral ligation vs embolization: efficacy review and cost analysis. Otolaryngol Head Neck Surg. 1995 Dec;113(6):674-8.[Abstract]
37. Christensen N, Smith D, Barnwell S, et al. Arterial embolization in the management of posterior epistaxis. Otolaryngol Head Neck Surg. 2005 Nov;133(5):748-53.[Abstract]
38. Leung RM, Smith TL, Rudmik L. Developing a laddered algorithm for the management of intractable epistaxis: a risk analysis. JAMA Otolaryngol Head Neck Surg. 2015 May 1;141(5):405-9.[Abstract][Full Text]
39. Douglas R, Wormald PJ. Update on epistaxis. Curr Opin Otolaryngol Head Neck Surg. 2007 Jun;15(3):180-3.[Abstract]
40. Scaramuzzi N, Walsh R, Brennan P, et al. Treatment of intractable epistaxis using arterial embolization. Clin Otolaryngol Allied Sci. 2001 Aug;26(4):307-9.[Abstract]
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46. Ruddy J, Proops DW, Pearman K, et al. Management of epistaxis in children. Int J Paediatr Otorhinolaryngol. 1991 Apr;21(2):139-42.[Abstract]
47. Zahed R, Moharamzadeh P, Alizadeharasi S, et al. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. Am J Emerg Med. 2013 Sep;31(9):1389-92.[Abstract]
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50. Royal Children's Hospital Melbourne. Clinical guideline: epistaxis. 2019 [internet publication].[Full Text]
Key Articles
Referenced Articles
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