Highlights & Basics
- Epistaxis (nosebleed) is a common condition with a bimodal age distribution, occurring more frequently in the young and the old.
- 90% arise at Little's area of the anterior septum, the location of the Kiesselbach plexus. The remainder are posterior bleeds, most commonly from terminal branches of the anterior and posterior ethmoid arteries or the sphenopalatine artery.
- Precipitating factors include dry weather and other causes of nasal mucosal inflammation or hyperemia, such as allergy, viral rhinitis, bacterial rhinosinusitis, intranasal drug use, dust, or chemicals. Although rare, neoplasm may also cause nosebleeds.
- Topical anesthesia and vasoconstriction are essential for initial treatment of active bleeding. If initial measures fail, almost all episodes may be controlled with anterior or anterior-posterior packing techniques.
- Bleeding may be refractory in the presence of coagulopathy.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images

Nasal pledgets for application of decongestant and local anesthetic

Expanding nasal sponge tampons

Expanding nasal sponge pack in place

Deflated and inflated double-balloon nasal catheter

Double-balloon nasal catheter in place

Anterior-posterior traditional Foley catheter-gauze pack

Diagram of bleeding sites in nose to accompany written patient information
Citations
Womack JP, Kropa J, Jimenez Stabile M. Epistaxis: outpatient management. Am Fam Physician. 2018 Aug 15;98(4):240-5.[Abstract][Full Text]
Tunkel DE, Anne S, Payne SC, et al. Clinical practice guideline: nosebleed (epistaxis). Otolaryngol Head Neck Surg. 2020 Jan;162(1 suppl):S1-38.[Abstract][Full Text]
Seikaly H. Epistaxis. N Engl J Med. 2021 Mar 11;384(10):944-51.
1. Santos P, Lepore M. Epistaxis. In: Bailey B, Healy G, Johnson J, et al., eds. Head & neck surgery-otolaryngology. Philadelphia: Lippincott, Williams & Wilkins; 2001:415-28.
2. Massick D, Tobin E. Epistaxis. In: Cummings C, Flint P, Harker L, et al., eds. Otolaryngology-head and neck surgery. Philadelphia: Elsevier Mosby; 2005:942-61.
3. Womack JP, Kropa J, Jimenez Stabile M. Epistaxis: outpatient management. Am Fam Physician. 2018 Aug 15;98(4):240-5.[Abstract][Full Text]
4. Yau S. An update on epistaxis. Aust Fam Physician. 2015 Sep;44(9):653-6.[Abstract][Full Text]
5. Tunkel DE, Anne S, Payne SC, et al. Clinical practice guideline: nosebleed (epistaxis). Otolaryngol Head Neck Surg. 2020 Jan;162(1 suppl):S1-38.[Abstract][Full Text]
6. Viehweg TL, Roberson JB, Hudson JW. Epistaxis: diagnosis and treatment. J Oral Maxillofac Surg. 2006 Mar;64(3):511-8.[Abstract]
7. Tan L, Calhoun K. Epistaxis. Med Clin North Am. 1999 Jan;83(1):43-56.[Abstract]
8. Perretta L, Denslow B, Brown C. Emergency evaluation and management of epistaxis. Emerg Med Clin North Am. 1987 May;5(2):265-77.[Abstract]
9. Pond F, Sizeland A. Epistaxis: strategies for management. Aust Fam Physician. 2000 Oct;29(10):933-8.[Abstract]
10. Seikaly H. Epistaxis. N Engl J Med. 2021 Mar 11;384(10):944-51.
11. Tawagi K, Akaraz-Avedissian R, Burman-Solovyeva I. Recurrent epistaxis leading to diagnosis of primary sinonasal melanoma. BMJ Case Rep. 2018 Feb 16;2018:bcr2017219832.[Abstract][Full Text]
12. Davis KR. Embolization of epistaxis and juvenile nasopharyngeal angiofibromas. AJR Am J Roentgenol. 1987 Jan;148(1):209-18.[Abstract][Full Text]
13. Pryor SG, Moore EJ, Kasperbauer JL. Endoscopic versus traditional approaches for excision of juvenile nasopharyngeal angiofibroma. Laryngoscope. 2005 Jul;115(7):1201-7.[Abstract]
14. Viducich R, Blanda MP, Gerson LW. Posterior epistaxis: clinical features and acute complications. Ann Emerg Med. 1995 May;25(5):592-6.[Abstract]
15. Herkner H, Havel C, Müllner M, et al. Active epistaxis at ED presentation is associated with arterial hypertension. Am J Emerg Med. 2002 Mar;20(2):92-5.[Abstract]
16. Min HJ, Kang H, Choi GJ, et al. Association between hypertension and epistaxis: systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2017 Dec;157(6):921-7.[Abstract]
17. Byun H, Chung JH, Lee SH, et al. Association of hypertension with the risk and severity of epistaxis. JAMA Otolaryngol Head Neck Surg. 2020 Sep 10;147(1):1-7.[Abstract]
18. Gregory I, Grewal A. Cochrane corner: Intranasal corticosteroids for non-allergic rhinitis. Clin Exp Allergy. 2022 Jul;52(7):836-8.[Full Text]
19. Sanders YV, Fijnvandraat K, Boender J, et al. Bleeding spectrum in children with moderate or severe von Willebrand disease: relevance of pediatric-specific bleeding. Am J Hematol. 2015 Dec;90(12):1142-8.[Abstract][Full Text]
20. Rosenberg T, Fialla AD, Kjeldsen J, et al. Does severe bleeding in HHT patients respond to intravenous bevacizumab? review of the literature and case series. Rhinology. 2019 Aug 1;57(4):242-51.[Abstract]
21. Soyka MB, Rufibach K, Huber A, et al. Is severe epistaxis associated with acetylsalicylic acid intake? Laryngoscope. 2010 Jan;120(1):200-7.[Abstract][Full Text]
22. Reibez EE, Bryan DJ, Ehrlichman RJ, et al. Surgical management of life threatening epistaxis in Osler-Weber-Rendu disease. Ann Plast Surg. 1995 Aug;35(2):208-13.[Abstract]
23. Lund VJ, Howard DJ. A treatment algorithm for the management of epistaxis in hereditary hemorrhagic telangiectasias. Am J Rhinol. 1999 Jul-Aug;13(4):319-22.[Abstract]
24. Potentas-Policewicz M, Fijolek J. Granulomatosis with polyangiitis: clinical characteristics and updates in diagnosis. Front Med (Lausanne). 2024;11:1369233.[Abstract][Full Text]
25. Cereceda-Monteoliva N, Rouhani MJ, Maughan EF, et al. Sarcoidosis of the ear, nose and throat: a review of the literature. Clin Otolaryngol. 2021 Sep;46(5):935-40.[Abstract][Full Text]
26. Javed F, Golagani A, Sharp H, et al. Potential effects of herbal medicines and nutritional supplements on coagulation in ENT practice. J Laryngol Otol. 2008 Feb;122(2):116-9.[Abstract]
27. Kucik CJ, Clenney T. Management of epistaxis. Am Fam Physician. 2005 Jan 15;71(2):305-11.[Abstract][Full Text]
28. Neutze D, Roque J. Clinical evaluation of bleeding and bruising in primary care. Am Fam Physician. 2016 Feb 15;93(4):279-86.[Abstract][Full Text]
29. American College of Radiology. ACR appropriateness criteria: imaging of facial trauma following primary survey. 2021 [internet publication].[Full Text]
30. Reyre A, Michel J, Santini L, et al. Epistaxis: The role of arterial embolization. Diagn Interv Imaging. 2015 Jul-Aug;96(7-8):757-73.[Abstract][Full Text]
31. Simundic AM, Bölenius K, Cadamuro J, et al. Joint EFLM-COLABIOCLI recommendation for venous blood sampling. Clin Chem Lab Med. 2018;56(12):2015-38.[Abstract]
32. ENT UK. Nose bleed (epistaxis) - Global ENT guideline. Mar 2023 [internet publication].[Full Text]
33. Birmingham AR, Mah ND, Ran R, et al. Topical tranexamic acid for the treatment of acute epistaxis in the emergency department. Am J Emerg Med. 2018 Jul;36(7):1242-5.[Abstract]
34. Whitworth K, Johnson J, Wisniewski S, et al. Comparative effectiveness of topically administered tranexamic acid versus topical oxymetazoline spray for achieving hemostasis in epistaxis. J Emerg Med. 2020 Feb;58(2):211-6.[Abstract]
35. Janapala RN, Tran QK, Patel J, et al. Efficacy of topical tranexamic acid in epistaxis: a systematic review and meta-analysis. Am J Emerg Med. 2022 Jan;51:169-75.[Abstract]
36. Hosseinialhashemi M, Jahangiri R, Faramarzi A, et al. Intranasal topical application of tranexamic acid in atraumatic anterior epistaxis: a double-blind randomized clinical trial. Ann Emerg Med. 2022 Sep;80(3):182-8.[Abstract][Full Text]
37. Bridwell RE, April MD, Long B. Does oral or topical tranexamic acid control bleeding from epistaxis? Ann Emerg Med. 2019 Aug;74(2):300-2.[Abstract][Full Text]
38. Bequignon E, Vérillaud B, Robard L, et al. Guidelines of the French Society of Otorhinolaryngology (SFORL). First-line treatment of epistaxis in adults. Eur Ann Otorhinolaryngol Head Neck Dis. 2017 May;134(3):185-9.[Abstract][Full Text]
39. Richardson C, Abrol A, Cabrera CI, et al. The power of a checklist: decrease in emergency department epistaxis transfers after clinical care pathway implementation. Am J Otolaryngol. 2021 Jul-Aug;42(4):102941.[Abstract]
40. Milinis K, Swords C, Hardman JC, et al. Dissolvable intranasal haemostatic agents for acute epistaxis: a systematic review and meta-analysis. Clin Otolaryngol. 2021 May;46(3):485-93.[Abstract]
41. Dehn R, Asprey D. Essential clinical procedures. 4th ed. Chapter 10: Epistaxis and nasal foreign body removal. Philadelphia, PA: Elsevier Saunders.
42. Kucik CJ, Clenney T. Management of epistaxis. Am Fam Physician. 2005;71(2):305-11.[Abstract][Full Text]
43. Biggs TC, Nightingale K, Patel NN, et al. Should prophylactic antibiotics be used routinely in epistaxis patients with nasal packs? Ann R Coll Surg Engl. 2013 Jan;95(1):40-2.[Abstract][Full Text]
44. Randall DA. Epistaxis packing. Practical pointers for nosebleed control. Postgrad Med. 2006 Jun-Jul;119(1):77-82.[Abstract]
45. National ENT Trainee Research Network. The British Rhinological Society multidisciplinary consensus recommendations on the hospital management of epistaxis. J Laryngol Otol. 2017 Dec;131(12):1142-56.[Abstract]
46. Beck R, Sorge M, Schneider A, et al. Current approaches to epistaxis treatment in primary and secondary care. Dtsch Arztebl Int. 2018 Jan 8;115(1-02):12-22.[Abstract][Full Text]
47. Barr G. Silver nitrate cautery and epistaxis. Arch Emerg Med. 1989 Sep;6(3):233.[Abstract][Full Text]
48. Upile T, Jerjes W, Sipaul F, et al. A change in UK epistaxis management. Eur Arch Otorhinolaryngol. 2008 Nov;265(11):1349-54.[Abstract]
49. Tran QK, Barnett J, O'Connell F, et al. Nasal packing in the emergency department: a practical review for emergency providers. Open Access Emerg Med. 2021;13:527-33.[Abstract][Full Text]
50. Anon JB, Jacobs MR, Poole MD, et al. Antimicrobial treatment guidelines for acute bacterial rhinosinusitis. Otolaryngol Head Neck Surg. 2004 Jan;130(1 suppl):1-45.[Abstract][Full Text]
51. Kemppainen T, Kokki H, Tuomilehto H, et al. Acetaminophen is highly effective in pain treatment after endoscopic sinus surgery. Laryngoscope. 2006 Dec;116(12):2125-8.[Abstract]
52. Morganstein S. Surgical management of epistaxis. Arch Otolaryngol Head Neck Surg. 1987 Dec;113(12):1338.[Abstract]
53. Moshaver A, Harris JR, Liu R, et al. Early operative intervention versus conventional treatment in epistaxis: randomized prospective trial. J Otolaryngol. 2004 Jun;33(3):185-8.[Abstract]
54. Durr DG. Endoscopic electrosurgical management of posterior epistaxis: shifting paradigm. J Otolaryngol. 2004 Aug;33(4):211-6.[Abstract]
55. Stankiewicz J. Nasal endoscopy and control of epistaxis. Curr Opin Otolaryngol Head Neck Surg. 2004 Feb;12(1):43-5.[Abstract]
56. Kumar S, Shetty A, Rockey J, et al. Contemporary surgical treatment of epistaxis: what is the evidence for sphenopalatine artery ligation? Clin Otolaryngol Allied Sci. 2003 Aug;28(4):360-3.[Abstract]
57. Strong E, Bell D, Johnson L, et al. Intractable epistaxis: transantral ligation vs embolization: efficacy review and cost analysis. Otolaryngol Head Neck Surg. 1995 Dec;113(6):674-8.[Abstract]
58. Christensen N, Smith D, Barnwell S, et al. Arterial embolization in the management of posterior epistaxis. Otolaryngol Head Neck Surg. 2005 Nov;133(5):748-53.[Abstract]
59. Leung RM, Smith TL, Rudmik L. Developing a laddered algorithm for the management of intractable epistaxis: a risk analysis. JAMA Otolaryngol Head Neck Surg. 2015 May 1;141(5):405-9.[Abstract][Full Text]
60. Douglas R, Wormald PJ. Update on epistaxis. Curr Opin Otolaryngol Head Neck Surg. 2007 Jun;15(3):180-3.[Abstract]
61. Scaramuzzi N, Walsh R, Brennan P, et al. Treatment of intractable epistaxis using arterial embolization. Clin Otolaryngol Allied Sci. 2001 Aug;26(4):307-9.[Abstract]
62. Webster J, Osborne S, Rickard CM, et al. Clinically-indicated replacement versus routine replacement of peripheral venous catheters. Cochrane Database Syst Rev. 2019 Jan 23;(1):CD007798.[Abstract][Full Text]
63. Qureishi A, Burton MJ. Interventions for recurrent idiopathic epistaxis (nosebleeds) in children. Cochrane Database Syst Rev. 2012 Sep 12;(9):CD004461.[Abstract][Full Text]
64. Loughran S, Spinou E, Clement E, et al. A prospective, single blind, randomised controlled trial of petroleum jelly/Vaseline for recurrent paediatric epistaxis. Clin Otolaryngol Allied Sci. 2004 Jun;29(3):266-9.[Abstract]
65. Calder N, Kang S, Fraser L, et al. A double-blind randomized controlled trial of management of recurrent nosebleeds in children. Otolaryngol Head Neck Surg. 2009 May;140(5):670-4.[Abstract]
66. Zohar Y, Straus M. Epistaxis due to hereditary hemorrhagic telangiectasia. Laryngoscope. 1995 Apr;105(4 Pt 1):445-6.[Abstract]
67. Ruddy J, Proops DW, Pearman K, et al. Management of epistaxis in children. Int J Paediatr Otorhinolaryngol. 1991 Apr;21(2):139-42.[Abstract]
68. Al-Samkari H, Kasthuri RS, Iyer VN, et al. Pomalidomide for epistaxis in hereditary hemorrhagic telangiectasia. N Engl J Med. 2024 Sep 19;391(11):1015-27.[Abstract][Full Text]
69. Royal Children's Hospital Melbourne. Clinical guideline: epistaxis. 2019 [internet publication].[Full Text]
70. ENT UK. Guideline for management of idiopathic epistaxis in adults. Mar 2019 [internet publication].[Full Text]
71. International HHT Guidelines. Epistaxis (nosebleed) management [internet publication].[Full Text]
