Highlights & Basics
- A benign skin disease which often reflects underlying medical conditions.
- Most commonly associated with obesity and insulin resistance.
- Some cases are associated with underlying malignancy and, where no other association is identified, malignancy is investigated by complete history and examination with relevant diagnostic tests.
- Treatment of lesions is often not necessary unless they are extensive or cosmetically unacceptable and do not resolve with treatment of the underlying condition.
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Definition
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Citations
Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol. 1994 Jul;31(1):1-19.[Abstract]
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40. Blobstein SH. Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity. Cutis. 2003 Jan;71(1):33-4.[Abstract]
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42. Dai WS, LaBraico JM, Stern RS. Epidemiology of isotretinoin exposure during pregnancy. J Am Acad Dermatol. 1992 Apr;26(4):599-606.[Abstract]
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48. US Food and Drug Administration. FDA drug safety communication: FDA revises warnings regarding use of the diabetes medicine metformin in certain patients with reduced kidney function. April 2016 [internet publication].[Full Text]
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