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Diseases

Cerebral aneurysm

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Cerebral aneurysms are typically asymptomatic until ruptured, resulting in a subarachnoid hemorrhage.

  • Head CT usually confirms the diagnosis of subarachnoid hemorrhage if performed within 6 hours of symptom onset, but lumbar puncture is indicated if the CT is negative after 6 hours and suspicion persists. 

  • Cerebral angiogram is the definitive investigation. CT angiography or magnetic resonance angiography may also be used.

  • Definitive treatment aims to obliterate the aneurysm from the cerebral circulation. Options include microsurgical clipping or endovascular techniques.

  • Screening with noninvasive neuroangiography is recommended for at-risk populations.

Cerebral angiogram showing aneurysm
Cerebral angiogram showing aneurysm
From the personal collection of Dr M. Chen, Columbia College of Physicians and Surgeons

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Cerebral angiogram showing aneurysm

            Cerebral angiogram showing aneurysm

          • Comparison of 2-dimensional catheter angiography (left) with 3-dimensional catheter angiography (rig

            Comparison of 2-dimensional catheter angiography (left) with 3-dimensional catheter angiography (right) showing a basilar tip aneurysm

          • Three-dimensional catheter angiogram showing a basilar tip aneurysm

            Three-dimensional catheter angiogram showing a basilar tip aneurysm

          • Example of a coil used to treat cerebral aneurysms

            Example of a coil used to treat cerebral aneurysms

          • Progressive angiography images of a small dissecting aneurysm of the distal basilar artery after a s

            Progressive angiography images of a small dissecting aneurysm of the distal basilar artery after a subarachnoid and intraventricular hemorrhage on day 3 (A), day 23 (B), and day 30 (C), and 6 months after stent-assisted coiling (D). Arrows indicate proximal and distal stent markers

          Citations

            Key Articles

            • Thompson BG, Brown RD Jr, Amin-Hanjani S, et al. Guidelines for the management of patients with unruptured intracranial aneurysms: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015 Aug;46(8):2368-400.[Abstract][Full Text]

            • Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 Guideline for the management of patients with aneurysmal subarachnoid hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2023 Jul;54(7):e314-70.[Abstract][Full Text]

            • Expert Panel on Neurological Imaging., Ledbetter LN, Burns J, et al. ACR Appropriateness Criteria® Cerebrovascular diseases - aneurysm, vascular malformation, and subarachnoid hemorrhage. J Am Coll Radiol. 2021 Nov;18(11s):S283-S304.[Abstract][Full Text]

            • Etminan N, de Sousa DA, Tiseo C, et al. European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms. Eur Stroke J. 2022 Sep;7(3):V.[Abstract][Full Text]

            Referenced Articles

            • 1. Chen M, Caplan L. Intracranial dissections. Front Neurol Neurosci. 2005;20:160-173.[Abstract]

            • 2. Wiebers DO, Whisnant JP, Huston J 3rd, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet. 2003;362:103-110.[Abstract]

            • 3. Korja M, Kaprio J. Controversies in epidemiology of intracranial aneurysms and SAH. Nat Rev Neurol. 2016 Jan;12(1):50-5.[Abstract]

            • 4. Atkinson JL, Sundt TM Jr, Houser OW, et al. Angiographic frequency of anterior circulation intracranial aneurysms. J Neurosurg. 1989 Apr;70(4):551-5.[Abstract]

            • 5. Vlak MH, Algra A, Brandenburg R, et al. Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol. 2011 Jul;10(7):626-36.[Abstract]

            • 6. Asaithambi G, Adil MM, Chaudhry SA, et al. Incidences of unruptured intracranial aneurysms and subarachnoid hemorrhage: results of a statewide study. J Vasc Interv Neurol. 2014 Sep;7(3):14-7.[Abstract][Full Text]

            • 7. Norrgard O, Angquist KA, Fodstad H, et al. Intracranial aneurysms and heredity. Neurosurgery. 1987 Feb;20(2):236-9.[Abstract]

            • 8. Schievink WI. Intracranial aneurysms. N Engl J Med. 1997 Jan 2;336(1):28-40.[Abstract]

            • 9. Petitti DB, Wingerd J. Use of oral contraceptives, cigarette smoking, and risk of subarachnoid haemorrhage. Lancet. 1978 Jul 29;2(8083):234-5.[Abstract]

            • 10. Bonita R. Cigarette smoking, hypertension and the risk of subarachnoid hemorrhage: a population-based case-control study. Stroke. 1986 Sep-Oct;17(5):831-5.[Abstract][Full Text]

            • 11. Knekt P, Reunanen A, Aho K, et al. Risk factors for subarachnoid hemorrhage in a longitudinal population study. J Clin Epidemiol. 1991;44(9):933-9.[Abstract]

            • 12. Juvela S, Hillbom M, Numminen H, et al. Cigarette smoking and alcohol consumption as risk factors for aneurysmal subarachnoid hemorrhage. Stroke. 1993 May;24(5):639-46.[Abstract][Full Text]

            • 13. Schievink WI, Katzmann JA, Piepgras DG, et al. Alpha-1-anti-trypsin phenotypes among patients with intracranial aneurysms. J Neurosurg. 1996;84:781-784.[Abstract]

            • 14. Krex D, Schackert HK, Schackert G. Genesis of cerebral aneurysms - an update. Acta Neurochir. 2001;143:429-448.[Abstract]

            • 15. Juvela S, Porras M, Poussa K. Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture. J Neurosurg. 2000 Sep;93(3):379-87.[Abstract]

            • 16. Wermer MJ, van der Schaaf IC, Velthuis BK, et al. Follow-up screening after subarachnoid haemorrhage: frequency and determinants of new aneurysms and enlargement of existing aneurysms. Brain. 2005 Oct;128(pt 10):2421-9.[Abstract][Full Text]

            • 17. McEvoy AW, Kitchen ND, Thomas DG. Intracerebral haemorrhage and drug abuse in young adults. Br J Neurosurg. 2000 Oct;14(5):449-54.[Abstract]

            • 18. Thompson BG, Brown RD Jr, Amin-Hanjani S, et al. Guidelines for the management of patients with unruptured intracranial aneurysms: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2015 Aug;46(8):2368-400.[Abstract][Full Text]

            • 19. Schievink WI, Karemaker JM, Hageman LM, et al. Circumstances surrounding aneurysmal subarachnoid hemorrhage. Surg Neurol. 1989 Oct;32(4):266-72.[Abstract]

            • 20. Hoh BL, Ko NU, Amin-Hanjani S, et al. 2023 Guideline for the management of patients with aneurysmal subarachnoid hemorrhage: a guideline from the American Heart Association/American Stroke Association. Stroke. 2023 Jul;54(7):e314-70.[Abstract][Full Text]

            • 21. National Institute for Health and Care Excellence. Subarachnoid haemorrhage caused by a ruptured aneurysm: diagnosis and management​. Nov 2022 [nternet publication].[Full Text]

            • 22. Leblanc R. The minor leak preceding subarachnoid hemorrhage. J Neurosurg. 1987 Jan;66(1):35-9.[Abstract]

            • 23. van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. Lancet. 2007 Jan 27;369(9558):306-18.[Abstract]

            • 24. Brisman JL, Song JK, Newell DW. Cerebral aneurysms. N Engl J Med. 2006 Aug 31;355(9):928-39.[Abstract]

            • 25. Perry JJ, Stiell IG, Sivilotti ML, et al. Sensitivity of computed tomography performed within six hours of onset of headache for diagnosis of subarachnoid haemorrhage: prospective cohort study. BMJ. 2011 Jul 18;343:d4277.[Abstract][Full Text]

            • 26. Edlow JA, Caplan LR. Avoiding pitfalls in the diagnosis of subarachnoid hemorrhage. N Engl J Med. 2000 Jan 6;342(1):29-36.[Abstract]

            • 27. Expert Panel on Neurological Imaging., Ledbetter LN, Burns J, et al. ACR Appropriateness Criteria® Cerebrovascular diseases - aneurysm, vascular malformation, and subarachnoid hemorrhage. J Am Coll Radiol. 2021 Nov;18(11s):S283-S304.[Abstract][Full Text]

            • 28. Menke J, Larsen J, Kallenberg K. Diagnosing cerebral aneurysms by computed tomographic angiography: meta-analysis. Ann Neurol. 2011 Apr;69(4):646-54.[Abstract]

            • 29. Sailer AM, Wagemans BA, Nelemans PJ, et al. Diagnosing intracranial aneurysms with MR angiography: systematic review and meta-analysis. Stroke. 2014 Jan;45(1):119-26.[Abstract][Full Text]

            • 30. Samaniego EA, Roa JA, Hasan D. Vessel wall imaging in intracranial aneurysms. J Neurointerv Surg. 2019 Nov;11(11):1105-12.[Abstract][Full Text]

            • 31. Texakalidis P, Hilditch CA, Lehman V, et al. Vessel wall imaging of intracranial aneurysms: systematic review and meta-analysis. World Neurosurg. 2018 Sep;117:453-8.e1.[Abstract]

            • 32. Molenberg R, Aalbers MW, Appelman APA, et al. Intracranial aneurysm wall enhancement as an indicator of instability: a systematic review and meta-analysis. Eur J Neurol. 2021 Nov;28(11):3837-48.[Abstract][Full Text]

            • 33. Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg. 1968;28:14-20.[Abstract]

            • 34. Ogungbo B. The World Federation of Neurological Surgeons scale for subarachnoid haemorrhage. Surg Neurol. 2003;59:236-237.[Abstract]

            • 35. Fisher CM, Kistler JP, Davis JM. Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery. 1980 Jan;6(1):1-9.[Abstract]

            • 36. Maeder PP, Meuli RA, de Tribolet N. Three-dimensional volume rendering for magnetic resonance angiography in the screening and preoperative workup of intracranial aneurysms. J Neurosurg. 1996 Dec;85(6):1050-5.[Abstract]

            • 37. Van Hoe W, van Loon J, Demeestere J, et al. Screening for intracranial aneurysms in individuals with a positive first-degree family history: a systematic review. World Neurosurg. 2021 Jul;151:235-48.e5.[Abstract]

            • 38. Rinne JK, Hernesniemi JA. De novo aneurysms: special multiple intracranial aneurysms. Neurosurgery. 1993 Dec;33(6):981-5.[Abstract]

            • 39. Etminan N, Brown RD Jr, Beseoglu K, et al. The unruptured intracranial aneurysm treatment score: a multidisciplinary consensus. Neurology. 2015 Sep 8;85(10):881-9.[Abstract][Full Text]

            • 40. Guglielmi G, Vinuela F, Sepetka I, et al. Electrothrombosis of saccular aneurysms via endovascular approach. Part 1: Electrochemical basis, technique, and experimental results. J Neurosurg. 1991 Jul;75(1):1-7.[Abstract]

            • 41. Kurre W, Berkefeld J. Materials and techniques for coiling of cerebral aneurysms: how much scientific evidence do we have? Neuroradiology. 2008 Nov;50(11):909-27.[Abstract]

            • 42. White PM, Lewis SC, Gholkar A, et al; HELPS trial collaborators. Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial. Lancet. 2011 May 14;377(9778):1655-62.[Abstract]

            • 43. Bodily KD, Cloft HJ, Lanzino G, et al. Stent-assisted coiling in acutely ruptured intracranial aneurysms: a qualitative, systematic review of the literature. AJNR Am J Neuroradiol. 2011 Aug;32(7):1232-6.[Abstract][Full Text]

            • 44. Etminan N, de Sousa DA, Tiseo C, et al. European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms. Eur Stroke J. 2022 Sep;7(3):V.[Abstract][Full Text]

            • 45. Pontes FGB, da Silva EM, Baptista-Silva JC, et al. Treatments for unruptured intracranial aneurysms. Cochrane Database Syst Rev. 2021 May 10;5:CD013312.[Abstract][Full Text]

            • 46. Jelen MB, Clarke RE, Jones B, et al. Psychological and functional impact of a small unruptured intracranial aneurysm diagnosis: a mixed‐methods evaluation of the patient journey. Stroke vasc. interv. neurol. 2022 Sep 26;3(1):e000531.[Full Text]

            • 47. Brinjikji W, Murad MH, Lanzino G, et al. Endovascular treatment of intracranial aneurysms with flow diverters: a meta-analysis. Stroke. 2013 Feb;44(2):442-7.[Abstract]

            • 48. Li YL, Roalfe A, Chu EY, et al. Outcome of flow diverters with surface modifications in treatment of cerebral aneurysms: systematic review and meta-analysis. AJNR Am J Neuroradiol. 2021 Jan;42(2):327-33.[Abstract][Full Text]

            • 49. Lee KB, Suh CH, Song Y, et al. Trends of expanding indications of woven EndoBridge devices for the treatment of intracranial aneurysms: a systematic review and meta-analysis. Clin Neuroradiol. 2023 Mar;33(1):227-35.[Abstract]

            • 50. Liebig T, Killer-Oberpfalzer M, Gal G, et al. The safety and effectiveness of the contour neurovascular system (contour) for the treatment of bifurcation aneurysms: the CERUS study. Neurosurgery. 2022 Mar 1;90(3):270-7.[Abstract][Full Text]

            • 51. Chen CJ, Dabhi N, Snyder MH, et al. Intrasaccular flow disruption for brain aneurysms: a systematic review of long-term outcomes. J Neurosurg. 2021 Dec 24;1-13.[Abstract][Full Text]

            • 52. Molyneux A, Kerr R, Stratton I, et al. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002 Oct 26;360(9342):1267-74.[Abstract]

            • 53. Molyneux AJ, Birks J, Clarke A, et al. The durability of endovascular coiling versus neurosurgical clipping of ruptured cerebral aneurysms: 18 year follow-up of the UK cohort of the International Subarachnoid Aneurysm Trial (ISAT). Lancet. 2015 Feb 21;385(9969):691-7. [Abstract][Full Text]

            • 54. Lindgren A, Vergouwen MD, van der Schaaf I, et al. Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev. 2018 Aug 15;8:CD003085.[Abstract][Full Text]

            • 55. Schaller B. Extracranial-intracranial bypass to reduce the risk of ischemic stroke in intracranial aneurysms of the anterior cerebral circulation: a systematic review. J Stroke Cerebrovasc Dis. 2008 Sep;17(5):287-98.[Abstract]

            • 56. Giorgianni A, Agosti E, Molinaro S, et al. Flow diversion for acutely ruptured intracranial aneurysms treatment: a retrospective study and literature review. J Stroke Cerebrovasc Dis. 2022 Mar;31(3):106284.[Abstract]

            • 57. Ten Brinck MFM, Jäger M, de Vries J, et al. Flow diversion treatment for acutely ruptured aneurysms. J Neurointerv Surg. 2020 Mar;12(3):283-8.[Abstract]

            • 58. Diestro JDB, Dibas M, Adeeb N, et al. Intrasaccular flow disruption for ruptured aneurysms: an international multicenter study. J Neurointerv Surg. 2022 Jul 22;neurintsurg-2022-019153. [Epub ahead of print].[Abstract]

            • 59. Diringer MN, Bleck TP, Claude Hemphill J 3rd, et al. Critical care management of patients following aneurysmal subarachnoid hemorrhage: recommendations from the Neurocritical Care Society's Multidisciplinary Consensus Conference. Neurocrit Care. 2011 Sep;15(2):211-40.[Abstract]

            • 60. Steiner T, Juvela S, Unterberg A, et al. European Stroke Organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis. 2013;35(2):93-112.[Abstract][Full Text]

            • 61. National Institute for Health and Care Excellence. Endovascular insertion of an intrasaccular wire-mesh blood-flow disruption device for intracranial aneurysms. Aug 2019 [internet publication].[Full Text]

            • 62. National Institute for Health and Care Excellence. Coil embolisation of ruptured intracranial aneurysms. Jan 2005 [internet publication].[Full Text]

            • 63. National Institute for Health and Care Excellence. Coil embolisation of unruptured intracranial aneurysms. Jan 2005 [internet publication].[Full Text]

            • 64. Ogilvy CS, Cheung AC, Mitha AP, et al. Outcomes for surgical and endovascular management of intracranial aneurysms using a comprehensive grading system. Neurosurgery. 2006;59:1037-1042.[Abstract]

            • 65. Schievink WI, Wijdicks EF, Parisi JE, et al. Sudden death from aneurysmal subarachnoid hemorrhage. Neurology. 1995 May;45(5):871-4.[Abstract]

            • 66. Sacco RL, Wolf PA, Bharucha NE, et al. Subarachnoid and intracerebral hemorrhage: natural history, prognosis, and precursive factors in the Framingham Study. Neurology. 1984 Jul;34(7):847-54.[Abstract]

            • 67. Findlay JM, Weir BK, Kanamaru K, et al. Arterial wall changes in cerebral vasospasm. Neurosurgery. 1989 Nov;25(5):736-45; discussion 745-6.[Abstract]

            • 68. Biller J, Godersky JC, Adams HP Jr. Management of aneurysmal subarachnoid hemorrhage. Stroke. 1988 Oct;19(10):1300-5.[Abstract][Full Text]

            • 69. Raymond J, Guilbert F, Weill A, et al. Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke. 2003 Jun;34(6):1398-403.[Abstract][Full Text]

            • 70. van Gijn J, Rinkel GJ. Subarachnoid haemorrhage: diagnosis, causes and management. Brain. 2001 Feb;124(Pt 2):249-78.[Abstract][Full Text]

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