Highlights & Basics
- Sudden onset of respiratory or cardiovascular compromise, usually with a history of allergen exposure in sensitized individuals.
- Skin rash, wheezing and inspiratory stridor, hypotension, anxiety, nausea, and vomiting are the cardinal signs and symptoms.
- The diagnosis is clinical. Allergy testing is helpful only for secondary prophylaxis.
- Securing the airway and initiating prompt treatment with epinephrine (adrenaline) may save lives.
- Comorbidities (e.g., coronary artery disease and COPD) may pose a treatment challenge and warrant expert consultation.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
Shaker MS, Wallace DV, Golden DBK, et al. Anaphylaxis - a 2020 practice parameter update, systematic review, and Grading of Recommendations, Assessment, Development and Evaluation (GRADE) analysis. J Allergy Clin Immunol. 2020 Apr;145(4):1082-123.[Abstract][Full Text]
Cardona V, Ansotegui IJ, Ebisawa M, et al. World allergy organization anaphylaxis guidance 2020. World Allergy Organ J. 2020 Oct 30;13(10):100472.[Abstract][Full Text]
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