Highlights & Basics
- Keloid is a form of abnormal scarring that occurs in susceptible individuals.
- More common in darker skin types.
- Diagnosis is clinical.
- Treatment options include injectable preparations, cryotherapy, as well as surgery and radiation therapy.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Images
Elevated, red, smooth, nodule of scar tissue; arose in the site of an acne lesion that had been squeezed
Red, elevated keloid; edges blend into the surrounding skin; arose in a vaccination site in the left upper arm
An extensive keloid has been previously excised and the defect skin grafted; keloid scarring has subsequently developed at the peripheries
The timelines for normal, hypertrophic, and keloid scar formation. Keloid scarring is different in that it does not mature (involute); expansion may occur but, in contrast to hypertrophic scarring, contraction does not occur either in the scar or in the surrounding tissue
Stable keloid due to ear piercing
A typical presternal keloid; presence of central bridging, an elevated rolled edge and flattened peripheral extensions
Keloid reaction following a vaccination in the deltoid region; following surgical excision the entire length of the scar developed a keloid-like appearance
A hypertrophic scar before excision to correct contraction deformity following a burn
Contraction deformity of little finger corrected by excision
Citations
Ogawa R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg. 2022 Jan 1;149(1):79e-94e.[Abstract][Full Text]
Ogawa R, Akita S, Akaishi S, et al. Diagnosis and treatment of keloids and hypertrophic scars - Japan Scar Workshop consensus document 2018. Burns Trauma. 2019;7:39.[Abstract]
Gold MH, Berman B, Clementoni MT, et al. Updated international clinical recommendations on scar management: part 1 - evaluating the evidence. Dermatol Surg. 2014 Aug;40(8):817-24.[Abstract]
Royal College of Radiologists. Recommendations for using radiotherapy for benign disease in the UK. 2023 [internet publication].[Full Text]
1. Ogawa R. Keloid and hypertrophic scars are the result of chronic inflammation in the reticular dermis. Int J Mol Sci. 2017 Mar 10;18(3):606.[Abstract][Full Text]
2. Limandjaja GC, Niessen FB, Scheper RJ, et al. The keloid disorder: heterogeneity, histopathology, mechanisms and models. Front Cell Dev Biol. 2020;8:360.[Abstract][Full Text]
3. Huang C, Wu Z, Du Y, Ogawa R. The epidemiology of keloids. In: Téot L, Mustoe TA, Middelkoop E, et al., eds. Textbook on scar management: state of the art management and emerging technologies [Internet]. Cham: Springer; 2020.[Abstract][Full Text]
4. Ung CY, Warwick A, Onoufriadis A, et al. Comorbidities of keloid and hypertrophic scars among participants in UK biobank. JAMA Dermatol. 2023 Feb 1;159(2):172-81.[Abstract][Full Text]
5. Tulandi T, Al-Sannan B, Akbar G, et al. Prospective study of intraabdominal adhesions among women of different races with or without keloids. Am J Obstet Gynecol. 2011 Feb;204(2):132.e1-4.[Abstract][Full Text]
6. Bayat A, Arscott G, Ollier WE, et al. Keloid disease: clinical relevance of single versus multiple site scars. Br J Plast Surg. 2005 Jan;58(1):28-37.[Abstract]
7. Ogawa R. Keloid and hypertrophic scarring may result from a mechanoreceptor or mechanosensitive nociceptor disorder. Med Hypotheses. 2008 Oct;71(4):493-500.[Abstract]
8. Akaishi S, Akimoto M, Ogawa R, et al. The relationship between keloid growth pattern and stretching tension: visual analysis using the finite element method. Ann Plast Surg. 2008 Apr;60(4):445-51.[Abstract]
9. Kiprono SK, Chaula BM, Masenga JE, et al. Epidemiology of keloids in normally pigmented Africans and African people with albinism: population-based cross-sectional survey. Br J Dermatol. 2015 Sep;173(3):852-4.[Abstract]
10. Nakashima M, Chung S, Takahashi A, et al. A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population. Nat Genet. 2010 Sep;42(9):768-71.[Abstract]
11. Marneros AG, Norris JE, Watanabe S, et al. Genome scans provide evidence for keloid susceptibility loci on chromosomes 2q23 and 7p11. J Invest Dermatol. 2004 May;122(5):1126-32.[Abstract][Full Text]
12. Chen Y, Gao JH, Yan X, et al. [Location of predisposing gene for one Han Chinese keloid pedigree]. [in chi]. Zhonghua Zheng Xing Wai Ke Za Zhi. 2007 Mar;23(2):137-40.[Abstract]
13. Robles DT, Moore E, Draznin M, et al. Keloids: pathophysiology and management. Dermatology Online J. 2007 Jul 13;13(3):9.[Abstract][Full Text]
14. Butler PD, Longaker MT, Yang GP. Current progress in keloid research and treatment. J Am Coll Surg. 2008 Apr;206(4):731-41.[Abstract]
15. Mari W, Alsabri SG, Tabal N, et al. Novel insights on understanding of keloid scar: article review. J Am Coll Clin Wound Spec. 2016 Nov 30;7(1-3):1-7.[Abstract][Full Text]
16. Gauglitz GG, Korting HC, Pavicic T, et al. Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med. 2011 Jan-Feb;17(1-2):113-25.[Abstract][Full Text]
17. Ogawa R. The most current algorithms for the treatment and prevention of hypertrophic scars and keloids: a 2020 update of the algorithms published 10 years ago. Plast Reconstr Surg. 2022 Jan 1;149(1):79e-94e.[Abstract][Full Text]
18. Burd A, Huang L. Hypertrophic response and keloid diathesis: two very different forms of scar. Plast Reconstr Surg. 2005 Dec;116(7):150e-7e.[Abstract]
19. Knowles A, Glass DA 2nd. Keloids and hypertrophic scars. Dermatol Clin. 2023 Jul;41(3):509-17.[Abstract]
20. Ogawa R, Okai K, Tokumura F, et al. The relationship between skin stretching/contraction and pathologic scarring: the important role of mechanical forces in keloid generation. Wound Repair Regen. 2012 Mar-Apr;20(2):149-57.[Abstract]
21. Ogawa R, Akita S, Akaishi S, et al. Diagnosis and treatment of keloids and hypertrophic scars - Japan Scar Workshop consensus document 2018. Burns Trauma. 2019;7:39.[Abstract]
22. Ogawa R, Akaishi S, Hyakusoku H. Differential and exclusive diagnosis of diseases that resemble keloids and hypertrophic scars. Ann Plast Surg. 2009 Jun;62(6):660-4.[Abstract][Full Text]
23. Nguyen CM, Burch JM, Fitzpatrick JE, et al. Giant cell fibroblastoma in a child misdiagnosed as a dermatofibroma. Pediatr Dermatol. 2002 Jan-Feb;19(1):28-32.[Abstract]
24. Durani P, Bayat A. Levels of evidence for the treatment of keloid disease. J Plast Reconstr Aesthet Surg. 2008;61(1):4-17.[Abstract]
25. Elsaie ML. Update on management of keloid and hypertrophic scars: a systemic review. J Cosmet Dermatol. 2021 Sep;20(9):2729-38.[Abstract]
26. Wolfram D, Tzankov A, Pülzl P, et al. Hypertrophic scars and keloids - a review of their pathophysiology, risk factors, and therapeutic management. Dermatol Surg. 2009 Feb;35(2):171-81.[Abstract][Full Text]
27. Guthmann R, Williams CC, De Groote S. Clinical inquiry: what treatment is best for hypertrophic scars and keloids? J Fam Pract. 2011 Dec;60(12):757-8.[Abstract]
28. Lv K, Xia Z, Chinese consensus panel on the prevention and treatment of scars. Chinese expert consensus on clinical prevention and treatment of scar. Burns Trauma. 2018;6:27.[Abstract][Full Text]
29. Gold MH, Berman B, Clementoni MT, et al. Updated international clinical recommendations on scar management: part 1 - evaluating the evidence. Dermatol Surg. 2014 Aug;40(8):817-24.[Abstract]
30. Ren Y, Zhou X, Wei Z, et al. Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis. Int Wound J. 2017 Jun;14(3):480-7.[Abstract][Full Text]
31. Kang N, Sivakumar B, Sanders R, et al. Intra-lesional injections of collagenase are ineffective in the treatment of keloid and hypertrophic scars. J Plast Reconstr Aesthet Surg. 2006;59(7):693-9.[Abstract]
32. McCoy BJ, Diegelmann RF, Cohen IK. In vitro inhibition of cell growth, collagen synthesis, and prolyl hydroxylase activity by triamcinolone acetonide. Proc Soc Exp Biol Med. 1980 Feb;163(2):216-22.[Abstract]
33. Morelli Coppola M, Salzillo R, Segreto F, et al. Triamcinolone acetonide intralesional injection for the treatment of keloid scars: patient selection and perspectives. Clin Cosmet Investig Dermatol. 2018;11:387-96.[Abstract][Full Text]
34. Yin Q, Niessen FB, Gibbs S, et al. Intralesional corticosteroid administration in the treatment of keloids: a survey among Dutch dermatologists and plastic surgeons. J Dermatolog Treat. 2023 Dec;34(1):2159308.[Abstract][Full Text]
35. Fredman R, Tenenhaus M. Cushing's syndrome after intralesional triamcinolone acetonide: a systematic review of the literature and multinational survey. Burns. 2013 Jun;39(4):549-57.[Abstract][Full Text]
36. Darzi MA, Chowdri NA, Kaul SK, et al. Evaluation of various methods of treating keloids and hypertrophic scars: a 10-year follow-up study. Br J Plast Surg. 1992 Jul;45(5):374-9.[Abstract][Full Text]
37. Jalali M, Bayat A. Current use of steroids in management of abnormal raised skin scars. Surgeon. 2007 Jun;5(3):175-80.[Abstract]
38. Gold MH, McGuire M, Mustoe TA, et al. Updated international clinical recommendations on scar management: part 2 - algorithms for scar prevention and treatment. Dermatol Surg. 2014 Aug;40(8):825-31.[Abstract]
39. Martinsson T, Haegerstrand A, Dalsgaard CJ. Ropivacaine and lidocaine inhibit proliferation of non-transformed cultured adult human fibroblasts, endothelial cells, and keratinocytes. Agents Actions. 1993 Sep;40(1-2):78-85.[Abstract]
40. Eichhorn JH, Peterkofsky B. Local anesthetic-induced inhibition of collagen secretion in cultured cells under conditions where microtubules are not depolymerized by these agents. J Cell Biol. 1979 Apr;81(1):26-42.[Abstract][Full Text]
41. Goutos I, Ogawa R. Steroid tape: A promising adjunct to scar management. Scars Burn Heal. 2017 Jan-Dec;3:2059513117690937.[Abstract][Full Text]
42. Goldman L, Igelman JM, Kitzmiller KW. Clinical investigative studies with flurandrenolone tape. Cutis 1967; 3: 367-71.
43. Ratzer MA. A clinical trial of flurandrenolone tape. Br J Clin Pract. 1970 Apr;24(4):185-9.[Abstract]
44. Ogawa R. Effectiveness of corticosteroid tapes and plasters for keloids and hypertrophic scars. In: Téot L, Mustoe TA, Middelkoop E, et al., eds. Textbook on scar management: state of the art management and emerging technologies [Internet]. Cham: Springer; 2020. [Abstract]
45. Nast A, Gauglitz G, Lorenz K, et al. S2k guidelines for the therapy of pathological scars (hypertrophic scars and keloids) - update 2020. J Dtsch Dermatol Ges. 2021 Feb;19(2):312-27.[Abstract][Full Text]
46. Yii NW and Frame JD. Evaluation of cynthaskin and topical steroid in the treatment of hypertrophic scars and keloids. Eur J Plast Surg 1996;19:162-5.
47. Marsden CW. Fluocinolone acetonide 0.2 per cent cream - a co-operative clinical trial. Br J Dermatol. 1968 Sep;80(9):614-7.[Abstract]
48. Shah VV, Aldahan AS, Mlacker S, et al. 5-Fluorouracil in the treatment of keloids and hypertrophic scars: a comprehensive review of the literature. Dermatol Ther (Heidelb). 2016 Jun;6(2):169-83.[Abstract][Full Text]
49. Bijlard E, Steltenpool S, Niessen FB. Intralesional 5-fluorouracil in keloid treatment: a systematic review. Acta Derm Venereol. 2015 Sep;95(7):778-82.[Abstract][Full Text]
50. Saha AK, Mukhopadhyay M. A comparative clinical study on role of 5-flurouracil versus triamcinolone in the treatment of keloids. Indian J Surg. 2012 Aug;74(4):326-9.[Abstract][Full Text]
51. Prabhu A, Sreekar H, Powar R, et al. A randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids. J Sci Soc. 2012;39:19-25.[Full Text]
52. Asilian A, Darougheh A, Shariati F. New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars. Dermatol Surg. 2006 Jul;32(7):907-15.[Abstract]
53. Chen XE, Liu J, Bin Jameel AA, et al. Combined effects of long-pulsed neodymium-yttrium-aluminum-garnet laser, diprospan and 5-fluorouracil in the treatment of keloid scars. Exp Ther Med. 2017 Jun;13(6):3607-12.[Abstract][Full Text]
54. Davison SP, Dayan JH, Clemens MW, et al. Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids. Aesthet Surg J. 2009 Jan-Feb;29(1):40-6.[Abstract][Full Text]
55. Kim WI, Kim S, Cho SW, et al. The efficacy of bleomycin for treating keloid and hypertrophic scar: a systematic review and meta-analysis. J Cosmet Dermatol. 2020 Dec;19(12):3357-66.[Abstract]
56. Shin JY, Yun SK, Roh SG, et al. Efficacy of 2 representative topical agents to prevent keloid recurrence after surgical excision. J Oral Maxillofac Surg. 2017 Feb;75(2):401.e1-401.e6.[Abstract]
57. Khansa I, Harrison B, Janis JE. Evidence-based scar management: how to improve results with technique and technology. Plast Reconstr Surg. 2016 Sep;138(3 suppl):165S-78S.[Abstract]
58. Kuo YR, Wu WS, Jeng SF, et al. Suppressed TGF-beta1 expression is correlated with up-regulation of matrix metalloproteinase-13 in keloid regression after flashlamp pulsed-dye laser treatment. Lasers Surg Med. 2005 Jan;36(1):38-42.[Abstract]
59. Bouzari N, Davis SC, Nouri K, et al. Laser treatment of keloids and hypertrophic scars. Int J Dermatol. 2007 Jan;46(1):80-8.[Abstract]
60. de las Alas JM, Siripunvarapon AH, Dofitas BL. Pulsed dye laser for the treatment of keloid and hypertrophic scars: a systematic review. Expert Rev Med Devices. 2012 Nov;9(6):641-50.[Abstract]
61. Al-Mohamady Ael-S, Ibrahim SM, Muhammad MM. Pulsed dye laser versus long-pulsed Nd:YAG laser in the treatment of hypertrophic scars and keloid: a comparative randomized split-scar trial. J Cosmet Laser Ther. 2016 Aug;18(4):208-12.[Abstract]
62. Rossi A, Lu R, Frey MK, et al. The use of the 300 microsecond 1064 nm Nd:YAG laser in the treatment of keloids. J Drugs Dermatol. 2013 Nov;12(11):1256-62.[Abstract]
63. Leszczynski R, da Silva CA, Pinto ACPN, et al. Laser therapy for treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2022 Sep 26;9(9):CD011642.[Abstract][Full Text]
64. Forbat E, Ali FR, Al-Niaimi F. Treatment of keloid scars using light-, laser- and energy-based devices: a contemporary review of the literature. Lasers Med Sci. 2017 Dec;32(9):2145-54.[Abstract]
65. Apfelberg DB, Maser MR, White DN, et al. Failure of carbon dioxide laser excision of keloids. Lasers Surg Med. 1989;9(4):382-8.[Abstract]
66. Connell PG, Harland CC. Treatment of keloid scars with pulsed dye laser and intralesional steroid. J Cutan Laser Ther. 2000 Sep;2(3):147-50.[Abstract]
67. Garg GA, Sao PP, Khopkar US. Effect of carbon dioxide laser ablation followed by intralesional steroids on keloids. J Cutan Aesthet Surg. 2011 Jan;4(1):2-6.[Abstract][Full Text]
68. Wang J, Wu J, Xu M, et al. Combination therapy of refractory keloid with ultrapulse fractional carbon dioxide (CO2) laser and topical triamcinolone in Asians-long-term prevention of keloid recurrence. Dermatol Ther. 2020 Nov;33(6):e14359.[Abstract]
69. Cavalié M, Sillard L, Montaudié H, et al. Treatment of keloids with laser-assisted topical steroid delivery: a retrospective study of 23 cases. Dermatol Ther. 2015 Mar-Apr;28(2):74-8.[Abstract]
70. Abd El-Dayem DH, Nada HA, Hanafy NS, et al. Laser-assisted topical steroid application versus steroid injection for treating keloids: a split side study. J Cosmet Dermatol. 2021 Jan;20(1):138-42.[Abstract]
71. O'Boyle CP, Shayan-Arani H, Hamada MW. Intralesional cryotherapy for hypertrophic scars and keloids: a review. Scars Burn Heal. 2017 Jan-Dec;3:2059513117702162.[Abstract][Full Text]
72. Mustoe TA, Cooter RD, Gold MH, et al. International clinical recommendations on scar management. Plast Reconstr Surg. 2002 Aug;110(2):560-71.[Abstract]
73. Ogawa R, Akaishi S, Huang C, et al. Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction. J Nippon Med Sch. 2011;78(2):68-76.[Abstract][Full Text]
74. Goutos I. Intralesional excision as a surgical strategy to manage keloid scars: what's the evidence? Scars Burn Heal. 2019 Jan-Dec;5:2059513119867297.[Abstract][Full Text]
75. Royal College of Radiologists. Recommendations for using radiotherapy for benign disease in the UK. 2023 [internet publication].[Full Text]
76. Ogawa R, Tosa M, Dohi T, et al. Surgical excision and postoperative radiotherapy for keloids. Scars Burn Heal. 2019 Jan-Dec;5:2059513119891113.[Abstract][Full Text]
77. Malaker K, Vijayraghavan K, Hodson I, et al. Retrospective analysis of treatment of unresectable keloids with primary radiation over 25 years. Clin Oncol (R Coll Radiol). 2004 Jun;16(4):290-8.[Abstract]
78. McKeown SR, Hatfield P, Prestwich RJ, et al. Radiotherapy for benign disease; assessing the risk of radiation-induced cancer following exposure to intermediate dose radiation. Br J Radiol. 2015;88(1056):20150405.[Abstract][Full Text]
79. O'Brien L, Jones DJ. Silicone gel sheeting for preventing and treating hypertrophic and keloid scars. Cochrane Database Syst Rev. 2013 Sep 12;(9):CD003826.[Abstract][Full Text]
80. Tian F, Jiang Q, Chen J, et al. Silicone gel sheeting for treating keloid scars. Cochrane Database Syst Rev. 2023 Jan 3;1(1):CD013878.[Abstract][Full Text]
81. de Oliveira GV, Nunes TA, Magna LA, et al. Silicone versus nonsilicone gel dressings: a controlled trial. Dermatol Surg. 2001 Aug;27(8):721-6.[Abstract]
82. Lin YS, Ting PS, Hsu KC. Comparison of silicone sheets and paper tape for the management of postoperative scars: a randomized comparative study Adv Skin Wound Care. 2020 Jun;33(6):1-6.[Abstract][Full Text]
83. Ekstein SF, Wyles SP, Moran SL, et al. Keloids: a review of therapeutic management. Int J Dermatol. 2021 Jun;60(6):661-71.[Abstract]
84. Sohrabi C, Goutos I. The use of botulinum toxin in keloid scar management: a literature review. Scars Burn Heal. 2020 Jan-Dec;6:2059513120926628.[Abstract][Full Text]
85. Alser OH, Goutos I. The evidence behind the use of platelet-rich plasma (PRP) in scar management: a literature review. Scars Burn Heal. 2018 Jan-Dec;4:2059513118808773.[Abstract][Full Text]
86. Jones ME, Hardy C, Ridgway J. Keloid management: a retrospective case review on a new approach using surgical excision, platelet-rich plasma, and in-office superficial photon x-ray radiation therapy. Adv Skin Wound Care. 2016 Jul;29(7):303-7.[Abstract][Full Text]
87. Jones ME, McLane J, Adenegan R, et al. Advancing keloid treatment: a novel multimodal approach to ear keloids. Dermatol Surg. 2017 Sep;43(9):1164-9.[Abstract]
88. Hersant B, SidAhmed-Mezi M, Picard F, et al. Efficacy of autologous platelet concentrates as adjuvant therapy to surgical excision in the treatment of keloid scars refractory to conventional treatments: a pilot prospective study. Ann Plast Surg. 2018 Aug;81(2):170-5.[Abstract]
89. Hewedy ES, Sabaa BEI, Mohamed WS, et al. Combined intralesional triamcinolone acetonide and platelet rich plasma versus intralesional triamcinolone acetonide alone in treatment of keloids. J Dermatolog Treat. 2022 Feb;33(1):150-6.[Abstract]
90. Bandyopadhyay B, Fan J, Guan S, et al. A "traffic control" role for TGFbeta3: orchestrating dermal and epidermal cell motility during wound healing. J Cell Biol. 2006 Mar 27;172(7):1093-105.[Abstract]
91. Liebl H, Kloth LC. Skin cell proliferation stimulated by microneedles. J Am Coll Clin Wound Spec. 2012 Mar;4(1):2-6.[Abstract][Full Text]
92. Fabbrocini G, Marasca C, Ammad S, et al. Assessment of the combined efficacy of needling and the use of silicone gel in the treatment of C-section and other surgical hypertrophic scars and keloids. Adv Skin Wound Care. 2016 Sep;29(9):408-11.[Abstract]
93. Iosifidis C, Goutos I. Percutaneous collagen induction (microneedling) for the management of non-atrophic scars: literature review. Scars Burn Heal. 2019 Jan-Dec;5:2059513119880301.[Abstract][Full Text]
94. Lu W, Chu H, Zheng X. Effects on quality of life and psychosocial wellbeing in Chinese patients with keloids. Am J Transl Res. 2021;13(3):1636-42.[Abstract][Full Text]
95. Liang Z, Zhang M, Hao Y, et al. Risk factors associated with keloid infections: a five-year retrospective study. Int Wound J. 2023 Aug;20(6):2215-23.[Abstract][Full Text]
96. Delaleu J, Duverger L, Shourick J, et al. Suppurative keloids: a complication of severe keloid disease. Int J Dermatol. 2021 Nov;60(11):1392-6.[Abstract]
97. Liu R, Xiao H, Wang R, et al. Risk factors associated with the progression from keloids to severe keloids. Chin Med J (Engl). 2022 Apr 5;135(7):828-36.[Abstract][Full Text]
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