Highlights & Basics
- Cervicitis is common and often asymptomatic, but if left undiagnosed or untreated can result in pelvic inflammatory disease, which can lead to substantial long-term ill effects such as infertility and chronic pelvic pain.
- Implementing screening protocols for high-risk populations may reduce adverse outcomes from cervicitis. Screening for other sexually transmitted infections (STIs) should be offered concomitantly.
- While Neisseria gonorrhoeae and Chlamydia trachomatis are the most commonly isolated organisms, in most cases no organism is identified.
- Clinical suspicion is generally sufficient to justify therapy, but of the diagnostic aids, nucleic acid amplification testing remains the most sensitive and specific tool for accurately diagnosing N gonorrhoeae and C trachomatis.
- If the presentation suggests cervicitis, and the patient is deemed at high risk for STI, patients are empirically treated with a regimen targeting STIs.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.[Abstract][Full Text]
Boyer CB, Shafer MB, Pollack LM, et al. Sociodemographic markers and behavioral correlates of STIs in a nonclinical sample of adolescent and young adult women. J Infect Dis. 2006 Aug 1;194(3):307-15.[Abstract][Full Text]
Marrazzo JM, Weisenfeld HC, Murray PJ, et al. Risk factors for cervicitis among women with bacterial vaginosis. J Infect Dis. 2006 Mar 1;193(5):617-24. [Abstract][Full Text]
Scholes D, Grothaus L, McClure J, et al. A randomized trial of strategies to increase Chlamydia screening in young women. Prev Med. 2006 Oct;43(4):343-50.[Abstract]
1. Workowski KA, Bachmann LH, Chan PA, et al. Sexually transmitted infections treatment guidelines, 2021. MMWR Recomm Rep. 2021 Jul 23;70(4):1-187.[Abstract][Full Text]
2. Groetsch S. Cervicitis. Clin Fam Pract. 2005;7:43-56.
3. Boyer CB, Shafer MB, Pollack LM, et al. Sociodemographic markers and behavioral correlates of STIs in a nonclinical sample of adolescent and young adult women. J Infect Dis. 2006 Aug 1;194(3):307-15.[Abstract][Full Text]
4. Centers for Disease Control and Prevention. Sexually transmitted infections surveillance: national overview of STIs, 2022. Jan 2024 [internet publication].[Full Text]
5. Public Health England. Sexually transmitted infections (STIs): annual data tables. Oct 2022 [internet publication].[Full Text]
6. Blanchard A, Bébéar C. The evolution of Mycoplasma genitalium. Ann N Y Acad Sci. 2011 Aug;1230:E61-4. [Abstract]
7. Bjartling C, Osser S, Persson K. Mycoplasma genitalium in cervicitis and pelvic inflammatory disease among women at a gynecologic outpatient service. Am J Obstet Gynecol. 2012 Jun;206(6):476;e1-8.[Abstract]
8. Jensen JS, Cusini M, Gomberg M, et al. 2021 European guideline on the management of Mycoplasma genitalium infections. J Eur Acad Dermatol Venereol. 2022 May;36(5):641-50.[Abstract][Full Text]
9. Marrazzo JM, Martin DH. Management of women with cervicitis. Clin Infect Dis. 2007 Apr 1;44(suppl 3):S102-10.[Abstract][Full Text]
10. Geisler WM, Suchland RJ, Whittington WL, et al. Quantitative culture of Chlamydia trachomatis: a relationship of inclusion-forming units produced in culture to clinical manifestations and acute inflammation in urogenital disease. J Infect Dis. 2001 Nov 15;184(10):1350-4. [Abstract][Full Text]
11. Marrazzo JM, Weisenfeld HC, Murray PJ, et al. Risk factors for cervicitis among women with bacterial vaginosis. J Infect Dis. 2006 Mar 1;193(5):617-24. [Abstract][Full Text]
12. Newman LM, Warner L, Weinstock HS. Predicting subsequent infection in patients attending sexually transmitted disease clinics. Sex Transm Dis. 2006 Dec;33(12):737-42.[Abstract]
13. Wiesenfeld HC, Hillier SL, Krohn MA, et al. Bacterial vaginosis is a strong predictor of Neisseria gonorrhoeae and Chlamydia trachomatis infection. Clin Infect Dis. 2003 Mar 1;36(5):663-8.[Abstract][Full Text]
14. US Preventive Services Task Force; Davidson KW, Barry MJ, Mangione CM, et al. Screening for chlamydia and gonorrhea: US Preventive Services Task Force recommendation statement. JAMA. 2021 Sep 14;326(10):949-56.[Abstract][Full Text]
15. National Institute for Health and Care Excellence. Reducing sexually transmitted infections. Jun 2022 [internet publication].[Full Text]
16. Scholes D, Stergachis A, Heidrich FE, et al. Prevention of pelvic inflammatory disease by screening for cervical chlamydial infection. N Engl J Med. 1996 May 23;334(21):1362-6.[Abstract][Full Text]
17. Scholes D, Grothaus L, McClure J, et al. A randomized trial of strategies to increase Chlamydia screening in young women. Prev Med. 2006 Oct;43(4):343-50.[Abstract]
18. Hakakha MM, Davis J, Korst LM, et al. Leukorrhea and bacterial vaginosis as in-office predictors of cervical infection in high risk women. Obstet Gynecol. 2002 Oct;100(4):808-12.[Abstract]
19. Sherrard J, Pitt R, Hobbs KR, et al. British Association for Sexual Health and HIV (BASHH) United Kingdom national guideline on the management of Trichomonas vaginalis 2021. Int J STD AIDS. 2022 Jul;33(8):740-50.[Abstract]
20. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol. 1991 Feb;29(2):297-301.[Abstract][Full Text]
21. Amsel R, Totten PA, Spiegel CA, et al. Nonspecific vaginitis: diagnostic criteria and microbial and epidemiologic associations. Am J Med. 1983 Jan;74(1):14-22.[Abstract]
22. World Health Organization. WHO guideline on self-care interventions for health and well-being, 2022 revision. Geneva: World Health Organization; 2022.[Abstract][Full Text]
23. Crotchfelt KA, Pare B, Gaydos C, et al. Detection of Chlamydia trachomatis by the Gen-Probe AMPLIFIED Chlamydia trachomatis assay (AMP CT) in urine specimens from men and women and endocervical specimens from women. J Clin Microbiol. 1998 Feb;36(2):391-4.[Abstract][Full Text]
24. Schoeman SA, Stewart CM, Booth RA, et al. Assessment of best single sample for finding chlamydia in women with and without symptoms: a diagnostic test study. BMJ. 2012 Dec 12;345:e8013.[Abstract][Full Text]
25. Centers for Disease Control and Prevention. National estimate shows not enough young women tested for chlamydia (press release). March 2012 [internet publication].[Full Text]
26. Centers for Disease Control and Prevention. Recommendations for the laboratory-based detection of Chlamydia trachomatis and Neisseria gonorrhoeae - 2014. MMWR Recomm Rep. 2014 Mar 14;63(rr-02):1-19.[Abstract][Full Text]
27. American College of Obstetricians and Gynecologists. Committee opinion no. 737: expedited partner therapy. June 2018 [internet publication].[Full Text]
28. Rusu A, Munteanu AC, Arbănași EM, et al. Overview of side-effects of antibacterial fluoroquinolones: new drugs versus old drugs, a step forward in the safety profile? Pharmaceutics. 2023 Mar 1;15(3):804.[Abstract][Full Text]
29. Centers for Disease Control and Prevention. Update to CDC's sexually transmitted diseases treatment guidelines, 2010: oral cephalosporins no longer a recommended treatment for gonococcal infections. MMWR Morb Mortal Wkly Rep. 2012 Aug 10;61(31):590-4.[Abstract][Full Text]
30. Oh MK, Cloud, GA, Fleenor, M, et al. Risk for gonococcal and chlamydial cervicitis in adolescent females: incidence and recurrence in a prospective cohort study. J Adolesc Health. 1996;18:270-5.[Abstract]
31. Wiesenfeld HC, Hillier SL, Meyn LA, et al. Subclinical pelvic inflammatory disease and infertility. Obstet Gynecol. 2012;120:37-43.[Abstract]
32. Yang K, Li J, Liu Y, et al. Microwave therapy for cervical ectropion. Cochrane Database Syst Rev. 2007;(4):CD006227.[Abstract][Full Text]
Key Articles
Other Online Resources
Referenced Articles
Sign in to access our clinical decision support tools