Highlights & Basics
- Migraine has a high prevalence in children (10%) and is a significant source of morbidity.
- Careful consideration of the broad differential diagnosis is important when evaluating a child with headache.
- The expectations for the success of treatment should take account of the level to which psychological factors are contributing to symptoms.
- Not all treatments (acute or prophylactic) work for every patient.
- Spontaneous remission with increasing age may occur in 25% to 50% of children.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
Ryan S. Medicines for migraine. Arch Dis Child Educ Pract Ed. 2007 Apr;92(2):ep50-5.[Abstract]
Fisher E, Law E, Dudeney J, et al. Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2018 Sep 29;(9):CD003968. [Abstract][Full Text]
Richer L, Billinghurst L, Linsdell MA, et al. Drugs for the acute treatment of migraine in children and adolescents. Cochrane Database Syst Rev. 2016 Apr 19;(4):CD005220.[Abstract][Full Text]
Oskoui M, Pringsheim T, Holler-Managan Y, et al. Practice guideline update summary: acute treatment of migraine in children and adolescents: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):487-99. [Abstract][Full Text]
Oskoui M, Pringsheim T, Billinghurst L, et al. Practice guideline update summary: pharmacologic treatment for pediatric migraine prevention: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):500-9. [Abstract][Full Text]
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3. Goadsby PJ. To scan or not to scan in headache. BMJ. 2004 Aug 28;329(7464):469-70.[Abstract][Full Text]
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9. Bille BS. Migraine in school children. A study of the incidence and short-term prognosis, and a clinical, psychological and electroencephalographic comparison between children with migraine and matched controls. Acta Paediatr Suppl. 1962 May;136:1-151.[Abstract]
10. Deubner DC. An epidemiologic study of migraine and headache in 10-20 year olds. Headache. 1977 Sep;17(4):173-80.[Abstract]
11. Evers S. Drug treatment of migraine in children. A comparative review. Paediatr Drugs. 1999 Jan-Mar;1(1):7-18.[Abstract]
12. Linet MS, Stewart WF, Celentano DD, et al. An epidemiologic study of headache among adolescents and young adults. JAMA. 1989 Apr 21;261(15):2211-6.[Abstract]
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16. Stewart WF, Staffa J, Lipton RB, et al. Familial risk of migraine: a population-based study. Ann Neurol. 1997 Feb;41(2):166-72.[Abstract]
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20. Amery WK, Vandenbergh V. What can precipitating factors teach us about the pathogenesis of migraine? Headache. 1987 Mar;27(3):146-50.[Abstract]
21. Barnes NP, Jayawant S. Migraine. Arch Dis Child Educ Pract Ed. 2005;90:ep53-7.[Full Text]
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23. American College of Radiology. ACR appropriateness criteria: headache - child. 2017 [internet publication].[Full Text]
24. Headache Classification Committee of the International Headache Society. The international classification of headache disorders, 3rd edition. Cephalalgia. 2018 Jan;38(1):1-211.[Abstract][Full Text]
25. National Institute for Health and Care Excellence. Headaches in over 12s: diagnosis and management. November 2015 [internet publication].[Full Text]
26. Bonfert M, Straube A, Schroeder AS, et al. Primary headache in children and adolescents: update on pharmacotherapy of migraine and tension-type headache. Neuropediatrics. 2013 Feb;44(1):3-19.[Abstract]
27. Fisher E, Law E, Dudeney J, et al. Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2018 Sep 29;(9):CD003968. [Abstract][Full Text]
28. Bruijn J, Locher H, Passchier J, et al. Psychopathology in children and adolescents with migraine in clinical studies: a systematic review. Pediatrics. 2010 Aug;126(2):323-32.[Abstract]
29. Silver S, Gano D, Gerretsen P. Acute treatment of paediatric migraine: a meta-analysis of efficacy. J Paediatr Child Health. 2008 Jan;44(1-2):3-9.[Abstract]
30. Richer L, Billinghurst L, Linsdell MA, et al. Drugs for the acute treatment of migraine in children and adolescents. Cochrane Database Syst Rev. 2016 Apr 19;(4):CD005220.[Abstract][Full Text]
31. Oskoui M, Pringsheim T, Holler-Managan Y, et al. Practice guideline update summary: acute treatment of migraine in children and adolescents: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):487-99. [Abstract][Full Text]
32. US Food and Drug Administration. FDA drug safety communication: FDA restricts use of prescription codeine pain and cough medicines and tramadol pain medicines in children; recommends against use in breastfeeding women. April 2017 [internet publication].[Full Text]
33. Medicines and Healthcare Products Regulatory Agency. Codeine: restricted use as analgesic in children and adolescents after European safety review. Drug Safety Update. 2013 June;6(11):S1.[Full Text]
34. European Medicines Agency. Restrictions on use of codeine for pain relief in children - CMDh endorses PRAC recommendation. June 2013 [internet publication].[Full Text]
35. Brenner M, Lewis D. The treatment of migraine headaches in children and adolescents. J Pediatr Pharmacol Ther. 2008 Jan;13(1):17-24.[Abstract][Full Text]
36. Damen L, Bruijn JK, Verhagen AP, et al. Symptomatic treatment of migraine in children: a systematic review of medication trials. Pediatrics. 2005 Aug;116(2):e295-302.[Abstract][Full Text]
37. Eiland LS, Hunt MO. The use of triptans for pediatric migraines. Paediatr Drugs. 2010 Dec 1;12(6):379-89.[Abstract]
38. Lewis DW, Winner P, Hershey AD, et al; Adolescent Migraine Steering Committee. Efficacy of zolmitriptan nasal spray in adolescent migraine. Pediatrics. 2007 Aug;120(2):390-6.[Abstract]
39. Winner P, Lewis D, Visser WH, et al; Rizatriptan Adolescent Study Group. Rizatriptan 5 mg for the acute treatment of migraine in adolescents: a randomized, double-blind, placebo-controlled study. Headache. 2002 Jan;42(1):49-55.[Abstract]
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41. Ho TW, Pearlman E, Lewis D, et al. Efficacy and tolerability of rizatriptan in pediatric migraineurs: results from a randomized, double-blind, placebo-controlled trial using a novel adaptive enrichment design. Cephalalgia. 2012 Jul;32(10):750-65.[Abstract]
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47. Oskoui M, Pringsheim T, Billinghurst L, et al. Practice guideline update summary: pharmacologic treatment for pediatric migraine prevention: report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Headache Society. Neurology. 2019 Sep 10;93(11):500-9. [Abstract][Full Text]
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51. Sorge F, De Simone R, Marano E, et al. Flunarizine in prophylaxis of childhood migraine. A double-blind, placebo-controlled, crossover study. Cephalalgia. 1988;8:1-6.[Abstract]
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54. Blau JN, Thavapalan M. Preventing migraine: a study of precipitating factors. Headache. 1988 Aug;28(7):481-3.[Abstract]
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