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Diseases

Intussusception

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Intussusception most commonly occurs in infants between the ages of 3 and 12 months, with a peak between ages 5 and 9 months.

  • Presentation often includes colicky abdominal pain, flexing of the legs, fever, lethargy, and vomiting, with blood in the stool in some cases.

  • When there is clinical suspicion, imaging has a valuable role. Plain abdominal x-ray may reveal an intestinal obstruction and paucity of wind in the right lower quadrant; the presence or absence of free intra-abdominal gas will influence subsequent management, because pneumoperitoneum indicates bowel perforation and requires prompt surgical evaluation. Abdominal ultrasound undertaken by an experienced radiologist will usually establish the diagnosis; contrast enema (most often air but may be liquid contrast) is the most specific and sensitive test for diagnosis. As well as being used therapeutically, it can also be used diagnostically where doubt remains. 

  • The pathologic location is typically ileocecal.

  • If the patient is clinically stable and perforation is not suspected, treatment involves reduction by contrast enema; air is likely to be more effective and safer than liquid. In cases where this is contraindicated or unsuccessful, or where peritonitis exists, urgent surgery is required. Open reduction is performed in uncomplicated cases and intestinal resection of threatened nonviable bowel is necessary for cases complicated by bowel ischemia, necrosis and perforation.

Transverse sonogram of the abdomen showing the donut sign (concentric rings within the lumen of a di
Transverse sonogram of the abdomen showing the donut sign (concentric rings within the lumen of a distended loop of bowel)
Adapted from the Student BMJ. 2008;16:76. Copyright 2010 by the BMJ Publishing Group; used with permission

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

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      • Diagnostics Tests

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          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Transverse sonogram of the abdomen showing the donut sign (concentric rings within the lumen of a di

            Transverse sonogram of the abdomen showing the donut sign (concentric rings within the lumen of a distended loop of bowel)

          • Abdominal x-ray showing impaired passage of barium at site of obstruction due to intussusception

            Abdominal x-ray showing impaired passage of barium at site of obstruction due to intussusception

          • Ultrasound image showing invagination of a segment of bowel into the adjacent segment

            Ultrasound image showing invagination of a segment of bowel into the adjacent segment

          • Site of intussusception as revealed by abdominal x-ray, showing the meniscus

            Site of intussusception as revealed by abdominal x-ray, showing the meniscus

          Citations

            Key Articles

            • American College of Radiology. ACR Appropriateness Criteria: Vomiting in Infants. 2020 [internet publication].[Full Text]

            • Gluckman S, Karpelowsky J, Webster AC, et al. Management for intussusception in children. Cochrane Database Syst Rev. 2017 Jun 1;6:CD006476.[Abstract]

            • American College of Radiology. ACR-SPR practice parameter for the performance of pediatric fluoroscopic contrast enema examinations. 2021 [internet publication].[Full Text]

            Referenced Articles

            • 1. Marsicovetere P, Ivatury SJ, White B, et al. Intestinal intussusception: etiology, diagnosis, and treatment. Clin Colon Rectal Surg. 2017 Feb;30(1):30-9.[Abstract][Full Text]

            • 2. McCollough M, Sharieff GQ. Abdominal pain in children. Pediatr Clin North Am. 2006 Feb;53(1):107-37.[Abstract]

            • 3. Justice FA, Auldist AW, Bines JE. Intussusception: trends in clinical presentation and management. J Gastroenterol Hepatol. 2006 May;21(5):842-6.[Abstract]

            • 4. Kuppermann N, O'Dea T, Pinckney L, et al. Predictors of intussusception in young children. Arch Pediatr Adolesc Med. 2000 Mar;154(3):250-5.[Abstract][Full Text]

            • 5. Carnevale E, Graziani M, Fasanelli S. Post-operative ileo-ileal intussusception: sonographic approach. Pediatr Radiol. 1994;24(3):161-3.[Abstract]

            • 6. Jiang J, Jiang B, Parashar U, et al. Childhood intussusception: a literature review. PLoS One. 2013;8(7):e68482.[Abstract][Full Text]

            • 7. Clark AD, Hasso-Agopsowicz M, Kraus MW, et al. Update on the global epidemiology of intussusception: a systematic review of incidence rates, age distributions and case-fatality ratios among children aged <5 years, before the introduction of rotavirus vaccination. Int J Epidemiol. 2019 Aug 1;48(4):1316-26.[Abstract][Full Text]

            • 8. Parashar UD, Holman RC, Cummings KC, et al. Trends in intussusception-associated hospitalizations and deaths among US infants. Pediatrics. 2000 Dec;106(6):1413-21.[Abstract]

            • 9. Fischer TK, Bihrmann K, Perch M, et al. Intussusception in early childhood: a cohort study of 1.7 million children. Pediatrics. 2004 Sep;114(3):782-5.[Abstract]

            • 10. Samad L, Marven S, El Bashir H, et al. Prospective surveillance study of the management of intussusception in UK and Irish infants. Br J Surg. 2012 Mar;99(3):411-5.

            • 11. O'Ryan M, Lucero Y, Pena A, et al. Two year review of intestinal intussusception in six large hospitals of Santiago, Chile. Pediatr Infect Dis J. 2003 Aug;22(8):717-21.[Abstract]

            • 12. Murphy TV, Gargiullo PM, Massoudi MS, et al. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med. 2001 Feb 22;344(8):564-72[Abstract][Full Text]

            • 13. Zanardi LR, Haber P, Mootrey GT, et al. Intussusception among recipients of rotavirus vaccine: reports to the vaccine adverse event reporting system. Pediatrics. 2001 Jun;107(6):E97.[Abstract][Full Text]

            • 14. Patel MM, López-Collada VR, Bulhões MM, et al. Intussusception risk and health benefits of rotavirus vaccination in Mexico and Brazil. N Engl J Med. 2011 Jun 16;364(24):2283-92.[Abstract][Full Text]

            • 15. Lu HL, Ding Y, Goyal H, et al. Association between rotavirus vaccination and risk of intussusception among neonates and Infants: a systematic review and meta-analysis. JAMA Netw Open. 2019 Oct 2;2(10):e1912458.[Abstract][Full Text]

            • 16. Centers for Disease Control and Prevention (CDC). Addition of history of intussusception as a contraindication for rotavirus vaccination. MMWR Morb Mortal Wkly Rep. 2011 Oct 21;60(41):1427.[Abstract][Full Text]

            • 17. American College of Radiology. ACR Appropriateness Criteria: Vomiting in Infants. 2020 [internet publication].[Full Text]

            • 18. Blanch AJ, Perel SB, Acworth JP. Paediatric intussusception: epidemiology and outcome. Emerg Med Australas. 2007 Feb;19(1):45-50.[Abstract]

            • 19. Plut D, Phillips GS, Johnston PR, et al. Practical imaging strategies for intussusception in children. AJR Am J Roentgenol. 2020 Dec;215(6):1449-63.[Abstract][Full Text]

            • 20. American Academy of Pediatrics. Ten things physicians and patients should question. Choosing Wisely, an initiative of the ABIM Foundation. 2022 [internet publication].​[Full Text]

            • 21. Sorantin E, Lindbichler F. Management of intussusception. Eur Radiol. 2004 Mar;14(suppl 4):L146-54.[Abstract]

            • 22. del-Pozo G, Albillos JC, Tejedor D, et al. Intussusception in children: current concepts in diagnosis and enema reduction. Radiographics. 1999 Mar-Apr;19(2):299-319.[Abstract][Full Text]

            • 23. Gluckman S, Karpelowsky J, Webster AC, et al. Management for intussusception in children. Cochrane Database Syst Rev. 2017 Jun 1;6:CD006476.[Abstract]

            • 24. Tsou PY, Wang YH, Ma YK, et al. Accuracy of point-of-care ultrasound and radiology-performed ultrasound for intussusception: a systematic review and meta-analysis. Am J Emerg Med. 2019 Sep;37(9):1760-9.[Abstract][Full Text]

            • 25. Khasawneh R, El-Heis M, Al-Omari M, et al. The radiological characteristics of childhood intussusception including unusual features and rare pathological lead points. Heliyon. 2021 Jun;7(6):e07231.[Abstract][Full Text]

            • 26. Lim HK, Bae SH, Lee KH, et al. Assessment of reducibility of ileocolic intussusception in children: usefulness of color doppler sonography. Radiology. 1994 Jun;191(3):781-5.[Abstract][Full Text]

            • 27. Daneman A, Navarro O. Intussusception. Part 1: a review of diagnostic approaches. Pediatr Radiol. 2003 Feb;33(2):79-85.[Abstract]

            • 28. American College of Radiology. ACR-SPR practice parameter for the performance of pediatric fluoroscopic contrast enema examinations. 2021 [internet publication].[Full Text]

            • 29. Kelley-Quon LI, Arthur LG, Williams RF, et al. Management of intussusception in children: a systematic review. J Pediatr Surg. 2021 Mar;56(3):587-96.[Abstract][Full Text]

            • 30. Hwang J, Yoon HM, Kim PH, et al. Current diagnosis and image-guided reduction for intussusception in children. Clin Exp Pediatr. 2023 Jan;66(1):12-21.[Abstract][Full Text]

            • 31. Beres AL, Baird R. An institutional analysis and systematic review with meta-analysis of pneumatic versus hydrostatic reduction for pediatric intussusception. Surgery. 2013 Aug;154(2):328-34.[Abstract]

            • 32. Beasley SW. The 'ins' and 'outs' of intussusception: Where best practice reduces the need for surgery. J Paediatr Child Health. 2017 Nov;53(11):1118-1122.[Abstract][Full Text]

            • 33. Xie X, Wu Y, Wang Q, et al. A randomized trial of pneumatic reduction versus hydrostatic reduction for intussusception in pediatric patients. J Pediatr Surg. 2018 Aug;53(8):1464-1468.[Abstract][Full Text]

            • 34. Flaum V, Schneider A, Gomes Ferreira C, et al. Twenty years' experience for reduction of ileocolic intussusceptions by saline enema under sonography control. J Pediatr Surg. 2016 Jan;51(1):179-82.[Abstract][Full Text]

            • 35. Kia KF, Mony VK, Drongowski RA, et al. Laparoscopic vs open surgical approach for intussusception requiring operative intervention. J Pediatr Surg. 2005 Jan;40(1):281-4.[Abstract]

            • 36. van der Laan M, Bax NM, van der Zee DC, et al. The role of laparoscopy in the management of childhood intussusception. Surg Endosc. 2001 Apr;15(4):373-6.[Abstract]

            • 37. Daneman A, Navarro O. Intussusception. Part 2: an update on the evolution of management. Pediatr Radiol. 2004 Feb;34(2):97-108.[Abstract]

            • 38. Beres AL, Baird R, Fung E, et al. Comparative outcome analysis of the management of pediatric intussusception with or without surgical admission. J Pediatr Surg. 2014 May;49(5):750-2.[Abstract]

            • 39. Gray MP, Li SH, Hoffmann RG, et al. Recurrence rates after intussusception enema reduction: a meta-analysis. Pediatrics. 2014 Jul;134(1):110-9.[Abstract]

            • 40. Ugwu BT, Legbo JN, Dakum NK, et al. Childhood intussusception: a 9-year review. Ann Trop Pediatr. 2000 Jun;20(2):131-5.[Abstract]

            • 41. Yehouenou Tessi RT, El Haddad S, Oze KR, et al. A child's acute intestinal intussusception and literature review. Glob Pediatr Health. 2021;8:2333794X211059110.[Abstract][Full Text]

            • 42. Stringer MD, Pablot SM, Brereton RJ. Paediatric intussusception. Br J Surg. 1992 Sep;79(9):867-6.[Abstract]

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