Highlights & Basics
- Pyloric stenosis is a benign condition associated with recurrent projectile nonbilious vomiting, typically in a 2- to-12-week-old male infant.
- Features may include a history of feeding intolerance with multiple formula changes.
- Failure to thrive/weight loss may progress to increasing volume depletion. An olive-shaped mass may be palpable in the right upper abdomen.
- Ultrasound shows pyloric channel length >15 mm and pyloric muscle thickness >3 mm.
- Treatment is with intravenous fluid and electrolyte replacement, followed by pyloromyotomy (open or laparascopic).
Quick Reference
History & Exam
Key Factors
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Diagnostics Tests
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Definition
Epidemiology
Etiology
Pathophysiology
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Citations
Aspelund G, Langer JC. Current management of hypertrophic pyloric stenosis. Semin Pediatr Surg. 2007 Feb;16(1):27-33.[Abstract]
Expert Panel on Pediatric Imaging., Alazraki AL, Rigsby CK, et al. ACR Appropriateness Criteria® Vomiting in infants. J Am Coll Radiol. 2020 Nov;17(11s):S505-S515.[Abstract][Full Text]
Staerkle RF, Lunger F, Fink L, et al. Open versus laparoscopic pyloromyotomy for pyloric stenosis. Cochrane Database Syst Rev. 2021 Mar 9;3:CD012827.[Abstract][Full Text]
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44. White MC, Langer JC, Don S, et al. Sensitivity and cost minimization analysis of radiology versus olive palpation for the diagnosis of hypertrophic pyloric stenosis. J Pediatr Surg. 1998 Jun;33(6):913-7.[Abstract]
45. Hulka F, Campbell TJ, Campbell JR, et al. Evolution in the recognition of infantile hypertrophic pyloric stenosis. Pediatrics. 1997 Aug;100(2):E9.[Abstract]
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47. Poon TS, Zhang AL, Cartmill T, et al. Changing patterns of diagnosis and treatment of infantile hypertrophic pyloric stenosis: a clinical audit of 303 patients. J Pediatr Surg. 1996 Dec;31(12):1611-5.[Abstract]
48. Touloukian RJ, Higgins E. The spectrum of serum electrolytes in hypertrophic pyloric stenosis. J Pediatr Surg. 1983 Aug;18(4):394-7.[Abstract]
49. Expert Panel on Pediatric Imaging., Alazraki AL, Rigsby CK, et al. ACR Appropriateness Criteria® Vomiting in infants. J Am Coll Radiol. 2020 Nov;17(11s):S505-S515.[Abstract][Full Text]
50. Hernanz-Schulman M, Sells LL, Ambrosino MM, et al. Hypertrophic pyloric stenosis in the infant without a palpable olive: accuracy of sonographic diagnosis. Radiology. 1994 Dec;193(3):771-6.[Abstract]
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52. Iqbal CW, Rivard DC, Mortellaro VE, et al. Evaluation of ultrasonographic parameters in the diagnosis of pyloric stenosis relative to patient age and size. J Pediatr Surg. 2012 Aug;47(8):1542-7.[Abstract]
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63. Staerkle RF, Lunger F, Fink L, et al. Open versus laparoscopic pyloromyotomy for pyloric stenosis. Cochrane Database Syst Rev. 2021 Mar 9;3:CD012827.[Abstract][Full Text]
64. Lunger F, Staerkle RF, Muff JL, et al. Open versus laparoscopic pyloromyotomy for pyloric stenosis - a systematic review and meta-analysis. J Surg Res. 2022 Jun;274:1-8.[Abstract][Full Text]
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66. Hall NJ, Pacilli M, Eaton S, et al. Recovery after open versus laparoscopic pyloromyotomy for pyloric stenosis: a double-blind multicentre randomised controlled trial. Lancet. 2009 Jan 31;373(9661):390-8.[Abstract]
67. Danielson J, Svenningsson A, Jansson P, et al. Controlled long term outcome of pyloromyotomy for pyloric stenosis: no long-term adverse effect. J Pediatr Surg. 2022 Apr 18:S0022-3468(22)00277-9.[Abstract][Full Text]
68. Yamataka A, Tsukada K, Yokoyama-Laws Y, et al. Pyloromyotomy versus atropine sulfate for infantile hypertrophic pyloric stenosis. J Pediatr Surg. 2000 Feb;35(2):338-41.[Abstract]
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70. Lukac M, Antunovic SS, Vujovic D, et al. Is abandonment of nonoperative management of hypertrophic pyloric stenosis warranted? Eur J Pediatr Surg. 2013 Feb;23(1):80-4.[Abstract]
71. Hayashi AH, Giacomantonio JM, Lau HY, et al. Balloon catheter dilatation for hypertrophic pyloric stenosis. J Pediatr Surg. 1990 Nov;25(11):1119-21.[Abstract]
72. Miozzari HH, Tonz M, von Vigier RO, et al. Fluid resuscitation in infantile hypertrophic pyloric stenosis. Acta Paediatr. 2001 May;90(5):511-4.[Abstract]
73. Bertozzi M, Prestipino M, Nardi N, et al. Preliminary experience with a new approach for infantile hypertrophic pyloric stenosis: the single-port, laparoscopic-assisted pyloromyotomy. Surg Endosc. 2011 Jun;25(6):2039-43.[Abstract]
74. Yu LJ, Su BL, Shan WY, et al. Single-site umbilical laparoscopic pyloromyotomy using a pyloric electrocoagulation chisel combined with a left-handed main operation for congenital hypertrophic pyloric stenosis. J Laparoendosc Adv Surg Tech A. 2020 Nov;30(11):1248-52.[Abstract][Full Text]
75. Ji Y, Lai X, Xu Z. Transumbilical single-site two incision laparoscopic pyloromyotomy for pediatric hypertrophic pyloric stenosis. BMC Surg. 2022 Jun 7;22(1):218.[Abstract]
76. Papadakis K, Chen EA, Luks FI, et al. The changing presentation of pyloric stenosis. Am J Emerg Med. 1999 Jan;17(1):67-9.[Abstract]
77. Flageole HH, Pemberton J. Post-operative impact of nasogastric tubes on length of stay in infants with pyloric stenosis (POINTS): a prospective randomized controlled pilot trial. J Pediatr Surg. 2015 Oct;50(10):1681-5.[Abstract]
78. Adibe OO, Nichol PF, Lim FY, et al. Ad libitum feeds after laparoscopic pyloromyotomy: a retrospective comparison with a standardized feeding regimen in 227 infants. J Laparoendosc Adv Surg Tech A. 2007 Apr;17(2):235-7.[Abstract]
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