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Diseases

Periorbital and orbital cellulitis

OVERVIEW

  • Highlights & Basics
  • Images

DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Periorbital cellulitis (also known as preseptal cellulitis) is an infective process occurring in the eyelid tissues superficial to (anterior to) the orbital septum. It is usually due to superficial tissue injury (e.g., insect bite or chalazion) or adjacent sinusitis.

  • Orbital cellulitis is an infective process affecting soft tissue within the orbit, posterior or deep to the orbital septum, not involving the globe. It is usually due to underlying bacterial sinusitis.

  • Periorbital cellulitis is of concern in children because it may be secondary to occult underlying bacterial sinusitis or, rarely, due to bacteremic spread from a primary infection (e.g., pneumonia), and may rapidly progress to orbital cellulitis in children.

  • Complications include subperiosteal abscess, cavernous sinus thrombosis, intracranial abscess, and subsequent loss of vision and/or death.

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

        More information...
      • Diagnostics Tests

          More information...
        • Treatment Options

            More information...

          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Images

          • Swollen and red left eyelid

            Swollen and red left eyelid

          • Coronal CT post contrast: opacified ethmoid and frontoethmoidal recess on the left side

            Coronal CT post contrast: opacified ethmoid and frontoethmoidal recess on the left side

          • Axial CT post contrast: opacified ethmoid and frontoethmoidal recess on the left side

            Axial CT post contrast: opacified ethmoid and frontoethmoidal recess on the left side

          Citations

            Key Articles

            • Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-7.[Abstract]

            • Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.[Abstract]

            • Hamed-Azzam S, AlHashash I, Briscoe D, et al. Common orbital infections ~ state of the art ~ Part I. J Ophthalmic Vis Res. 2018 Apr-Jun;13(2):175-82.[Abstract][Full Text]

            • American Academy of Ophthalmology. Orbital cellulitis​. Apr 2024 [internet publication].[Full Text]

            Referenced Articles

            • 1. Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-7.[Abstract]

            • 2. Hamed-Azzam S, AlHashash I, Briscoe D, et al. Common orbital infections ~ state of the art ~ part I. J Ophthalmic Vis Res. 2018 Apr-Jun;13(2):175-82.[Abstract][Full Text]

            • 3. Georgakopoulos CD, Eliopoulou MI, Stasinos S, et al. Periorbital and orbital cellulitis: a 10-year review of hospitalized children. Eur J Ophthalmol. 2010 Nov-Dec;20(6):1066-72.[Abstract]

            • 4. Ambati B, Ambati J, Azar N, et al. Periorbital and orbital cellulitis before and after the advent of Haemophilus influenzae type b vaccination. Ophthalmology. 2000;107:1450-3.[Abstract]

            • 5. Shih EJ, Chen JK, Tsai PJ, et al. Differences in characteristics, aetiologies, isolated pathogens, and the efficacy of antibiotics in adult patients with preseptal cellulitis and orbital cellulitis between 2000-2009 and 2010-2019. Br J Ophthalmol. 2023 Mar;107(3):331-6.[Abstract]

            • 6. Murphy C, Livingstone I, Foot B, et al. Orbital cellulitis in Scotland: current incidence, aetiology, management and outcomes. Br J Ophthalmol. 2014 Nov;98(11):1575-8.[Abstract]

            • 7. ​A. Soroudi, R. Casey, D. Pan, et al. An epidemiologic survey of orbital cellulitis. Invest Ophthalmol Vis Sci. 2003 May; 44(13):786.[Full Text]

            • 8. Bal M, Sanjay C, Vivek B, et al. Orbital cellulitis - incidence, management and outcome from coastal hospitals. J. Pediatr. Crit. CARE. 2019 May-Jun; 6(3): 25-30.[Full Text]

            • 9. Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-7.

            • 10. Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.[Abstract]

            • 11. Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006 Spring;46(2):57-68.

            • 12. Swift AC, Charlton G. Sinusitis and the acute orbit in children. J Laryngol Otol. 1990;104:213-216.[Abstract]

            • 13. Howe L, Jones NS. Guidelines for the management of periorbital cellulitis/abscess. Clin Otolaryngol Allied Sci. 2004;29:725-8.[Abstract]

            • 14. Miller JM, Binnicker MJ, Campbell S, et al. Guide to utilization of the microbiology laboratory for diagnosis of infectious diseases: 2024 update by the Infectious Diseases Society of America (IDSA) and the American Society for Microbiology (ASM). Clin Infect Dis. 2024 Mar 5:ciae104.[Abstract][Full Text]

            • 15. Leal SM Jr, Rodino KG, Fowler WC, et al. Practical guidance for clinical microbiology laboratories: diagnosis of ocular infections. Clin Microbiol Rev. 2021 Jun 16;34(3):e0007019.[Abstract][Full Text]

            • 16. Wald ER, Pang D, Milmoe GJ, et al. Sinusitis and its complications in the pediatric patient. Pediatr Clin North Am. 1981;28:777-796.[Abstract]

            • 17. Uzcategui N, Warman R, Smith A, et al. Clinical practice guidelines for the management of orbital cellulitis. J Pediatr Ophthalmol Strabismus. 1998;35:73-79.[Abstract]

            • 18. Rumelt S, Rubin PA. Potential sources for orbital cellulitis. Int Ophthalmol Clin. 1996;36:207-221.[Abstract]

            • 19. Hamed-Azzam S, AlHashash I, Briscoe D, et al. Common orbital infections ~ state of the art ~ Part I. J Ophthalmic Vis Res. 2018 Apr-Jun;13(2):175-82.[Abstract][Full Text]

            • 20. American Academy of Ophthalmology. Orbital cellulitis​. Apr 2024 [internet publication].[Full Text]

            • 21. Schramm VL, Myers EN, Kennerdell JS. Orbital complications of acute sinusitis: evaluation, management, and outcome. Otolaryngology. 1978;86:221-230.

            • 22. Dudin A, Othman A. Acute periorbital swelling: evaluation of management protocol. Pediatr Emerg Care. 1996;12:16-20.[Abstract]

            • 23. Patt BS, Manning SC. Blindness resulting from orbital complications of sinusitis. Otolaryngol Head Neck Surg. 1991;104:789-795.[Abstract]

            • 24. American College of Radiology. ACR appropriateness criteria: orbital imaging and visual loss - child. 2023​ [internet publication].[Full Text]

            • 25. Anwar MR, Mahant S, Agbaje-Ojo T, et al. Diagnostic test accuracy of ultrasound for orbital cellulitis: a systematic review. PLoS One. 2023;18(7):e0288011.[Abstract][Full Text]

            • 26. Yadalla D, Jayagayathri R, Padmanaban K, et al. Bacterial orbital cellulitis - a review. Indian J Ophthalmol. 2023 Jul;71(7):2687-93.[Abstract][Full Text]

            • 27. Moloney JR, Badham NJ, McRae A. The acute orbit: preseptal (periorbital) cellulitis, subperiosteal abscess and orbital cellulitis due to sinusitis. J Laryngol Otol Suppl. 1987;12:1-18.[Abstract]

            • 28. Ryan JT, Preciado DA, Bauman N, et al. Management of pediatric orbital cellulitis in patients with radiographic findings of subperiosteal abscess. Otolaryngol Head Neck Surg. 2009;140:907-911.[Abstract]

            • 29. Oxford LE, McClay J. Medical and surgical management of subperiosteal orbital abscess secondary to acute sinusitis in children. Int J Pediatr Otorhinolaryngol. 2006;70:1853-1861.[Abstract]

            • 30. Harris GJ. Subperiosteal abscess of the orbit. Age as a factor in the bacteriology and response to treatment. Ophthalmology. 1994;101:585-95.[Abstract]

            • 31. Wong SJ, Levi J. Management of pediatric orbital cellulitis: a systematic review. Int J Pediatr Otorhinolaryngol. 2018 Jul;110:123-9.[Abstract]

            • 32. Kornelsen E, Mahant S, Parkin P, et al. Corticosteroids for periorbital and orbital cellulitis. Cochrane Database Syst Rev. 2021 Apr 28;4(4):CD013535.[Abstract][Full Text]

            • 33. Kim BY, Bae JH. Role of systemic corticosteroids in orbital cellulitis: a meta-analysis and literature review. Braz J Otorhinolaryngol. 2022 Mar-Apr;88(2):257-62.[Abstract][Full Text]

            • 34. American Academy of Ophthalmology. Preseptal cellulitis​. Apr 2024 [internet publication].[Full Text]

            • 35. Tolhurst-Cleaver M, Evans J, Waterfield T, et al. Periorbital and orbital cellulitis in children: a survey of emergency physicians and analysis of clinical practice guidelines across the PERUKI network. Emerg Med J. 2022 Mar 9:emermed-2021-211713.[Abstract]

            • 36. British Society For Antimocrobial Chemotherapy. Paediatric pathways: pre-septal and postseptal (orbital) cellulitis pathway for children presenting to hospital​. 2021 [internet publication].[Full Text]

            • 37. Bae C, Bourget D. Periorbital Cellulitis. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019[Full Text]

            • 38. Danishyar A, Sergent SR. Orbital Cellulitis. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019[Full Text]

            • 39. ​University of California San Francisco. Infectious diseases management program: orbital cellulitis/abscess. Jul 2021 [internet publication].[Full Text]

            • 40. Kingsley J, Mehra P, Lawrence LE, et al. A randomized, double-blind, Phase 2 study to evaluate subjective and objective outcomes in patients with acute bacterial skin and skin structure infections treated with delafloxacin, linezolid or vancomycin. J Antimicrob Chemother. 2016 Mar;71(3):821-9.[Abstract][Full Text]

            • 41. Tirupathi R, Areti S, Salim SA, et al. Acute bacterial skin and soft tissue infections: new drugs in ID armamentarium. J Community Hosp Intern Med Perspect. 2019;9(4):310-313.[Abstract][Full Text]

            • 42. Boucher HW, Wilcox M, Talbot GH, et al. Once-weekly dalbavancin versus daily conventional therapy for skin infection. N Engl J Med. 2014 Jun 5;370(23):2169-79.[Abstract][Full Text]

            • 43. Corey GR, Kabler H, Mehra P, et al. Single-dose oritavancin in the treatment of acute bacterial skin infections. N Engl J Med. 2014 Jun 5;370(23):2180-90.[Abstract][Full Text]

            • 44. Lan SH, Lin WT, Chang SP, et al. Tedizolid Versus Linezolid for the Treatment of Acute Bacterial Skin and Skin Structure Infection: A Systematic Review and Meta-Analysis. Antibiotics (Basel). 2019 Sep 4;8(3):.[Abstract][Full Text]

            • 45. The Royal Childresn's Hospital Melbourne.​ Clinical practice guidelines: periorbital and orbital cellulitis. Dec 2021 [internet publication].[Full Text]

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