Highlights & Basics
- Bipolar disorder in children is an uncommon condition that becomes more frequent in teens, approaching the rate seen in adults.
- The adult criteria describe a disorder of fluctuating mood cycles, consisting of episodes of elevated mood and persistently increased activity or energy (mania) lasting at least 1 week, and episodes of lowered mood and activity (depression); an episode of mania is necessary for a diagnosis to be made.
- A serious illness with recurrent episodes, leading to considerable impairment and an increased risk of suicide.
- Diagnosis can be controversial, as criteria overlap with other childhood conditions such as ADHD and comorbid oppositional defiant disorder.
- First-line treatment for manic episodes is antipsychotic therapy or mood stabilizers; the evidence base in children and adolescents is small, and comes mostly from industry-supported trials.
Quick Reference
History & Exam
Key Factors
Other Factors
Diagnostics Tests
Treatment Options
Definition
Epidemiology
Etiology
Pathophysiology
Citations
McClellan J, Kowatch R, Findling RL, et al. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007 Jan;46(1):107-25.[Abstract][Full Text]
Kowatch RA, Fristad M, Birmaher B, et al. Treatment guidelines for children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005 Mar;44(3):213-35.[Abstract]
National Institute for Health and Care Excellence. Bipolar disorder: assessment and management. Dec 2023 [internet publication].[Full Text]
McClellan J, Kowatch R, Findling RL, et al. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007 Jan;46(1):107-25.[Abstract][Full Text]
1. Carlson GA, Weller EB. Phenomenology and treatment of bipolar I disorder in children: a critical review. In: Yatham LN, Maj M, eds. Bipolar disorder: clinical and neurobiological foundations. Chichester, UK: Wiley-Blackwell; 2010.
2. Roy AK, Lopes V, Klein RG. Disruptive mood dysregulation disorder: a new diagnostic approach to chronic irritability in youth. Am J Psychiatry. 2014 Sep;171(9):918-24.[Abstract][Full Text]
3. Axelson DA, Birmaher B, Findling RL, et al. Concerns regarding the inclusion of temper dysregulation disorder with dysphoria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. J Clin Psychiatry. 2011 Sep;72(9):1257-62.[Abstract][Full Text]
4. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.
5. Kessing LV, Vradi E, McIntyre RS, et al. Causes of decreased life expectancy over the life span in bipolar disorder. J Affect Disord. 2015 Jul 15;180:142-7.[Abstract]
6. Khazanov GK, Cui L, Merikangas KR, et al. Treatment patterns of youth with bipolar disorder: results from the National Comorbidity Survey-Adolescent Supplement (NCS-A). J Abnorm Child Psychol. 2015 Feb;43(2):391-400.[Abstract]
7. World Health Organization. The ICD-11 classification of mental, behavioural and neurodevelopment disorders: clinical descriptions and diagnostic guidelines. 2022 [internet publication].[Full Text]
8. Lewinsohn PM, Klein DN, Seeley JR. Bipolar disorders in a community sample of older adolescents: prevalence, phenomenology, comorbidity, and course. J Am Acad Child Adolesc Psychiatry. 1995 Apr;34(4):454-63.[Abstract]
9. Meltzer H, Gatward R, Goodman R, et al. The mental health of children and adolescents in Great Britain. London, UK: The Stationery Office; 2000.
10. Dubicka B, Carlson GA, Vail A, et al. Prepubertal mania: diagnostic differences between US and UK clinicians. Eur Child Adolesc Psychiatry. 2008 Apr;17(3):153-61.[Abstract]
11. Carlson GA, Bromet EJ, Sievers S. Phenomenology and outcome of subjects with early-and adult-onset psychotic mania. Am J Psychiatry. 2000 Feb;157(2):213-9.[Abstract]
12. Lázaro L, Castro-Fornieles J, de la Fuente JE, et al. Differences between prepubertal- versus adolescent-onset bipolar disorder in a Spanish clinical sample. Eur Child Adolesc Psychiatry. 2007 Dec;16(8):510-16.[Abstract]
13. Wozniak J, Biederman J, Kiely K, et al. Mania-like symptoms suggestive of childhood-onset bipolar disorder in clinically referred children. J Am Acad Child Adolesc Psychiatry. 1995 Jul;34(7):867-76.[Abstract]
14. McClellan JM, Hamilton JD. An evidence-based approach to an adolescent with emotional and behavioral dysregulation. J Am Acad Child Adolesc Psychiatry. 2006 Apr;45(4):489-93.[Abstract]
15. Wilens TE, Biederman J, Adamson JJ, et al. Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled study. Drug Alcohol Depend. 2008 Jun 1;95(3):188-98.[Abstract][Full Text]
16. Schaffer A, McIntosh D, Goldstein BI, et al. The CANMAT task force recommendations for the management of patients with mood disorders and comorbid anxiety disorders. Ann Clin Psychiatry. 2012 Feb;24(1):6-22.[Abstract]
17. Lee S, Tsang A, Kessler RC, et al. Rapid-cycling bipolar disorder: cross-national community study. Br J Psychiatry. 2010 Mar;196(3):217-25.[Abstract][Full Text]
18. McClellan J, Kowatch R, Findling RL, et al. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007 Jan;46(1):107-25.[Abstract][Full Text]
19. Merikangas KR, Lamers F. The 'true' prevalence of bipolar II disorder. Curr Opin Psychiatry. 2012 Jan;25(1):19-23.[Abstract]
20. Van Meter AR, Moreira AL, Youngstrom EA. Meta-analysis of epidemiologic studies of pediatric bipolar disorder. J Clin Psychiatry. 2011 Sep;72(9):1250-56.[Abstract]
21. Merikangas KR, Cui L, Kattan G, et al. Mania with and without depression in a community sample of US adolescents. Arch Gen Psychiatry. 2012 Sep;69(9):943-51.[Abstract]
22. Merikangas KR, Akiskal HS, Angst J, et al. Lifetime and 12-month prevalence of bipolar spectrum disorder in the national comorbidity survey replication. Arch Gen Psychiatry. 2007 May;64(5):543-52.[Abstract][Full Text]
23. Costello EJ, Angold A, Burns BJ, et al. The Great Smoky Mountains study of youth: goals, design, methods, and the prevalence of DSM-III-R disorders. Arch Gen Psychiatry. 1996 Dec;53(12):1129-36.[Abstract]
24. Soutullo CA, Chang KD, Diez-Suarez A, et al. Bipolar disorder in children and adolescents: international perspective on epidemiology and phenomenology. Bipolar Disord. 2005 Dec;7(6):497-506.[Abstract]
25. Carlson GA. Will the child with mania please stand up? Br J Psychiatry. 2011 Mar;198(3):171-2.[Abstract]
26. Biederman J, Faraone SV, Wozniak J, et al. Clinical correlates of bipolar disorder in a large, referred sample of children and adolescents. J Psychiatr Res. 2005 Nov;39(6):611-22.[Abstract]
27. Youngstrom EA, Duax J. Evidence-based assessment of pediatric bipolar disorder, Part I: base rate and family history. J Am Acad Child Adolesc Psychiatry. 2005 Jul;44(7):712-7.[Abstract]
28. Harrington R, Myatt T. Is preadolescent mania the same condition as adult mania? A British perspective. Biol Psychiatry. 2003 Jun 1;53(11):961-9.[Abstract]
29. Chan J, Stringaris A, Ford T. Bipolar disorder in children and adolescents recognised in the UK: a clinic-based study. Child Adolesc Ment Health. 2011 May;16(2):71-8.[Full Text]
30. Hassan A, Agha SS, Langley K, et al. Prevalence of bipolar disorder in children and adolescents with attention-deficit hyperactivity disorder. Br J Psychiatry. 2011 Mar;198(3):195-8.[Abstract][Full Text]
31. James A, Hoang U, Seagroatt V, et al. A comparison of American and English hospital discharge rates for pediatric bipolar disorder, 2000 to 2010. J Am Acad Child Adolesc Psychiatry. 2014 Jun;53(6):614-24.[Abstract][Full Text]
32. Mick E, Faraone SV. Family and genetic association studies of bipolar disorder in children. Child Adolesc Psychiatr Clin N Am. 2009 Apr;18(2):441-53;x.[Abstract]
33. Fullerton JM, Koller DL, Edenberg HJ, et al. Assessment of first and second degree relatives of individuals with bipolar disorder shows increased genetic risk scores in both affected relatives and young at-risk individuals. Am J Med Genet B Neuropsychiatr Genet. 2015 Oct;168(7):617-29.[Abstract][Full Text]
34. Meyer SE, Carlson GA, Wiggs EA, et al. A prospective high-risk study of the association among maternal negativity, apparent frontal lobe dysfunction, and the development of bipolar disorder. Dev Psychopathol. 2006 Spring;18(2):573-89.[Abstract]
35. Anand A, Koller DL, Lawson WB, et al. Genetic and childhood trauma interaction effect on age of onset in bipolar disorder: An exploratory analysis. J Affect Disord. 2015 Jul 1;179:1-5.[Abstract]
36. Pfeifer JC, Welge J, Strakowski SM, et al. Meta-analysis of amygdala volumes in children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008 Nov;47(11):1289-98.[Abstract]
37. Bitter SM, Mills NP, Adler CM, et al. Progression of amygdala volumetric abnormalities in adolescents after their first manic episode. J Am Acad Child Adolesc Psychiatry. 2011 Oct;50(10):1017-26.[Abstract]
38. Kim P, Thomas LA, Rosen BH, et al. Differing amygdala responses to facial expressions in children and adults with bipolar disorder. Am J Psychiatry. 2012 Jun;169(6):642-9.[Abstract][Full Text]
39. Wegbreit E, Cushman GK, Puzia ME, et al. Developmental meta-analyses of the functional neural correlates of bipolar disorder. JAMA Psychiatry. 2014 Aug;71(8):926-35.[Abstract][Full Text]
40. Garrett AS, Miklowitz DJ, Howe ME, et al. Changes in brain activation following psychotherapy for youth with mood dysregulation at familial risk for bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2015 Jan 2;56:215-20.[Abstract]
41. Geller B, Harms MP, Wang L, et al. Effects of age, sex, and independent life events on amygdala and nucleus accumbens volumes in child bipolar I disorder. Biol Psychiatry. 2009 Mar 1;65(5):432-7.[Abstract][Full Text]
42. Bearden CE, Soares JC, Klunder AD, et al. Three-dimensional mapping of hippocampal anatomy in adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2008 May;47(5):515-25.[Abstract][Full Text]
43. Singh MK, Chang KD, Chen MC, et al. Volumetric reductions in the subgenual anterior cingulate cortex in adolescents with bipolar I disorder. Bipolar Disord. 2012 Sep;14(6):585-96.[Abstract][Full Text]
44. Ladouceur CD, Almeida JR, Birmaher B, et al. Subcortical gray matter volume abnormalities in healthy bipolar offspring: potential neuroanatomical risk marker for bipolar disorder? J Am Acad Child Adolesc Psychiatry. 2008 May;47(5):532-9.[Abstract][Full Text]
45. McDonald C, Bullmore ET, Sham PC, et al. Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry. 2004 Oct;61(10):974-84.[Abstract][Full Text]
46. Rich BA, Fromm SJ, Berghorst LH, et al. Neural connectivity in children with bipolar disorder: impairment in the face emotion processing circuit. J Child Psychol Psychiatry. 2008 Jan;49(1):88-96.[Abstract][Full Text]
47. Chang K, Adleman NE, Dienes K, et al. Anomalous prefrontal-subcortical activation in familial pediatric bipolar disorder: a functional magnetic resonance imaging investigation. Arch Gen Psychiatry. 2004 Aug;61(8):781-92.[Abstract][Full Text]
48. Singh MK, Kelley RG, Chang KD, et al. Intrinsic amygdala functional connectivity in youth with bipolar I disorder. J Am Acad Child Adolesc Psychiatry. 2015 Sep;54(9):763-70.[Abstract]
49. Ladouceur CD, Diwadkar VA, White R, et al. Fronto-limbic function in unaffected offspring at familial risk for bipolar disorder during an emotional working memory paradigm. Dev Cogn Neurosci. 2013 Jul;5:185-96.[Abstract]
50. Olsavsky AK, Brotman MA, Rutenberg JG, et al. Amygdala hyperactivation during face emotion processing in unaffected youth at risk for bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2012 Mar;51(3):294-303.[Abstract]
51. Roybal DJ, Barnea-Goraly N, Kelley R, et al. Widespread white matter tract aberrations in youth with familial risk for bipolar disorder. Psychiatry Res. 2015 May 30;232(2):184-92.[Abstract]
52. Liu X, Akula N, Skup M, et al. A genome-wide association study of amygdala activation in youths with and without bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2010 Jan;49(1):33-41.[Abstract]
53. Pavuluri MN, Passarotti AM, Lu LH, et al. Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder: fMRI outcomes. Psychiatry Res. 2011 Jul 30;193(1):28-37.[Abstract]
54. Gigante AD, Bond DJ, Lafer B, et al. Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis. Bipolar Disord. 2012 Aug;14(5):478-87.[Abstract]
55. Pandey GN, Rizavi HS, Dwivedi Y, et al. Brain-derived neurotrophic factor gene expression in pediatric bipolar disorder: effects of treatment and clinical response. J Am Acad Child Adolesc Psychiatry. 2008 Sep;47(9):1077-85.[Abstract]
56. Mick E, Wozniak J, Wilens TE, et al. Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in children. BMC Psychiatry. 2009 Feb 4;9:2.[Abstract][Full Text]
57. Mitchell RH, Goldstein BI. Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review. J Am Acad Child Adolesc Psychiatry. 2014 Mar;53(3):274-96.[Abstract]
58. Mourão-Miranda J, Oliveira L, Ladouceur CD, et al. Pattern recognition and functional neuroimaging help to discriminate healthy adolescents at risk for mood disorders from low risk adolescents. PLoS One. 2012;7(2):e29482.[Abstract][Full Text]
59. Nieto RG, Castellanos FX. A meta-analysis of neuropsychological functioning in patients with early onset schizophrenia and pediatric bipolar disorder. J Clin Child Adolesc Psychol. 2011;40(2):266-80.[Abstract]
60. Sugranyes G, de la Serna E, Romero S, et al. Gray matter volume decrease distinguishes schizophrenia from bipolar offspring during childhood and adolescence. J Am Acad Child Adolesc Psychiatry. 2015 Aug;54(8):677-84.e2.[Abstract]
61. Birmaher B, Axelson D, Monk K, et al. Lifetime psychiatric disorders in school-aged offspring of parents with bipolar disorder: the Pittsburgh Bipolar Offspring study. Arch Gen Psychiatry. 2009 Mar;66(3):287-96.[Abstract][Full Text]
62. Nurnberger JI Jr, McInnis M, Reich W, et al. A high-risk study of bipolar disorder. Childhood clinical phenotypes as precursors of major mood disorders. Arch Gen Psychiatry. 2011 Oct;68(10):1012-20.[Abstract][Full Text]
63. Wozniak J, Faraone SV, Martelon M, et al. Further evidence for robust familiality of pediatric bipolar I disorder: results from a very large controlled family study of pediatric bipolar I disorder and a meta-analysis. J Clin Psychiatry. 2012 Oct;73(10):1328-34.[Abstract]
64. Duffy A, Horrocks J, Doucette S, et al. The developmental trajectory of bipolar disorder. Br J Psychiatry. 2014 Feb;204(2):122-8.[Abstract][Full Text]
65. James A, Wotton CJ, Duffy A, et al. Conversion from depression to bipolar disorder in a cohort of young people in England, 1999-2011: a national record linkage study. J Affect Disord. 2015 Oct 1;185:123-8.[Abstract]
66. Chen MH, Chen YS, Hsu JW, et al. Comorbidity of ADHD and subsequent bipolar disorder among adolescents and young adults with major depression: a nationwide longitudinal study. Bipolar Disord. 2015 May;17(3):315-22.[Abstract]
67. Leverich GS, McElroy SL, Suppes T, et al. Early physical and sexual abuse associated with an adverse course of bipolar illness. Biol Psychiatry. 2002 Feb 15;51(4):288-97.[Abstract]
68. Neria Y, Bromet EJ, Carlson GA, et al. Assaultive trauma and illness course in psychotic bipolar disorder: findings from the Suffolk county mental health project. Acta Psychiatr Scand. 2005 May;111(5):380-83.[Abstract]
69. Daruy-Filho L, Brietzke E, Lafer B, et al. Childhood maltreatment and clinical outcomes of bipolar disorder. Acta Psychiatr Scand. 2011 Dec;124(6):427-34.[Abstract]
70. Du Rocher Schudlich T, Youngstrom EA, Martinez M, et al. Physical and sexual abuse and early-onset bipolar disorder in youths receiving outpatient services: frequent, but not specific. J Abnorm Child Psychol. 2015 Apr;43(3):453-63.[Abstract]
71. Ritter PS, Höfler M, Wittchen HU, et al. Disturbed sleep as risk factor for the subsequent onset of bipolar disorder - data from a 10-year prospective-longitudinal study among adolescents and young adults. J Psychiatr Res. 2015 Sep;68:76-82.[Abstract]
72. Selten JP, Lundberg M, Rai D, et al. Risks for nonaffective psychotic disorder and bipolar disorder in young people with autism spectrum disorder: a population-based study. JAMA Psychiatry. 2015 May;72(5):483-9.[Abstract]
73. Duffy A. The nature of the association between childhood ADHD and the development of bipolar disorder: a review of prospective high-risk studies. Am J Psychiatry. 2012 Dec;169(12):1247-55.[Abstract]
74. Geller B, Tillman R, Bolhofner K, et al. Child bipolar I disorder: prospective continuity with adult bipolar I disorder; characteristics of second and third episodes; predictors of 8-year outcome. Arch Gen Psychiatry. 2008 Oct;65(10):1125-33.[Abstract][Full Text]
75. Kemner SM, Mesman E, Nolen WA, et al. The role of life events and psychological factors in the onset of first and recurrent mood episodes in bipolar offspring: results from the Dutch Bipolar Offspring Study. Psychol Med. 2015;45(12):2571-81.[Abstract]
76. Higier RG, Jimenez AM, Hultman CM, et al. Enhanced neurocognitive functioning and positive temperament in twins discordant for bipolar disorder. Am J Psychiatry. 2014 Nov 1;171(11):1191-8.[Abstract]
77. Tijssen MJ, van Os J, Wittchen HU, et al. Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study. Br J Psychiatry. 2010 Feb;196(2):102-8.[Abstract]
78. Parker G. Predicting onset of bipolar disorder from subsyndromal symptoms: a signal question? Br J Psychiatry. 2010 Feb;196(2):87-8.[Abstract]
79. Findling RL, Youngstrom EA, Fristad MA, et al. Characteristics of children with elevated symptoms of mania: the Longitudinal Assessment of Manic Symptoms (LAMS) study. J Clin Psychiatry. 2010 Dec;71(12):1664-72.[Abstract][Full Text]
80. Carlson GA, Meyer SE. Phenomenology and diagnosis of bipolar disorder in children, adolescents, and adults: complexities and developmental issues. Dev Psychopathol. 2006 Fall;18(4):939-69.[Abstract]
81. MacCabe JH, Lambe MP, Cnattingius S, et al. Excellent school performance at age 16 and risk of adult bipolar disorder: national cohort study. Br J Psychiatry. 2010 Feb;196(2):109-15.[Abstract]
82. Sullivan AE, Judd CM, Axelson DA, et al. Family functioning and the course of adolescent bipolar disorder. Behav Ther. 2012 Dec;43(4):837-47.[Abstract]
83. Luby J, Navsaria N. Pediatric bipolar disorder: evidence for prodromal states and early markers. J Child Psychol Psychiatry. 2010 Apr;51(4):459-71.[Abstract]
84. Miklowitz DJ, Schneck CD, Singh MK, et al. Early intervention for symptomatic youth at risk for bipolar disorder: a randomized trial of family-focused therapy. J Am Acad Child Adolesc Psychiatry. 2013 Feb;52(2):121-31.[Abstract]
85. Carlson GA, Meyer SE. Bipolar disorder. In: Dulcan M, ed. Dulcan's textbook of child and adolescent psychiatry. Arlington, VA: APP; 2010.
86. Duffy A, Alda M, Milin R, et al. A consecutive series of treated affected offspring of parents with bipolar disorder: is response associated with the clinical profile? Can J Psychiatry. 2007 Jun;52(6):369-76.[Abstract]
87. Frías Á, Palma C, Farriols N. Comorbidity in pediatric bipolar disorder: prevalence, clinical impact, etiology and treatment. J Affect Disord. 2015 Mar 15;174:378-89.[Abstract]
88. Rucklidge JJ. Retrospective parent report of psychiatric histories: do checklists reveal specific prodromal indicators for postpubertal-onset pediatric bipolar disorder? Bipolar Disord. 2008 Feb;10(1):56-66.[Abstract]
89. Carlson GA, Jensen PS, Findling RL, et al. Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conference. J Child Adolesc Psychopharmacol. 2003 Spring;13(1):13-27.[Abstract]
90. Kowatch RA, Youngstrom EA, Danielyan A, et al. Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord. 2005 Dec;7(6):483-96.[Abstract]
91. Fonseka TM, Swampillai B, Timmins V, et al. Significance of borderline personality-spectrum symptoms among adolescents with bipolar disorder. J Affect Disord. 2015 Jan 1;170:39-45.[Abstract]
92. MacKinnon DF, Pies R. Affective instability as rapid cycling: theoretical and clinical implications for borderline personality and bipolar spectrum disorders. Bipolar Disord. 2006 Feb;8(1):1-14.[Abstract][Full Text]
93. Brotman MA, Kassem L, Reising MM, et al. Parental diagnoses in youth with narrow phenotype bipolar disorder or severe mood dysregulation. Am J Psychiatry. 2007 Aug;164(8):1238-41.[Abstract]
94. Youngstrom E, Youngstrom JK, Starr M. Bipolar diagnoses in community mental health: Achenbach Child Behavior Checklist profiles and patterns of comorbidity. Biol Psychiatry. 2005 Oct 1;58(7):569-75.[Abstract]
95. Birmaher B, Axelson D, Strober M, et al. Clinical course of children and adolescents with bipolar spectrum disorders. Arch Gen Psychiatry. 2006 Feb;63(2):175-83.[Abstract][Full Text]
96. Van Meter A, Youngstrom EA, Youngstrom JK, et al. Examining the validity of cyclothymic disorder in a youth sample. J Affect Disord. 2011 Jul;132(1-2):55-63.[Abstract][Full Text]
97. Van Meter A, Youngstrom EA, Demeter C, et al. Examining the validity of cyclothymic disorder in a youth sample: replication and extension. J Abnorm Child Psychol. 2013 Apr;41(3):367-78.[Abstract]
98. Pavuluri MN, Birmaher B, Naylor MW. Pediatric bipolar disorder: a review of the past 10 years. J Am Acad Child Adolesc Psychiatry. 2005 Sep;44(9):846-71.[Abstract]
99. Romero S, Birmaher B, Axelson D, et al. Prevalence and correlates of physical and sexual abuse in children and adolescents with bipolar disorder. J Affect Disord. 2009 Jan;112(1-3):144-50.[Abstract]
100. Seymour KE, Pescosolido MF, Reidy BL, et al. Emotional face identification in youths with primary bipolar disorder or primary attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2013 May;52(5):537-46.e3.[Abstract]
101. Faraone SV, Biederman J, Mennin D, et al. Attention-deficit hyperactivity disorder with bipolar disorder: a familial subtype? J Am Acad Child Adolesc Psychiatry. 1997 Oct;36(10):1378-87.[Abstract]
102. Faraone SV, Biederman J, Monuteaux MC. Attention deficit hyperactivity disorder with bipolar disorder in girls: further evidence for a familial subtype? J Affect Disord. 2001 Apr;64(1):19-26.[Abstract]
103. Wozniak J, Biederman J, Mundy E, et al. A pilot family study of childhood-onset mania. J Am Acad Child Adolesc Psychiatry. 1995 Dec;34(12):1577-83.[Abstract]
104. van Os J, Jones P, Lewis G, et al. Developmental precursors of affective illness in a general population birth cohort. Arch Gen Psychiatry. 1997 Jul;54(7):625-31.[Abstract]
105. Sigurdsson E, Fombonne E, Sayal K, et al. Neurodevelopmental antecedents of early-onset bipolar affective disorder. Br J Psychiatry. 1999 Feb;174:121-7.[Abstract]
106. Dekker MC, Koot HM, van der Ende J, et al. Emotional and behavioral problems in children and adolescents with and without intellectual disability. J Child Psychol Psychiatry. 2002 Nov;43(8):1087-98.[Abstract]
107. Wozniak J, Biederman J, Faraone S, et al. Mania in children with pervasive developmental disorder revisited. J Am Acad Child Adolescent Psychiatry. 1997 Nov;36(11):1552-9.[Abstract]
108. Wozniak J, Biederman J, Kwon A, et al. How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlates. Biol Psychiatry. 2005 Oct 1;58(7):583-8.[Abstract]
109. Achenbach TM. Manual for the child behaviour checklist/4-18 and 1991 profile. Burlington, VT: Dept Psychiatry, University of Vermont; 1991.
110. Holtmann M, Buchmann AF, Esser G, et al. The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis. J Child Psychol Psychiatry 2011 Feb;52(2):139-47.[Abstract]
111. Freeman AJ, Youngstrom EA, Frazier TW, et al. Portability of a screener for pediatric bipolar disorder to a diverse setting. Psychol Assess. 2012 Jun;24(2):341-51.[Abstract][Full Text]
112. Pavuluri MN, Henry DB, Devineni B, et al. Child mania rating scale: development, reliability, and validity. J Am Acad Child Adolesc Psychiatry. 2006 May;45(5):550-60.[Abstract]
113. Fristad MA, Weller ER, Weller EB. The Mania Rating Scale (MRS): further reliability and validity studies with children. Ann Clin Psychiatry. 1995 Sep;7(3):127-32.[Abstract]
114. Saidinejad M, Duffy S, Wallin D, et al. The management of children and youth with pediatric mental and behavioral health emergencies. Pediatrics. 2023 Sep 1;152(3).[Abstract][Full Text]
115. Horowitz LM, Bridge JA, Teach SJ, et al. Ask Suicide-Screening Questions (ASQ): a brief instrument for the pediatric emergency department. Arch Pediatr Adolesc Med. 2012 Dec;166(12):1170-6.[Abstract][Full Text]
116. Gipson PY, Agarwala P, Opperman KJ, et al. Columbia-suicide severity rating scale: predictive validity with adolescent psychiatric emergency patients. Pediatr Emerg Care. 2015 Feb;31(2):88-94.[Abstract][Full Text]
117. Kowatch RA, Fristad M, Birmaher B, et al. Treatment guidelines for children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2005 Mar;44(3):213-35.[Abstract]
118. National Institute for Health and Care Excellence. Bipolar disorder: assessment and management. Dec 2023 [internet publication].[Full Text]
119. Goodwin GM, Haddad PM, Ferrier IN, et al. Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology. J Psychopharmacol. 2016 Jun;30(6):495-553.[Abstract][Full Text]
120. Goodwin FK, Jamison KR. Manic-depressive illness: bipolar disorders and recurrent depression. New York, NY: Oxford University Press; 2007:907-35.
121. Liu HY, Potter MP, Woodworth KY, et al. Pharmacologic treatments for pediatric bipolar disorder: a review and meta-analysis. J Am Acad Child Adolesc Psychiatry. 2011 Aug;50(8):749-62.e39.[Abstract]
122. Kowatch RA, Scheffer RE, Monroe E, et al. Placebo-controlled trial of valproic acid versus risperidone in children 3-7 years of age with bipolar I disorder. J Child Adolesc Psychopharmacol. 2015 May;25(4):306-13.[Abstract]
123. Lohr WD, Chowning RT, Stevenson MD, et al. Trends in atypical antipsychotics prescribed to children six years of age or less on Medicaid in Kentucky. J Child Adolesc Psychopharmacol. 2015 Jun;25(5):440-43.[Abstract][Full Text]
124. Nguyen HT, Sharma V, McIntyre RS. Teratogenesis associated with antibipolar agents. Adv Ther. 2009 Mar;26(3):281-94.[Abstract]
125. American Epilepsy Society. Position statement on the use of valproate by women of childbearing potential. Jun 2021 [internet publication].[Full Text]
126. Brohan E, Chowdhary N, Dua T, et al. The WHO mental health gap action programme for mental, neurological, and substance use conditions: the new and updated guideline recommendations. Lancet Psychiatry. 2023 Nov 16:S2215-0366(23)00370-X.[Abstract]
127. European Medicines Agency. New measures to avoid valproate exposure in pregnancy endorsed. Mar 2018 [internet publication].[Full Text]
128. Diav-Citrin O, Shechtman S, Tahover E, et al. Pregnancy outcome following in utero exposure to lithium: a prospective, comparative, observational study. Am J Psychiatry. 2014 Jul;171(7):785-94.[Abstract]
129. Malhi GS, Tanious M, Das P, et al. The science and practice of lithium therapy. Aust N Z J Psychiatry. 2012 Mar;46(3):192-211.[Abstract]
130. National Institute for Health and Care Excellence. Aripiprazole for treating moderate to severe manic episodes in adolescents with bipolar I disorder. Jul 2013 [internet publication].[Full Text]
131. McClellan J, Kowatch R, Findling RL, et al. Practice parameter for the assessment and treatment of children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2007 Jan;46(1):107-25.[Abstract][Full Text]
132. Findling RL, Nyilas M, Forbes RA, et al. Acute treatment of pediatric bipolar I disorder, manic or mixed episode, with aripiprazole: a randomized, double-blind, placebo-controlled study. J Clin Psychiatry. 2009 Oct;70(10):1441-51.[Abstract]
133. Haas M, DelBello MP, Pandina G, et al. Risperidone for the treatment of acute mania in children and adolescents with bipolar disorder: a randomized, double-blind, placebo-controlled study. Bipolar Disord. 2009 Nov;11(7):687-700.[Abstract]
134. Tohen M, Kryzhanovskaya L, Carlson G, et al. Olanzapine versus placebo in the treatment of adolescents with bipolar mania. Am J Psychiatry. 2007 Oct;164(10):1547-56.[Abstract]
135. Tramontina S, Zeni CP, Ketzer CR, et al. Aripiprazole in children and adolescents with bipolar disorder comorbid with attention-deficit/hyperactivity disorder: a pilot randomized clinical trial. J Clin Psychiatry. 2009 Apr 21;70(5):756-64.[Abstract]
136. Doey T. Aripiprazole in pediatric psychosis and bipolar disorder: a clinical review. J Affect Disord. 2012;138(suppl):S15-21.[Abstract]
137. Gentile S. Clinical usefulness of second-generation antipsychotics in treating children and adolescents diagnosed with bipolar or schizophrenic disorders. Paediatr Drugs. 2011 Oct 1;13(5):291-302.[Abstract]
138. Seida JC, Schouten JR, Boylan K, et al. Antipsychotics for children and young adults: a comparative effectiveness review. Pediatrics. 2012 Mar;129(3):e771-84.[Abstract]
139. Findling RL, Youngstrom EA, McNamara NK, et al. Double-blind, randomized, placebo-controlled long-term maintenance study of aripiprazole in children with bipolar disorder. J Clin Psychiatry. 2012 Jan;73(1):57-63.[Abstract]
140. Pathak S, Findling RL, Earley WR, et al. Efficacy and safety of quetiapine in children and adolescents with mania associated with bipolar I disorder: a 3-week, double-blind, placebo-controlled trial. J Clin Psychiatry. 2013 Jan;74(1):e100-09.[Abstract]
141. Brown R, Taylor MJ, Geddes J. Aripiprazole alone or in combination for acute mania. Cochrane Database Syst Rev. 2013 Dec 17;(12):CD005000.[Abstract][Full Text]
142. Zuddas A, Zanni R, Usala T. Second generation antipsychotics (SGAs) for non-psychotic disorders in children and adolescents: a review of the randomized controlled studies. Eur Neuropsychopharmacol. 2011 Aug;21(8):600-20.[Abstract]
143. McClellan JM, Werry JS. Evidence-based treatments in child and adolescent psychiatry: an inventory. J Am Acad Child Adolesc Psychiatry. 2003 Dec;42(12):1388-1400.[Abstract]
144. Findling RL, Robb A, McNamara NK, et al. Lithium in the acute treatment of bipolar I disorder: a double-blind, placebo-controlled study. Pediatrics. 2015 Nov;136(5):885-94.[Abstract]
145. Correll CU, Detraux J, De Lepeleire J, et al. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry. 2015 Jun;14(2):119-36.[Abstract][Full Text]
146. Malhi GS, Bell E, Bassett D, et al. The 2020 Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for mood disorders. Aust N Z J Psychiatry. 2021 Jan;55(1):7-117.[Abstract][Full Text]
147. Ben Amor L. Antipsychotics in pediatric and adolescent patients: a review of comparative safety data. J Affect Disord. 2012;138 Suppl:S22-30.[Abstract]
148. Fraguas D, Correll CU, Merchán-Naranjo J, et al. Efficacy and safety of second-generation antipsychotics in children and adolescents with psychotic and bipolar spectrum disorders: comprehensive review of prospective head-to-head and placebo-controlled comparisons. Eur Neuropsychopharmacol. 2011 Aug;21(8):621-45.[Abstract]
149. Hirschowitz J, Kolevzon A, Garakani A. The pharmacological treatment of bipolar disorder: the question of modern advances. Harv Rev Psychiatry. 2010 Sep-Oct;18(5):266-78.[Abstract]
150. Cipriani A, Hawton K, Stockton S, et al. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ. 2013 Jun 27;346:f3646.[Abstract][Full Text]
151. McClellan JM, Werry JS. Evidence-based treatments in child and adolescent psychiatry: an inventory. J Am Acad Child Adolesc Psychiatry. 2003 Dec;42(12):1388-400.[Abstract]
152. Geller B, Luby JL, Joshi P, et al. A randomized controlled trial of risperidone, lithium, or divalproex sodium for initial treatment of bipolar I disorder, manic or mixed phase, in children and adolescents. Arch Gen Psychiatry. 2012 May;69(5):515-28.[Abstract][Full Text]
153. Wagner KD, Redden L, Kowatch RA, et al. A double-blind, randomized, placebo-controlled trial of divalproex extended-release in the treatment of bipolar disorder in children and adolescents. J Am Acad Child Adolesc Psychiatry. 2009 May;48(5):519-32.[Abstract]
154. Pavuluri MN, Henry DB, Findling RL, et al. Double-blind randomized trial of risperidone versus divalproex in pediatric bipolar disorder. Bipolar Disord. 2010 Sep;12(6):593-605.[Abstract][Full Text]
155. Jochim J, Rifkin-Zybutz RP, Geddes J, et al. Valproate for acute mania. Cochrane Database Syst Rev. 2019 Oct 7;(10):CD004052.[Abstract][Full Text]
156. Yatham LN, Kennedy SH, Parikh SV, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018 Mar;20(2):97-170.[Abstract][Full Text]
157. Correll CU, Sheridan EM, DelBello MP. Antipsychotic and mood stabilizer efficacy and tolerability in pediatric and adult patients with bipolar I mania: a comparative analysis of acute, randomized, placebo-controlled trials. Bipolar Disord. 2010 Mar;12(2):116-41.[Abstract]
158. de Leon J, Santoro V, D'Arrigo C, et al. Interactions between antiepileptics and second-generation antipsychotics. Expert Opin Drug Metab Toxicol. 2012 Mar;8(3):311-34.[Abstract]
159. Vitiello B, Riddle MA, Yenokyan G, et al. Treatment moderators and predictors of outcome in the Treatment of Early Age Mania (TEAM) study. J Am Acad Child Adolesc Psychiatry. 2012 Sep;51(9):867-78.[Abstract][Full Text]
160. DelBello MP, Hanseman D, Adler CM, et al. Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode. Am J Psychiatry. 2007 Apr;164(4):582-90.[Abstract]
161. Sala R, Strober MA, Axelson DA, et al. Effects of comorbid anxiety disorders on the longitudinal course of pediatric bipolar disorders. J Am Acad Child Adolesc Psychiatry. 2014 Jan;53(1):72-81.[Abstract][Full Text]
162. Vasudev A, Macritchie K, Vasudev K, et al. Oxcarbazepine for acute affective episodes in bipolar disorder. Cochrane Database Syst Rev. 2011 Dec 7;(12):CD004857.[Abstract][Full Text]
163. Benson NM, Seiner SJ. Electroconvulsive therapy in children and adolescents: clinical indications and special considerations. Harv Rev Psychiatry. 2019 Nov/Dec;27(6):354-8.[Abstract]
164. Walter G, Rey JM, Mitchell PB. Practitioner review: electroconvulsive therapy in adolescents. J Child Psychol Psychiatry. 1999 Mar;40(3):325-34.[Abstract]
165. Pagsberg AK, Jeppesen P, Klauber DG, et al. Quetiapine extended release versus aripiprazole in children and adolescents with first-episode psychosis: the multicentre, double-blind, randomised tolerability and efficacy of antipsychotics (TEA) trial. Lancet Psychiatry. 2017 Aug;4(8):605-18.[Abstract]
166. Selle V, Schalkwijk S1, Vázquez GH, et al. Treatments for acute bipolar depression: meta-analyses of placebo-controlled, monotherapy trials of anticonvulsants, lithium and antipsychotics. Pharmacopsychiatry. 2014 Mar;47(2):43-52.[Abstract]
167. Taylor DM, Cornelius V, Smith L, et al. Comparative efficacy and acceptability of drug treatments for bipolar depression: a multiple-treatments meta-analysis. Acta Psychiatr Scand. 2014 Dec;130(6):452-69.[Abstract]
168. Vázquez GH, Holtzman JN, Tondo L, et al. Efficacy and tolerability of treatments for bipolar depression. J Affect Disord. 2015 Sep 1;183:258-62.[Abstract]
169. DelBello MP, Chang K, Welge JA, et al. A double-blind, placebo-controlled pilot study of quetiapine for depressed adolescents with bipolar disorder. Bipolar Disord. 2009 Aug;11(5):483-93.[Abstract]
170. Findling RL, Pathak S, Earley WR, et al. Efficacy and safety of extended-release quetiapine fumarate in youth with bipolar depression: an 8 week, double-blind, placebo-controlled trial. J Child Adolesc Psychopharmacol. 2014 Aug;24(6):325-35.[Abstract]
171. Detke HC, DelBello MP, Landry J, et al. Olanzapine/fluoxetine combination in children and adolescents with bipolar I depression: a randomized, double-blind, placebo-controlled trial. J Am Acad Child Adolesc Psychiatry. 2015 Mar;54(3):217-24.[Abstract]
172. DelBello MP, Goldman R, Phillips D, et al. Efficacy and safety of lurasidone in children and adolescents with bipolar I depression: a double-blind, placebo-controlled study. J Am Acad Child Adolesc Psychiatry. 2017 Dec;56(12):1015-25.[Abstract][Full Text]
173. Nierenberg AA. An analysis of the efficacy of treatments for bipolar depression. J Clin Psychiatry. 2008;69(suppl 5):4-8.[Abstract]
174. Cruz N, Sanchez-Moreno J, Torres F, et al. Efficacy of modern antipsychotics in placebo-controlled trials in bipolar depression: a meta-analysis. Int J Neuropsychopharmacol. 2010 Feb;13(1):5-14.[Abstract]
175. Sachs GS, Nierenberg AA, Calabrese JR, et al. Effectiveness of adjunctive antidepressant treatment for bipolar depression. N Engl J Med. 2007 Apr 26;356(17):1711-22.[Abstract][Full Text]
176. Sidor MM, Macqueen GM. Antidepressants for the acute treatment of bipolar depression: a systematic review and meta-analysis. J Clin Psychiatry. 2011 Feb;72(2):156-67.[Abstract]
177. Tamayo JM, Zarate CA Jr, Vieta E, et al. Level of response and safety of pharmacological monotherapy in the treatment of acute bipolar I disorder phases: a systematic review and meta-analysis. Int J Neuropsychopharmacol. 2010 Jul;13(6):813-32.[Abstract][Full Text]
178. Vieta E, Locklear J, Günther O, et al. Treatment options for bipolar depression: a systematic review of randomized, controlled trials. J Clin Psychopharmacol. 2010 Oct;30(5):579-90.[Abstract]
179. Bridge JA, Iyengar S, Salary CB, et al. Clinical response and risk for reported suicidal ideation and suicide attempts in pediatric antidepressant treatment: a meta-analysis of randomized controlled trials. JAMA. 2007 Apr 18;297(15):1683-96.[Abstract]
180. Cooper WO, Callahan ST, Shintani A, et al. Antidepressants and suicide attempts in children. Pediatrics. 2014 Feb;133(2):204-10.[Abstract][Full Text]
181. Nivoli AM, Colom F, Murru A, et al. New treatment guidelines for acute bipolar depression: a systematic review. J Affect Disord. 2011 Mar;129(1-3):14-26.[Abstract]
182. Sidor MM, MacQueen GM. An update on antidepressant use in bipolar depression. Curr Psychiatry Rep. 2012 Dec;14(6):696-704.[Abstract]
183. Carlson GA, Finch SJ, Fochtmann LJ, et al. Antidepressant-associated switches from depression to mania in severe bipolar disorder. Bipolar Disord. 2007 Dec;9(8):851-9.[Abstract]
184. Vázquez G, Tondo L, Baldessarini RJ. Comparison of antidepressant responses in patients with bipolar vs. unipolar depression: a meta-analytic review. Pharmacopsychiatry. 2011 Jan;44(1):21-6.[Abstract]
185. Safer DJ, Zito JM. Treatment-emergent adverse events from selective serotonin reuptake inhibitors by age group: children versus adolescents. J Child Adolesc Psychopharmacol. 2006 Feb-Apr;16(1-2):159-69.[Abstract]
186. Offidani E, Fava GA, Tomba E, et al. Excessive mood elevation and behavioral activation with antidepressant treatment of juvenile depressive and anxiety disorders: a systematic review. Psychother Psychosom. 2013;82(3):132-41.[Abstract][Full Text]
187. Goldsmith M, Singh M, Chang K. Antidepressants and psychostimulants in pediatric populations: is there an association with mania? Paediatr Drugs. 2011 Aug 1;13(4):225-43.[Abstract][Full Text]
188. Correll CU, Manu P, Olshanskiy V, et al. Cardiometabolic risk of second-generation antipsychotic medications during first-time use in children and adolescents. JAMA. 2009 Oct 28;302(16):1765-73.[Abstract][Full Text]
189. Panagiotopoulos C, Ronsley R, Elbe D, et al. First do no harm: promoting an evidence-based approach to atypical antipsychotic use in children and adolescents. J Can Acad Child Adolesc Psychiatry. 2010 May;19(2):124-37.[Abstract][Full Text]
190. Greenaway M, Elbe D. Focus on aripiprazole: a review of its use in child and adolescent psychiatry. J Can Acad Child and Adolesc Psychiatry. 2009 Aug;18(3):250-60.[Abstract][Full Text]
191. Ng F, Mammen OK, Wilting I, et al. The International Society for Bipolar Disorders (ISBD) consensus guidelines for the safety monitoring of bipolar disorder treatments. Bipolar Disord. 2009 Sep;11(6):559-95.[Abstract][Full Text]
192. Ho BC, Andreasen NC, Ziebell S, et al. Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia. Arch Gen Psychiatry. 2011 Feb;68(2):128-37.[Abstract][Full Text]
193. Findling RL, Drury SS, Jensen PS, et al. Practice parameter for the use of atypical antipsychotic medications in children and adolescents. 2011 [internet publication].[Full Text]
194. Cipriani A, Reid K, Young AH, et al. Valproic acid, valproate and divalproex in the maintenance treatment of bipolar disorder. Cochrane Database Syst Rev. 2013 Oct 17;(10):CD003196.[Abstract][Full Text]
195. Fristad MA, Verducci JS, Walters K, et al. Impact of multifamily psychoeducational psychotherapy in treating children aged 8 to 12 years with mood disorders. Arch Gen Psychiatry. 2009 Sep;66(9):1013-21.[Abstract][Full Text]
196. Miklowitz DJ, Axelson DA, Birmaher B, et al. Family-focused treatment for adolescents with bipolar disorder: results of a 2-year randomized trial. Arch Gen Psychiatry. 2008 Sep;65(9):1053-61.[Abstract][Full Text]
197. Miklowitz DJ, Efthimiou O, Furukawa TA, et al. Adjunctive psychotherapy for bipolar disorder: a systematic review and component network meta-analysis. JAMA Psychiatry. 2021 Feb 1;78(2):141-50.[Abstract][Full Text]
198. Goldstein TR, Fersch-Podrat RK, Rivera M, et al. Dialectical behavior therapy for adolescents with bipolar disorder: results from a pilot randomized trial. J Child Adolesc Psychopharmacol. 2015 Mar;25(2):140-9.[Abstract]
199. West AE, Jacobs RH, Westerholm R, et al. Child and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: pilot study of group treatment format. J Can Acad Child Adolesc Psychiatry. 2009 Aug;18(3):239-46.[Abstract][Full Text]
200. Inder ML, Crowe MT, Luty SE, et al. Randomized, controlled trial of Interpersonal and Social Rhythm Therapy for young people with bipolar disorder. Bipolar Disord. 2015 Mar;17(2):128-38.[Abstract]
201. Goldstein BI, Birmaher B, Carlson GA, et al. The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research. Bipolar Disord. 2017 Nov;19(7):524-43.[Abstract][Full Text]
202. Soh NL, Walter G, Baur L, et al. Nutrition, mood and behaviour: a review. Acta Neuropsychiatrica. 2009 Oct;21(5):214-27.[Full Text]
203. Gracious BL, Chirieac MC, Costescu S, et al. Randomized, placebo-controlled trial of flax oil in pediatric bipolar disorder. Bipolar Disord. 2010 Mar;12(2):142-54.[Abstract][Full Text]
204. Amminger GP, Schäfer MR, Papageorgiou K, et al, Long-chain omega-3 fatty acids for indicated prevention of psychotic disorders: a randomized, placebo-controlled trial. Arch Gen Psychiatry. 2010 Feb;67(2):146-54.[Abstract][Full Text]
205. Sikoglu EM, Navarro AA, Starr D, et al. Vitamin D3 supplemental treatment for mania in youth with bipolar spectrum disorders. J Child Adolesc Psychopharmacol. 2015 Jun;25(5):415-24.[Abstract]
206. Chun TH, Mace SE, Katz ER, et al. Evaluation and management of children and adolescents with acute mental health or behavioral problems. Part I: common clinical challenges of patients with mental health and/or behavioral emergencies. Pediatrics. 2016 Sep;138(3):e20161570.[Abstract][Full Text]
207. Chun TM, Mace SE, Katz ER, et al. Evaluation and management of children with acute mental health or behavioral problems. Part II: recognition of clinically challenging mental health related conditions presenting with medical or uncertain symptoms. 2016 Sep;138(3):e20161573.[Full Text]
208. Srinath S, Janardhan Reddy YC, Girimaji SR, et al. A prospective study of bipolar disorder in children and adolescents from India. Acta Psychiatr Scand. 1998 Dec;98(6):437-42.[Abstract]
209. Duffy A, Alda M, Kutcher S, et al. A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatment. J Clin Psychiatry. 2002 Dec;63(12):1171-8.[Abstract]
210. Birmaher B, Axelson D, Goldstein B, et al. Four-year longitudinal course of children and adolescents with bipolar spectrum disorders: the Course and Outcome of Bipolar Youth (COBY) study. Am J Psychiatry. 2009 Jul;166(7):795-804.[Abstract]
211. Birmaher B, Gill MK, Axelson DA, et al. Longitudinal trajectories and associated baseline predictors in youths with bipolar spectrum disorders. Am J Psychiatry. 2014 Sep;171(9):990-99.[Abstract][Full Text]
212. Birmaher B, Axelson D. Course and outcome of bipolar spectrum disorder in children and adolescents: a review of the existing literature. Dev Psychopathol. 2006 Fall;18(4):1023-35.[Abstract]
213. Bond DJ, Hadjipavlou G, Lam RW, et al. The Canadian Network for Mood and Anxiety Treatments (CANMAT) task force recommendations for the management of patients with mood disorders and comorbid attention-deficit/hyperactivity disorder. Ann Clin Psychiatry. 2012 Feb;24(1):23-37.[Abstract]
214. Holtzman JN, Miller S, Hooshmand F, et al. Childhood- compared to adolescent-onset bipolar disorder has more statistically significant clinical correlates. J Affect Disord. 2015 Jul 1;179:114-20.[Abstract]
215. Carlson GA, Potegal M, Margulies D, et al. Rages - what are they and who has them? J Child Adolesc Psychopharmacol. 2009 Jun;19(3):281-8.[Abstract]
216. Medici CR, Videbech P, Gustafsson LN, et al. Mortality and secular trend in the incidence of bipolar disorder. J Affect Disord. 2015 Sep 1;183:39-44.[Abstract]
217. Brent DA, Perper JA, Moritz G, et al. Psychiatric risk factors for adolescent suicide: a case-control study. J Am Acad Child Adolesc Psychiatry. 1993 May;32(3):521-9.[Abstract]
218. Halfon N, Labelle R, Cohen D, et al. Juvenile bipolar disorder and suicidality: a review of the last 10 years of literature. Eur Child Adolesc Psychiatry. 2013 Mar;22(3):139-51.[Abstract]
219. Moor S, Crowe M, Luty S, et al. Effects of comorbidity and early age of onset in young people with bipolar disorder on self harming behaviour and suicide attempts. J Affect Disord. 2012 Feb;136(3):1212-5.[Abstract]
220. Goldstein TR, Ha W, Axelson DA, et al. Predictors of prospectively examined suicide attempts among youth with bipolar disorder. Arch Gen Psychiatry. 2012 Nov;69(11):1113-22.[Abstract][Full Text]
221. Pavuluri MN, Passarotti AM, Harral EM, et al. An fMRI study of the neural correlates of incidental versus directed emotion processing in pediatric bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2009 Mar;48(3):308-19.[Abstract][Full Text]
222. Pavuluri MN, West A, Hill SK, et al. Neurocognitive function in pediatric bipolar disorder: 3-year follow-up shows cognitive development lagging behind healthy youths. J Am Acad Child Adolesc Psychiatry. 2009 Mar;48(3):299-307.[Abstract][Full Text]
223. Lera-Miguel S, Andrés-Perpiñá S, Fatjó-Vilas M, et al. Two-year follow-up of treated adolescents with early-onset bipolar disorder: changes in neurocognition. J Affect Disord. 2015 Feb 1;172:48-54.[Abstract]
224. Pavuluri MN, Henry DB, Nadimpalli SS, et al. Biological risk factors in pediatric bipolar disorder. Biol Psychiatry. 2006 Nov 1;60(9):936-41.[Abstract]
225. Correll CU, Carlson HE. Endocrine and metabolic adverse effects of psychotropic medications in children and adolescents. J Am Acad Child Adolesc Psychiatry. 2006 Jul;45(7):771-91.[Abstract]
226. Jewell L, Abtan R, Scavone A, et al. Preliminary evidence of disparities in physical activity among adolescents with bipolar disorder. Ment Health Phys Act. 2015 Apr;8:62-7.
227. Maayan L, Vakhrusheva J, Correll CU. Effectiveness of medications used to attenuate antipsychotic-related weight gain and metabolic abnormalities: a systematic review and meta-analysis. Neuropsychopharmacology. 2010 Jun;35(7):1520-30.[Abstract][Full Text]
228. Davanzo P, McCracken J. Mood stabilizers: lithium and anticonvulsants. In: Martin A, Scalhill LL, Charney DS, et al, eds. Pediatric psychopharmacology. New York, NY: Oxford University Press; 2003:309-27.
229. Guberman AH, Besag FM, Brodie MJ, et al. Lamotrigine-associated rash: risk/benefit considerations in adults and children. Epilepsia. 1999 Jul;40(7):985-91.[Abstract]
230. Birrell L, Newton NC, Teesson M, et al. Early onset mood disorders and first alcohol use in the general population. J Affect Disord. 2016 Aug;200:243-9.[Abstract]
231. Meyer SE, Carlson GA, Youngstrom E, et al. Long-term outcomes of youth who manifested the CBCL-Pediatric Bipolar Disorder phenotype during childhood and/or adolescence. J Affect Disord. 2009 Mar;113(3):227-35.[Abstract]
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