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Diseases

Persistent depressive disorder

OVERVIEW

  • Highlights & Basics
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DIAGNOSIS

  • Diagnostic Approach
  • Risk Factors
  • History & Exam
  • Tests
  • Differential Diagnosis
  • Criteria
  • Screening

TREATMENT

  • Tx Approach
  • Tx Options
  • Emerging Tx
  • Prevention

FOLLOW-UP

  • Overview
  • Complications

REFERENCES

  • Citations
  • Guidelines
  • Credits

PATIENT RESOURCES

  • Patient Instructions

Highlights & Basics

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Key Highlights
  • Persistent depressive disorder (PDD) includes common forms of depression, but lasting longer than acute major depressive disorder.

  • Frequently misdiagnosed because the correct criteria to diagnose this condition are often not applied. Affected patients have a depressed mood most of the day, for more days than not, for at least 2 years. While depressed, patients have at least 2 of: poor appetite/overeating, insomnia or hypersomnia, low energy/fatigue, low self-esteem, poor concentration or difficulty making decisions, or feelings of hopelessness. Symptoms do not remit for more than 2 months at a time.

  • Associated with significant functional impairment (including unemployment, difficulty establishing intimate relationships, greater healthcare utilization, greater utilization of public entitlements).

  • Patients may respond to pharmacotherapy, psychotherapy, or a combination of both.

  • Patients require a longer treatment period, more psychotherapy sessions, and/or higher doses of antidepressants compared with patients with acute forms of depression.

Quick Reference

  • History & Exam

    • Key Factors

      • Other Factors

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      • Diagnostics Tests

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        • Treatment Options

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          Definition

          Epidemiology

          Etiology

          Pathophysiology

          content by BMJ Group
          Last updated

          Citations

            Key Articles

            • American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.

            • Lam RW, Kennedy SH, Adams C, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) 2023 update on clinical guidelines for management of major depressive disorder in adults: réseau canadien pour les traitements de l'humeur et de l'anxiété (CANMAT) 2023 : mise à jour des lignes directrices cliniques pour la prise en charge du trouble dépressif majeur chez les adultes. Can J Psychiatry. 2024 Sep;69(9):641-87.[Abstract][Full Text]

            • National Institute for Health and Care Excellence. Depression in adults: treatment and management. Jun 2022 [internet publication].[Full Text]

            • Bauer M, Severus E, Köhler S, et al; World Federation of Societies of Biological Psychiatry Task Force on Unipolar Depressive Disorders. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of unipolar depressive disorders, part 2: maintenance treatment of major depressive disorder - update 2015. World J Biol Psychiatry. 2015 Feb;16(2):76-95.[Abstract][Full Text]

            Other Online Resources

            • Patient Health Questionnaire (PHQ-9)
            • Quick Inventory of Depressive Symptoms (QIDS)

            Referenced Articles

            • 1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 5th ed., text revision (DSM-5-TR). Washington, DC: American Psychiatric Publishing; 2022.

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